<p><strong>🎤Amanda Guiraldelli Mahr&nbsp;</strong></p><p><strong>Amanda shares insights from her work across small molecules, peptides, proteins, and biopharmaceuticals, including her experience with LC-MS, metabolomics, impurity analysis, and oligonucleotide therapeutics.</strong></p><h4><strong>What You’ll Learn in This Episode:</strong></h4><ul><li>What AQbD actually means (in simple terms)</li><li>How DOE differs from traditional one-factor-at-a-time experiments</li><li>Why modern labs are shifting toward predictive, data-driven method development</li><li>The biggest benefits of DOE: more insight with fewer experiments*</li><li>Real-world example: optimizing oligonucleotide impurity separations using AQbD&nbsp;</li><li>Key LC parameters that impact performance (pH, gradient, column, temperature)</li><li>Challenges of working with large molecules vs. small molecules</li><li>Tools and software for DOE and chromatographic modeling</li><li>How AI and modeling are shaping the future of chromatography</li></ul><blockquote><p><strong>Key Takeaway: </strong>“Shift your mindset from testing to understanding.”</p></blockquote><h4><strong>Who This Episode Is For:</strong></h4><ul><li>Undergraduate and graduate chemistry students</li><li>Analytical scientists and method developers</li><li>Pharma &amp; biopharma professionals</li><li>Anyone working with LC, LC-MS, or chromatography method development</li></ul><h3><strong>Video Transcription</strong></h3><p>In this episode of <i>Concentrating on Chromatography</i>, David interviews <strong>Amanda Guiraldelli Mahr</strong>, an analytical chemist whose career has spanned pharmaceuticals, metabolomics, regulatory science, mass spectrometry, and biopharmaceutical analysis. Amanda discusses her journey from pharmacy and biochemistry studies to working with chromatography and mass spectrometry in academic, regulatory, and industrial environments.</p><p>The conversation focuses on the growing role of <strong>Analytical Quality by Design (AQbD)</strong>, <strong>Design of Experiments (DOE)</strong>, predictive modeling, and the future integration of artificial intelligence into chromatographic method development. Amanda also shares practical insights into method development for small molecules, peptides, proteins, oligonucleotides, and emerging therapeutics.</p><h4><strong>Early Career and Introduction to Chromatography</strong></h4><p>Amanda's interest in analytical chemistry began during her studies in pharmacy and biochemistry. An internship focused on chromatography for botanical medicine analysis introduced her to separation science and inspired her to pursue a PhD in analytical chemistry.</p><p>During her doctoral research, she worked extensively with <strong>LC-MS-based metabolomics</strong>, which led her to explore experimental design approaches and method development strategies. Her passion for chromatography and mass spectrometry deepened further while working at the United States Pharmacopeia (USP), where she routinely applied chromatographic and mass spectrometric techniques to characterize:</p><ul><li>Small-molecule drug substances</li><li>Pharmaceutical ingredients</li><li>Dietary supplements</li><li>Botanical products</li><li>Peptides</li><li>Proteins</li></ul><p>Her work increasingly involved understanding chromatographic separation mechanisms through experimental design and modeling approaches.</p><h4><strong>Expanding into Proteomics, Nitrosamines, and Biopharmaceuticals</strong></h4><p>Amanda's scientific curiosity led her beyond traditional small-molecule analysis.</p><p>Throughout her career she gained experience in:</p><ul><li>High-resolution mass spectrometry</li><li>Structural elucidation</li><li>Proteomics</li><li>Bioanalysis</li><li>Trace impurity analysis</li><li>Nitrosamine monitoring</li><li>Oligonucleotide therapeutics</li><li>Large proteins and peptides</li></ul><p>She worked with advanced fragmentation techniques including:</p><ul><li>CID (Collision-Induced Dissociation)</li><li>HCD (Higher-Energy Collisional Dissociation)</li><li>UV Photodissociation</li></ul><p>Later, she became involved in developing highly sensitive LC-MS and GC-MS methods for monitoring <strong>nitrosamines</strong>, a major regulatory concern due to their genotoxic potential. She also trained regulatory agencies in mass spectrometry applications and method validation before moving into biopharmaceutical research and contract research activities focused on proteins, peptides, oligonucleotides, and RNA therapeutics.</p><h4><strong>What Does a Chromatographer Do Every Day?</strong></h4><p>When asked to summarize the day-to-day work of a chromatographer, Amanda highlighted three core activities:</p><ul><li>Designing experiments</li><li>Troubleshooting analytical methods</li><li>Interpreting unexpected results</li></ul><p>She emphasized that a large portion of her work involves data analysis and learning from experimental outcomes in order to optimize methods and better understand chromatographic behavior.</p><h4><strong>Understanding Analytical Quality by Design (AQbD)</strong></h4><p>One of the central topics of the discussion was <strong>Analytical Quality by Design (AQbD)</strong>.</p><p>Amanda describes AQbD as a systematic approach for understanding how analytical methods perform and identifying factors that influence method variability.</p><p>Key objectives of AQbD include:</p><ul><li>Identifying critical method parameters</li><li>Understanding sources of variability</li><li>Building robustness into methods from the beginning</li><li>Improving method reliability throughout its lifecycle</li></ul><p>Rather than correcting problems after implementation, AQbD focuses on proactively designing analytical procedures that consistently deliver high-quality results.</p><p>Amanda noted that AQbD principles are strongly linked to pharmaceutical quality frameworks established through ICH guidelines such as:</p><ul><li>ICH Q8 (Pharmaceutical Development)</li><li>ICH Q14 (Analytical Procedure Development)</li></ul><p>These guidelines have significantly influenced modern pharmaceutical method development practices.</p><h4><strong>AQbD vs. Traditional Trial-and-Error Development</strong></h4><p>Amanda contrasted AQbD with the traditional <strong>one-factor-at-a-time (OFAT)</strong> approach.</p><h5><strong>Traditional Approach</strong></h5><ul><li>Changes one parameter at a time</li><li>Provides limited understanding of interactions</li><li>Often misses important relationships between variables</li></ul><h5><strong>AQbD Approach</strong></h5><ul><li>Uses multivariate experimental designs</li><li>Studies multiple variables simultaneously</li><li>Reveals interactions between parameters</li><li>Enables predictive modeling</li><li>Defines robust operating ranges</li></ul><p>According to Amanda, AQbD provides significantly more knowledge about method behavior while reducing unnecessary experimentation.</p><h4><strong>Design of Experiments (DOE): A Core AQbD Tool</strong></h4><p>Amanda clarified an important misconception:</p><p><strong>DOE is not the same as AQbD.</strong></p><p>Instead:</p><ul><li>AQbD is a broader philosophy and lifecycle approach.</li><li>DOE is one of the most powerful tools used within AQbD.</li></ul><p>DOE helps scientists:</p><ul><li>Identify critical factors</li><li>Evaluate interactions</li><li>Map regions of good and poor performance</li><li>Support risk assessment</li><li>Build predictive models</li></ul><p>However, AQbD also includes risk management, control strategies, and lifecycle monitoring beyond experimental design itself.</p><h4><strong>Practical Advice for Scientists New to DOE</strong></h4><p>For scientists interested in implementing DOE, Amanda recommends starting with simple screening studies.</p><p>Examples include evaluating:</p><ul><li>LC column chemistry</li><li>Mobile-phase pH</li><li>Organic modifiers</li><li>Temperature</li></ul><p>Important responses to monitor may include:</p><ul><li>Resolution</li><li>Peak tailing</li><li>Selectivity</li><li>Efficiency</li></ul><p>She encourages scientists to focus not only on collecting data but on understanding the patterns revealed by experimental results. As experience grows, more advanced optimization studies and predictive models can be developed.</p><h4><strong>Which LC Parameters Matter Most?</strong></h4><p>Amanda emphasized that critical parameters depend on:</p><ul><li>Sample type</li><li>Separation mode</li><li>Intended method purpose</li><li>Development stage</li></ul><p>For reversed-phase LC, common screening parameters include:</p><ul><li>Column chemistry</li><li>Mobile-phase pH</li><li>Organic solvent composition</li><li>Temperature</li></ul><p>For ion-pair chromatography, additional factors such as:</p><ul><li>Ion-pairing reagent type</li><li>Ion-pairing reagent concentration</li></ul><p>can strongly influence selectivity and retention behavior.</p><p>She stresses that proper risk assessment should always guide parameter selection.</p><h4><strong>Case Study: Oligonucleotide Impurity Profiling</strong></h4><p>Amanda shared an example involving impurity analysis of <strong>oligonucleotide therapeutics</strong>.</p><p>One major challenge is that impurities are often structurally very similar to the active pharmaceutical ingredient (API), making chromatographic separation difficult.</p><p>Using AQbD and DOE, her team systematically evaluated:</p><ul><li>LC column chemistries</li><li>Ion-pairing reagents</li><li>Temperature</li><li>Gradient conditions</li></ul><p>A desirability-function approach allowed simultaneous optimization of multiple critical resolutions rather than focusing on a single impurity pair.</p><p>This strategy enabled the development of an LC-UV method capable of separating impurities that might otherwise require LC-MS for quantification.</p><h4><strong>The Challenges of Large Molecules</strong></h4><p>Amanda identifies large biomolecules as some of the most challenging analytes in chromatography.</p><p>Compared with small molecules, proteins and oligonucleotides exhibit:</p><ul><li>Slower mass transfer kinetics</li><li>Peak broadening</li><li>Reduced sensitivity</li><li>Greater sensitivity to system-related factors</li></ul><p>Even seemingly minor differences can affect performance, including:</p><ul><li>Dwell volume</li><li>Tubing dimensions</li><li>System dispersion</li></ul><p>She also highlighted non-specific adsorption as a major challenge.</p><p>Examples include:</p><h5><strong>Oligonucleotides</strong></h5><p>Negatively charged phosphate backbones can interact strongly with metal surfaces, reducing recovery and reproducibility.</p><h5><strong>Peptides</strong></h5><p>Basic amino acid residues may interact with residual silanol groups on silica-based stationary phases, affecting chromatographic performance.</p><p>These challenges have driven innovation in:</p><ul><li>Low-adsorption LC systems</li><li>Surface-modified columns</li><li>Hybrid particle technologies</li><li>Improved consumables and hardware design</li></ul><h4><strong>Software and Modeling Tools</strong></h4><p>Amanda discussed several software platforms commonly used for DOE and method optimization:</p><h5><strong>DOE Software</strong></h5><ul><li>Design-Expert</li><li>JMP</li><li>Minitab</li><li>MODDE</li></ul><h5><strong>Chromatographic Modeling Software</strong></h5><ul><li>DryLab</li><li>ACD/AutoChrom</li><li>ChromSword</li></ul><p>She also noted that modern software increasingly integrates directly with chromatographic data systems, enabling automated experiment execution and data analysis.</p><h4><strong>Essential Skills Beyond Instrument Operation</strong></h4><p>According to Amanda, successful chromatographers need more than technical instrument expertise.</p><p>Key skills include:</p><ul><li>Chromatographic fundamentals</li><li>Statistics</li><li>Chemometrics</li><li>Data interpretation</li><li>Predictive modeling</li><li>Risk assessment</li></ul><p>She emphasized that statistical literacy is particularly important for implementing AQbD principles and validating predictive models.</p><h4><strong>The Future of Chromatography</strong></h4><p>Looking ahead, Amanda is particularly excited about the integration of:</p><ul><li>Artificial intelligence</li><li>Predictive modeling</li><li>Knowledge-driven method development</li></ul><p>She believes these technologies will help scientists better understand separation mechanisms and accelerate development of methods for increasingly complex therapeutics.</p><p>Ultimately, she expects analytical science to play an even more central role in pharmaceutical development, manufacturing, and quality assurance.</p><h4><strong>Conclusion</strong></h4><p>Amanda's career illustrates how chromatography has evolved from traditional small-molecule analysis into a highly interdisciplinary field spanning proteomics, biopharmaceuticals, oligonucleotide therapeutics, and advanced regulatory science. Her experience demonstrates the value of combining chromatographic expertise with AQbD principles, DOE, risk assessment, and predictive modeling.</p><p>As analytical challenges continue to grow in complexity, approaches that emphasize understanding, prediction, and quality by design are becoming increasingly important. The future of chromatography is likely to be shaped by data-driven decision making, advanced modeling, and artificial intelligence—tools that will enable scientists to develop more robust, efficient, and reliable analytical methods.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

AQbD Explained: How Design of Experiments is Transforming Chromatography

Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

<p><strong>In the week of June 22, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Simplifying Complexity in GLP-1 Receptor Agonist Analysis: From Structural Characterization to Impurity Monitoring</strong></h5><ul><li>Tu, 23.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6275">Registration</a></li></ul><p>Simplify GLP-1 receptor agonist analysis. Learn how a streamlined LC-MS workflow combines UHPLC and high-resolution MS for peptide characterization and impurity monitoring.</p><h5><strong>2. Tosoh Bioscience: Tosoh Tuesday - Exploring the AAV Toolkit</strong></h5><ul><li>Tu, 23.6.2026 15:45 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6273">Registration</a></li></ul><p>Improve AAV analysis and purification. Learn how to increase recovery and purity using the TOYOPEARL GigaCap Q-650S resin and columns from Tosoh Bioscience.</p><h5><strong>3. Phenomenex: Sustainable Strategies for High Sensitivity Analysis for Clinical Research LC-MS/MS Methods</strong></h5><ul><li>We, 24.6.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6278">Registration</a></li></ul><p>Optimize clinical LC-MS/MS methods using sustainable ethyl acetate SLE to extract steroids, MMA, and estrogens from human serum with high recovery.</p><h5><strong>4. Agilent Technologies: Preparing for LC Analysis: What to Consider Ahead of Time</strong></h5><ul><li>We, 24.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6288">Registration</a></li></ul><p>Avoid chromatography problems before they start. Learn how to prepare sample matrices, select and maintain LC columns, and establish an effective system housekeeping list.</p><h5><strong>5. SelectScience: Next-generation metabolomics: From annotation to discovery at scale</strong></h5><ul><li>We, 24.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6281">Registration</a></li></ul><p>Explore how next-generation mass spectrometry, ion mobility, and advanced computational tools accelerate confident small-molecule annotation and discovery in metabolomics.</p><h5><strong>6. Waters Corporation: Clear the Noise: Improving Resolution of GLP-1 Receptor Agonist and Insulin Impurities</strong></h5><ul><li>We, 24.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6262">Registration</a></li></ul><p>Learn how to gain greater resolution for your GLP-1 RA and insulin impurity analysis separations.</p><h5><strong>7. Shimadzu Corporation: Meet LCMS-8065XE: Achieving High-Throughput Ultra-Trace Analysis</strong></h5><ul><li>Th, 25.6.2026 08:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6290">Registration</a></li></ul><p>In this webinar, we will analyze real-world performance data demonstrating how LCMS-8065XE enables high sensitivity analysis even in complex matrices.</p><h5><strong>8. Waters Corporation: Creating Better Chromatographic Methods Using a Systematic Approach</strong></h5><ul><li>Th, 25.6.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6284">Registration</a></li></ul><p>Stop guessing and start separating. Learn a structured, systematic approach to LC method development to improve robustness and accelerate column selection.</p><h5><strong>9. Waters Corporation: Lower the Flow to see even more</strong></h5><ul><li>Th, 25.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6285">Registration</a></li></ul><p>Boost large molecule sensitivity in bioanalysis. Learn how switching to microflow LC-MS/MS improves limits of quantification, cuts costs, and reduces solvent usage.</p><h5><strong>10. Separation Science: Advancing PFAS Analysis: From Hidden Precursors to Food Safety Workflows</strong></h5><ul><li>Th, 25.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6286">Registration</a></li></ul><p>Discover practical approaches for detecting, analyzing, and addressing PFAS contamination in environmental and food-related samples.</p><h5><strong>11. Waters Corporation: Achieving Accurate BOD Results: What Your Questions Revealed</strong></h5><ul><li>Th, 25.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6283">Registration</a></li></ul><p>Get consistent and defensible BOD results by learning how to troubleshoot common testing errors and standardize your laboratory procedures.</p><h5><strong>12. SelectScience: Future-ready biobanking starts with smarter sample storage</strong></h5><ul><li>Fr, 26.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6289">Registration</a></li></ul><p>Safeguard your specimens in biobanking and clinical research. Learn from Thermo Fisher Scientific experts how to optimize sample storage, traceability, and compliance.</p><h5><strong>13. SelectScience: Enhancing Empower software data with cloud-based applications</strong></h5><ul><li>Fr, 26.6.2026 17:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6287">Registration</a></li></ul><p>Connect your chromatography data with Waters’ new cloud-based software solutions. Learn how to track system status in real time and enable AI-powered data analytics.</p>

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Waters ACQUITY QDa II Mass Detector

The ACQUITY™ QDa™ II Mass Detector enhances efficiency and productivity in separations workflows with advanced technology.

<h3><strong>Advancing the Power of Mass Detection</strong></h3><ul><li><strong>Identify Everything in Your Sample with Complete Confidence&nbsp;</strong></li></ul><h5><strong>Information-rich mass spectral data starts here&nbsp;</strong></h5><p><strong>Built on a solid foundation of groundbreaking technology, the ACQUITY™ QDa™ II Mass Detector provides even more efficiency and productivity of separations workflows, providing information-rich mass spectral data, ensuring compliance, and regulatory certainty.</strong></p><h4><strong>SEE MORE COMPOUNDS</strong></h4><p>Greater compound coverage from an extended mass range to support small molecules, large molecules and new modalities. A complementary technique to analog detection for chemicals with no chromophores, ACQUITY QDa II Mass Detector enables you to confirm the identity and purity of more compounds with the power of mass detection.</p><h4><strong>ANALYZE MORE SAMPLES</strong></h4><p>Robust, reliable and requiring no sample-specific adjustment. Simply power on to make informed decisions with the full picture of what’s in your sample. Minimal maintenance along with system performance monitoring ensures maximum uptime.&nbsp;</p><h4><strong>HAVE MORE CONFIDENCE IN THE ROBUSTNESS OF YOUR SEPARATIONS</strong></h4><p>The addition of mass detection to your method development workflow enables fast peak tracking and greater confidence in peak purity, for more robust separations. Combined with industry-leading AQbD method development software, your lab can achieve unprecedented MS peak tracking functionality with the ACQUITY QDa II Mass Detector.</p><h4><strong>STRIVE FOR MORE SUSTAINABILITY</strong></h4><p>Achieve up to a 70% reduction in energy consumption and heat output compared to other vendor’s MS systems. The ACT Environmental Impact Factor Label<strong>*</strong> -- available and published by My Green Lab – provides clear, third-party verified information about the environmental impact of laboratory products, enabling you to make the most sustainable decisions for your organization.</p><p><strong>* </strong>ACT - About (<a target="_blank" rel="noopener noreferrer" href="https://www.mygreenlab.org/">mygreenlab.org</a>)</p><h3><strong>Continuing to Separate Beyond Question</strong></h3><ul><li><strong>Ensure your laboratory is prepared for the future</strong></li></ul><h4><strong>MORE PERFORMANCE</strong></h4><p>Plug and play performance with its intuitive design, complementary to optical detection with the robustness to handle all of your analyses. Working in harmony with your chromatography, it’s pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers.</p><h4><strong>MORE EFFICIENCY</strong></h4><p>The intuitive design of the ACQUITY QDa II Mass Detector provides additional data without cost or complexity. The most information you can get out of your separation for complete characterization. In synergy with optical detection, you can significantly reduce the chance that a sample component will go undetected helping to mitigate risk and ensuring a sound return on your investment.</p><h4><strong>MORE SUSTAINABILITY</strong></h4><p>Purposeful innovation, a stackable mass detector that seamlessly integrates into existing workflows resulting in less bench space and more energy efficient. Minimal cleaning and routine maintenance ensuring maximum uptime. Compatible with green solvents ensuring reduced environmental impact.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg" alt="Waters ACQUITY QDa II Mass Detector." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg 234w," sizes="100vw" width="1024" height="682"></p><ul><li>Simply power on, and you’re ready to go</li><li>Zero user set-up optimization, calibration, or adjustment</li><li>Run your analyses − it just works</li><li>When you’re done, just power-off</li></ul><h3><strong>The Perfect Partner</strong></h3><h4><strong>Designed for compatibility with your chromatography&nbsp;</strong></h4><p>Meet all your chromatography requirements with Waters chromatography systems, including our dependability and flexibility ranges of HPLC systems, performance range of UPLC systems, and our purification and specialty systems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg" alt="Waters ACQUITY QDa II Mass Detector: The Perfect Partner. Designed for compatibility with your chromatography." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg 189w," sizes="100vw" width="1299" height="1074"></p><h3><strong>Effortless Integration</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>Process, Interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. With integrated optical and mass detector data processing workflows, you can also analyze mass spectral data in the same way as you do photo diode array (PDA) data.</p><p>The ACQUITY QDa II Mass Detector is fully compatible with Masslynx™ Software and its suite of data processing application managers. Empower™ Software, our industry-leading chromatography data software platform is also fully compatible providing the ultimate flexibility.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Effortless_Integration_Achieve_more_with_flexible_software_solutions_4fd6e9f0d8.jpg" alt="Waters ACQUITY QDa II Mass Detector: Effortless Integration. Achieve more with flexible software solutions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Effortless_Integration_Achieve_more_with_flexible_software_solutions_4fd6e9f0d8.jpg 245w," sizes="100vw" width="1397" height="422"></p><h4><strong>EMPOWER CHROMATOGRAPHY DATA SYSTEM (CDS)</strong></h4><p>Simplifying the way you collect, manage, and report chromatography test results is critical to your lab efficiency. With a suite of flexible functionalities that grows to meet your changing quality, business, and laboratory needs, Empower CDS has been purposefully designed to help you address your most demanding chromatographic, regulatory, and networking challenges.</p><h4><strong>EMPOWER LAB MANAGEMENT SYSTEM (LMS)</strong></h4><p>Automating your lab workflow, from sample creation to data archival, is critical for maintaining data integrity and enhancing productivity. Manage your data all from a single, simple dashboard for an integrated approach to your product lifecycle management so you can reduce transcription errors, increase efficiency, and maximize data durability.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect™</strong></a><strong> SYSTEM MONITORING</strong></h4><p>Monitor all Empower Software-controlled chromatography systems remotely, at any time, from anywhere. Dynamically plan laboratory activities, monitor the status of your laboratory and maximize productivity. Troubleshoot and respond to errors faster, increasing system uptime.</p><h3><strong>Identify More in Released Glycan Analysis</strong></h3><h4><strong>Unlock the full potential of your QC glycan testing</strong></h4><p>While non-MS methods offer routine QC capabilities, they fall short in delivering the detailed characterization, crucial for biopharmaceutical development. The ACQUITY QDa II Mass Detector with extended mass range revolutionizes routine analysis, offering accurate QC monitoring of N-glycan species with speed and precision. Coupled with Waters chromatography systems, enjoy enhanced MS response with uniform charge state for accurate quantitation, enabling scrutiny of released N-glycan profiles in under 40 minutes per sample. Complement fluorescence (FLR) detection and embrace reproducible, quantitative separation for rapid decision-making.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Selected_Ion_Recording_SIR_chromatogram_of_doubly_charged_components_of_a_glycan_sample_Highlighted_additional_components_identified_s_a_result_of_the_extended_mass_range_ac0160e74d.jpg" alt="Waters ACQUITY QDa II Mass Detector: Selected Ion Recording (SIR) chromatogram of doubly charged components of a glycan sample. Highlighted additional components identified s a result of the extended mass range." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Selected_Ion_Recording_SIR_chromatogram_of_doubly_charged_components_of_a_glycan_sample_Highlighted_additional_components_identified_s_a_result_of_the_extended_mass_range_ac0160e74d.jpg 238w," sizes="100vw" width="1347" height="883"></p><h3><strong>Unparalleled Robustness for More Qualitative and Quantitative Performance</strong></h3><h4><strong>Reduce the risk of genotoxic impurities formation in drug manufacturing</strong></h4><p data-start="0" data-end="296">Support risk assessment through routine monitoring of excipients and raw materials in drug manufacturing. Accessible, regulatory compliant-ready LC-MS solutions provide an efficient and cost-effective approach in mitigating the risk of impurity formation during the manufacture of drug product.</p><p data-start="298" data-end="768">Nitrite, a critical risk factor in N-Nitrosamine formation, presents as an impurity in pharmaceutical excipients, often in parts per million (ppm). The ACQUITY QDa II Mass Detector is a robust and reliable solution for routine analysis of nitrite in excipients. With automated resolution, tuning, and calibration during start-up, the ACQUITY QDa II Mass Detector eliminates the need for analyst intervention, ensuring seamless operation and precise results every time.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Over_29_days_of_rigorous_testing_it_flawlessly_executed_approximately_6000_injections_with_minimal_downtime_02a496f422.jpg" alt="Waters ACQUITY QDa II Mass Detector: Over 29 days of rigorous testing, it flawlessly executed approximately 6000 injections with minimal downtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Over_29_days_of_rigorous_testing_it_flawlessly_executed_approximately_6000_injections_with_minimal_downtime_02a496f422.jpg 245w," sizes="100vw" width="1185" height="529"></p><p data-start="770" data-end="1012" data-is-last-node="" data-is-only-node="">Empower CDS reporting functionality offers simple reviewing of excipient nitrite concentration within a sample batch. This allows for fast and comprehensive decision making, while ensuring compliance and data integrity within your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Example_of_Empower_CDS_generated_data_report_for_nitrite_content_in_a_maize_starch_sample_2f106193ee.jpg" alt="Waters ACQUITY QDa II Mass Detector: Example of Empower CDS generated data report for nitrite content in a maize starch sample." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Example_of_Empower_CDS_generated_data_report_for_nitrite_content_in_a_maize_starch_sample_2f106193ee.jpg 245w," sizes="100vw" width="937" height="585"></p><h3><strong data-start="0" data-end="62">Improving Efficiency with a More Sustainable Mass Detector</strong></h3><h4><strong>Low operational costs and environmental footprint</strong></h4><p data-start="123" data-end="346"><strong>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.</strong></p><p data-start="348" data-end="674" data-is-last-node="" data-is-only-node="">Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. Waters has addressed these challenges by providing an instrument with low electricity consumption and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg" alt="Waters ACQUITY QDa II Mass Detector: Improving Efficiency with a More Sustainable Mass Detector. Low operational costs and environmental footprint." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg 245w," sizes="100vw" width="1124" height="389"></p><p><strong>*</strong>From competitor A Specification Sheet.</p><p><strong>**</strong>From competitor B Site Preparation Checklist</p><h3><strong>Unrivaled Support</strong></h3><h3><strong>Ensure your success with world-renowned services</strong></h3><p data-start="77" data-end="464" data-is-last-node="" data-is-only-node="">Waters Service and Support helps maintain peak system performance, minimize downtime, address scientific challenges, and meet compliance requirements.&nbsp;</p><p>Waters award-winning consistent quality support, professional services, and education ensure your success wherever your laboratory is located in the world. With Waters service and support offerings<strong>*</strong> for your ACQUITY QDa II Mass Detector, you can</p><h4><strong data-start="0" data-end="30">GET UP AND RUNNING QUICKLY</strong></h4><p data-start="0" data-end="235">Get the onsite training and consultation you need to integrate the ACQUITY QDa II Mass Detector into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong data-start="237" data-end="276">MEET YOUR LAB’S UNIQUE REQUIREMENTS</strong></h4><p data-start="237" data-end="460">Protect your instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong data-start="462" data-end="487">FACILITATE COMPLIANCE</strong></h4><p data-start="462" data-end="635">Simplify the process of qualification, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong data-start="637" data-end="671">REDUCE TOTAL COST OF OWNERSHIP</strong></h4><p data-start="637" data-end="864">FlexCAPITAL™ <strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong data-start="866" data-end="903">LEVERAGE YOUR EXISTING TECHNOLOGY</strong></h4><p data-start="866" data-end="1104" data-is-last-node="" data-is-only-node="">With the FlexUP™ Technology renewal program, you can upgrade your older single quadrupole mass spectrometry system to the ACQUITY QDa II Mass Detector -- improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong> Availability of offerings varies by country. Contact Waters or your local Waters representative for details<br><strong>**</strong> FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters RADIAN ASAP Direct Mass Detector

Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.

<div><div id="title-a9e634f6cb" data-locator="title-with-text"><h3><strong>The power of knowing now</strong></h3></div></div><div><div id="text-c687cac6aa" data-locator="text"><p><strong>Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times, integrating direct mass spectrometry (MS) analysis can drive multiple system-wide efficiencies helping to achieve your operational goals.</strong></p><p>Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.</p><ul><li>Simple operation and data interpretation</li><li>Minimal sample preparation</li><li>No separation required</li><li>Real-time results and classification</li></ul><figure class="image"><img style="aspect-ratio:454/321;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_7cfe24b23d/Waters-RADIAN-ASAP_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="454" height="321"></figure><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-6b896f6da4" data-locator="text"><ul><li>Ensure users get up and running quickly with RADIAN ASAP’s easy to learn and fully automated set up, streamlined workflow, and minimal training requirements</li><li>Minimize sample prep with direct sampling onto glass probe</li><li>Minimize the need for solvent use and disposal with no chromatography</li><li>Save time with 30 second analysis and real-time sample classification</li></ul></div></div><div><div id="text-161a2a5c01" data-locator="text"><h4><strong>Recommended Use</strong></h4><p>For rapid, easy, and low-cost analysis of liquids and solids.</p><div><div id="text-4973311325" data-locator="text"><h3 data-locator="modal-title"><strong>Compact without compromise</strong></h3><p>The RADIAN ASAP is a novel, dedicated direct analysis system specifically designed for rapid, easy and low-cost analysis of liquids and solids. Engineered using proven and robust single quadrupole mass spectrometry technology combined with the Atmospheric Pressure Solids Analysis Probe (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/services/instrument-services/instrument-upgrades/mass-spectrometry-ms-upgrades/atmospheric-solids-analysis-probe.html" data-di-id="di-id-70d78c77-7e033f9d">ASAP</a>), the RADIAN ASAP delivers quality and ease of use in a compact footprint.&nbsp;</p><p>This single quadrupole mass detector provides high quality mass spectral data, without the need for any special training or expertise, eliminating any need to contract out and wait for results from specialist analytical service laboratories.</p></div></div><div><div id="text-08366f2c0d" data-locator="text"><h3 data-locator="modal-title"><strong>Flexible workflow solutions in 4 simple steps</strong></h3><p>Operation of the RADIAN ASAP is simple and intuitive, allowing users to generate results with minimal or no sample preparation, making it an ideal tool for laboratories to make informed decisions. Capable of ionizing molecules directly from a liquid or solid makes the system available to a wide range of applications and workflows.</p><h4><strong>Generate results in 4 simple steps:</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg" alt="Waters RADIAN ASAP Direct Mass Detector: Flexible workflow solutions in 4 simple steps" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/thumbnail_Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg 245w," sizes="100vw" width="1683" height="490"></p><h3><strong>Ideal for numerous application requirements</strong></h3><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=135078611" data-di-id="di-id-7f758d90-ccee23de"><strong>Rapid triage of seized drug materials for Forensics</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and LiveID ensure crime labs can quickly screen samples against a library of known compounds for rapid, confident identification of illicit drugs. The sensitivity and selectivity of mass spectrometry provides confidence in detecting drugs with an easy, efficient triage workflow.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134528742" data-di-id="di-id-3a3c46e4-ccee23de"><strong>Assess food integrity for Food &amp; Environmental</strong></a>&nbsp;<strong>—</strong> The threat posed by food fraud has created additional demands on both the food industry and regulators to protect food consumers and maintain brand reputation. RADIAN ASAP and LiveID offer a powerful combination of mass spectrometry and chemometric modeling, allowing users to easily and efficiently screen samples and make quicker decisions.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.tainstruments.com/radian-asap-direct-mass-detector/" data-di-id="di-id-2fac456-44144a9d"><strong>Fast chemical analysis for improved formulation testing in Chemical and Materials</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and IonLynx supports quality control (QC) and development labs in the chemical industry to reduce costs and increase efficiencies. Streamline workflows like fast chemical analysis for improved formulation testing or&nbsp;material release testing. Features including thermal gradient analysis are ideal for the complex samples in the chemical industry.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134751395" data-di-id="di-id-76921eaa-ccee23de"><strong>Discovery reaction monitoring&nbsp;for Pharma</strong></a>&nbsp;<strong>—</strong> The demand to accelerate the drug discovery and development process has never been higher.&nbsp;RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near-instantaneous assessment of reaction progress and identification of purification fractions, increasing lab efficiency.</p><div><div><div><div id="text-8b0fa56c8c" data-locator="text"><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134971387" data-di-id="di-id-10e51f17-ccee23de"><strong>Undergraduate teaching&nbsp;and method development&nbsp;in Academia</strong></a><strong> —&nbsp;</strong>Simplicity and ease of use makes RADIAN ASAP the ideal tool for busy academic laboratories that need a robust and reliable solution.</p><figure class="image"><img style="aspect-ratio:474/308;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_2_87ddc46f15/Waters-RADIAN-ASAP-2_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="474" height="308"></figure><div><div id="text-a5e5e26910" data-locator="text"><h3 data-locator="modal-title"><strong>Software solutions for your data requirements</strong></h3><p><strong>RADIAN ASAP</strong> is compatible with software solutions for rapid interpretation and classification as well as automated data processing and reporting.</p><p>For customers investigating the authenticity, adulteration, and quality of food or raw materials, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=5&amp;search=liveid"><strong>LiveID</strong></a> uses statistical models to classify samples. First, authentic or verified samples are used to create and validate a statistical model. The validated model can then be used with test samples and generate live classifications with a simple yes/no answer output. LiveID can also do real time <strong>library</strong> matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of <strong>1000</strong>, where values close to 1000 indicate the compound of interest is likely in the sample and lower scores indicate unlikely presence in the sample.</p><p><strong>OpenLynx</strong> processing provides user customizable processing capabilities to generate automated mass confirmation reports in either pdf, printed or browser format.&nbsp;</p><p><strong>IonLynx</strong> allows users to determine levels and relative ratios of analytes of interest in complex samples to aid decision making in QC and formulation monitoring. IonLynx provides automated processing and reporting of non-chromatographic data sets, such as those generated by RADIAN ASAP.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Products from category Single quadrupoles from Waters - page 1

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