Scalable chromatographic clarification platform for mAb manufacturing in CHO systems

As CHO-based processes for recombinant proteins continue to have increased cell densities and titers, the need for advancement in clarification technologies is of importance to enable manufacturing scalability. A novel technology, anion exchange (AEX) fiber chromatography, aims to address this challenge and has proven to be scalable up to large commercial manufacturing. This approach combines the ease of filter-like flowthrough operation and scalability, as well as the separation precision of chromatography.

Join Dr. Masa Nakamura, Senior Application Development Specialist, Solventum, as he showcases a new clarification platform strategy that can offer seamless implementation and deployment from discovery to clinical and commercial manufacturing. It can also provide consistent and high-quality clarified fluid to enhance commercialization productivity.

Key learning objectives

• Learn about the application of synthetic fiber chromatography to the clarification unit operation
• Explore a novel approach to harvest and clarification in CHO processes
• Understand options to overcome scale up challenges and to reduce soluble impurities during clarification

Who should attend?

Scientists, Engineers, and Heads of process development, manufacturing, MSAT, and CMC from biopharmaceutical organizations focused on recombinant protein production in CHO expression systems.

Certificate of attendance

All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes

Presenter: Masa Nakamura, PhD (Senior Application Development Specialist, Solventum, Bioprocessing Filtration)