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MethodsCalibratorsCalibrators containing cyclosporin A, everolimus, sirolimus, and tacrolimus in whole bloodwere purchased from Chromsystems Instruments & Chemicals GmbH (TABLE 1).Evaluation of Benchtop QuadrupoleOrbitrap Ultra-High-Resolution MassSpectrometer in Rapid QuantitativeAnalysisof ImmunosuppressantEvaluationof BenchtopQuadrupole Orbitrap Ultra-High-ResolutioDrugs in BloodSamplesImmunosuppressantDrugsin Blood SamplesTABLE 1. Concentrations of calibrators.Cal...
Key words
cyclosporin, cyclosporintacrolimus, tacrolimuseverolimus, everolimussirolimus, sirolimusimmunosuppressant, immunosuppressantquantifier, quantifierrelative, relativeanalyte, analyteabundance, abundanceblood, bloodascomycin, ascomycinorbitrap, orbitrappositive, positivequadrupole, quadrupoleclinical
A Robustness Study for theAgilent 6470 LC-MS/MS MassSpectrometerApplication NoteClinical ResearchAuthorsAbstractLinda Côté, Siji Joseph, SreelakshmyLong-term robustness studies were conducted on the Agilent 6470 LC-MS/MSMenon, and Kevin McCannmass spectrometer. Four common immunosuppressants in whole blood wereAgilent Technologies, Inc.used as a model system...
Key words
relative, relativesirolimus, sirolimuscyclosporin, cyclosporineverolimus, everolimustacrolimus, tacrolimusvariation, variationresponses, responsesstress, stresswere, weresets, setsblood, bloodconcentration, concentrationarea, areacalibration, calibrationthreshold
Rapid Analysis of Cyclosporine A,Everolimus, Sirolimus, and TacrolimusDrugs in Whole Blood Using anAgilent Triple Quadrupole LC/MS/MSSystem with Automated OnlineSample CleanupApplication NoteClinical ResearchAuthorsAbstractLinda Côté, Siji Joseph,A highly sensitive and specific analytical method has been developed forSreelakshmy Menon, andquantitation of a panel...
Key words
relative, relativetacrolimus, tacrolimusresponses, responsescyclosporin, cyclosporineverolimus, everolimussirolimus, sirolimusvariation, variationtac, tacwere, wereconcentration, concentrationwhole, wholeblood, bloodanalytes, analytesthreshold, thresholdcsa
Simultaneous Analysis of Tacrolimus,Sirolimus, Everolimus, andCyclosporin A in Whole Blood Usingthe Agilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteClinical ResearchAuthorsIntroductionKari E. Schlicht and Vaughn P. MillerAgilent Technologies, Inc.Wakefield, MA USAIn many clinical research laboratories, liquid chromatography-mass spectrometry(LC/MS) methods for the analysis of...
Key words
auc, auccyclosporin, cyclosporinrapidfire, rapidfiresirolimus, sirolimuseverolimus, everolimustacrolimus, tacrolimusqualifier, qualifierquantifier, quantifierprecision, precisionaccuracy, accuracywhole, wholemid, midquant, quantwere, wereblood
 

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MethodsCalibratorsCalibrators containing cyclosporin A, everolimus, sirolimus, and tacrolimus in whole bloodwere purchased from Chromsystems Instruments & Chemicals GmbH (TABLE 1).Evaluation of Benchtop QuadrupoleOrbitrap Ultra-High-Resolution MassSpectrometer in Rapid QuantitativeAnalysisof ImmunosuppressantEvaluationof BenchtopQuadrupole Orbitrap Ultra-High-ResolutioDrugs in BloodSamplesImmunosuppressantDrugsin Blood SamplesTABLE 1. Concentrations of calibrators.Cal...
Key words
cyclosporin, cyclosporintacrolimus, tacrolimuseverolimus, everolimussirolimus, sirolimusimmunosuppressant, immunosuppressantquantifier, quantifierrelative, relativeanalyte, analyteabundance, abundanceblood, bloodascomycin, ascomycinorbitrap, orbitrappositive, positivequadrupole, quadrupoleclinical
A Robustness Study for theAgilent 6470 LC-MS/MS MassSpectrometerApplication NoteClinical ResearchAuthorsAbstractLinda Côté, Siji Joseph, SreelakshmyLong-term robustness studies were conducted on the Agilent 6470 LC-MS/MSMenon, and Kevin McCannmass spectrometer. Four common immunosuppressants in whole blood wereAgilent Technologies, Inc.used as a model system...
Key words
relative, relativesirolimus, sirolimuscyclosporin, cyclosporineverolimus, everolimustacrolimus, tacrolimusvariation, variationresponses, responsesstress, stresswere, weresets, setsblood, bloodconcentration, concentrationarea, areacalibration, calibrationthreshold
Rapid Analysis of Cyclosporine A,Everolimus, Sirolimus, and TacrolimusDrugs in Whole Blood Using anAgilent Triple Quadrupole LC/MS/MSSystem with Automated OnlineSample CleanupApplication NoteClinical ResearchAuthorsAbstractLinda Côté, Siji Joseph,A highly sensitive and specific analytical method has been developed forSreelakshmy Menon, andquantitation of a panel...
Key words
relative, relativetacrolimus, tacrolimusresponses, responsescyclosporin, cyclosporineverolimus, everolimussirolimus, sirolimusvariation, variationtac, tacwere, wereconcentration, concentrationwhole, wholeblood, bloodanalytes, analytesthreshold, thresholdcsa
Simultaneous Analysis of Tacrolimus,Sirolimus, Everolimus, andCyclosporin A in Whole Blood Usingthe Agilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteClinical ResearchAuthorsIntroductionKari E. Schlicht and Vaughn P. MillerAgilent Technologies, Inc.Wakefield, MA USAIn many clinical research laboratories, liquid chromatography-mass spectrometry(LC/MS) methods for the analysis of...
Key words
auc, auccyclosporin, cyclosporinrapidfire, rapidfiresirolimus, sirolimuseverolimus, everolimustacrolimus, tacrolimusqualifier, qualifierquantifier, quantifierprecision, precisionaccuracy, accuracywhole, wholemid, midquant, quantwere, wereblood
 

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