Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS) Data Quality

Technical notes | 2020 | WatersInstrumentation
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Pressurized Online Pepsin Digestion of mAb IgG2 forHydrogen Deuterium Exchange Mass SpectrometryJing Fang, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAn enhanced-pressure (up to ~ 15,000 psi),Pepsin digestion is an integral part of hydrogen deuterium exchange masssustainable...
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digestion, digestionpepsin, pepsinchain, chainquench, quenchhdx, hdxdeuterium, deuteriumcoverage, coveragepeptides, peptidesheavy, heavybradykinin, bradykininsequence, sequencelight, lightredundancy, redundancyhold, holdpressure
Application NoteHydrogen Deuterium Exchange Coupledwith SELECT SERIES Cyclic IMS MassSpectrometer for Higher WorkflowEfficiencyLindsay Morrison, Malcolm Anderson, Alexandre GomesWaters CorporationFor research use only. Not for use in diagnostic procedures. AbstractHydrogen deuterium exchange is increasingly employed in the study of larger proteins and...
Key words
ims, imscyclic, cyclichdx, hdxracetrack, racetrackhydrogen, hydrogendeuterium, deuteriumselect, selectexchange, exchangeseries, seriessynapt, synaptundertaken, undertakenpeptides, peptidesadc, adcpeptide, peptideexperiments
PRESSURIZED ONLINE PEPSIN DIGESTION OF PROTEINS FOR HYDROGEN/DEUTERIUM EXCHANGEMASS SPECTROMETRYJing Fang, Ying Qing Yu, Rose Lawler, Keith Fadgen, Michael Eggertson, and Asish ChakrabortyWaters Corp., Milford, MA, USRESULTS AND DISCUSSIONINTRODUCTIONOnline pepsin digestion has been widely utilized in hydrogen/deuterium exchange massspectrometry (HDX...
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digestion, digestioncoverage, coveragepeptides, peptidesquench, quenchsequence, sequencedesalting, desaltingdeuterium, deuteriumbradykinin, bradykininexchange, exchangepepsin, pepsinhdx, hdxhold, holdnumber, numberdeuterated, deuteratedpressurized
HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTSWITH EXTENDED ION MOBILITY SEPARATIONAlexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1][1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA[2] Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9...
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hdx, hdxcyclic, cyclicpeptides, peptidesdeuterium, deuteriumims, imspeptide, peptidesynapt, synaptcoverage, coveragepepsin, pepsinphosb, phosbadc, adcsequence, sequenceexperiments, experimentsleap, leapmobility