Breaking Barriers: The Rise of Inert Column Technologies for Small Molecule HPLC
Metal-analyte interactions can derail even the most optimized HPLC methods, especially for compounds containing phosphates, carboxylates, or chelating groups. This session explores the evolution of surface deactivation technologies—specifically hybrid organic/inorganic coatings—and their ability to reduce peak tailing, improve analyte recovery, and enhance reproducibility.
See how new inert column solutions are reshaping workflows in pharmaceutical analysis and metabolomics.
Presenter: Tom Walter (Corporate Fellow, Consumables and Lab Automation, Waters Corporation)
Thomas Walter received a Ph. D. in Chemistry from the University of Illinois at Urbana-Champaign, working on multinuclear solid-state NMR spectroscopy of heterogeneous catalysts. Joining the Chemistry R&D group of Waters in 1987, he held positions of increasing responsibility, including serving as the Director of Chemistry R&D from 2000 – 2015. He is a coinventor of hybrid organic/inorganic particle technology with 15 issued US patents. He has authored 43 publications on chromatographic materials, columns, and NMR spectroscopy. He is currently a Corporate Fellow in the Consumables and Lab Automation Division. He is a member of the Jim Waters Society and the 2023 recipient of the Uwe Neue award.
