Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOFApplications | 2020 | Agilent TechnologiesInstrumentationLC/TOF, LC/HRMS, LC/MS, LC/MS/MSIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordscapsid, counts, gene, viral, mass, peptide, charge, adeno, vector, deconvoluted, proteins, therapy, cqas, advancebio, iterative, aavs, ptms, aav, tof, virus, amu, feature, unmodified, sheath, retinal, vital, raw, acetylation, oxidation, associated, mapping, swarm, agilent, from, parameter, workflow, deamidation, vcap, molecule, gas, tics, runs, confirm, data, value, mobile, flow, temperature, characterization, acquisition
Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS
Optimizing Adeno-Associated Virus (AAV) Capsid Protein AnalysisUsing UPLC and UPLC-MSXimo Zhang, Stephan Koza, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■INTRODUCTIONAn optimized LC-MS solution for theRecombinant adeno-associated viruses (rAAVs) are the most widelyseparation and intact mass analysisused...
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Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies
Developing the analytics and analytical workflows supporting the analysisof the next generation of biotherapeutic and gene therapies.Scott J. Berger, Ph.D. and Ximo Zhang, Ph.D.Waters Lunch SeminarTuesday January 28, 2020WCBP 2020DiamondProgram Partner©2020 Waters Corporation. COMPANY CONFIDENTIAL1Ralph Waldo Emersonb. 1803 - d.1882©2020...
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LC/MS of Intact Adeno-Associated Virus Capsid Proteins for Rapid Confirmation of Product Identity
Application NoteLC/MS of Intact Adeno-AssociatedVirus Capsid Proteins for RapidConfirmation of Product IdentityAuthorBrian LiauAgilent Technologies, Inc.IntroductionAdeno-associated viruses (AAVs) are a promising new class of biotherapeuticcapable of treating a host of rare and intractable genetic diseases such as spinalmuscular atrophy and inherited...
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Purity and Identity Characterization of Adeno-Associated Virus Capsid Particles by Intact and Bottom-Up Based Liquid Chromatography-Mass Spectrometry Methods
Poster ReprintASMS 2020ThP 466Purity and IdentityCharacterization of AdenoAssociated Virus CapsidParticles by Intact and BottomUp Based LiquidChromatography-MassSpectrometry MethodsWendi A. Hale1, Dominique Garceau2,Tristan Cano2, Caitlin Jaeger2, RoyHegedus2, William Hermans2, NormanGarceau2, Christopher M. Colangelo11Agilent,Lexington, MA2LakePharma,Worcester, MAIntroductionAdeno-associated viruses (AAVs) are the main viralvectors for...
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