Complete solutions for nitrosamine analysis in different sartans and metformin drug formulations by LC-MS/MS
One of the largest challenges facing the pharmaceutical industry in the coming years is the prevalence of nitrosamine impurities in various drug formulations and products. As this evolves, analytical techniques are necessary to quantitate these impurities within various matrices at challenging levels of sensitivity.
Various matrices including sartans and metformin will be covered as well as SCIEX’s solution for NDMA and DMF separation, now that it has been implicated by the FDA to potentially cause elevated analytical results.
Key learning objectives:
- Use of LC-MS to assist nitrosamine risk assessments
- Enhancing analytical methods to get more information about your impurities
- Decide on the most adequate LC-MS technology depending on the analytical need
- Developing analytical methods in regulated environments
- Separating and identifying unexpected impurities in your samples
Who should attend?
- PIs, lab heads, technicians, lab managers and researchers
- Departments concerned with: Impurities, toxicology, QA/QC, stability tests, drug impurity, analytical development, analytical chemistry, drug development R&D or chemical characterization
Presenter: Jack Steed (Technical Marketing Specialist, SCIEX)
Technical specialist with substantial experience of the pharma sector. In the last 5 years my main emphasis has been on small molecule analysis, specialising in high performance liquid chromatography (HPLC) and high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS)
Presenter: Pankaj Partani, PhD (Application Support Manager, SCIEX)
Pharmaceutical professional experienced in the field of pharmaceutical research with a expertise in bioanalytical method development & validations for Small molecules, Quantification of Genotoxic impurities, Combinatorial Synthesis, Impurity Profiling, pharmacokinetics and bio-clinical portfolio management.
Presenter: Moderator: Finn Price (Editorial Team, SelectScience)
Fionnbhar Price is a member of the SelectScience Editorial Team, who plays a core role in sourcing and publishing content for the site, with a particular focus on the field of applied chemistry. He has an MChem in Chemistry from Cardiff University, UK, and undertook a year in research characterizing bacterial protein.
