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A WORKFLOW DRIVEN PLATFORM SOLUTION FOR MAM-BASED CRTICAL QUALITY ATTRIBUTE MONITORING OF BIOTHERAPEUTICS IN PROCESS DEVELOPMENT AND QC

 

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POSTER T1530-06-41 Simplifying workflows for MAM-based critical quality attribute monitoring of biotherapeutics in process development and QC using a novel LCMS platform Scott J Berger, Nilini Ranbaduge, Ying Qing Yu, Min Du, Weibin Chen Waters Corporation, Milford, MA CONTACT INFORMATION:…
Key words
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[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…
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PEPTIDE CHARACTERIZATION AND MONITORING WORKFLOW FOR BIOSIMILAR mAb DRUG PRODUCTS USING A COMPLIANCE READY LC-MS AND INFORMATICS PLATFORM 20221115_Remicade T0_200ng_03 2 TOF MSe (50 2000) 6V ESI (BPI) 1/2 20221115_Inflectra T0_200ng_12 2 TOF MSe (50 2000) 6V ESI (BPI) Kellen…
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[ TECHNOLOGY BRIEF ] Routine Peptide Mapping Analysis using the BioAccord System Nilini Ranbaduge, Henry Shion, and Ying Qing Yu Waters Corporation, Milford, MA, USA SmartMS-enabled BioAccord System improves the operational efficiency for routine peptide mapping analysis. GOAL Demonstrate how…
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