Meeting EU Drinking Water Standards: The Critical Role of Sample Prep in Trace Contaminant Analysis

<h3><strong>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</strong></h3><p><strong>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711"></p><p>Among the analytical techniques available today, <strong>anion exchange chromatography (AEX)</strong> stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808"><strong>Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</strong></a></p></blockquote><h4><strong>How Scientists Read Oligonucleotides Using Charge</strong></h4><p>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.</p><p>As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.</p><h4><strong>Why Ion Exchange Works: Binding, Retention, and Release</strong></h4><p>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, <strong>anion exchange</strong> is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.</p><p>The system consists of two main components:</p><ul><li><strong>Stationary phase:</strong> A positively charged resin that binds anionic analytes.</li><li><strong>Mobile phase:</strong> An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul><p>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"></p><h4><strong>The Five-Step Workflow of Ion Exchange Chromatography</strong></h4><p>AEX separations generally follow a well-established sequence of steps:</p><ol><li><strong>Column equilibration</strong><br>The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li><strong>Sample loading</strong><br>Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li><strong>Washing</strong><br>The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li><strong>Elution</strong><br>Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li><strong>Regeneration and re-equilibration</strong><br>A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2  Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"></p><h4><strong>Why AEX Is Especially Effective for Oligonucleotides</strong></h4><p>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.</p><p>Key factors influencing AEX behavior include:</p><ul><li><strong>Charge density:</strong> Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li><strong>Resin chemistry:</strong> Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li><strong>Buffer composition:</strong> The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul><p>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"></p><h4><strong>AEX as the Gold Standard for Oligonucleotide Separation</strong></h4><p>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:</p><ul><li><strong>High resolving power:</strong> Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li><strong>Predictable retention behavior:</strong> In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li><strong>Compatibility with modified oligonucleotides:</strong> Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li><strong>Excellent control via gradient elution:</strong> Salt gradients provide precise tuning of selectivity and resolution.</li></ul><p>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"></p><h4><strong>Final Perspective: Mastering AEX with Confidence</strong></h4><p>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.</p><p>For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.</p><blockquote><p>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at <strong>sales@knauer.net</strong>. More insights into practical oligonucleotide analysis will follow in our <i>“Oligos Made Easy”</i> series.</p><p>For technical questions or in-depth discussion, the author can be reached at <strong>kindler@knauer.net</strong></p></blockquote>

Oligos Made Easy - Part 2: AEX

<p><strong>Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal </strong><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1"><i><strong>Nature Communications</strong></i></a><strong>.</strong></p><p>“<i>Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials</i>,” said the article’s first author, <strong>David Panáček</strong> from CATRIN, who worked on the study during his internship at Imperial College London.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152"></p><p>Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “<i>Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration</i>,” said one of the corresponding authors, <strong>Michal Otyepka</strong>.</p><p>The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"><strong> CEITEC – VUT</strong></a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.</p><p>“<i>This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,</i>” added another corresponding author, <strong>Nuria De Diego</strong>.</p>

Current sensors are not good enough. Scientists propose a new way to monitor plant health

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The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Waters ACQUITY QDa II Mass Detector

The ACQUITY™ QDa™ II Mass Detector enhances efficiency and productivity in separations workflows with advanced technology.

<h3><strong>Advancing the Power of Mass Detection</strong></h3><ul><li><strong>Identify Everything in Your Sample with Complete Confidence&nbsp;</strong></li></ul><h5><strong>Information-rich mass spectral data starts here&nbsp;</strong></h5><p><strong>Built on a solid foundation of groundbreaking technology, the ACQUITY™ QDa™ II Mass Detector provides even more efficiency and productivity of separations workflows, providing information-rich mass spectral data, ensuring compliance, and regulatory certainty.</strong></p><h4><strong>SEE MORE COMPOUNDS</strong></h4><p>Greater compound coverage from an extended mass range to support small molecules, large molecules and new modalities. 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The ACT Environmental Impact Factor Label<strong>*</strong> -- available and published by My Green Lab – provides clear, third-party verified information about the environmental impact of laboratory products, enabling you to make the most sustainable decisions for your organization.</p><p><strong>* </strong>ACT - About (<a target="_blank" rel="noopener noreferrer" href="https://www.mygreenlab.org/">mygreenlab.org</a>)</p><h3><strong>Continuing to Separate Beyond Question</strong></h3><ul><li><strong>Ensure your laboratory is prepared for the future</strong></li></ul><h4><strong>MORE PERFORMANCE</strong></h4><p>Plug and play performance with its intuitive design, complementary to optical detection with the robustness to handle all of your analyses. 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Compatible with green solvents ensuring reduced environmental impact.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg" alt="Waters ACQUITY QDa II Mass Detector." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg 234w," sizes="100vw" width="1024" height="682"></p><ul><li>Simply power on, and you’re ready to go</li><li>Zero user set-up optimization, calibration, or adjustment</li><li>Run your analyses − it just works</li><li>When you’re done, just power-off</li></ul><h3><strong>The Perfect Partner</strong></h3><h4><strong>Designed for compatibility with your chromatography&nbsp;</strong></h4><p>Meet all your chromatography requirements with Waters chromatography systems, including our dependability and flexibility ranges of HPLC systems, performance range of UPLC systems, and our purification and specialty systems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg" alt="Waters ACQUITY QDa II Mass Detector: The Perfect Partner. Designed for compatibility with your chromatography." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg 189w," sizes="100vw" width="1299" height="1074"></p><h3><strong>Effortless Integration</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>Process, Interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. With integrated optical and mass detector data processing workflows, you can also analyze mass spectral data in the same way as you do photo diode array (PDA) data.</p><p>The ACQUITY QDa II Mass Detector is fully compatible with Masslynx™ Software and its suite of data processing application managers. 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Highlighted additional components identified s a result of the extended mass range." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Selected_Ion_Recording_SIR_chromatogram_of_doubly_charged_components_of_a_glycan_sample_Highlighted_additional_components_identified_s_a_result_of_the_extended_mass_range_ac0160e74d.jpg 238w," sizes="100vw" width="1347" height="883"></p><h3><strong>Unparalleled Robustness for More Qualitative and Quantitative Performance</strong></h3><h4><strong>Reduce the risk of genotoxic impurities formation in drug manufacturing</strong></h4><p data-start="0" data-end="296">Support risk assessment through routine monitoring of excipients and raw materials in drug manufacturing. 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Waters has addressed these challenges by providing an instrument with low electricity consumption and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg" alt="Waters ACQUITY QDa II Mass Detector: Improving Efficiency with a More Sustainable Mass Detector. Low operational costs and environmental footprint." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg 245w," sizes="100vw" width="1124" height="389"></p><p><strong>*</strong>From competitor A Specification Sheet.</p><p><strong>**</strong>From competitor B Site Preparation Checklist</p><h3><strong>Unrivaled Support</strong></h3><h3><strong>Ensure your success with world-renowned services</strong></h3><p data-start="77" data-end="464" data-is-last-node="" data-is-only-node="">Waters Service and Support helps maintain peak system performance, minimize downtime, address scientific challenges, and meet compliance requirements.&nbsp;</p><p>Waters award-winning consistent quality support, professional services, and education ensure your success wherever your laboratory is located in the world. With Waters service and support offerings<strong>*</strong> for your ACQUITY QDa II Mass Detector, you can</p><h4><strong data-start="0" data-end="30">GET UP AND RUNNING QUICKLY</strong></h4><p data-start="0" data-end="235">Get the onsite training and consultation you need to integrate the ACQUITY QDa II Mass Detector into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong data-start="237" data-end="276">MEET YOUR LAB’S UNIQUE REQUIREMENTS</strong></h4><p data-start="237" data-end="460">Protect your instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong data-start="462" data-end="487">FACILITATE COMPLIANCE</strong></h4><p data-start="462" data-end="635">Simplify the process of qualification, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong data-start="637" data-end="671">REDUCE TOTAL COST OF OWNERSHIP</strong></h4><p data-start="637" data-end="864">FlexCAPITAL™ <strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong data-start="866" data-end="903">LEVERAGE YOUR EXISTING TECHNOLOGY</strong></h4><p data-start="866" data-end="1104" data-is-last-node="" data-is-only-node="">With the FlexUP™ Technology renewal program, you can upgrade your older single quadrupole mass spectrometry system to the ACQUITY QDa II Mass Detector -- improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong> Availability of offerings varies by country. Contact Waters or your local Waters representative for details<br><strong>**</strong> FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters RADIAN ASAP Direct Mass Detector

Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.

<div><div id="title-a9e634f6cb" data-locator="title-with-text"><h3><strong>The power of knowing now</strong></h3></div></div><div><div id="text-c687cac6aa" data-locator="text"><p><strong>Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times, integrating direct mass spectrometry (MS) analysis can drive multiple system-wide efficiencies helping to achieve your operational goals.</strong></p><p>Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.</p><ul><li>Simple operation and data interpretation</li><li>Minimal sample preparation</li><li>No separation required</li><li>Real-time results and classification</li></ul><figure class="image"><img style="aspect-ratio:454/321;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_7cfe24b23d/Waters-RADIAN-ASAP_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="454" height="321"></figure><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-6b896f6da4" data-locator="text"><ul><li>Ensure users get up and running quickly with RADIAN ASAP’s easy to learn and fully automated set up, streamlined workflow, and minimal training requirements</li><li>Minimize sample prep with direct sampling onto glass probe</li><li>Minimize the need for solvent use and disposal with no chromatography</li><li>Save time with 30 second analysis and real-time sample classification</li></ul></div></div><div><div id="text-161a2a5c01" data-locator="text"><h4><strong>Recommended Use</strong></h4><p>For rapid, easy, and low-cost analysis of liquids and solids.</p><div><div id="text-4973311325" data-locator="text"><h3 data-locator="modal-title"><strong>Compact without compromise</strong></h3><p>The RADIAN ASAP is a novel, dedicated direct analysis system specifically designed for rapid, easy and low-cost analysis of liquids and solids. Engineered using proven and robust single quadrupole mass spectrometry technology combined with the Atmospheric Pressure Solids Analysis Probe (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/services/instrument-services/instrument-upgrades/mass-spectrometry-ms-upgrades/atmospheric-solids-analysis-probe.html" data-di-id="di-id-70d78c77-7e033f9d">ASAP</a>), the RADIAN ASAP delivers quality and ease of use in a compact footprint.&nbsp;</p><p>This single quadrupole mass detector provides high quality mass spectral data, without the need for any special training or expertise, eliminating any need to contract out and wait for results from specialist analytical service laboratories.</p></div></div><div><div id="text-08366f2c0d" data-locator="text"><h3 data-locator="modal-title"><strong>Flexible workflow solutions in 4 simple steps</strong></h3><p>Operation of the RADIAN ASAP is simple and intuitive, allowing users to generate results with minimal or no sample preparation, making it an ideal tool for laboratories to make informed decisions. Capable of ionizing molecules directly from a liquid or solid makes the system available to a wide range of applications and workflows.</p><h4><strong>Generate results in 4 simple steps:</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg" alt="Waters RADIAN ASAP Direct Mass Detector: Flexible workflow solutions in 4 simple steps" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/thumbnail_Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg 245w," sizes="100vw" width="1683" height="490"></p><h3><strong>Ideal for numerous application requirements</strong></h3><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=135078611" data-di-id="di-id-7f758d90-ccee23de"><strong>Rapid triage of seized drug materials for Forensics</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and LiveID ensure crime labs can quickly screen samples against a library of known compounds for rapid, confident identification of illicit drugs. The sensitivity and selectivity of mass spectrometry provides confidence in detecting drugs with an easy, efficient triage workflow.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134528742" data-di-id="di-id-3a3c46e4-ccee23de"><strong>Assess food integrity for Food &amp; Environmental</strong></a>&nbsp;<strong>—</strong> The threat posed by food fraud has created additional demands on both the food industry and regulators to protect food consumers and maintain brand reputation. RADIAN ASAP and LiveID offer a powerful combination of mass spectrometry and chemometric modeling, allowing users to easily and efficiently screen samples and make quicker decisions.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.tainstruments.com/radian-asap-direct-mass-detector/" data-di-id="di-id-2fac456-44144a9d"><strong>Fast chemical analysis for improved formulation testing in Chemical and Materials</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and IonLynx supports quality control (QC) and development labs in the chemical industry to reduce costs and increase efficiencies. Streamline workflows like fast chemical analysis for improved formulation testing or&nbsp;material release testing. Features including thermal gradient analysis are ideal for the complex samples in the chemical industry.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134751395" data-di-id="di-id-76921eaa-ccee23de"><strong>Discovery reaction monitoring&nbsp;for Pharma</strong></a>&nbsp;<strong>—</strong> The demand to accelerate the drug discovery and development process has never been higher.&nbsp;RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near-instantaneous assessment of reaction progress and identification of purification fractions, increasing lab efficiency.</p><div><div><div><div id="text-8b0fa56c8c" data-locator="text"><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134971387" data-di-id="di-id-10e51f17-ccee23de"><strong>Undergraduate teaching&nbsp;and method development&nbsp;in Academia</strong></a><strong> —&nbsp;</strong>Simplicity and ease of use makes RADIAN ASAP the ideal tool for busy academic laboratories that need a robust and reliable solution.</p><figure class="image"><img style="aspect-ratio:474/308;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_2_87ddc46f15/Waters-RADIAN-ASAP-2_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="474" height="308"></figure><div><div id="text-a5e5e26910" data-locator="text"><h3 data-locator="modal-title"><strong>Software solutions for your data requirements</strong></h3><p><strong>RADIAN ASAP</strong> is compatible with software solutions for rapid interpretation and classification as well as automated data processing and reporting.</p><p>For customers investigating the authenticity, adulteration, and quality of food or raw materials, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=5&amp;search=liveid"><strong>LiveID</strong></a> uses statistical models to classify samples. First, authentic or verified samples are used to create and validate a statistical model. The validated model can then be used with test samples and generate live classifications with a simple yes/no answer output. LiveID can also do real time <strong>library</strong> matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of <strong>1000</strong>, where values close to 1000 indicate the compound of interest is likely in the sample and lower scores indicate unlikely presence in the sample.</p><p><strong>OpenLynx</strong> processing provides user customizable processing capabilities to generate automated mass confirmation reports in either pdf, printed or browser format.&nbsp;</p><p><strong>IonLynx</strong> allows users to determine levels and relative ratios of analytes of interest in complex samples to aid decision making in QC and formulation monitoring. IonLynx provides automated processing and reporting of non-chromatographic data sets, such as those generated by RADIAN ASAP.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Products focused on LC/SQ from Waters - page 1

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