Fundamentals and Applications of Dynamic Light Scattering (DLS) for Biotherapeutic Development

Dynamic Light Scattering (DLS) is a powerful and established technique for determining the size of submicron particles, including proteins, liposomes, nanoparticles, and compound aggregates. Widely used in biotherapeutic development, DLS provides critical insights into size, aggregation, and stability throughout the research and formulation pipeline.

This webinar will introduce the fundamentals of DLS and explore its practical applications in biopharmaceutical workflows—from formulation optimization to accelerated stability testing. Special emphasis will be placed on high-throughput DLS using the DynaPro™ Plate Reader instrument, which enables automated screening of sample conditions such as buffer composition, concentration, temperature, and time-based stability directly in disposable microwell plates.

Key Learning Objectives:

• An introduction/review of Dynamic Light Scattering (DLS)
• Understanding kD and A2 stability metrics
• Example applications including formulation development and stability

Who Should Attend:

• Scientists and Researchers working in biopharmaceuticals, particularly those involved in biologic drug development, formulation, and characterization
• Lab Managers looking to understand state-of-the-art instruments for enhancing analytical capabilities in their labs
• Learners and Newcomers eager to gain a foundational understanding of dynamic light scattering (DLS) for applications in biopharmaceuticals
   

Presenter: Paul Velander, Ph.D. (Waters | Wyatt Technology)

Paul joined Wyatt Technology in 2022 and currently serves as an Application Scientist on the Customer Support team, as well as the Dean of our Light Scattering University training program. Paul completed his Ph.D. in Biochemistry at Virginia Tech, with a focus on small molecule drug discovery against toxic amyloid aggregation pathways. Before joining Wyatt, Paul spent time at the University of Nebraska-Lincoln, where he served as a postdoctoral associate and assistant professor. His research during this time primarily focused on developing murine model systems to investigate gut microbiome associations with heart disease. He now provides consultation and training for customers across a broad array of fields and is responsible for advanced training for our field scientists and Wyatt representatives worldwide.