HRMS workflows for peptide impurity characterization
RECORD | Already taken place We, 20.5.2026
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SCIEX: HRMS workflows for peptide impurity characterization
Join us for an insightful webinar on Join us for an insightful webinar exploring advanced HRMS and CMC approaches for the characterization of impurities in synthetic peptides.
This session will cover the use of high‑resolution mass spectrometry (HRMS) for precise impurity analysis using intact mass and MS/MS workflows. It will also highlight key CMC considerations for GLP‑1 receptor agonists (RAs) and oligonucleotides, including impurity profiling strategies, regulatory expectations, and critical quality attributes.
Speaker: Saurabh Nagpal (Sales Development Manager, SCIEX)
Key highlights
- High sensitivity of the 7600 ZenoTOF system enables characterization of low‑abundance peptide impurities at the MS/MS level.
- Alternative fragmentation (EAD) combined with high sensitivity improves sequence coverage and differentiation of isobaric impurities.
- Modification sites can be identified using EAD, supporting deeper insights, and synthesis optimization.
Speaker: Dr. Ravi Shah (Professor at NIPER-Ahmedabad)Key highlights
- Regulatory requirements for advanced characterization of peptides and oligonucleotides
- Use of LC‑HRMS as a powerful analytical tool
- Case studies using advanced MS/MS
- Case study using online H/D exchange with LC‑HRMS
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