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2030Conjugation Site (ADC)403203402035001010035020340CASE STUDY03OxfordMass Technologies200503303134000003130603029003060902700122702502402600122030240211100Driving Native Mass Spectrometry of MembraneProteins for Pharmaceutical Research018019001301401701801701801901600220131501900232002201702101202423021220200Deamidation20029070280301211025002409028030120100260100306080003390903060902702702003280280260101607029025003503031060350340301600033153401803500100151000 180 15015350140210150200New technology for advanced protein characterization190160170180180170190Oxford Mass Technologies (OMass)specializes in native mass spectrometrytons | participates in the immune reaction as the antibodyplatforms for multidimensional analysisypes: IgA,...
Key words
omass, omassnative, nativeprotein, proteinproteins, proteinsbinding, bindingmembrane, membranemass, massuhmr, uhmrtechnologies, technologiesdrug, drugmational, mationalresearch, researchbasic, basictechnology, technologypharmaceutical
Conformational Characterization of Calmodulin by Hydrogen DeuteriumExchange Mass SpectrometryJoomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing YuWaters Corporation, Milford, MA, U.S.A P P L I C AT I O N B E N E F I T...
Key words
deuterium, deuteriumcalmodulin, calmodulinhdx, hdxconformational, conformationalapo, apoholo, holoexchange, exchangeprotein, proteinhydrogen, hydrogenuptake, uptakepepsin, pepsinpep, pepcharacterization, characterizationnanoacquity, nanoacquityconformation
1PhDDile Holton,Colette Quin, PhD.1Characterizing Weak Binding Events with TwoAdvanced Biophysical Techniques: HydrogenDeuterium Exchange (HDX-MS) and DifferentialScanning Calorimetry (DSC)12AhnJoomi2Asish Chakraborty2Ying Qing Yu, PhD– TA Instruments, New Castle, DE;(A)Background:(B)2– Waters LLC, Milford, MA(C)(C)(D)The objective of this study was to probe the conformational...
Key words
hdx, hdxdsc, dscbinding, bindingweak, weakchanges, changesmutated, mutatedcalorimetry, calorimetrysites, sitesdeuterium, deuteriumvariant, variantstructure, structureahn, ahnasish, asishchakraborty, chakrabortyjoomi
LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRYJoomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang21Waters Corporation, 2 MedImmune, 3TA InstrumentsOVERVIEWSamples: 3 batches of humanized...
Key words
mutated, mutatedpeptide, peptidedeuterium, deuteriumhdx, hdxuptake, uptakeconformational, conformationalchanges, changesdeuteration, deuterationdynamx, dynamxplgs, plgscontrol, controlmhp, mhpsite, siteuptakes, uptakesdeuterated
 

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2030Conjugation Site (ADC)403203402035001010035020340CASE STUDY03OxfordMass Technologies200503303134000003130603029003060902700122702502402600122030240211100Driving Native Mass Spectrometry of MembraneProteins for Pharmaceutical Research018019001301401701801701801901600220131501900232002201702101202423021220200Deamidation20029070280301211025002409028030120100260100306080003390903060902702702003280280260101607029025003503031060350340301600033153401803500100151000 180 15015350140210150200New technology for advanced protein characterization190160170180180170190Oxford Mass Technologies (OMass)specializes in native mass spectrometrytons | participates in the immune reaction as the antibodyplatforms for multidimensional analysisypes: IgA,...
Key words
omass, omassnative, nativeprotein, proteinproteins, proteinsbinding, bindingmembrane, membranemass, massuhmr, uhmrtechnologies, technologiesdrug, drugmational, mationalresearch, researchbasic, basictechnology, technologypharmaceutical
Conformational Characterization of Calmodulin by Hydrogen DeuteriumExchange Mass SpectrometryJoomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing YuWaters Corporation, Milford, MA, U.S.A P P L I C AT I O N B E N E F I T...
Key words
deuterium, deuteriumcalmodulin, calmodulinhdx, hdxconformational, conformationalapo, apoholo, holoexchange, exchangeprotein, proteinhydrogen, hydrogenuptake, uptakepepsin, pepsinpep, pepcharacterization, characterizationnanoacquity, nanoacquityconformation
1PhDDile Holton,Colette Quin, PhD.1Characterizing Weak Binding Events with TwoAdvanced Biophysical Techniques: HydrogenDeuterium Exchange (HDX-MS) and DifferentialScanning Calorimetry (DSC)12AhnJoomi2Asish Chakraborty2Ying Qing Yu, PhD– TA Instruments, New Castle, DE;(A)Background:(B)2– Waters LLC, Milford, MA(C)(C)(D)The objective of this study was to probe the conformational...
Key words
hdx, hdxdsc, dscbinding, bindingweak, weakchanges, changesmutated, mutatedcalorimetry, calorimetrysites, sitesdeuterium, deuteriumvariant, variantstructure, structureahn, ahnasish, asishchakraborty, chakrabortyjoomi
LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRYJoomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang21Waters Corporation, 2 MedImmune, 3TA InstrumentsOVERVIEWSamples: 3 batches of humanized...
Key words
mutated, mutatedpeptide, peptidedeuterium, deuteriumhdx, hdxuptake, uptakeconformational, conformationalchanges, changesdeuteration, deuterationdynamx, dynamxplgs, plgscontrol, controlmhp, mhpsite, siteuptakes, uptakesdeuterated
 

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