ASMS 2023: Metabolic profiling, mass spectrometry and the National Phenome Centre

The main goal of metabolic profiling is to understand the metabolic changes that occur in response to specific stimuli, such as diseases, environmental factors, drugs, or genetic modifications.

By comparing the metabolic profiles of healthy and diseased samples, researchers can identify unique metabolic signatures associated with specific conditions.

These biomarkers can be potentially valuable for the early detection of disease, monitoring treatment response, and understanding disease mechanisms. In this webinar Dr. Gómez-Romero at the NPC, London, discusses how they undertake large scale metabolic phenotyping studies and the opportunities and challenges they face.

This webinar focuses on:

• What is metabolic phenotyping?

• The workflow for large-scale LC/MS based metabolomic

• Experimental design for untargeted biomarker discovery

Key learning objectives:

• The importance of study design in large-scale metabolomic phenotyping

• How platform stability increases confidence in results

• How to maximize metabolomic phenotyping data from LC/MS experiments

Who should attend:

• Scientists in academia, industry, core research laboratories and biomedical research

• Researchers undertaking metabolomic and lipidomic experiments particularly those conducting large scale experiments

• Anyone with an interest in mass spectrometry who wants to learn more

Presenter: Dr María Gómez- Romero (Mass Spectrometry and Chromatography Manager, MRC-NIHR National Phenome Centre, Imperial College London, UK)

As LC-MS platform lead in the National Phenome Centre (NPC) at Imperial College London (ICL), Maria oversees the application of mature LC-MS methods and technologies to collaborative projects, ensuring timely completion of the ongoing project deliverables. Her primary research interest focuses on the development, validation and application of profiling and targeted UHPLC-MS methodologies in metabolic phenotyping for the analysis of biological samples (e.g. urine, blood products, faecal and tissue extracts, cells,) with epidemiological and clinical applications.

Maria studied Chemical Engineering at the University of Granada (UGR, Spain) completing her final year design project in University College London. Upon completing her BSc she undertook an MSc in Chemistry and Ph.D. in Analytical Chemistry at UGR. In 2011 she started working at ICL as a research associate until 2017, when she joined NPC.