Targeted MS quantitation - Controlled and accessed from anywhere (Thermo Scientific™ Chromeleon™ 7.4 software)

Importance of the Topic

Mass spectrometry underpins critical analyses in biopharma, environmental monitoring and food safety. A unified software platform streamlines data handling, enhances compliance and supports targeted quantitative workflows.

Objectives and Study Overview

Thermo Scientific Chromeleon 7.4 software is designed to centralize instrument control, method management and data processing for MS laboratories. It aims to connect users, instruments and data in a scalable server-based system with remote access and full compliance support.

Methodology and Instrumentation

Native control is provided for Thermo Scientific single and triple quadrupole and high-resolution accurate mass instruments. Central management of methods, templates and reports ensures consistency. The software supports targeted quantitation, screening, intact mass deconvolution, and multi-stage MSn workflows.

Key Results and Discussion

Deployment of Chromeleon 7.4 delivers a single software solution for LC, GC, IC, CE and quantitative MS applications. Users benefit from consistent workflows, remote operation, automated network failure protection and regulatory compliance (GxP, ISO, 21 CFR Part 11). Case studies demonstrate rapid SEC(UV)-MS screening, efficient multi-site data management, and high-throughput sample analysis with automatic target detection.

Benefits and Practical Applications

Users experience reduced training and administration effort, improved data integrity, and enhanced reporting capabilities. The software facilitates bioanalysis with automated system suitability testing, advanced deconvolution of intact proteins, HR multi-attribute methods, pollutant quantitation using isotope dilution, PFAS discovery workflows, and streamlined pesticide analysis.

Future Trends and Potential Uses

Future developments may include deeper integration with laboratory informatics, cloud-based deployment, AI-powered data interrogation, real-time reaction monitoring and expanded support for emerging therapeutic modalities such as modified oligonucleotides, lipid nanoparticles and viral vectors.

Conclusion

Chromeleon 7.4 redefines mass spectrometry laboratory operations by merging instrument control, data management and compliance into a single platform. It enhances efficiency, traceability and analytical performance across diverse applications.

Instrumentation

• Thermo Scientific single and triple quadrupole mass spectrometers
• Thermo Scientific high-resolution accurate mass instruments
• Integration with BioPharma Finder and Compound Discoverer software