From start to finish: How Agilent Technologies can provide trusted answers for producing IVT mRNA-based vaccines

Development and production of IVT mRNA vaccines requires measurements of Critical Quality Attributes (CQAs), such as identity, purity, quality, and quantity. Orthogonal methods developed for such purposes are outlined in the USP guidelines for mRNA vaccines.

Agilent Technologies provides many analytical solutions that are used by leading pharmaceutical companies in early-stage drug development through production quality control (QC) and final product release. These systems help users save time and money with optimized workflows, streamlined processes, and fast time to results.

Whitney Pike, M.Sc, Application Scientist and Dr. Sonja Schneider, Manager Application Development, Agilent Technologies, will discuss how the automated electrophoresis and LC/MS systems solutions from Agilent provide trusted answers for IVT mRNA workflows at many steps, from QC of the initial plasmid DNA, throughout the IVT process, and the finished mRNA drug product.

Key learning objectives

• Explore QC throughout the entire IVT mRNA workflow, including data from various nucleic acids and LNP analyses

• Discover how Agilent instruments/technologies, such as the Fragment Analyzer and LC/MS systems, can be used for different CQAs

• Learn how Agilent is working together with its partners to provide trusted answers for all aspects of the IVT mRNA workflow

Who should attend?

• Researchers, lab managers, lab directors, QA/QC managers performing IVT mRNA analysis in biotherapeutics research and production

Presenter: Whitney Pike, MA (Application Scientist, Agilent Technologies)

Whitney Pike joined Agilent in 2016 and is an application scientist with a focus on Agilent’s automated electrophoresis instruments. She played a pivotal role in the release of the Femto Pulse system as a scientist on the product development team. She completed her master's degree in Biology, with an emphasis on cellular, molecular, and developmental biology, before working at a core facility at Iowa State University, responsible for performing next-generation sequencing studies.

Presenter: Dr. Sonja Schneider (Manager Application Development, Agilent Technologies)

Dr. Sonja Schneider joined Agilent in 2011 as an Application Scientist for biopharma applications. She has been leading the Application Development Team since 2016 and still works in the lab on up-to-date biopharma applications. She completed her diploma degree in Biology and her phD in Biochemistry before joining Agilent.

Presenter: Will Thompson (Editorial Team, SelectScience)

Will studied Biology at the University of Bristol, UK, and as a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.