Simple Drug Testing Solutions for Complex Samples
Overview
During this presentation we will review:
- Advantages of the biphenyl LC column chemistry for drug analysis
- Using phospholipid removal to produce cleaner samples and improve drug quantitation
- Implementing mixed-mode SPE with in-well room temperature hydrolysis to extract “designer” benzodiazepines and conjugated metabolites from urine using a streamlined workflow
- Strategies for removing endogenous constituents and collection device components from oral fluid samples prior to LC-MS/MS analysis using microelution SPE
Key Learning Points
- Understand how LC column chemistry impacts LC-MS/MS drug analysis
- Review how biological matrix components affect choices in sample extraction methods
- Learn about streamlined extraction protocols for cleaner samples for LC-MS/MS analysis
Who Should Attend
- Clinical and forensic toxicologists who want solutions to simplify and improve their LC-MS/MS drug analysis methods
Presenter: Stephanie J. Marin, Ph.D (Sr. Global Market Development Manager)
Stephanie J. Marin is the Applied Markets Global Market Development Manager at Phenomenex. She received her Ph.D. in chemistry from Arizona State University, and has expertise in sample preparation, liquid chromatography and mass spectrometry. Dr Marin has worked in marketing, product development, method development and method validation, in addition to customer facing roles in technical support, service, education and training. She has over 10 years of experience developing and validating clinical methods from her tenure at the ARUP Institute for Clinical and Experimental Pathology. She has also held positions as an Applications Chemist at Hamilton Company and Biotage, Marketing Manager at Selerity Technologies and as a Group Leader in analytical services for specialty chemicals and polymers at Rohm and Haas (now Dow). She was also a supervisor at an EPA certified laboratory. She is the author of over 30 peer reviewed publications and book chapters and over 100 abstracts presented at national and international meetings.
