Cannabinoid Profiling and Potency by HPLC-DAD and Single Quadrupole Mass Spectrometry

Cannabinoid profiling and quantitation are of increased interest due to the legalization of recreational and medicinal use of marijuana in a growing number of American states. Many commercial products that contain cannabinoids have not been fully evaluated to address the efficacy and effectiveness of these products because the materials possessing psychoactive Δ-9-tetrathydrocannabinol are considered Schedule I drugs as defined in the U.S. Controlled Substances Act. 

An alternative source of cannabinoids may be found in hemp. Hemp contains a low percentage of Δ-9-tetrathydrocannabinol by weight but relatively high amounts of non-psychoactive cannabinoids. This webinar will demonstrate the use of HPLC-DAD and LC-Single Quadrupole Mass Spectrometry to provide accurate and robust speciation, profiling and quantification of cannabinoids in hemp oil extracts and commercial cannabinoid products.

Presenter: Anthony Macherone, PhD (Senior Scientist, Agilent Technologies, Inc.)

For the past 4.5 years, Dr. Macherone has been leading a team of Agilent scientists for the development and deployment of analytical testing methodologies for cannabis and hemp products. Anthony has written extensively on cannabis testing, and contributed several chapters to books about cannabis. In June 2020, Anthony joined Cannabis Science and Technology®’s Editorial Advisory Board.