Unlocking High-Value Targets: The Power of Chemoproteomics and Covalent Mass Spectrometry

Covalent inhibitors are regaining attention in drug discovery for their enhanced potency, selectivity and their ability to tackle challenging targets.

Our expert speakers will showcase Evotec’s innovative strategy for identifying covalent hits using high-throughput mass spectrometry. By attending, you’ll learn how intact protein and peptide-based assays can rapidly highlight promising binders, precisely mapping their binding sites. Our speakers will also demonstrate the power of chemoproteomic profiling in live cells to validate target engagement and selectivity.

Join this webinar to discover how integrating these complementary approaches can reduce off-target risks, accelerate timelines and improve confidence in progressing from hit to lead – helping researchers strengthen their discovery pipeline.

Attend this webinar to:

• Explore the background of covalent inhibitors and their unique benefits in modern drug discovery
• Learn how high-throughput mass spectrometry (MS) accelerates covalent hit identification
• Gain an insight into site-specific analysis using peptide mapping and intact protein MS
• Take a dive into advanced chemoproteomic strategies for hit validation

Presenter: Julien Parra, PhD (Senior Research Scientist, High-Throughput Biology & Screening at Evotec)

Currently serving as a senior research scientist in the high-throughput biology and screening team at Evotec in Toulouse, Dr. Julien Parra is a highly experienced mass spectrometry specialist with over a decade of experience in analytical chemistry, proteomics and structural biology. Julien earned his PhD in analytical chemistry from the Université Évry Paris-Saclay and later joined the Institute of Pharmacology and Structural Biology as a postdoctoral researcher. His work is characterized by a deep understanding of protein chemistry, a strong command of mass spectrometry instrumentation and a passion for translating complex data into biological insights.

Presenter: Violette Gautier, PhD (Research Scientist, Proteomics at Evotec)

Dr. Violette Gautier is a proteomics research scientist with over fifteen years of experience in proteomics, including more than nine years in the pharmaceutical industry. At Evotec, she specializes in chemoproteomics approaches such as activity-based protein profiling and cysteine proteomics profiling. She contributes to covalent drug discovery programs by developing and applying chemoproteomic workflows that support key stages of compound progression - from target identification and ligand library screening to cellular target engagement and selectivity profiling. Violette earned her PhD in structural and functional biology from Toulouse III University and completed her postdoctoral research at Utrecht University. Both focused on advanced proteomic strategies to investigate protein networks, cellular mechanisms and post-translational modifications.