Thermo Scientific TSQ Fortis triple quadrupole mass spectrometer

Význam tématu

In environmental, food safety, clinical research, forensic toxicology, pharmaceutical analysis, and QA/QC, reliable quantitation of analytes in complex matrices is critical. The TSQ Fortis triple quadrupole mass spectrometer with Active Ion Management Plus (AIM+) addresses these challenges by delivering robust, high-throughput, and sensitive quantitative performance for diverse workflows.

Cíle a přehled studie / článku

This article introduces the Thermo Scientific TSQ Fortis MS featuring AIM+ technology. It outlines the instrument’s design, core components, and software workflows, and evaluates its performance across multiple application areas including environmental monitoring, food safety, clinical and forensic toxicology, pharmaceutical quantitation, and routine QA/QC.

Použitá metodika a instrumentace

• TSQ Fortis triple quadrupole mass spectrometer with AIM+ (Matrix Separator Ion Guide, segmented quadrupoles, ion beam guide with neutral blocker)
• OptaMax NG ion source compatible with HESI and APCI (automated gas and voltage connections)
• Ion transfer tube and sweep cone for enhanced robustness and tool-free maintenance
• Data acquisition in Selected Reaction Monitoring (SRM) and High-Resolution SRM (H-SRM) at short dwell times
• Compatible liquid chromatography: Vanquish Flex/Horizon/Duo UHPLC, Transcend II (Multi-channel, TurboFlow), Prelude SPLC (Multiplexing, TurboFlow), Dionex Integrion HPIC
• Software: TraceFinder for quantitative workflows; Chromeleon CDS for instrument control and compliance; AppsLab method library; Almanac for remote system monitoring

Hlavní výsledky a diskuse

• Robustness: AIM+ and MSIG maintain a clean ion path, enabling extended uptime and reproducible results (e.g. cyclosporin A quantitation over 2000 injections within ±20%, CV = 3%).
• Throughput: Fast SRM capabilities support analysis of hundreds of samples per day and multi-analyte panels in complex matrices.
• Sensitivity: Segmented quadrupoles and optimized ion optics achieve trace-level detection for contaminants and pharmaceutical compounds at regulatory limits.
• Usability: Intuitive, template-driven software workflows streamline method development, maintenance, and routine analysis, reducing training requirements and downtime.

Přínosy a praktické využití metody

• Environmental & Food Safety: Accurate quantitation of pesticides, haloacetic acids, and other regulated contaminants at trace levels.
• Clinical & Forensic Toxicology: High-throughput screening of drugs and metabolites in biological samples with consistent performance under challenging conditions.
• Pharmaceutical QA/QC: Reliable measurement of small molecules and biopharma analytes in high-flow, high-throughput workflows.
• Laboratory Efficiency: Integrated software and remote monitoring enhance productivity and resource utilization in routine and specialized laboratories.

Budoucí trendy a možnosti využití

Future developments may involve machine learning–driven data processing, further miniaturization for on-site analysis, enhanced multiplexing and real-time method adaptation, and deeper integration with laboratory information management systems (LIMS).

Závěr

The Thermo Scientific TSQ Fortis MS with AIM+ represents a significant advancement in triple quadrupole mass spectrometry. Its robust hardware design, advanced ion management, and comprehensive software ecosystem deliver reliable, sensitive, and high-throughput quantitation across a wide range of analytical applications.

Reference

No references were provided in the original document.