Mucinomics as the next frontier of mass spectrometry
Mucin-domain glycoproteins, a class of densely O-glycosylated extracellular proteins, play key roles in a host of biological functions. These proteins are integral in numerous diseases, including cancer, cystic fibrosis, and inflammatory bowel disease.
However, their dense O-glycosylation remains enigmatic both in glycoproteomic landscape and structural dynamics, primarily due to the challenges associated with studying mucin domains.
This webcast will present advances in the mass spectrometric analysis of mucins, including the characterization of mucinases, enrichment techniques, and complete mucinomic mapping of translationally relevant mucin proteins.
Learn:
- Mass spectrometry based glycoproteomics solutions
- Difficulties and limitations involved in O-glycosylation analysis
- Insights into the biological relevance of mucin-domain glycoproteins
Presenter: Stacy Malaker (Assistant Professor, Yale University)
Stacy Malaker is an Assistant Professor in the Department of Chemistry at Yale University. Her laboratory is focused on establishing methods and technology to study mucins, a class of densely O-glycosylated extracellular proteins, by MS. Additionally, the laboratory studies mucins in a biological context, since these proteins play integral, yet poorly understood, roles in numerous diseases. Dr. Malaker received her PhD in Chemistry from the University of Virginia in the laboratory of Professor Donald Hunt. She continued to investigate the role of aberrant glycosylation in cancer as an NIH postdoctoral fellow in Professor Carolyn Bertozzi’s laboratory at Stanford University before starting at Yale.
Moderator: Moderator: Nikki Forrester (Freelance science, writer and editor)
Nikki Forrester is a science journalist who covers biology, natural history, climate, and the culture of academic research. She earned a PhD. in ecology and evolutionary biology in 2019.
