MassHunter Study Manager for Ultivo LC/TQ - Quick Start Guide

Importance of the topic

MassHunter Study Manager for Ultivo LC/TQ offers an integrated solution to automate sample queue creation, execution and result handling for high-throughput liquid chromatography–tandem quadrupole mass spectrometry. By grouping samples and operations into standardized “studies,” laboratories can minimize manual intervention, improve data consistency and ensure compliance with industry workflows.

Objectives and Study Overview

The guide aims to introduce users to the Study Manager interface, describe how to configure study types (Worklist-Only, Worklist Import, Bioanalysis, Optimizer Automation), and demonstrate submission, execution and post-run tasks. Step-by-step exercises cover initial setup, study creation, queue management and result review.

Methodology and Instrumentation

The software interfaces with an Agilent Ultivo LC/TQ system via the MassHunter Workstation Data Acquisition program. Key components include:

• Home and Settings Ribbons for queue control and error handling
• Study Wizards to import or generate worklists from text, XML or Excel templates
• Automated plate assignment and file naming rules
• Optional Quantitative Analysis integration and report generation

Main Results and Discussion

Users can queue multiple studies, monitor real-time status, stop or resume runs on error, and reorder pending tasks. The interface logs each step, offers console locking for secure acquisition, and supports standby scripts for idle periods.

Benefits and Practical Applications

Implementing Study Manager accelerates method validation, routine QC, bioanalytical workflows and automated instrument optimization. Centralized study folders keep methods, worklists, data and reports together, simplifying audit trails and laboratory information management system (LIMS) integration.

Future Trends and Potential Applications

Advances may include cloud-based queue monitoring, AI-driven error resolution, further LIMS connectivity and expanded support for hybrid MS platforms. Enhanced compliance logging and real-time reporting dashboards will meet evolving regulatory demands.

Conclusion

MassHunter Study Manager for Ultivo LC/TQ delivers a unified framework for streamlined LC/TQ operations, reducing hands-on time, enhancing reproducibility and facilitating large-scale sample analyses in regulated and research environments.

Used Instrumentation

• Agilent Ultivo LC/TQ liquid chromatography–tandem quadrupole MS system
• Agilent MassHunter Workstation Study Manager and Data Acquisition software
• Agilent Quantitative Analysis and Reporting modules (optional)