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Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-MetaSite and WebMetabase

 

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ION MOBILITY-ENABLED METABOLITE IDENTIFICATION OF TIENILIC ACID AND TIENILIC ACID ISOMER Lauren Mullin1, Giorgis Isaac1, Ian Wilson2, Gordon Murray3, Nathan Anderson1, Robert Plumb1 1 Waters Corporation, 34 Maple St, Milford, MA 01757 Computational and Systems Medicine, Imperial College, London UK…
Key words
hydroxylation, hydroxylationtai, taitienilic, tienilicccs, ccsconjugation, conjugationglucuronidation, glucuronidationacetylation, acetylationmetabolites, metabolitesmetabolite, metabolitedealkylation, dealkylationcommon, commonthiophene, thiophenesvr, svrmethylation, methylationacid
[ APPLICATION NOTE ] Somatostatin Analogue Catabolite Screening and Identification Using Vion IMS QTof with WebMetabase Mark D. Wrona, 1 Jayne M. Kirk, 4 Ismael Zamora, 2 Tatiana Radchenko, 2 Anna Escola, 3 Antoni Riera, 3 Russell J. Mortishire-Smith4 Waters…
Key words
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[ APPLICATION NOTE ] Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, and Product Ion Confirmation Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ Ability to screen metabolism from The incorporation of unnatural amino acids,…
Key words
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ROUTINE METABOLITE IDENTIFICATION FOR COMPLEX PEPTIDES BASED ON IMS ENABLED QTOF DIA DATA ACQUISITION AND MASS-METASITE DATA PROCESSING Authors: Yun W. Alelyunas, Nathan Anderson, Mark D. Wrona Affiliations: Waters Corporation, Milford, MA, USA INTRODUCTION In therapeutic peptide drug discovery and…
Key words
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