Practical Purification Tactics for Improving Compound Isolation

Join us for this two-part webinar series where we will share successful techniques to effectively improve lab-scale HPLC purification to isolate and purify important target compounds.

In the development of drug therapeutics, preparative chromatography is especially useful in providing sufficient yields of compounds with high purity intermediates and final products. Lab scale purification is also essential for isolating compounds from complex mixtures in other industries including food and environmental, biopharmaceutical, and natural product research. We will present simple techniques that can be easily implemented to improve compound isolation quickly and effectively. These predictable strategies for scaling and optimizing separations, whether used alone, or in combination, ultimately lead to enhanced product purity and yield within reasonable timelines.

Key Learnings from this series include:

• Gain insights for applying simple techniques to improve lab-scale purifications

• Learn to scale your analytical – prep workflows predictably

• For problematic targets, gain confidence choosing successful strategies to meet purification goals

• Boost preparative workflow efficiency using Waters OBD columns

Who Should Attend?

• Scientists performing mg scale isolation and purification workflows

• Medicinal and Synthetic Chemists in Pharmaceutical & Academia

• Scientists, novices to experts, using HPLC for lab-scale purification of target molecules

Presenter: Jo-Ann Jablonski (Principal Scientist, Waters Corporation)

Jo-Ann Jablonski is a Principal Scientist in the Consumables and Lab Automation Group at Waters Corporation. Prior to joining Waters, she worked as an oligonucleotide chemist synthesizing and purifying DNA probes for research projects in a biotech company focused on developing cutting-edge therapeutics. Jo-Ann was later responsible for synthesizing, analyzing, isolating, and characterizing peptides for research at the small scale. She then transitioned to developing a process for the manufacture of a therapeutic peptide product. Since joining Waters 25 years ago, Jo-Ann has provided technical support, training, and application assistance for Waters’ chemistry products and purification systems.