Expedite Process Development with Automated PQA and Spent Media Analysis with the BioAccord LC-MS System
The necessity to develop a robust process for complex biologics manufacturing poses significant challenges for analytical testing. This demands automated, high-throughput, and comprehensive analytical results with rapid feedback to enable timely adjustments for process optimization. Therefore, mass spectrometry-based high-throughput, rapid product quality attribute (PQA) analysis and media metabolite analysis are crucial for the manufacturing of complex antibody drugs.
In this webinar, we will present an automation-assisted at-line Process Analytical Technology (PAT) for PQA and spent media analysis designed to expedite process development. Samples were prepared using an automated workstation, ensuring a fast turnaround time and high-throughput approach. Data acquired and analyzed with the BioAccord LC-MS system, coupled with the waters_connect platform, provided robust feedback for process development.
We will demonstrate two examples: one illustrating how to understand process parameters affecting the mispaired bispecific antibody ratio, and another facilitating process troubleshooting.
Presenter: Li Wang (Associate Director, Analytical Sciences, WuXi Biologics)
Li Wang is the Associate Director of the Analytical Sciences Department at WuXi Biologics. He earned his Ph.D. in Chemistry from the University of South Carolina, Columbia. His expertise lies in analytical method development and the characterization of polypeptides and proteins. He and his team has been focusing on developing automated platforms for various analytical methods and advancing process analytical technology.
