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Structure Characterization and Differentiation of Biosimilar and Reference Products Using Unique Combination of Complementary Fragmentation Mechanisms

Posters | 2014 | Thermo Fisher Scientific | ASMSInstrumentation
LC/HRMS, LC/MS/MS, LC/Orbitrap, LC/MS
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
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Application Note Biotherapeutics and Biosimilars LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab Author Suresh Babu C.V. Agilent Technologies, Inc. Abstract The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products. This Application Note presents…
Key words
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Enhancing The Quality Of Peptide Mapping Separation For The Analysis Of PTM Application Note Biotherapeutics and Biosimilars Author Introduction Suresh Babu C.V. Post-translational modifications (PTMs) on proteins such as monoclonal antibodies (mAbs) are critical quality attributes (CQAs) that define the…
Key words
peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiodltmisr, dltmisrmab, mabeeeqynstr, eeeqynstrptms, ptmsdeamidated, deamidatedplus, plusdigest, digestmapping, mappingseparation, separationnonoxidized, nonoxidizedtryptic
An Integrated Workflow for Peptide Mapping of Monoclonal Antibodies Application Note Biotherapeutics and Biosimilars Authors Introduction David L. Wong Monoclonal antibodies (mAbs) represent one of the fastest growing classes of drugs in the pharmaceutical industry. As a protein drug, the…
Key words
peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowcharge, chargewere, weresequence, sequencenist, nistdigestion, digestiondiqmtqspstlsasvgdrvtitcsassr, diqmtqspstlsasvgdrvtitcsassrmtqspstlsasvgdrvtitcsassr
m a s s s p e c t r o m e t r y P PSB 126 Page 1 of 2 R O D U C S T U P P O R B T U L L…
Key words
etd, etdcid, cidscans, scansabundance, abundancerelative, relativeraw, rawpeptides, peptidesmerging, mergingmerged, mergedltq, ltqadjacent, adjacentdependent, dependentsearch, searchalternating, alternatingpeptide
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