Resolving GLP-1 Impurities Using Orthogonal RPLC and HILIC Approaches
A five-part webinar series unlocking advanced insights across the Peptide therapeutics workflows
Peptide therapeutics are reshaping modern medicine, with GLP-1 receptor agonists driving rapid advances in metabolic disease treatment. As peptide and GLP-1 programs scale, scientists face increasing pressure to generate data that is accurate, defensible, and decision-ready across development stages.
Peptide 360 is designed to guide scientists through this complexity, following the peptide workflow from sequence insight to confident development decisions.
Who Should Attend?
This series is designed for scientists and technical leaders working in peptide and GLP-1 discovery and development, analytical development, characterization, Bioanalysis, DMPK, translational research, CMC, QA/QC, and regulatory-facing analytical roles
How the Series Works?
- Register once for the full series
- Pre-submit questions for live expert responses
- Access recordings anytime after each session
- Certificate of attendance provided
Episode 5: Resolving GLP-1 Impurities Using Orthogonal RPLC and HILIC Approaches
GLP-1 receptor agonists exhibit structural complexity and susceptibility to degradation, making robust impurity separation essential for quality control and regulatory compliance. This session highlights the use of orthogonal chromatographic approaches, reversed-phase liquid chromatography (RPLC) and hydrophilic interaction chromatography (HILIC), to improve impurity resolution and detection.
Attendees will learn practical method development strategies, including gradient design, column selection, temperature control, and mobile phase optimization. The session demonstrates how combining orthogonal separations enhances confidence in impurity profiling and supports reliable characterization of GLP-1 analogs in development and QC environments.
Presenter: Andrea Ngai (Biopharma Technical Specialist, Agilent Technologies, Inc.)
Presenter: Ashish Pargaonkar, Ph.D. (Biopharma Applications Specialist, Agilent Technologies, Inc.)
