Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF

Applications | 2020 | Agilent TechnologiesInstrumentation
Pharma & Biopharma
Agilent Technologies
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Application NoteLC/MS of Intact Adeno-AssociatedVirus Capsid Proteins for RapidConfirmation of Product IdentityAuthorBrian LiauAgilent Technologies, Inc.IntroductionAdeno-associated viruses (AAVs) are a promising new class of biotherapeuticcapable of treating a host of rare and intractable genetic diseases such as spinalmuscular atrophy and inherited...
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Poster ReprintASMS 2020ThP 466Purity and IdentityCharacterization of AdenoAssociated Virus CapsidParticles by Intact and BottomUp Based LiquidChromatography-MassSpectrometry MethodsWendi A. Hale1, Dominique Garceau2,Tristan Cano2, Caitlin Jaeger2, RoyHegedus2, William Hermans2, NormanGarceau2, Christopher M. Colangelo11Agilent,Lexington, MA2LakePharma,Worcester, MA IntroductionAdeno-associated viruses (AAVs) are the main viralvectors for...
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Consumables Workflow Ordering GuideAdeno-Associated Virus IdentityConfirmation in Biopharma by LC/MSWhile adeno-associated viruses (AAVs) have their own unique set of critical qualityattributes, many of the traditional assays used to monitor more established proteinbased therapeutics can still be used. AAV capsids comprise...
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Application NoteBiopharma/PharmaAdeno-Associated VirusCharacterization with Agilent 6545XTAdvanceBio LC/Q-TOF and ProteinMetrics Byos SoftwareAuthorsWendi A. Hale andChristopher M. ColangeloAgilent Technologies Inc.Lexington, MA, USAMichelle EnglishProtein MetricsCupertino, CA, USAAbstractThis application note describes a workflow for the characterization of somecritical quality attributes (CQAs) of adeno-associated viruses...
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byos, byosprotein, proteinvariant, variantpeptide, peptideiterative, iterativeaavs, aavsreconstruction, reconstructionaav, aavsva, svametrics, metricsxle, xlemapping, mappingintact, intactamino, aminosequence