Direct Karl-Fischer Titration or Gas Phase Extraction – A Closer Look

Three Webinars and a Roundtable with Experts from Merck KGaA, Darmstadt, Germany, Metrohm & Mettler Toledo

A Week Dedicated to Karl Fischer Titration!

Karl Fischer titration is still the most used, most accurate, and fastest method to determine water content in all kinds of sample matrices. This titration week covers different aspects that need to be considered when determining the water content in products, raw materials, and other substances. Experts from the life science business of Merck KGaA, Darmstadt, Germany, Metrohm AG, and Mettler Toledo will present and discuss different steps of the Karl Fischer titration process and how to improve it. Learnings include:

• Karl Fischer titration process and tips for how to improve it
• Karl Fischer oven method and its advantages
• Reference materials to use for titer determination, instrument check, and result verification
• Parameters needed to validate a Karl Fischer titration application
• News and future aspects of Karl Fischer titration

Direct Karl-Fischer Titration or Gas Phase Extraction – A Closer Look

In this presentation we will compare the direct addition with the gas phase extraction method. For this purpose, various sample types were analyzed by either direct addition, gas phase extraction, or both. Among the tested sample types are powders, oils, and cannabis flower. We will discuss the challenges that such samples represent and highlight the analytical measures that will ensure to obtain the best results possible. By attending this presentation, you will learn about:

• Direct titration vs. gas phase extraction method
• Advantages of the Karl Fischer oven method (gas phase extraction)
• Application examples: oils / cannabis flower

Presenter: Thomas Hitz, PhD (Application Development, Automated Karl-Fischer Titration, Mettler Toledo)