Chromeleon 7 Chromatography Data System - From sample to report: Chromeleon CDS end-to-end workflow for bioanalysis

Význam tématu

Bioanalytical studies are essential for drug development, providing quantitative measurements of compounds and metabolites in biological matrices. The increasing complexity of therapeutic agents drives the adoption of high resolution accurate mass spectrometry and stringent regulatory compliance.

Cíle a přehled studie / článku

This article presents Thermo Scientific Chromeleon Chromatography Data System (CDS) as a unified software platform that integrates LC and MS control, data acquisition, processing, and reporting for bioanalysis workflows.

Použitá metodika a instrumentace

• High-performance liquid chromatography coupled with tandem quadrupole mass spectrometry (HPLC-MS/MS)
• High resolution accurate mass (HRAM) mass spectrometry
• Chromeleon CDS software platform, including eWorkflow procedures and SmartLink functionality
• Centralized database storage and networked workstation configuration
• Integration with Watson LIMS via out-of-the-box bi-directional gateway

Hlavní výsledky a diskuse

The Chromeleon CDS delivers comprehensive compliance features (GLP, GMP, 21 CFR Part 11) with audit trails and privilege-controlled tune applications for full traceability. Integrated MS and MS/MS processing offers interactive quantitation templates, QC tolerance tables, and clear pass/fail indications. Automated eWorkflow sequence creation minimizes errors and streamlines routine analyses, while SmartLink provides component-centric, tiled data review. Network scalability supports both stand-alone and enterprise deployments with remote instrument access and central data management.

Přínosy a praktické využití metody

• Single software solution reduces training time and enhances user familiarity
• End-to-end workflow ensures reproducibility and error reduction
• Built-in regulatory controls and audit support facilitate compliance
• Remote access capabilities enable flexible laboratory operations
• Seamless integration with Watson LIMS streamlines study management and reporting

Budoucí trendy a možnosti využití

As bioanalytical targets grow in complexity, demand for HRAM solutions and cloud-ready software will increase. Future developments may include AI-driven data analysis, real-time monitoring, enhanced LIMS integration, and expanded global network implementations to support multi-site bioanalysis workflows.

Závěr

Thermo Scientific Chromeleon CDS offers a scalable, compliant, and fully integrated bioanalysis workflow from sample to report. Its advanced features and enterprise capabilities position it as a future-proof solution for modern analytical laboratories.

Reference

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