Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF | LabRulez LCMS
 

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Application NoteLC/MS of Intact Adeno-AssociatedVirus Capsid Proteins for RapidConfirmation of Product IdentityAuthorBrian LiauAgilent Technologies, Inc.IntroductionAdeno-associated viruses (AAVs) are a promising new class of biotherapeuticcapable of treating a host of rare and intractable genetic diseases such as spinalmuscular atrophy and inherited...
Key words
deconvoluted, deconvolutedamu, amucapsid, capsidaav, aavmass, massrresponse, rresponseadeno, adenocounts, countsvirus, virusacquisition, acquisitionfld, fldassociated, associatedprotein, proteintime, timemin
Poster ReprintASMS 2020ThP 466Purity and IdentityCharacterization of AdenoAssociated Virus CapsidParticles by Intact and BottomUp Based LiquidChromatography-MassSpectrometry MethodsWendi A. Hale1, Dominique Garceau2,Tristan Cano2, Caitlin Jaeger2, RoyHegedus2, William Hermans2, NormanGarceau2, Christopher M. Colangelo11Agilent,Lexington, MA2LakePharma,Worcester, MA IntroductionAdeno-associated viruses (AAVs) are the main viralvectors for...
Key words
capsid, capsidviral, viralspectrum, spectrumaavs, aavsswarm, swarmcqas, cqastherapy, therapyintact, intactptms, ptmsgene, geneautotune, autotunepeptide, peptideproteins, proteinstranslational, translationaladvancebiolc
Consumables Workflow Ordering GuideAdeno-Associated Virus IdentityConfirmation in Biopharma by LC/MSWhile adeno-associated viruses (AAVs) have their own unique set of critical qualityattributes, many of the traditional assays used to monitor more established proteinbased therapeutics can still be used. AAV capsids comprise...
Key words
capsid, capsidpeptide, peptidemapping, mappingadeno, adenoadvancebio, advancebioproteins, proteinsinfinitylab, infinitylabaav, aavintact, intactagilent, agilentvirus, viruscolumn, columnmobile, mobilecolumns, columnsquick
Application NoteBiopharma/PharmaAdeno-Associated VirusCharacterization with Agilent 6545XTAdvanceBio LC/Q-TOF and ProteinMetrics Byos SoftwareAuthorsWendi A. Hale andChristopher M. ColangeloAgilent Technologies Inc.Lexington, MA, USAMichelle EnglishProtein MetricsCupertino, CA, USAAbstractThis application note describes a workflow for the characterization of somecritical quality attributes (CQAs) of adeno-associated viruses...
Key words
byos, byosprotein, proteinvariant, variantiterative, iterativepeptide, peptideaavs, aavsreconstruction, reconstructionaav, aavsva, svametrics, metricsxle, xlemapping, mappingintact, intactamino, aminosequence
 

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Application NoteLC/MS of Intact Adeno-AssociatedVirus Capsid Proteins for RapidConfirmation of Product IdentityAuthorBrian LiauAgilent Technologies, Inc.IntroductionAdeno-associated viruses (AAVs) are a promising new class of biotherapeuticcapable of treating a host of rare and intractable genetic diseases such as spinalmuscular atrophy and inherited...
Key words
deconvoluted, deconvolutedamu, amucapsid, capsidaav, aavmass, massrresponse, rresponseadeno, adenocounts, countsvirus, virusacquisition, acquisitionfld, fldassociated, associatedprotein, proteintime, timemin
Poster ReprintASMS 2020ThP 466Purity and IdentityCharacterization of AdenoAssociated Virus CapsidParticles by Intact and BottomUp Based LiquidChromatography-MassSpectrometry MethodsWendi A. Hale1, Dominique Garceau2,Tristan Cano2, Caitlin Jaeger2, RoyHegedus2, William Hermans2, NormanGarceau2, Christopher M. Colangelo11Agilent,Lexington, MA2LakePharma,Worcester, MA IntroductionAdeno-associated viruses (AAVs) are the main viralvectors for...
Key words
capsid, capsidviral, viralspectrum, spectrumaavs, aavsswarm, swarmcqas, cqastherapy, therapyintact, intactptms, ptmsgene, geneautotune, autotunepeptide, peptideproteins, proteinstranslational, translationaladvancebiolc
Consumables Workflow Ordering GuideAdeno-Associated Virus IdentityConfirmation in Biopharma by LC/MSWhile adeno-associated viruses (AAVs) have their own unique set of critical qualityattributes, many of the traditional assays used to monitor more established proteinbased therapeutics can still be used. AAV capsids comprise...
Key words
capsid, capsidpeptide, peptidemapping, mappingadeno, adenoadvancebio, advancebioproteins, proteinsinfinitylab, infinitylabaav, aavintact, intactagilent, agilentvirus, viruscolumn, columnmobile, mobilecolumns, columnsquick
Application NoteBiopharma/PharmaAdeno-Associated VirusCharacterization with Agilent 6545XTAdvanceBio LC/Q-TOF and ProteinMetrics Byos SoftwareAuthorsWendi A. Hale andChristopher M. ColangeloAgilent Technologies Inc.Lexington, MA, USAMichelle EnglishProtein MetricsCupertino, CA, USAAbstractThis application note describes a workflow for the characterization of somecritical quality attributes (CQAs) of adeno-associated viruses...
Key words
byos, byosprotein, proteinvariant, variantiterative, iterativepeptide, peptideaavs, aavsreconstruction, reconstructionaav, aavsva, svametrics, metricsxle, xlemapping, mappingintact, intactamino, aminosequence
 

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