Accelerating Downstream Process Development for Biologics, Gene Vectors and Vaccines
Downstream process development usually requires numerous iterations until optimization is achieved. Offline analytics are often a bottleneck for timely development. The antidote to lagging offline analytics is inline or online process analytical technology (PAT).
Real-time multi-angle light scattering (RT-MALS) is a PAT that monitors fundamental biophysical product attributes like molar mass, size and titer, every second during downstream operations such as FPLC or UF/DF. For AAVs, RT-MALS also monitors the full capsid ratio. This webinar describes the technology of RT-MALS and its implementation with a variety of bioprocess unit operations and modalities, from proteins to viral vectors, LNPs and pneumococcal vaccines.
In this webinar, you will learn:
- What are the CQAs and other attributes determined by RT-MALS for different modalities
- How RT-MALS accelerates bioprocess DSP development
- How process control with RT-MALS can enhance yield and lot consistency
Who Should Attend:
- PAT experts for biologics, vaccines and gene therapies
- Biopharm process development scientists
- Downstream bioprocess engineers
- Biopharm MSAT leaders
Presenter: Dan Some, Ph.D. (Sr. Principal Scientist, Waters | Wyatt Technology)
Dr. Daniel Some is a Sr. Principal Scientist at Waters | Wyatt Technology, where he contributes to product and application development as well as scientific and technical marketing. Currently he leads Wyatt’s program for commercializing real-time MALS PAT products.
