🎤Daniel DeBord (Chief Technology Officer at MOBILion Systems)Liquid chromatography–mass spectrometry (LC-MS) has been the backbone of modern analytical workflows for decades — but what if one of its most trusted components is also its biggest bottleneck?In Episode 50 of Concentrating on Chromatography, host Dave Oliva sits down with Daniel DeBord to explore how high-resolution ion mobility may be changing the way scientists think about precursor isolation in tandem MS.Traditional MS/MS workflows rely on quadrupole filtering to isolate precursor ions prior to fragmentation. But because quadrupoles operate as mass filters, they routinely discard the vast majority of incoming ions — often more than 99% — contributing to signal loss, slower acquisition speeds, and chimeric spectra in complex mixtures.Daniel explains how Structures for Lossless Ion Manipulations (SLIM) technology introduces an additional gas-phase separation step between LC and MS — enabling:<ul><li>Near-lossless ion transmission through the instrument</li><li>Separation based on size-to-charge rather than mass-to-charge</li><li>Cleaner MS/MS spectra with reduced spectral chimerism</li><li>LC gradient compression without sacrificing analytical resolution</li><li>Peak capacities comparable to 20–30 minute LC separations — achieved in milliseconds</li></ul>For chromatographers, this raises an important question:If critical separations can occur in the mobility domain, how much chromatography do we actually need?<h4>Daniel also discusses:</h4><ul><li>Whether HRIM could supplement or replace quadrupoles in future instruments</li><li>Applications in proteomics, metabolomics, and environmental analysis</li><li>Integrating ion mobility into triple quadrupole workflows</li><li>Challenges around method development and data processing</li><li>What the next generation of LC-ion mobility-MS platforms may look like</li></ul><h3>Video Transcription</h3><h4>From Chemistry to Instrument Development</h4>Nelson’s path into analytical chemistry combined interests in chemistry, mathematics, engineering, and instrumentation design. During graduate studies at Texas A&amp;M University, he became fascinated by the ability to build custom instruments capable of measuring molecules invisible to the naked eye.Unlike laboratories relying primarily on commercial systems, his research environment involved designing and constructing mass spectrometers from the ground up. This experience provided exposure to:<ul><li>Mechanical design</li><li>Electronics</li><li>Software development</li><li>Vacuum systems</li><li>Instrument integration</li></ul>The ability to understand multiple engineering disciplines proved valuable later in industry, where instrument development requires collaboration among specialists from numerous technical fields.<h4>Transforming a Research Prototype into a Commercial Instrument</h4>When Nelson joined MOBILion Systems in 2018, the company’s primary challenge was converting a laboratory prototype licensed from the Pacific Northwest National Laboratory into a robust commercial platform.The original system was essentially a research prototype requiring substantial redesign before deployment in routine laboratories. The development team focused on improving:<ul><li>Safety</li><li>Reliability</li><li>Reproducibility</li><li>Manufacturability</li><li>User friendliness</li><li>Scalability</li></ul>Within approximately eighteen months, the company transformed the prototype into a commercial ion mobility platform suitable for integration with modern mass spectrometry workflows.<h4>What Is SLIM Technology?</h4>SLIM (Structures for Lossless Ion Manipulations) is a form of high-resolution ion mobility spectrometry that separates ions in the gas phase before mass analysis.Nelson describes ion mobility as conceptually similar to chromatography:<div><div><figure class="table"><table><thead><tr><th>Chromatography</th><th>Ion Mobility</th></tr></thead><tbody><tr><td>Retention time</td><td>Arrival time</td></tr><tr><td>Stationary/mobile phase interactions</td><td>Gas-phase ion transport</td></tr><tr><td>Gradient elution</td><td>Voltage ramping</td></tr><tr><td>Peak capacity</td><td>Mobility peak capacity</td></tr></tbody></table></figure></div></div>Instead of separating molecules based on interactions with a stationary phase, ion mobility separates ions according to their size-to-charge ratio using carefully controlled electric fields.A key advantage is speed. While chromatographic separations typically require minutes, ion mobility separations occur on millisecond timescales, often making them approximately one thousand times faster than conventional LC separations.<h4>How SLIM Differs from Traditional Ion Mobility</h4>Several ion mobility approaches already exist, including:<ul><li>Drift tube ion mobility (DTIMS)</li><li>Trapped ion mobility spectrometry (TIMS)</li><li>Other mobility-based separation technologies</li></ul>According to Nelson, SLIM was designed specifically to overcome traditional trade-offs between:<ul><li>Resolution</li><li>Sensitivity</li><li>Ion transmission efficiency</li></ul>The technology enables:<ul><li>Near-complete ion transmission</li><li>Extended separation path lengths</li><li>Resolving powers exceeding 2,000</li><li>Separation of extremely subtle molecular differences</li></ul>Examples include distinguishing molecules that differ only by the position of a single isotopic atom—an analytical challenge beyond the capabilities of conventional chromatography or mass spectrometry alone.<h4>What Does “Lossless” Really Mean?</h4>The phrase Lossless Ion Manipulations is central to the SLIM concept.Traditional ion mobility systems often sacrifice sensitivity because a significant fraction of ions are lost during transport through the device. SLIM was designed to minimize these losses and maintain nearly complete ion transmission.To verify this claim, MOBILion evaluates mass spectrometer sensitivity before and after integration of SLIM modules. According to Nelson, the technology can add meters of ion travel distance while preserving the sensitivity specifications of the original instrument.The practical implication is straightforward:<blockquote>The ions entering the system are largely the same ions reaching the detector.</blockquote>This enables high-resolution separations without sacrificing analytical sensitivity.<h4>Why Challenge the Quadrupole?</h4>One of the interview’s most provocative ideas is Nelson’s statement that:<blockquote>“The problem is the quadrupole.”</blockquote>Although intentionally provocative, the comment highlights limitations associated with traditional precursor isolation.<h5>Limitation 1: Isobaric Co-Isolation</h5>Quadrupoles isolate ions based on mass-to-charge ratio (m/z).When multiple compounds share identical or nearly identical masses:<ul><li>They may be isolated simultaneously.</li><li>Fragmentation produces mixed spectra.</li><li>Interpretation becomes more difficult.</li></ul>High-resolution ion mobility introduces an orthogonal separation mechanism based on size-to-charge ratio, allowing some compounds with identical masses to be separated before fragmentation. This generates cleaner MS/MS spectra and reduces spectral interference.<h4>Faster MS/MS Acquisition Through Ion Mobility</h4>Quadrupole performance is constrained by the speed at which electrical fields can change and stabilize.Modern high-resolution tandem mass spectrometers typically achieve acquisition rates around:<ul><li>50–270 Hz for MS/MS workflows</li></ul>In contrast, Nelson reports that mobility-based precursor selection can exceed:<ul><li>1,300 Hz</li></ul>This improvement is possible because ion mobility packets are separated on millisecond timescales and introduced rapidly into the collision cell and time-of-flight analyzer.The result is:<ul><li>Faster MS/MS acquisition</li><li>Higher precursor sampling rates</li><li>Improved utilization of available ion signal</li></ul><h4>Where Do the Missing Ions Go?</h4>A striking point discussed during the interview concerns ion utilization.Conventional quadrupole isolation inherently filters out most ions entering the instrument. According to Nelson, approximately 99% of ions may be discarded during precursor selection. These rejected ions typically accumulate on quadrupole rods and other internal surfaces, contributing to contamination and maintenance requirements.Ion mobility operates differently:<ul><li>Ions are separated temporally rather than discarded.</li><li>Much larger fractions of the ion population reach the detector.</li><li>Signal utilization increases substantially.</li></ul>This improves sensitivity while reducing waste of potentially informative ions.<h4>Is Ion Mobility Another Dimension Like 2D-LC?</h4>Nelson compares ion mobility to adding an additional orthogonal separation dimension, much like two-dimensional liquid chromatography (2D-LC).Combining:<ul><li>Liquid chromatography</li><li>Ion mobility</li><li>Mass spectrometry</li></ul>creates a multidimensional analytical workflow capable of resolving complex mixtures with greater specificity than any single technique alone.However, unlike conventional multidimensional chromatography, ion mobility separations occur in milliseconds and therefore integrate seamlessly into standard LC-MS experiments without significantly increasing analysis time.<h4>Can Ion Mobility Reduce Chromatography Time?</h4>One of the most practical advantages discussed is the possibility of shortening LC methods.Many chromatographic methods are designed primarily to separate a few difficult analytes. Achieving adequate chromatographic resolution often requires:<ul><li>Long gradients</li><li>Extended run times</li><li>Reduced sample throughput</li></ul>If critical analytes can instead be separated in the ion mobility dimension, chromatographic requirements become less stringent.Potential benefits include:<ul><li>Shorter LC gradients</li><li>Increased throughput</li><li>Reduced solvent consumption</li><li>Simplified method development</li></ul>while maintaining analytical specificity and quantitative performance.<h4>Applications Driving Adoption</h4>The current commercial focus of MOBILion technology spans several sectors:<h5>Biopharmaceutical Analysis</h5><ul><li>Characterization of complex biologics</li><li>Enhanced molecular specificity</li></ul><h5>Environmental Analysis</h5><ul><li>Untargeted contaminant screening</li><li>Improved identification confidence</li></ul><h5>Food and Beverage Testing</h5><ul><li>Analysis of complex sample matrices</li></ul><h5>Proteomics</h5><ul><li>Data-independent acquisition (DIA)</li><li>High-throughput peptide identification</li></ul><h5>Metabolomics</h5><ul><li>Characterization of unknown metabolites</li><li>Improved confidence in untargeted studies</li></ul>Nelson identifies metabolomics as one of the most promising future growth areas because of its reliance on identifying unknown compounds within highly complex biological matrices.<h4>Challenges and Limitations</h4>Despite its advantages, ion mobility introduces new considerations.<h5>Additional Method Complexity</h5>Users must understand:<ul><li>Mobility separation principles</li><li>Method optimization strategies</li><li>Appropriate application workflows</li></ul><h5>Data Processing</h5>An additional separation dimension generates richer datasets but also increases analytical complexity. Laboratories must adapt software workflows and learn new visualization and interpretation approaches.These challenges resemble those encountered when implementing multidimensional chromatography systems.<h4>The Future of LC-Ion Mobility-MS</h4>Looking ahead, Nelson predicts that ion mobility will become increasingly integrated into routine analytical workflows.He points to the widespread adoption of ion mobility in proteomics and expects expansion into:<ul><li>Metabolomics</li><li>Environmental testing</li><li>Quantitative LC-MS workflows</li><li>Triple quadrupole applications</li></ul>Rather than replacing quadrupoles entirely, he anticipates that future instruments will increasingly combine both technologies to maximize analytical performance. Nevertheless, specialized systems may eventually emerge where high-resolution ion mobility performs much of the functionality traditionally assigned to quadrupoles.<h4>Advice for Future Instrument Scientists</h4>For students interested in next-generation analytical instrumentation, Nelson emphasizes the importance of:<ul><li>Reading primary scientific literature</li><li>Understanding instrument design principles</li><li>Exploring engineering concepts</li><li>Developing interdisciplinary skills</li><li>Building professional networks</li></ul>He encourages young scientists to engage directly with researchers and technology developers rather than relying solely on published literature, noting that many valuable insights are shared through personal interactions and collaboration.<h4>Conclusion</h4>Daniel Nelson presents a compelling vision for the future of analytical instrumentation, where high-resolution ion mobility becomes a central component of LC-MS workflows. By providing fast, high-resolution gas-phase separations with near-lossless ion transmission, technologies such as SLIM offer opportunities to increase sensitivity, improve spectral clarity, reduce chromatographic burden, and accelerate analytical measurements. While quadrupoles remain essential components of many mass spectrometers, the growing adoption of ion mobility suggests that future analytical platforms may increasingly rely on multidimensional separations to address the challenges of modern proteomics, metabolomics, environmental analysis, and biopharmaceutical characterization.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

 LC-MS Is Throwing Away 99% of Your Signal — Can Ion Mobility Fix It?

<div><div>Dr. Tomáš Cihlář, Senior Vice President of Research, Virology at Gilead Sciences, and Dr. Jeffrey Birnbaum, an American pediatrician who has long worked with young Americans at risk of HIV infection or living with the virus, visited IOCB Prague for a joint lecture. The event focused on the future of long-acting HIV prevention and treatment.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_f5ca13985a.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague: Dr. Tomáš Cihlář, Gilead Sciences" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_f5ca13985a.jpg 234w," sizes="100vw" width="2000" height="1333"></div></div><div>Modern HIV treatment is shifting from daily medication to long-acting prevention. This was the central theme of the joint lecture titled <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/en/event-calendar/372/joint-lecture-tomas-cihlar-jeffrey-birnbaum">HIV Treatment – From Bench to Clinical Practice</a>. “HIV is by no means just a medical problem, but also a social, economic, psychological, and legal one,” said Institute Director Prof. Jan Konvalinka in his opening remarks.In 2022, Gilead Sciences’ drug lenacapavir was launched on the U.S. market. The company has a long-standing collaboration with OICB Prague, for example on tenofovir – a substance that became the basis for modern HIV drugs.“During the development of lenacapavir, we broke all the rules we’re supposed to follow when searching for new drugs,” said Dr. Tomáš Cihlář in his lecture, describing the creation of the drug that targets the virus’s protein envelope. Today, it is used not only for treatment but also for preventing infection. Its development took several decades. “Around 2010, we even wanted to give up, but then a new candidate molecule emerged,” concluded Tomáš Cihlář, recounting the story of the drug’s development.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_2_4e1804920e.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague: Jeffrey Birnbaum, M.D., MPH, SUNY Downstate Health Sciences University, NY, USA" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_2_4e1804920e.jpg 234w," sizes="100vw" width="2000" height="1333">The FDA and the European Commission approved the preventive use of lenacapavir in 2025, but research continues. The ongoing international clinical trial PURPOSE 365 is investigating whether the drug can be administered just once a year instead of the currently approved two injections.Dr. Jeffrey Birnbaum shared his experiences from daily hospital practice at SUNY Downstate Health Sciences University in Brooklyn. In his practice, he primarily sees young people from the transgender community, for whom a long-acting preventive injection is a particularly attractive option. “Patients don’t have to worry that someone will discover their medication. There’s also no risk of forgetting to take it, and they avoid pill fatigue, the long-term psychological exhaustion associated with the need to take medication regularly.”Although lenacapavir represents a significant medical advance, the way the drug reaches people is also crucial. Approximately 400 million people are currently at risk of HIV infection, particularly in sub-Saharan Africa. Although Gilead Sciences has six manufacturing partners on the African continent, current U.S. government cuts to HIV prevention funding are dramatically affecting the availability of HIV prevention programs.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_3_e7f4f6a043.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_3_e7f4f6a043.jpg 234w," sizes="100vw" width="2000" height="1335"></div>

From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague

A special photocatalytic material based on graphitic carbon nitride, developed at the University of Ostrava and VŠB - Technical University of Ostrava can effectively break down antibiotics and other pharmaceutical substances that commonly used wastewater treatment technologies are generally unable to remove, meaning drug residues end up in waterways via the sewer system. This is the conclusion of research conducted in collaboration with experts from the Department of Analytical Chemistry at the Faculty of Science, Palacký University.The study’s results were published in the international journal iScience. The scientists will continue to test the potential use of the photocatalytic material in wastewater treatment.<div><blockquote>“Analytical chemistry plays a crucial role in the development of new environmental technologies.” Petr Bednář</blockquote></div>The research team focused on the efficiency of photocatalysis, a process in which a special light-activated material triggers chemical reactions that break down organic pollutants in water. The graphitic carbon nitride used contains no metals, is chemically stable, and works not only under ultraviolet radiation but also under ordinary visible light.“Laboratory experiments showed that within two hours, the material was able to remove more than 95 percent of the antibiotic ofloxacin and the drug diclofenac. In the case of caffeine, the efficiency reached approximately 80 percent,” said Petr Bednář from the Department of Analytical Chemistry at the Faculty of Science.The experts also described the degradation mechanisms and, using liquid chromatography coupled with high-resolution mass spectrometry, identified the intermediates formed during the ongoing reactions. The results suggest that most of these substances pose a lower environmental burden than the original drugs. “Without modern analytical methods, we would not be able to determine whether harmful substances actually degrade safely and what chemical processes occur during water treatment. Analytical chemistry therefore plays a crucial role in the development of new environmental technologies,” noted Petr Bednář.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KACH_UPOL_Novy_material_pomaha_rozkladat_antibiotika_v_odpadnich_vodach_04bd4942d4.jpg" alt="UPOL/Petr Bednář: New material helps break down antibiotics in wastewater: A combination of liquid chromatography and mass spectrometry used to measure antibiotic degradation products. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KACH_UPOL_Novy_material_pomaha_rozkladat_antibiotika_v_odpadnich_vodach_04bd4942d4.jpg 208w," sizes="100vw" width="1280" height="960"><blockquote><h4>Original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.cell.com/iscience/fulltext/S2589-0042(25)02160-1">Photocatalytic degradation and transformation of pharmaceuticals using exfoliated metal-free g-C3N4</a></h4>Petr Praus, Anna Gavlová, Jan Hrbáč, Kristina Schmidtová, Petr BednářPraus et al., 2025, iScience 28, 113899<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.isci.2025.113899">https://doi.org/10.1016/j.isci.2025.113899</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Pharmaceuticals are micropollutants of global concern that contribute to environmental contamination alongside other anthropogenic and natural chemical compounds. This study addresses the photocatalytic degradation of model pharmaceutical compounds ofloxacin, diclofenac, and caffeine using bulk and thermally exfoliated graphitic carbon nitride (g-C3N4). Bulk g-C3N4 was synthesized from dicyandiamide at 550°C and exfoliated at 500 °C for 1-3 h in an ambient atmosphere. The structural, textural, and electronic properties of the prepared materials were evaluated.Graphitic carbon nitride exfoliated for 2 h provided the best photocatalytic degradation efficiencies (&gt;95%) for both ofloxacin and diclofenac and approximately 80% for caffeine, determined for 120 min under irradiation at 420 nm. The pharmaceuticals were degraded, and their intermediate degradation products were investigated using liquid chromatography combined with high-resolution tandem mass spectrometry. The successful identification of the main degradation products allowed us to propose transformation pathways for the studied pharmaceuticals.

New material helps break down antibiotics in wastewater

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Palacký University Olomouc (UP) is an internationally respected and scientifically and academically highly productive university in Central Europe. Founded 22 December 1573, it is the second-oldest university in the Czech Republic and the oldest one in Moravia. For 450 years it has contributed to the intellectual wealth of society and to its scientific, cultural, and social development.

Palacký University Olomouc

Trajan Mitra Microsampling Devices - Specimen bag

The Specimen Bag Mitra format is perfect for those looking to create their own collection kits for remote sampling or maintain bulk devices for centralized sampling in clinical or field settings.

<h3>About</h3>The Specimen Bag Mitra format is perfect for those looking to create their own collection kits for remote sampling or maintain bulk devices for centralized sampling in clinical or field settings.Each Specimen Bag is sealed and includes a barcoded Mitra device with a unique identifier and desiccant. After collection, the device is placed back into the Specimen Bag to facilitate quick drying and protect the sample from external contamination.If you need logistics help, bioanalytical lab services, or kitting support, we can connect you with experienced organizations that specialize in microsampling.<h4>Build Your Own Kits or Sample Large Cohorts Remotely</h4>With this format you can collect many samples in the field and ship them back to the lab in bulk. You may prefer to insert them into your own all-in-one kit.<ul><li>10, 20, &amp; 30 µL volumes</li><li>Protective outer casing</li><li>Barcoding to manage chain of custody</li><li>Packed in specimen bag with desiccant for transport &amp; storage</li></ul><h3>Specifications</h3><div class="tabs__tab txt--light tabs__tab--active" id="tab_17218576460536_2"><ul><li>Indication for Use: A single-use, non-sterile device used as a specimen collector, and for the storage and transport of blood and other biological fluids for analytical and diagnostic analyses.&nbsp;</li><li>Sampler Tip Volume: 10, 20, or 30uL&nbsp;&nbsp;</li><li># of Samplers per Device: 2 or 4&nbsp;</li><li>Shelf Life: 18 months&nbsp;</li><li># Device per pack: 30/Pk</li><li>Pack content: Mitra Device, Specimen Bag with Desiccant, Sample ID Barcode, 1x IFU</li><li>Regulatory status: Mitra® devices are CE-IVD (IVDR) devices intended as a specimen collector, and for the storage and transport of blood and other biological fluids for analytical and diagnostic analyses. They are available as registered IVD Devices in the European Union and United Kingdom, Australia, Brazil, China, and Canada, as well as multiple Health Ministries worldwide. In the USA, Mitra devices are supplied as a research use only (RUO) product to assist in method development, other research-related and non-diagnostic activities. End-users and laboratories must validate the use of the Mitra devices for the particular diagnostic testing intended.</li></ul><h3>How to Use</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/IFUs/2023/Mitra%20Device%20Specimen%20Bag/VLBL-0125-Rrev00.pdf">Instructions for Use (RUO)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/IFUs/2023/Mitra%20Device%20Specimen%20Bag/VLBL-0125rev00.pdf">Instructions for Use (MD)</a></li></ul><h3>Resources</h3><ul style="list-style-type:disc;"><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_2022%20Mitra%20Collateral/Mitra%20Specification%20Sheet%20(3).pdf">Mitra Device Specification Sheet</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/User%20Guides/Mitra%20User%20Guide%20Extracting%20&amp;%20Processing%20Microsamples.pdf">User Guide | How to Extract &amp; Process Mitra Microsamples</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/Technical%20Briefs%20and%20Guidances/Long%20&amp;%20Short%20Term%20Storage%20of%20Mitra%20Samples_TG00010122.pdf">User Guide | How to Store Dried Mitra Microsamples</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/GenTegraRNA-NEO%20for%20Mitra%20devices%20USER%20GUIDE%2011.15.23.pdf">User Guide | How to Stabilizer RNA on Mitra Microsamples with GenTegraRNA-NEO™</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/frequently-asked-questions?hsLang=en">Frequently Asked Questions</a></li></ul><h3>Mitra devices deliver tremendous ease &amp; value to specimen collection!</h3></div>Mitra® Microsampling Devices offer a streamlined, flexible, and decentralized approach to biological specimen collection. Enjoy the benefits of easier trial recruitment, increased adherence / compliance, elimination of cold-chain shipping / storage &amp; reduced reliance on trained staff.<h4>The gold-standard in remote specimen collection</h4>Powered by VAMS® technology, the patented Mitra® Microsampling Device offers a streamlined, flexible, and decentralized approach to biological specimen collection, transport, and preparation. Use Mitra to facilitate sampling direct from animals, humans, or tubes to collect precise, reliable dried microsamples compatible with a wide variety of downstream applications as evidenced by the hundreds of published peer-reviewed manuscripts and the millions of devices that have been used in the field.<h4>Mitra: pioneering VAMS technology</h4>Trajan’s proprietary VAMS® Technology is at the heart of the Mitra device, featuring a sampler tip crafted from a porous, hydrophilic polymeric material. This 'precision sponge' rapidly and consistently absorbs a specific volume of biological fluid—simply by contacting the source. The fluid is then allowed to dry acting as a stabilizer for most analytes.Available in three tip sizes—10, 20, and 30 µL— and multiple formats, Mitra devices meet diverse end-user and analytical needs. Configurations include dual (2) or quad (4) samplers across various formats.&nbsp; Collect from 20 µL to 120 µL per device based on format selected. Our team of expert microsampling consultants is on hand to provide scientific support, helping you choose the optimal format and workflow for your specific applications.<ul><li>Reliable: Quantitative sampling with pipette-like precision (RSD ≤ 5%). VAMS eliminates traditional blood hematocrit biases and results in extremely low in-lab sample rejection rates. No glue used in assembly, no matrix interferences.</li><li>Versatile: Collect biological fluids—blood, plasma, urine, saliva, and even tears—efficiently from humans and animals (e.g., finger, arm, knee, tail, etc.) or containers. Manual to fully automated workflows are available.</li><li>User-Friendly: 99% sample acceptance rate validated by studies. VAMS tip acts as a fill indicator to confirm successful sampling. Outer housing protects against contamination and facilitates easy remote or home sampling.</li><li>Cost-Effective: Eliminate phlebotomy, couriers, and cold-chain shipping / storage requirements. Devices are compatible with standard automated liquid handling systems and available in various formats to suit different budgets.</li></ul><h4>Successful uses</h4>Have you seen the published, 3rd party literature of how others have successfully implemented Mitra devices?<ul><li>Preclinical</li><li>Clinical Trials / Research</li><li>Therapeutic Drug Monitoring</li><li>Omics</li><li>Biomonitoring</li><li>Toxicology</li><li>Hormones / Steroids</li><li>Biomarkers</li><li>Vitamins</li><li>Allergens</li><li>Population Screening</li><li>Infectious Diseases</li></ul>

Trajan Mitra Microsampling Devices - Microsample collection kit

The Microsample Collection Kit Mitra format streamlines the blood microsampling process, enabling both assisted and self-collection at home or in the field.

<h3>About</h3>The Microsample Collection Kit Mitra format streamlines the blood microsampling process, enabling both assisted and self-collection at home or in the field. Each kit is equipped with device, barcoding for secure chain of custody, easy-to-follow instructions, all necessary finger-prick sampling supplies, and a return-mailing envelope, all packaged for global distribution. Ideal for remote blood collection, these kits ensure that samples can be directly sent to accredited labs for precise analysis.For customization to meet the demands of large-scale projects or to optimize your workflows and logistics, please consult with our <a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/contact">Microsampling Consultants</a>. They will provide tailored recommendations to align with your project’s specific objectives.<h4>All-in-One Solution for Remote Specimen Collection</h4>Our Mitra devices can be packed in convenient kits with sterile components for safe sample collection. Kits can be shipped to your end-users.<ul><li>10, 20, &amp; 30 µL volumes</li><li>Protective outer casing</li><li>Barcoding to manage chain of custody</li><li>Packed in specimen bag with desiccant for transport &amp; storage</li><li>Contains devices &amp; supplies</li><li>Includes instructions for use &amp; return shipping envelope</li><li>Sized for easy global mailing</li></ul><h3>Specifications</h3><div class="tabs__tab txt--light tabs__tab--active" id="tab_1721774838869_2"><ul><li>Indication for Use: The Microsample Collection Kit is a single-use non-sterile procedure pack intended for the collection, storage and transport of capillary whole blood specimens of specified volume.</li><li>Sampler Tip Volume: 10, 20, or 30uL</li><li># of Samplers per Device: 2 or 4</li><li># Device per kit: 1/Pk</li><li>Pack content: 1x Mitra Device, 1x Specimen Bag with Desiccant, Sample ID Barcode, Lancet (x2 or x4), Gauze (x1 or x2), Bandage (x2 or x4), 1x Plastic Shipping Envelope, 1x IFU</li><li>Shelf Life: 18 months</li><li>Regulatory status: The Mitra Blood Sample Collection Kit is a procedure pack. The kits are available as registered Medical Device in the European Union and United Kingdom, Australia, Brazil, China, and Canada, as well as multiple Health Ministries worldwide. In the USA, procedure packs are supplied as a research use only (RUO) product to assist in method development, other research-related and non-diagnostic activities. End-users and laboratories must validate the use of the Mitra devices and Mitra Microsample collection kit for the particular diagnostic testing intended.</li></ul></div><h3>How to Use</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/IFUs/2023/Collection%20Kits/VLBL-0124-Rrev00.pdf">Instructions for Use (RUO)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/IFUs/2023/Collection%20Kits/VLBL-0124rev00.pdf">Instructions for Use (MD)</a></li></ul><h3>Resources</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_2022%20Mitra%20Collateral/Mitra%20Specification%20Sheet%20(3).pdf">Mitra Device Specification Sheet</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/Guidelines%20for%20Collecting%20Samples%20at%20Home-1.pdf">Guidelines for Collecting Samples at Home</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/Technical%20Briefs%20and%20Guidances/Long%20&amp;%20Short%20Term%20Storage%20of%20Mitra%20Samples_TG00010122.pdf">User Guide | How to Store Dried Mitra Microsamples</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/frequently-asked-questions">Frequently Asked Questions</a></li></ul><div class="tabs__tab txt--light tabs__tab--active" id="tab_1721774838869_4"><h3>Mitra devices deliver tremendous ease &amp; value to specimen collection!</h3>Mitra® Microsampling Devices offer a streamlined, flexible, and decentralized approach to biological specimen collection. Enjoy the benefits of easier trial recruitment, increased adherence / compliance, elimination of cold-chain shipping / storage &amp; reduced reliance on trained staff.<h4>The gold-standard in remote specimen collection</h4>Powered by VAMS® technology, the patented Mitra® Microsampling Device offers a streamlined, flexible, and decentralized approach to biological specimen collection, transport, and preparation. Use Mitra to facilitate sampling direct from animals, humans, or tubes to collect precise, reliable dried microsamples compatible with a wide variety of downstream applications as evidenced by the hundreds of published peer-reviewed manuscripts and the millions of devices that have been used in the field.<h4>Mitra: pioneering VAMS technology</h4>Trajan’s proprietary VAMS® Technology is at the heart of the Mitra device, featuring a sampler tip crafted from a porous, hydrophilic polymeric material. This 'precision sponge' rapidly and consistently absorbs a specific volume of biological fluid—simply by contacting the source. The fluid is then allowed to dry acting as a stabilizer for most analytes.Available in three tip sizes—10, 20, and 30 µL— and multiple formats, Mitra devices meet diverse end-user and analytical needs. Configurations include dual (2) or quad (4) samplers across various formats.&nbsp; Collect from 20 µL to 120 µL per device based on format selected. Our team of expert microsampling consultants is on hand to provide scientific support, helping you choose the optimal format and workflow for your specific applications.<ul><li>Reliable: Quantitative sampling with pipette-like precision (RSD ≤ 5%). VAMS eliminates traditional blood hematocrit biases and results in extremely low in-lab sample rejection rates. No glue used in assembly, no matrix interferences.</li><li>Versatile: Collect biological fluids—blood, plasma, urine, saliva, and even tears—efficiently from humans and animals (e.g., finger, arm, knee, tail, etc.) or containers. Manual to fully automated workflows are available.</li><li>User-Friendly: 99% sample acceptance rate validated by studies. VAMS tip acts as a fill indicator to confirm successful sampling. Outer housing protects against contamination and facilitates easy remote or home sampling.</li><li>Cost-Effective: Eliminate phlebotomy, couriers, and cold-chain shipping / storage requirements. Devices are compatible with standard automated liquid handling systems and available in various formats to suit different budgets.</li></ul><h4>Successful uses</h4>Have you seen the published, 3rd party literature of how others have successfully implemented Mitra devices?<ul><li>Preclinical</li><li>Clinical Trials / Research</li><li>Therapeutic Drug Monitoring</li><li>Omics</li><li>Biomonitoring</li><li>Toxicology</li><li>Hormones / Steroids</li><li>Biomarkers</li><li>Vitamins</li><li>Allergens</li><li>Population Screening</li><li>Infectious Diseases</li></ul></div>

Trajan Mitra Microsampling Devices - 96-autorack

The 96-Autorack™ format is designed for laboratories to efficiently batch and process Mitra microsamples using a standard 96-well format.

<h3>About</h3>The 96-Autorack™ format is designed for laboratories to efficiently batch and process Mitra microsamples using a standard 96-well format. Compatible with most 1mL &amp; 2mL collection plates and 96-channel pipettors &amp; liquid handling workstations, the 96-Autorack enhances lab productivity and integration. We provide two options: an empty 96-Autorack, perfect for accessioning microsamples from Mitra devices received from the field for building plates, extractions, and long-term storage; and prefilled 96-Autoracks with 96 Mitra samplers, ideal for method development and handling calibrators and QCs.<h4>Accession &amp; Process Multiple Mitra Samples at Once</h4>This high-throughput solution allows you to rapidly process Mitra microsamples for method development, plate building, extractions - or all of the above!<ul><li>Racks available empty or filled with 96 microsamplers (10, 20, &amp; 30 µL volumes)</li><li>Filled racks come with a 2mL deep well storage plate</li><li>Compatible with 96-channel pipettors &amp; liquid-handling workstations</li><li>Options with &amp; without barcoding</li></ul><h3>Specifications</h3><div class="tabs__tab txt--light tabs__tab--active" id="tab_17217760014256_2"><ul><li>Indication for Use: A single-use, non-sterile device used as a specimen collector, and for the storage and transport of blood and other biological fluids for analytical and diagnostic analyses.&nbsp;</li><li>Sampler Tip Volume: 10, 20, or 30uL&nbsp;&nbsp;</li><li># of Samplers per Device: 0 or 96&nbsp;</li><li># Device per pack: 1/Pk</li><li>Pack content: 1x 96-Autorack (empty or pre-filled), Sample ID Barcode, 1x Collection Plate, 1x IFU</li><li>Shelf Life: 18 months&nbsp;</li><li>Regulatory Status: Mitra® devices are CE-IVD (IVDR) devices intended as a specimen collector, and for the storage and transport of blood and other biological fluids for analytical and diagnostic analyses. They are available as registered IVD Devices in the European Union and United Kingdom, Australia, Brazil, China, and Canada, as well as multiple Health Ministries worldwide. In the USA, Mitra devices are supplied as a research use only (RUO) product to assist in method development, other research-related and non-diagnostic activities. End-users and laboratories must validate the use of the Mitra devices for the particular diagnostic testing intended.</li></ul><h3>How to Use</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Mitra%20IFUs/2024/VLBL-0098rev04.pdf">96-Autorack Instructions For Use (IVD)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/IFUs/2023/96%20autorack/VLBL-0098-Rrev01.pdf">96-Autorack Instructions For Use (RUO)</a></li></ul><h3>Resources</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/User%20Guides/Mitra%20User%20Guide%20Extracting%20&amp;%20Processing%20Microsamples.pdf">User Guide | How to Extract &amp; Process Mitra Microsamples</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/NEOX_Content/Technical%20Briefs%20and%20Guidances/Long%20&amp;%20Short%20Term%20Storage%20of%20Mitra%20Samples_TG00010122.pdf">User Guide | How to Store Dried Mitra Microsamples</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/hubfs/GenTegraRNA-NEO%20for%20Mitra%20devices%20USER%20GUIDE%2011.15.23.pdf">User Guide | How to Stabilizer RNA on Mitra Microsamples with GenTegraRNA-NEO™</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.neoteryx.com/frequently-asked-questions?hsLang=en">Frequently Asked Questions</a></li></ul><h3>Mitra devices deliver tremendous ease &amp; value to specimen collection!</h3><div class="tabs__tab txt--light tabs__tab--active" id="tab_17217760014256_3"><div class="tabs__tab txt--light tabs__tab--active" id="tab_17217760014256_4">Mitra® Microsampling Devices offer a streamlined, flexible, and decentralized approach to biological specimen collection. Enjoy the benefits of easier trial recruitment, increased adherence / compliance, elimination of cold-chain shipping / storage &amp; reduced reliance on trained staff.<h4>The gold-standard in remote specimen collection</h4>Powered by VAMS® technology, the patented Mitra® Microsampling Device offers a streamlined, flexible, and decentralized approach to biological specimen collection, transport, and preparation. Use Mitra to facilitate sampling direct from animals, humans, or tubes to collect precise, reliable dried microsamples compatible with a wide variety of downstream applications as evidenced by the hundreds of published peer-reviewed manuscripts and the millions of devices that have been used in the field.<h4>Mitra: pioneering VAMS technology</h4>Trajan’s proprietary VAMS® Technology is at the heart of the Mitra device, featuring a sampler tip crafted from a porous, hydrophilic polymeric material. This 'precision sponge' rapidly and consistently absorbs a specific volume of biological fluid—simply by contacting the source. The fluid is then allowed to dry acting as a stabilizer for most analytes.Available in three tip sizes—10, 20, and 30 µL— and multiple formats, Mitra devices meet diverse end-user and analytical needs. Configurations include dual (2) or quad (4) samplers across various formats.&nbsp; Collect from 20 µL to 120 µL per device based on format selected. Our team of expert microsampling consultants is on hand to provide scientific support, helping you choose the optimal format and workflow for your specific applications.<ul><li>Reliable: Quantitative sampling with pipette-like precision (RSD ≤ 5%). VAMS eliminates traditional blood hematocrit biases and results in extremely low in-lab sample rejection rates. No glue used in assembly, no matrix interferences.</li><li>Versatile: Collect biological fluids—blood, plasma, urine, saliva, and even tears—efficiently from humans and animals (e.g., finger, arm, knee, tail, etc.) or containers. Manual to fully automated workflows are available.</li><li>User-Friendly: 99% sample acceptance rate validated by studies. VAMS tip acts as a fill indicator to confirm successful sampling. Outer housing protects against contamination and facilitates easy remote or home sampling.</li><li>Cost-Effective: Eliminate phlebotomy, couriers, and cold-chain shipping / storage requirements. Devices are compatible with standard automated liquid handling systems and available in various formats to suit different budgets.</li></ul><h4>Successful uses</h4>Have you seen the published, 3rd party literature of how others have successfully implemented Mitra devices?<ul><li>Preclinical</li><li>Clinical Trials / Research</li><li>Therapeutic Drug Monitoring</li><li>Omics</li><li>Biomonitoring</li><li>Toxicology</li><li>Hormones / Steroids</li><li>Biomarkers</li><li>Vitamins</li><li>Allergens</li><li>Population Screening</li><li>Infectious Diseases&nbsp;</li></ul></div></div></div>

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