TRM - Bi, Ge, In, 6Li, Lu, Rh, Sc, Tb - Aqueous calibration solution ASTASOL® ASTASOL® INT-MIX4

Significance of the Topic

A reliable multi-element aqueous calibration standard is essential for ensuring accuracy and consistency in modern analytical chemistry. Such standards enable laboratories to validate instrument performance, compare results across techniques, and meet stringent quality requirements in research and industry.

Aims and Overview of the Document

This identification sheet provides a comprehensive description of ASTASOL® INT-MIX4, a traced reference material designed for quantitative analysis of eight elements. It outlines composition, certification, intended use, and handling instructions to support users in achieving high-confidence measurements.

Methodology and Instrumentation

The calibration solution is prepared gravimetrically from high-purity primary compounds under ISO Guide 31 guidelines. Concentrations are assigned at 100.0 mg/L for Bi, Ge, In, 6Li, Lu, Rh, Sc, and Tb, with expanded uncertainty (k=2) of ±0.5 mg/L at 20 °C. Traceability is established through a direct chain of calibrations and comparisons involving CRM AN series materials, ultimately linked to NIST SRMs.

Used Instrumentation

• Atomic Absorption Spectrometry (AAS) – flame and electrothermal modes
• Atomic Emission Spectrometry (AES)
• Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES)
• Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
• Molecular absorption and selected electroanalytical techniques for specialized applications

Main Results and Discussion

ASTASOL® INT-MIX4 demonstrates homogeneity and stability over its two-year shelf life when stored between 5–30 °C. Maximum trace impurities are below 0.2 mg/L total. Handling guidelines emphasize temperature control at 20 ± 0.5 °C before use, prevention of vapor losses, and avoidance of re-aliquoting to maintain integrity.

Benefits and Practical Applications

By providing a certified, multi-element reference matrix in dilute nitric acid, INT-MIX4 streamlines calibration workflows in environmental, pharmaceutical, and industrial laboratories. It supports cross-method validation and quality assurance in quantitative determination of trace metals.

Future Trends and Potential Uses

Emerging analytical demands include greater element coverage, lower uncertainty targets, and matrix-matched standards for complex sample types. Advances in instrument sensitivity and automation will drive development of customized multi-element solutions and integrated calibration protocols.

Conclusion

ASTASOL® INT-MIX4 is a robust, ISO-compliant reference material that underpins precise multi-element quantification. Its documented traceability, stability, and low impurity levels ensure confidence in diverse analytical applications.

References

• ISO Guide 31: Reference materials – Contents of certificates, labels and accompanying documentation.
• NIST Standard Reference Materials serving as the ultimate traceability anchors for CRM AN series.