LCMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Organizer
Thermo Fisher Scientific
A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.
Tags
LC/HRMS
LC/MS
LC/MS/MS
LC/Orbitrap
Logo of LinkedIn

Method considerations for therapeutic oligonucleotide (ASO) RNA analysis

RECORD | Already taken place Th, 25.4.2024
This webinar will present a successful routine method with optimized HRMS conditions developed for synthetic oligonucleotide impurity analysis which resolves all of these problems.
Go to the webinar
ThermoFisher Scientific: Method considerations for therapeutic oligonucleotide (ASO) RNA analysis

ThermoFisher Scientific: Method considerations for therapeutic oligonucleotide (ASO) RNA analysis

Oligonucleotide analysis has gained considerable interest over the last few years with the successful introduction of mRNA vaccines and the synthetic short interfering RNA therapeutics.

Synthetic RNA drug products extend the need for new analytics to accurately determine impurities generated during manufacture. The highly charged, linear chain structure already provides analytical challenges. The introduction of sulphur onto an asymmetric phosphate group for stability causes additional chromatography related problems. Amine ion pair and metal adducts create a quantitation problem due to multiple split signals. In-source generated impurities compound this problem.

This webinar will present a successful routine method with optimized HRMS conditions developed for synthetic oligonucleotide impurity analysis which resolves all of these problems. We hope to see you there!

Learning Points:

  • Routine method for synthetic oligonucleotide impurity analysis
  • How to resolve analytical challenges for ASO RNA analysis

Who should attend?

  • Biopharmaceutical Research Scientists
  • Analytical Scientists from Biopharma companies working on or interested in oligonucleotide-based therapies
  • PhD students and scientists looking to advance knowledge of oligonucleotide analysis

Short notice:

Can't attend the live broadcast? No problem! Register anyway and you will automatically receive the link to the webinar recording.

Presenter: Dr. Ken Cook (European Manager BioPharma Expert Support Group, Thermo Fisher Scientific)

Moved to industry from a University lectureship in Biochemistry, University of Newcastle upon Tyne, following 7 years’ experience in academia. Now with over 35 years’ experience with Thermo Fisher Scientific using a wide range of analytical equipment and software. Publications range from metabolomics, proteomics to large biopharmaceutical drug analysis. Current job title is the European manager for the BioPharma expert support group. This involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Characterization methods of Bio-therapeutics include, monoclonal antibodies, peptides, AAV analytical development, small and large RNA analysis including sequence mapping of mRNA by LC/HRMS.

Thermo Fisher Scientific
 

Related content

USP-Compliant Analysis of Antibody Drugs Using Size-Exclusion Chromatography (SEC)

Applications
| 2024 | Shimadzu
Instrumentation
GPC/SEC
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

ACQUITY QDa II Mass Detector brochure

Brochures and specifications
| 2024 | Waters
Instrumentation
LC/MS, LC/SQ
Manufacturer
Waters
Industries
Others

Analysis of Per- and Polyfluoroalkyl Substances in Fast Food Packaging by LC-MS/MS Method

Applications
| 2024 | Shimadzu
Instrumentation
LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

Watrex product catalog 2024

Brochures and specifications
| 2024 | Watrex Prague
Instrumentation
HPLC, GPC/SEC, Sample Preparation, LC columns, Consumables
Manufacturer
Watrex Prague
Industries
Others

IMPACT OF HPLC INSTRUMENTATION ON NON- SPECIFIC ADSORPTION OF PEPTIDES

Posters
| 2024 | Waters (Analytica)
Instrumentation
HPLC
Manufacturer
Waters
Industries
Proteomics
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike