Analytical Strategies To Conduct Oligonucleotide Stability Studies and Bioanalysis
Synthetic oligonucleotides are transforming modern therapeutics and advanced analytical strategies are driving confident decision-making to ensure safe and effective development of oligonucleotide drugs.
This webinar will cover chemical stability assessment and bioanalytical quantitation strategies, presenting a forced degradation study of an antisense oligonucleotide under thermal and oxidative stress. The approach enables precise identification of degradation products and sequence validation, supporting regulatory compliance and informed drug development.
The session will also explore the benefits of automated sample preparation combined with high-sensitivity mass spectrometry for oligonucleotide bioanalysis. Through real-world case studies, our speakers will demonstrate reliable quantitation from complex biological matrices, showcasing workflow efficiency and analytical performance.
Join this webinar for:
- Understand how forced degradation studies reveal oligonucleotide stability profiles under thermal and oxidative stress conditions
- Discover how advanced analytical workflows enable accurate identification of degradation products, supporting regulatory compliance in therapeutic development
- Learn how to fully automate a bioanalysis workflow for oligonucleotides
Presenter: Yulan Bian (Scientist at Agilent Technologies)
Yulan Bian is a scientist at Agilent Technologies Singapore, with over 15 years of experience in analytical chemistry and life sciences. She holds a master of science in biomedical engineering and a bachelor of science in biological engineering. Her expertise spans LC, LC-MS, and inductively coupled plasma-MS workflows, with a focus on biopharma application development. Yulan has led numerous technical projects, delivered global webinars and authored publications on oligonucleotide and monoclonal antibody characterization.
Presenter: Lee Bertram (Technical Product Manager at Agilent Technologies)
Lee Bertram currently serves as technical product manager for LC triple quadrupole mass spectrometers at Agilent Technologies. With over a decade of experience in analytical chemistry, Lee has held roles in both research and product development across biotech startups and global life sciences companies. His background includes extensive work in method development, good manufacturing practice compliance and LC-MS applications spanning single quadrupole, triple quadrupole and quadrupole time-of-flight technologies.
