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IMAGING MASS SPECTROMETRTY USING SYNAPT XSBindesh Shrestha and Roy MartinWaters Corporation, Beverly, MA, USAINTRODUCTIONDESI-MS SYSTEMDESI-MS IMAGESDESI IMAGE OVERLAYDESI IMAGING Minimal sample preparation Excels at lipid and small molecule imaging Complementary molecular profile to MALDI Ambient ionization sourceINFORMATICSMULTIDIMENSIONAL IMAGING♦ SONAR (scanning...
Key words
imaging, imagingdesi, desimolecular, molecularsonar, sonarmobility, mobilityhdmse, hdmsesynapt, synaptdia, diamaldi, maldiimage, imageoverlay, overlaybindesh, bindeshshrestha, shresthaspectrometrty, spectrometrtycomplementary
Utility of Desorption Electrospray Ionization(DESI) for Mass Spectrometry ImagingEmmanuelle Claude and Emrys JonesG OA LDESI imaging provides effective and meaningfulTo describe the DESI imaging technique asapplied to mass spectrometry imaging usingtime-of-flight (TOF) mass spectrometers, suchas the SYNAPT® G2-Si or the...
Key words
imaging, imagingdesi, desitissue, tissuestaining, staininghdi, hdigrant, grantvariety, varietymsi, msilocalization, localizationspatial, spatialmolecules, moleculesdesorption, desorptionlaser, laserdefinition, definitionioninze
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
[ TECHNOLOGY BRIEF ]Full Spectrum Molecular Imaging on the SYNAPT XS:Combined Imaging Techniques Yield Comprehensive ResultsEmmanuelle Claude, Mark Towers, and Joanne BallantyneWaters Corporation, Wilmslow, UKFeatures both fully integrated traditional MALDI andnew and improved DESI XS sources, providing a flexible,comprehensive, and...
Key words
imaging, imagingdesi, desisynapt, synaptmolecules, moleculesmaldi, maldimolecular, molecularhdi, hdispectrum, spectrumsmall, smalltechniques, techniquescomplementary, complementaryfsmi, fsmifull, fullbrief, briefsections
 

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IMAGING MASS SPECTROMETRTY USING SYNAPT XSBindesh Shrestha and Roy MartinWaters Corporation, Beverly, MA, USAINTRODUCTIONDESI-MS SYSTEMDESI-MS IMAGESDESI IMAGE OVERLAYDESI IMAGING Minimal sample preparation Excels at lipid and small molecule imaging Complementary molecular profile to MALDI Ambient ionization sourceINFORMATICSMULTIDIMENSIONAL IMAGING♦ SONAR (scanning...
Key words
imaging, imagingdesi, desimolecular, molecularsonar, sonarmobility, mobilityhdmse, hdmsesynapt, synaptdia, diamaldi, maldiimage, imageoverlay, overlaybindesh, bindeshshrestha, shresthaspectrometrty, spectrometrtycomplementary
Utility of Desorption Electrospray Ionization(DESI) for Mass Spectrometry ImagingEmmanuelle Claude and Emrys JonesG OA LDESI imaging provides effective and meaningfulTo describe the DESI imaging technique asapplied to mass spectrometry imaging usingtime-of-flight (TOF) mass spectrometers, suchas the SYNAPT® G2-Si or the...
Key words
imaging, imagingdesi, desitissue, tissuestaining, staininghdi, hdigrant, grantvariety, varietymsi, msilocalization, localizationspatial, spatialmolecules, moleculesdesorption, desorptionlaser, laserdefinition, definitionioninze
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
[ TECHNOLOGY BRIEF ]Full Spectrum Molecular Imaging on the SYNAPT XS:Combined Imaging Techniques Yield Comprehensive ResultsEmmanuelle Claude, Mark Towers, and Joanne BallantyneWaters Corporation, Wilmslow, UKFeatures both fully integrated traditional MALDI andnew and improved DESI XS sources, providing a flexible,comprehensive, and...
Key words
imaging, imagingdesi, desisynapt, synaptmolecules, moleculesmaldi, maldimolecular, molecularhdi, hdispectrum, spectrumsmall, smalltechniques, techniquescomplementary, complementaryfsmi, fsmifull, fullbrief, briefsections
 

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