Enhancing Biotherapeutic Characterization With MALDI Mass Spectrometry
Biotherapeutics such as monoclonal antibodies, fusion proteins, peptides and cytokines are increasingly complex, creating challenges for rapid and accurate quality characterization. Traditional liquid chromatography methods, such as size exclusion chromatography and hydrophobic interaction chromatography, often struggle with electrospray ionization mass spectrometry (MS) compatibility, slowing impurity identification.
This webinar introduces a refined matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS workflow that streamlines analysis, enables high-throughput screening and integrates with existing development pipelines. Attendees will gain insights into approaches that address structural complexity, enhance analytical efficiency and support faster decision-making in biotherapeutic development.
Join this webinar for:
- Learn about the development of cutting-edge biotherapeutic characterization methods using MALDI-MS
- Discover an automated impurity identification workflow, suitable for different modalities and based on MALDI
- Explore methodologies which analyze therapeutic polyethylene glycol linked proteins
- Assess the development of cell-based membrane permeability assay using MALDI-MS
Presenter: Gregory F. Pirrone, PhD (Associate Principal Scientist, Merck & Co., Inc.)
Dr. Gregory F. Pirrone is an associate principal scientist in analytical research and development at Merck research laboratories (MRL). He earned his PhD from Northeastern University under the guidance of Dr. John R. Engen.
Presenter: Alexey A. Makarov, PhD (Senior Principal Scientist, Merck & Co., Inc.)
Dr. Alexey A. Makarov is a senior principal scientist in the analytical research and development (ARD) department at Merck research laboratories (MRL). He earned his PhD in chemistry from Stevens Institute of Technology, New Jersey and has over 20 years of experience in the pharmaceutical industry.
Presenter: Elizabeth F. Bayne, PhD (Senior Scientist, Merck & Co., Inc.)
Dr. Elizabeth F. Bayne is a senior scientist in analytical research and development at Merck Research Laboratories. Elizabeth earned her PhD in chemistry from the University of Wisconsin - Madison in 2023 under Professor Ying Ge, specializing in mass spectrometry-based intact protein analysis, multi-omics integration of proteomics and metabolomics data to better understand cardiac systems.
