Amplify laboratory efficiency for known and unknown nitrosamines - Simultaneous QUAntitation and Discovery (SQUAD)
This is the first webinar of a two-part series.
Join us for an insightful webinar where we explore the cutting-edge SQUAD approach to nitrosamine and NDSRI testing. This innovative method focuses on confidently annotating and accurately quantifying a targeted set of compounds using authentic standards and calibration curves. Simultaneously, it performs untargeted analysis to identify novel impurities, all within a single injection, resulting in unparalleled laboratory efficiency.
Key Topics covered:
- SQUAD Approach: Learn how the SQUAD approach revolutionizes nitrosamine and NDSRI analysis by combining targeted and untargeted methods for comprehensive impurity detection
- Mass Spectrometry (MS): Discover why MS is the analytical tool of choice for analyzing pharmaceutical products and active pharmaceutical ingredients (API) with high selectivity and sensitivity
- Challenges in Nitrosamine Testing: Understand the distinct difficulties in analyzing small NAs with very low acceptable intake limits (AI) and NDSRIs with unknown structures
Presenter: Jessica Hoskins, PhD (Principal Research Scientist I, Predictive Stability and Structure Elucidation)
Jessica is a Principal Research Scientist at AbbVie where she and her team focus on Predictive Stability and Structure Elucidation to understand degradation pathways and other potential stability limiting attributes for new synthetic molecule drug substances and drug products. She has a PhD in Organic Chemistry from Tulane University with Scott Grayson, where she first became interested in mass spectrometry for polymers. Prior to joining AbbVie, she was an Adolf Martens Postdoctoral Fellow at the Federal Institute for Materials Research and Testing (BAM) in Berlin, Germany, and worked as an analytical chemist at Stepan Company in the surfactant and polymer industry.
Presenter: Sebastien Morin (Sr Manager, Business Development, Thermo Scientific)
Sebastien is a Senior Manager, Business Development at Thermo Fisher Scientific where he partners closely with Pharma and Biopharma Companies to address analytical challenges. He holds a M. SC. in Organic Chemistry from Universite de Montreal. Prior to joining Thermo Fisher Scientific, he was a Research Associate, Medicinal Chemistry for Boehringer Ingelheim, advancing virology research.
Moderator: Jon Bardsley (Market Development Manager, Thermo Fisher Scientific)
