Spectroscopy, Particle Measurements, and Modeling in Peptide and Oligonucleotide Development

Addressing Challenges in Reactor Design, Synthesis, Yield, Process Control and Purification

This free online event is for scientists and engineers who are interested in addressing challenges of peptide and oligonucleotide development by inline process characterization and modeling of critical process parameters and reaction mechanisms. 

Event Program

• Comparison of packed-bed solid-phase synthesis to fluidized-bed synthesis reactors
• Role of PAT used in fluidized-bed reactors for process characterization and kinetics
• Use of inline ATR-MidIR for synthesis control strategies of solid-phase synthesis
• Integration of inline PAT into process control systems
• Use of mechanistic reaction modeling to eliminate harmful reaction by-products from solid-phase Fmoc synthesis reactions
• Use of inline particle characterization and automated laboratory reactors to characterize design space for ideal peptide precipitation

Presenter: Marty Johnson (Eli Lilly and Company)

• Flow Chemistry Concepts and Techniques Applied to Solid Phase Oligonucleotide Synthesis

Presenter: Courtney Morder (Arrowhead Pharmaceuticals)

• Infrared Spectroscopy for Real-Time Oligonucleotide Synthesis Monitoring

Presenter: Jingyao Wang (Eli Lilly and Company)

• Control Strategy Development of a Solid Phase Peptide Cleavage Process via Kinetic Modelling and Integrated In-Situ FTIR/Oscillatory Shear Rheometry Approach

Presenter: Kyle Blakely (Eli Lilly and Company)

• Developing Robust and Scale-able Peptide Isolation Processes

Presenter: Emily Guinn (Eli Lilly and Company)

• Developing Robust and Scale-able Peptide Isolation Processes