Drug Testing by LC-MS: Oncology and Anti-Epileptic Drugs
A large number of AEDs are available, and it is often necessary to quantitatively determine each compound in one analysis. Assay methods include a range of gas- and liquid- chromatographic procedures, and specific immunoassays, although the latter are not available for all AEDs. This presentation describes a UPLC/MS/MS method capable of analysing a panel of AEDs, and, where appropriate, the active metabolite, simultaneously in a single procedure.
Agenda:
Topic 1: Analysis of Methotrexate, Busulfan and 5FU from Plasma and Serum for Clinical Research
Topic 2: Rapid Analysis of Panels of Anti-Epileptic Drugs (AEDs) for Clinical Research
Presenter: Stephen Balloch (Senior Scientist, Clinical Applications, Waters UK)
Stephen Balloch graduated from the University of York (UK) with a Masters degree in Chemistry which included a strong focus on analytical chemistry and a year in industry, in which he gained experience in a range of analytical techniques.
His first permanent post was at Charles River Laboratories, a GLP compliant contract research laboratory in Edinburgh, in which he progressed to the role of Study Director and gained further exposure to LC-MS and LC-MS/MS instrumentation, including Waters instruments.
Since 2010, he has been part of the clinical team in the Scientific Operations group in Waters (Wilmslow, UK). His principal focus has been on the development and validation of bioanalytical methods according to CLSI guidelines, with a focus on therapeutic drug monitoring. Additionally, he has supported newborn screening, steroid and vitamin analysis.
Presenter: Gareth Hammond (Principal Scientist, Waters UK)
Gareth Hammond is currently a Principal Scientist, within the Scientific Operations group, at Waters Corporation, Wilmslow, UK. He leads a small team of scientists which perform research and development activities for Waters applications and products in the Health Sciences field. His primary area of expertise is therapeutic drug monitoring and LC-MS/MS Method Development and Validation. He is also supports IVD system product development activities for Waters providing voice of the customer focus.
