HPLC Troubleshooting: A System Monitoring Approach
This seminar will guide you through troubleshooting HPLC systems and chromatographic issues using a structured workflow.
We will share a novel approach to emphasize the importance of system monitoring, as troubleshooting without monitoring is considerably more challenging. After introducing some key concepts and a troubleshooting workflow, we'll explore practical examples by applying the workflow to failed chromatograms to identify the cause of failure and then use a test cycle to confirm the fix.
Who should attend: Analysts working in regulated environments (eg. GLP, GMP) or in non-regulated environments (eg. R&D) who want to troubleshoot their HPLC systems and chromatographic problems effectively.
Key Learnings:
1. The importance of routine system monitoring
2. Using qualification checks to diagnose a failure
3. Understanding Failure Indicators (HOW the chromatogram failed) vs. Failure Causes (WHY the chromatogram failed)
4. Using troubleshooting workflows to quickly identify the failure cause
Presenter: Maureen DeLoffi (Senior Product Manager, Waters COrporation)
Maureen DeLoffi is a Senior Product Manager at Waters Corporation, where she manages the small molecule portfolio of Analytical HPLC columns. Prior to her Product Manager role, she spent over 12 years as a scientist in the Column Technology Development Lab at Waters. She holds a bachelor’s degree in Mechanical Engineering from the University of New Hampshire.
