Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking.

Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.

Attend this webinar to:

• Learn about innovative metabolomics workflows
• Discover how the Bruker timsTOF Pro and fleX systems can be used in metabolomics workflows
• Learn how the MALDI-2 post-ionization laser can see never before observed compounds

Presenter: Gary Patti, PhD (Professor, Department of Chemistry, Washington University in St. Louis)