The Agilent and Atturos pathway for the development of targeted biomarker measurements for precision medicine
Personalized medicine for improved human health outcomes will depend on the availability of better clinical research tests. These tests will incorporate data from multiple protein biomarkers and combine this with existing clinical research to provide subject-specific individual ‘scores’ and inform clinical decision making.
In this expert webinar, Prof. Stephen Pennington, Dr. Orla Coleman, and Dr. James Waddington outline the significant clinical need for better chronic disease testing and explain how this need can be met through an integrated workflow that enables simplified, robust, reproducible, and cost-effective analysis of readily collected human samples. Using supporting illustrative data, these experts demonstrate how it may be possible to use clinical research measurements for precision medicine.
Key learning objectives:
- Importance of standardized, reproducible, and simplified workflows for the generation of clinical-grade protein multiple reaction monitoring (MRM) data
- Impact of routine QCs and system suitability monitoring for large-scale clinical studies
- Key role of advanced diagnostic tests based on multiplexed protein MRM data in a future of personalized medicine
Who should attend:
- Clinical lab managers
- Clinical research scientists
- Clinical researchers
Presenter: Professor Stephen Pennington (Atturos founder, CSO and interim CEO. Professor of Proteomics at University College Dublin)
Steve graduated from Imperial College of Science and Technology with a joint honors degree in chemistry and biochemistry before completing a Ph.D. in biochemistry at the University of Cambridge.
His current research team at University College Dublin (UCD) is developing multiplexed protein biomarker measurements to support the translation of blood protein biomarkers to clinical diagnostic tests. He founded the UCD spin-out company Atturos in late 2016 and was awarded UCD's Innovator of the Year in 2018.
In 2017, he was the lead organizer of the 16th Human Proteome Organisation (HUPO) World Congress, which was held in Dublin and included a gala dinner at which then former US Vice-President, now US President Joe Biden was guest speaker. Steve is currently Professor of Proteomics and Senior Fellow, UCD Conway Institute, President of the British Society for Proteome Research, and past President of HUPO. He is co-coordinator of the recently funded IMI project ‘HIPPOCRATES’
Presenter: Dr. Orla Coleman (Senior Scientist, Atturos)
Orla graduated with a first-class honors degree in biomedical sciences from Maynooth University in 2014 before undertaking her Ph.D. at the National Institute for Cellular Biotechnology from 2014 to 2018. Her research interests focused on proteomic analyses and biomarker identification using mass spectrometry, which has led to 13 publications across multidisciplinary fields. Orla joined Atturos in 2019 as a senior scientist.
Presenter: Dr. James Waddington (Senior Scientist, Atturos)
James obtained his Ph.D. in molecular and clinical pharmacology from the University of Liverpool in 2019. Previous research focuses included the implementation of novel techniques to analyze microbial metagenomics signatures in order to identify disease biomarkers, and cellular responses to HIV viral infection. More recently, James has focused on the characterization of naturally processed MHC peptides that act as T cell antigens in patients with drug hypersensitivity. James joined the Atturos team in 2020 where he is actively involved in product development and the management of laboratory-based strategic research agreements.
Presenter: Tom Casburn (Editorial Team, SelectScience)
Tom studied biology at the University of Bristol, UK, and as a member of the editorial team, plays an integral role in helping to shape the content on SelectScience.
