Fundamentals and biotherapeutics applications of Multi-Angle and Dynamic Light Scattering

Biophysical techniques such as multi-angle light scattering (MALS) and dynamic light scattering (DLS) address numerous critical analytical challenges in biotherapeutic formulation development, including the screening for aggregation, colloidal and conformational stability, viscosity, and chemical modifications.

In this webinar, we will delve into the fundamentals and advantages of SEC-MALS and DLS for the biophysical characterization of monoclonal antibodies (mAbs), conjugated proteins, and adeno-associated viruses (AAVs). We will present key analytical methods utilizing the latest MALS, DLS, and refractive index (RI) instrumentation to obtain absolute molecular weight, size, and composition of biotherapeutics.

Event Overview:

• Biophysical techniques such as multi-angle light scattering (MALS) and dynamic light scattering (DLS) address numerous critical analytical challenges in biotherapeutic formulation development, including the screening for aggregation, colloidal and conformational stability, viscosity, and chemical modifications.
• In this webinar, we will delve into the fundamentals and advantages of SEC-MALS and DLS for the biophysical characterization of monoclonal antibodies (mAbs), conjugated proteins, and adeno-associated viruses (AAVs). We will present key analytical methods utilizing the latest MALS, DLS, and refractive index (RI) instrumentation to obtain absolute molecular weight, size, and composition of biotherapeutics.

Key Learning Objectives:

• Fundamentals of Multi-Angle and Dynamic Light Scattering.
• Application of advanced light scattering techniques (DLS, SEC-MALS) for biopharmaceutical characterization.
• Understanding the limitations of SEC/GPC and how does MALS and DLS address these challenges.

Who Should Attend:

• Researchers interested in learning more about light scattering.
• Any scientist working in the development or quality control space
• Researchers with chromatography systems that need accurate and precise molar mass and size distribution results.

Presenter: Udayabagya (Bud) Halim (Sr. Marketing Analyst)

Bud Halim is a senior marketing analyst at Wyatt Technology. He holds a B.S. and Ph.D. in physical chemistry from the UCLA. Bud started his career as an adjunct professor where he taught courses such as Biochem, Analytical, and Physical Chemistry, and served as an editor and contributor to several laboratory manuals. Prior to joining Wyatt Technology, Bud worked in the scientific instrumentation field as an applications scientist for three years. His experience spans the characterization of batteries, semiconductors, and the stability of biologics, LNPs, and viral vectors.