Developments for molecular imaging using AP/MALDI & Orbitrap

This webinar discusses the advancements and applications of the atmospheric pressure MALDI (APMALDI) source developed by MassTech. The AP/MALDI source is compatible with various mass spectrometers, including older LTQ Orbitrap systems and newer models like the Orbitrap Exploris range and Orbitrap Astral MS. 

The presentation highlights the benefits of high-resolution imaging mass spectrometry, emphasizing the balance between image acquisition time, mass resolving power, and pixel size. It showcases the use of the AP/MALDI source for detailed lipid analysis in brain tissue, demonstrating improved ionization efficiency and dynamic range. 

The speaker also discusses the workflow for imaging mass spectrometry, including sample preparation, image acquisition, and data processing using various software solutions. The presentation concludes with an invitation to demo the AP/MALDI source, underscoring its portability and ease of use across different laboratories. 

Learning points:

• Versatility and Compatibility: The atmospheric pressure MALDI (AP/MALDI) source developed by MassTech is compatible with a wide range of mass spectrometers, from older LTQ Orbitrap systems to the latest models like Explorice and Astral, enhancing its usability across different laboratories. 
• Enhanced Imaging Capabilities: The AP/MALDI source allows for high-resolution imaging mass spectrometry, balancing image acquisition time, mass resolving power, and pixel size. It supports detailed lipid analysis in brain tissue, demonstrating improved ionization efficiency and dynamic range. 
• Comprehensive Workflow: The presentation outlines a detailed workflow for imaging mass spectrometry, including sample preparation, image acquisition, and data processing using various software solutions, highlighting the importance of optimizing each step for accurate and efficient analysis. 

Who should attend?

• Mass Spectrometry Researchers and Technicians: Individuals involved in mass spectrometry, particularly those interested in high-resolution imaging and ionization efficiency improvements, would benefit from understanding the advancements in APMALDI technology. 
• Laboratory Managers and Scientists: Those managing or working in laboratories that utilize mass spectrometers, especially those looking to upgrade or enhance their current systems with the latest APMALDI source for better performance and compatibility. 
• Biological and Medical Researchers: Researchers focusing on detailed tissue analysis, such as lipid profiling in brain tissues or other biological samples, would find the presentation valuable for its insights into improved imaging mass spectrometry workflows and data processing techniques. 

Presenter: Gilles Frache, PhD (Project Manager, Luxembourg Institute of Science and Technology (LIST))