Per- and polyfluoroalkyl substances (PFAS) have become a major global concern due to their persistence, bioaccumulation, and potential health impacts. With thousands of known PFAS compounds, and new variants continuing to emerge, identifying and quantifying them across complex environmental and biological samples is an ongoing analytical challenge.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_From_Complexity_to_Clarity_Smarter_PFAS_Identification_Workflows_in_Compound_Discoverer_Software_2_8e83167891.jpg" alt="Thermo Fisher Scientific: From Complexity to Clarity: Smarter PFAS Identification Workflows in Compound Discoverer Software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_From_Complexity_to_Clarity_Smarter_PFAS_Identification_Workflows_in_Compound_Discoverer_Software_2_8e83167891.jpg 245w," sizes="100vw" width="1024" height="574"><h3>Why PFAS analysis matters</h3>PFAS are used in everything from firefighting foams to non-stick coatings, yet their chemical stability means they persist in the environment and accumulate in living organisms. Regulators and scientists around the world are racing to better understand their distribution, fate, and toxicity.But with tens of thousands of PFAS, many without available reference standards, traditional targeted analysis alone isn’t enough. Analysts increasingly rely on non-targeted analysis (NTA) workflows powered by high-resolution accurate-mass (HRAM) mass spectrometry and advanced software to uncover the full picture.<h3>Addressing the challenges of PFAS identification</h3>Successful non-targeted PFAS analysis requires overcoming several analytical hurdles:<ol><li>Acquiring high-quality MS¹ and MS² data with ultra-high mass resolution and accuracy.</li><li>Detecting low-abundance PFAS hidden within thousands of background compounds.</li><li>Leveraging comprehensive spectral libraries and databases for confident identification.</li><li>Applying data filtering and scoring tools to assign confidence levels to annotations.</li><li>Using visualization and statistical tools to interpret and compare complex datasets.</li></ol><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759">Thermo Scientific Compound Discoverer 3.5 software </a>brings together all the components needed for robust PFAS identification—integrating <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=22&amp;manufacturerItems=3">HRAM Orbitrap MS</a> data with an expanded suite of PFAS-specific libraries and databases.In a single workflow, users can:<ul><li>Detect and annotate compounds automatically from LC-MS data.</li><li>Determine possible elemental formulas using isotope pattern and accurate mass information.</li><li>Compare MS² spectra against <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764">mzCloud</a>, NIST 2023, and in silico PFAS libraries.</li><li>Cross-reference annotations with the EPA PFAS Structure List and the NIST Suspect List of PFAS.</li><li>Use PFAS-specific fragment and neutral loss databases to strengthen identification confidence.</li></ul>With these resources combined, the software enables confident annotation of more than 40,000 PFAS compounds!<h3>New tools for confident, streamlined PFAS identification</h3>Compound Discoverer software introduces several new features designed to simplify and accelerate PFAS NTA workflows:<ul><li>Apply PFAS Scoring Node: Automatically calculates PFAS-specific parameters and a new PFAS Score—no R scripting required.</li><li>PFAS Plot: A visual tool that uses mass-defect metrics to highlight probable PFAS in complex datasets, following methods from Kaufman et al. (2022).</li><li>Expanded suite of libraries and databases: Combines mzCloud, NIST, in silico, PFAS fragment databases, and a new neutral loss database for greater confidence.</li><li>Advanced data visualization: Tools like Kendrick Mass Defect and Molecular Network plots reveal homologous PFAS series and related compound families.</li><li>Built-in statistical analysis tools: Compare PFAS composition between samples using Principal Component Analysis, Differential analysis and Hierarchical Cluster Analysis.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_From_Complexity_to_Clarity_Smarter_PFAS_Identification_Workflows_in_Compound_Discoverer_Software_ed32c7f7c1.jpg" alt="Thermo Fisher Scientific From Complexity to Clarity Smarter PFAS Identification Workflows in Compound Discoverer Software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_From_Complexity_to_Clarity_Smarter_PFAS_Identification_Workflows_in_Compound_Discoverer_Software_ed32c7f7c1.jpg 245w," sizes="100vw" width="800" height="395"><h3>From complexity to clarity</h3>By uniting Orbitrap HRAM data with the most comprehensive PFAS libraries available, Compound Discoverer 3.5 software streamlines non-targeted PFAS analysis—helping laboratories move from data complexity to confident chemical clarity.<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5612">Watch the on-demand webinar</a> to see the full workflow in action and learn how Compound Discoverer software can enhance your PFAS analysis.<ul><li>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PFAS #CompoundDiscoverer #SpectralLibraries</li></ul><blockquote><h5>Zoe Julian</h5>Zoe Julian is a Product Marketing Manager for Chromatography and Mass Spectrometry software at Thermo Fisher Scientific. With over 12 years' experience of working with chromatography and mass spectrometry techniques with a background in GC and GC-MS(/MS) organic environmental analysis, she has helped many laboratories and industries improve their workflows through a unique understanding of their challenges. Transitioning to a focus on Chromeleon CDS she has shown customers how software solutions can improve their productivity and support their day-to-day operations.</blockquote>

From Complexity to Clarity: Smarter PFAS Identification Workflows in Compound Discoverer Software

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/">ISC 2026</a></h3>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314">International Symposium on Chromatography (ISC)</a> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.The major focus of the symposium will be on the impact of chromatography and separation science to meet the needs of the pharmaceutical, environmental, food and health industry, as well as science and medicine. The symposium programme will reflect these themes and highlight new challenges and emerging opportunities for the science and marketing of separation and detection systems and methods.As an integral part of the scientific programme of lectures and poster sessions, an international exhibition and vendor seminars on instrumentation and services for chromatography, separation science and mass spectrometry will be organised. ISC 2026 will provide the perfect forum for attendees from academia, industry and government research institutions for scientific exchange and networking.<h3>REGISTRATION</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Register HERE for the ISC 2026</a></blockquote><h3>AWARDS &amp; COMPETITIONS</h3><h4>Pavel Jandera Young Scientist Award</h4><h5>About Pavel Jandera</h5>Pavel Jandera was a world-leading analytical chemist who devoted his entire professional life to research in the field of high-performance liquid chromatography. During his scientific career, he worked at the Department of Analytical Chemistry at the University of Pardubice, Czech Republic. His greatest contribution to the field of liquid chromatography was the introduction of a comprehensive theory of liquid chromatography with programmed elution conditions. He was also involved in the research of gradient elution techniques in preparative chromatography, modeling retention and selectivity in various phase systems, preparing organic monolithic microcolumns, and, last but not least, in the development of theory and practical applications of two-dimensional liquid chromatography, primarily in the comprehensive form.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_Pavel_Jandera_480x480_04fa52613f.jpg" alt="ISC: Pavel Jandera" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_Pavel_Jandera_480x480_04fa52613f.jpg 156w," sizes="100vw" width="480" height="480">More information can be found in the <a target="_blank" rel="noopener noreferrer" href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.202200618">review article</a>, where a detailed overview of Pavel Jandera’s contribution to the evolution of separation sciences is outlined.<h5>About the award</h5>The purpose of the award is to honor the memory of Pavel Jandera and his significant contributions to separation science, including his dedication to fostering the careers of young scientists. The award includes a monetary prize of 1,000 Euros, a glassware medal bearing the recipient’s name, and an invitation to speak at the next ISC conference. The award will be presented during the closing ceremony and is sponsored by the Faculty of Chemical Technology at the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/15">University of Pardubice</a>.The award has been established for future editions of the ISC Symposium.<h5>Eligibility</h5>All young scientists who give an oral presentation at the meeting, indicate their interest in applying for this award in the <a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">registration form</a>, and are within 12 years of their PhD defense at the time of presentation are eligible. Justified career breaks are not counted in this period, e.g., parental leave.<h5>Selection Process</h5>The Award Jury evaluates eligible oral presentations, selecting a winner based on the overall quality and delivery of the presentation, as well as the scientific quality and relevance of the results.&nbsp;

Pavel Jandera Young Scientist Award at ISC 2026

<h4>1 - What is fitness for purpose?&nbsp;</h4>The test meets the necessary performance criteria for a clinical binary examination to ensure it is suitable for making accurate and reliable clinical decisions in the intended patient population. Among others, performance criteria include clinical sensitivity and clinical specificity.&nbsp;<h4>2 - How to assess clinical performance?&nbsp;</h4>Assessing the clinical performance of a binary examination, stating results as 'positive' or 'negative,' involves calculating the examination's Clinical Sensitivity and Clinical Specificity. From the physician's point of view, clinical performance is evaluated by using predictive values, i.e., how likely is it that a positive or negative result corresponds to the presence or absence of the condition, which is also influenced by the prevalence of the condition in the population being tested.&nbsp;<h4>3 - What is Clinical Sensitivity?&nbsp;</h4>Clinical sensitivity (SS), also known as the True Positive Rate, measures the proportion of true positives correctly identified by the test. Data from a group of subjects who have been confirmed to have the disease or condition through diagnosis or a gold standard test (D1 in Table 1) are needed to calculate clinical sensitivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Table_1_2x2_Contingency_table_for_clinical_diagnosis_241735a171.jpg" alt="Eurachem: Table 1. 2x2 Contingency table for clinical diagnosis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Table_1_2x2_Contingency_table_for_clinical_diagnosis_241735a171.jpg 245w," sizes="100vw" width="1401" height="461">The formula for clinical sensitivity is:&nbsp;SS = tp / (tp + fn), with:&nbsp;<ul><li>tp, True Positives are the cases where the test correctly identifies the presence of the disease.&nbsp;</li><li>fn, False Negatives are the cases where the test incorrectly identifies the absence of the disease when it is actually present.&nbsp;</li></ul>Table 1 represents the components of clinical sensitivity and specificity. Figure 1 illustrates an example of the overlapping of the number of components. The symbol "∩" represents the intersection of groups. For example, D1∩n denotes the set of negative results obtained for known positive cases, i.e., false negatives.<h4>4 - What is Clinical Specificity?&nbsp;</h4>Clinical Specificity (SP), also known as the True Negative Rate, measures the proportion of true negatives correctly identified by the test. Data from a group of subjects who have been confirmed not to have the disease or condition through a gold standard test (D0 in Table 1) are needed to calculate clinical specificity.The formula for clinical specificity is:&nbsp;SP = tn / (tn + fp), where:&nbsp;<ul><li>tn, True Negatives are the cases where the test correctly identifies the absence of the disease.&nbsp;</li><li>fp, False Positives are the cases where the test incorrectly identifies the presence of the disease when it is actually absent.&nbsp;</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Figure_1_Graphical_representation_of_an_example_of_85ab82a16b.jpg" alt="Eurachem: Figure 1. Graphical representation of an example of tp (D1∩p), tn (D0∩n), fn (D1∩n), and fp (D0∩p). " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Figure_1_Graphical_representation_of_an_example_of_85ab82a16b.jpg 245w," sizes="100vw" width="1300" height="736"><h4>5 - How to calculate the uncertainty of clinical sensitivity and specificity?</h4>Calculating clinical sensitivity and specificity uncertainty involves statistical methods that estimate each parameter's confidence interval (CI). These intervals provide a range of values within which the true sensitivity or specificity is expected to lie with a certain level of confidence, typically 95 %. Please refer to the AQA:2021 for information about statistical models to compute the 95 % CI [1].<h4>6 - How to define targets?&nbsp;</h4>Target minimum values for clinical sensitivity and specificity should be identified. These values may originate from regulations or criteria based on the intended use of the binary results. A target or minimum value for the lower limit of the 95 % CI for result rate, i.e., SS or SP, (LLSS.95 or LLSP.95) or the upper limit of the 95 % CI for result rate (HLSS.95 or HLSS.95) should also be defined according to the purpose of the analysis. The target or minimum value (LLSStg or LLSPtg) is particularly significant when the impact of false results is critical. For example, for blood components used in transfusions, the screening for infectious diseases should be performed with tests associated with an LLSS.95 close to 100 %.&nbsp;Figure 2 illustrates five different tests, each assessed for clinical sensitivity and its associated uncertainty. These cases reflect different levels of compliance with a target sensitivity of 0.5. Case 1 is non-compliant, Cases 2 to 4 are partially compliant, and Case 5 is compliant. From a simplified statistical power view, the laboratory should always take into account the minimum number of samples when defining its target. This number can be estimated by simulation. For example, for a clinical sensitivity of 90 % the evaluation will require a minimum of 10 samples. It should be emphasized that samples must be representative of the target population for a clinical power evaluation - for example, epidemiologically representative samples of the types and subtypes of a given virological agent are required.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Figure_2_Compliance_assessment_with_clinical_sensitivity_a21ece043c.jpg" alt="Eurachem: Figure 2. Compliance assessment with clinical sensitivity uncertainty using the lower 95% confidence interval limit for five performance assessment scenarios. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Figure_2_Compliance_assessment_with_clinical_sensitivity_a21ece043c.jpg 245w," sizes="100vw" width="1500" height="648">

Performance Assessment of Binary Output Examinations in Medical Laboratories

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Eurachem

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Separation Science

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Agilent Technologies

SIELC Technologies

Phenomenex

SCIEX

Waters Corporation

<h4>Expand Your Expertise with Our Chromatography Webinar Series 2025</h4>A comprehensive journey through fundamental principles, HPLC optimization, and cutting-edge mixed-mode techniques. Led by industry experts, these free sessions provide practical insights and real-world applications to enhance your analytical skills.<h5>Session 5: Real-World Applications &amp; Future Innovations in Mixed-Mode HPLC</h5><ul><li>Advanced applications in pharmaceuticals, biotechnology, and food analysis</li><li>Strategies for handling complex sample matrices with mixed-mode chromatography</li><li>Emerging research and novel stationary phases</li><li>Future trends and developments in mixed-mode HPLC</li></ul><blockquote>Presenter: Jovana Mitrovic (R&amp;D Chemist at SIELC Technologies)Jovana holds a Master of Science in Molecular Engineering from the Pritzker School of Molecular Engineering at the University of Chicago and a Bachelor of Science in Biomedical Sciences from St. John’s University. Her background in molecular and biomedical sciences supports a multidisciplinary approach to addressing complex analytical challenges.</blockquote>

SIELC Technologies: HPLC Educational Webinar Series

Real-World Applications & Future Innovations in Mixed-Mode HPLC

Join us for a webinar discussing advanced applications in pharmaceuticals, biotechnology, and food analysis 

Applications & Future Innovations in Mixed-Mode HPLC

<div>Light scattering techniques, are transforming the way we quantify and analyze nucleic acid (NA) and lipid nanoparticle (LNP) therapeutics, playing a critical role in development, RNA quality assessment, and quality control. This webinar will explore how combining multi-angle light scattering (MALS) with field-flow fractionation (FFF) or size-exclusion chromatography (SEC) provides high-resolution insights into critical attributes such as size distribution, NA integrity, overall stability, and payload encapsulation.&nbsp;Recent advances in SEC column technology has increased the quality and resolution of separations for complex mixtures of large NA constructs, as well as NA-protein complexes including Cas9 constructs. FFF-MALS allows for gentle, high-resolution separation, making it ideal for analyzing NA delivery systems like LNPs without compromising their integrity. Additionally, dynamic light scattering (DLS) and electrophoretic light scattering (ELS) enable rapid, automatable batch measurements, allowing for screening of factors such as size and surface charge.Join us to discover the latest advancements in light scattering technology and learn how these powerful tools can accelerate pharmaceutical development and enhance your research.<h5>Key Learning Objectives:</h5><ul><li>Applications of SEC-MALS to in-depth NA distribution, conformation, and stability characterization</li><li>An introduction of DLS/ELS characterization for NA and LNP formulation screening</li><li>High resolution characterization of LNPs and NA delivery vehicles via FFF-MALS for size distribution, conformation, and payload</li></ul><blockquote>Presenter: Parker Lee, Ph.D. (Waters | Wyatt Technology)Dr. Parker Lee is a Field Applications Scientist at Waters | Wyatt Technology, serving customers in San Diego and the surrounding areas. Dr. Lee received his Ph.D. in Macromolecular Science &amp; Engineering, with a focus on developing new methods for drug delivery. He joined Wyatt Technology in 2022 after five years of work in macromolecule analytical development for various startups. As a Field Applications Scientist, he is responsible for working with customers to ensure they can utilize Wyatt’s light scattering instrumentation effectively to improve and accelerate their research.Presenter: Lavelay Kizekai, Ph.D. (Waters Corporation)Lavelay Kizekai, BS, is a principal scientist at Waters Corporation. He joined Waters in 2009 and has since applied himself to developing new LC methods, leading column technology product development work, and establishing insight-based QC procedures for Waters products. His primary area of focus is biomolecule separations using size-exclusion chromatography (SEC). He was a core member of the team that recently brought to market a column suited to platform methods for monoclonal antibodies and antibody-drug conjugates. He is currently leveraging these SEC technologies and even newer breakthroughs for the characterization of gene-based therapeutics by multiangle light scattering.</blockquote></div>

Waters Corporation: Beyond Batch Methods: High Resolution Nucleic Acid and LNP Insights with Light Scattering Techniques

Beyond Batch Methods: High Resolution Nucleic Acid and LNP Insights with Light Scattering Techniques

Discover latest advancements in light scattering technology and learn how these tools can accelerate pharmaceutical development

High-Res Nucleic Acid & LNP Analysis via Light Scattering

It is critical to keep your lab current and one of the ways to achieve this is by leveraging new features and functionality. In this session, we will explore new and upcoming Empower Software features, including:<ul><li>Updated functionality to simplify workflows requiring more stringent technical controls</li><li>New features to support expanded workflows</li><li>New data processing features and options</li></ul>Please join us for a lively discussion as we explore this topic. &nbsp;As always, please bring your questions for this exclusive opportunity to ask our experts anything about using Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter: Dr. Andy Meyer (Senior Application Scientist, Wyatt Technology)Dr. Andy Meyer joined Wyatt Technology in 2001, serving for several years as an Applications Scientist, then as Dean of Wyatt's "Light Scattering University" and as Director of Customer Service &amp; Support. After managing multiple regions in North America, Dr. Meyer is now a Senior Application Scientist for Wyatt. As a Wyatt customer, he completed his Ph.D. in Applied Science – Polymer Chemistry from the College of William and Mary in Virginia.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About What's New in Empower Software

Empower Tips: Ask Me Anything About What's New in Empower Software

In this session, we will explore new and upcoming Empower Software features

Empower Tips What's New in Empower Software

&nbsp;Key Learning Points<ul><li>Learn best practices to optimize and utilize SLE for biological sample matrices</li><li>Review case studies to understand advantages of SLE and its limitations</li><li>Understand sustainable solvent use for SLE</li></ul><h4>Who Should Attend</h4><ul><li>Scientists and researchers pursuing research on low level analyte quantitation using LC-MS/MS.</li></ul><blockquote>Speaker: Rajashree Chakravarti, Ph.D. (Global Product Manager, Phenomenex)Rajashree Chakravarti, Ph.D., is a Global Product Manager at Phenomenex. With over a decade of experience in clinical diagnostics and research, she has a robust background in chromatography and mass spectrometry. Rajashree is a key contributor in innovation and new product development at Phenomenex, driving advancements in analytical techniques and solutions.</blockquote>

Phenomenex: Advancing Supported Liquid Extraction (SLE) with Strata SE – A Clean and Sustainable Solution

Advancing Supported Liquid Extraction (SLE) with Strata SE – A Clean and Sustainable Solution

Learn best practices to optimize and utilize SLE for biological sample matrices

Advancing Supported Liquid Extraction SLE with Strata SE

Veterinary drug residues are substances that can remain in animal products such as meat, dairy, eggs, and fish when these drugs are used to treat, prevent, or manage diseases in food-producing animals. These residues are of concern due to their potential to cause adverse effects on human health, including antimicrobial resistance (AMR), allergic reactions, and even carcinogenic or teratogenic outcomes. In light of these risks, countries and international regulatory bodies, such as the Codex Alimentarius and various governmental health agencies, have established maximum residue limits (MRLs) for specific drugs in food products. The control of these residues is critical not only for consumer safety but also for maintaining the integrity of food production systems globally.Join us for an in-depth webinar to gain insights into the latest regulatory requirements and analytical techniques for detecting veterinary drug residues in various food matrices. Learn how advanced technologies can enhance food safety and streamline testing processes.<h5>By attending this presentation, you will learn about:</h5><ul><li>Understanding regulations and MRL values for veterinary drugs</li><li>Innovative sample preparation methods to achieve low LOQs</li><li>Validation procedures, including single-laboratory validation (SLV) and multi-laboratory validation (MLV).</li><li>Utilizing the SCIEX 7500+ system for high-sensitivity quantitation and interference removal</li></ul><h5>Who should attend:</h5><ul><li>Food safety and quality control professionals</li><li>Analytical chemists and laboratory technicians</li><li>Regulatory affairs specialists in the food industry</li></ul><blockquote>Presenter: Jianru Stahl-Zeng (Senior Technical Marketing Manager, SCIEX)</blockquote>

Separation Science: Advancing Food Safety and Regulatory Compliance: Comprehensive Screening of Veterinary Drug Residues in Food using SCIEX LC-MS/MS Technology

Advancing Food Safety and Regulatory Compliance: Comprehensive Screening of Veterinary Drug Residues in Food using SCIEX LC-MS/MS Technology

Gain insights into the latest regulatory requirements and analytical techniques for detecting veterinary drug residues in various food matrices.

Screening Vet Drug Residues in Food with SCIEX LC-MS/MS

<h5>By attending this presentation, you will learn:</h5><ul><li>Non-targeted analytical methodologies for PFAS characterizations</li><li>Practical examples of identifying emerging PFAS in industrial wastewater, indoor dust, and outdoor air</li><li>Evaluation of impact from ski waxes and potentially hydrophobic coatings</li><li>Environmental transport, transformation, and degradation of commercial PFAS materials</li></ul><h4>Presentation 1: Non-targeted screening of per-/polyfluoroalkyl substances by cyclic ion mobility-mass spectrometry</h4><ul><li>Karl J. Jobst, Associate Professor, Memorial University of Newfoundland and Labrador</li></ul>Concerns regarding the persistence, bioaccumulation behaviour, and toxicity of perfluorooctanoic acid (PFOA) and perfluorosulfonic acid (PFSA) have resulted in the creation of thousands of replacements whose occurrence, environmental fate, and adverse health impacts are unknown. This has driven analytical chemists to develop non-targeted screening (NTS) methods to accelerate the identification of unknown PFAS. Unlike other halogens, such as chlorine or bromine, 19F exists as a single stable isotope; thus, PFAS are not characterized by diagnostic isotope patterns.This presentation describes a novel strategy to identify unknown PFAS using gas or liquid chromatographic cyclic ion mobility mass spectrometry (LCxcIMS or GCxcIMS). Unknown PFAS are recognized by having a collision-cross section (CCS) that is less than the sum of 100 Å2 and one fifth of their mass. By filtering the detected unknowns by mass and CCS, novel PFAS were revealed in a variety of environmental media, including industrial wastewater, indoor dust, and outdoor air, and their identities were confirmed through tandem mass spectrometry experiments with (synthesized) standards.<h4>Presentation 2: Explore a multidimensional, non-targeted analytical approach using advanced chromatography and mass spectrometry to improve PFAS identification</h4><ul><li>Frank Dorman, Senior Business Development Manager, Waters</li></ul>Poly/per-fluorinated aliphatic substances (PFAS) are of increasing concern in both the environment and food, and the understanding of their chemical complexity is strategically important. According to published literature, known PFAS chemicals, quantified on a targeted basis using available reference standards, have been shown to account for only 20-30% of total organic fluorine in “traditional source” samples. The remaining 70-80% is derived from other PFAS that are either commercial chemicals for which no reference standards are available, or downstream degradation/metabolism products of commercial chemicals with novel structures. Additionally, it is arguable if the target compound lists associated with regulatory methods even apply to “non-traditional” PFAS sources (non-AFFF, etc.).This presentation will describe an analytical approach capable of utilizing both liquid- and gas-chromatographic separations coupled to a high-resolution ion-mobility spectrometer in series with a high-resolution time-of-flight mass spectrometer. This multidimensional, non-targeted separation dramatically improves identification of PFAS compounds. In addition, a post-acquisition data reduction strategy will be discussed, which effectively enables more automated characterization of non-targeted PFAS, either as native or degradation compounds. This becomes especially beneficial in “non-traditional” source contamination or where degradation products are of interest. This methodology will be utilized for a series of environmental forensic applications towards winter sports activities, an emerging area of concern with respect to PFAS contamination in the environment.<h5>Who should attend:</h5><ul><li>Environmental scientists and chemists</li><li>Analytical chemists</li><li>Laboratory directors and technical leads</li><li>Contract testing organizations (CTOs)</li><li>Government and academic lab researchers</li><li>Regulatory and risk assessment professionals</li><li>Environmental forensics researchers</li><li>Food safety scientists</li><li>Toxicologists and exposure scientists</li><li>Winter sports organizations and sustainability officers</li></ul><blockquote>Presenter: Karl J. Jobst (Associate Professor, Department of Chemistry, Memorial University of Newfoundland and Labrador)Karl J. Jobst is an Associate Professor in the Department of Chemistry at Memorial University of Newfoundland and Labrador. He obtained his Ph.D. in gas-phase ion chemistry from McMaster University under the supervision of Professor Johan K. Terlouw. His interests in the chemistry of interstellar clouds soon evolved into more earth-oriented research as a Visiting Fellow at Environment Canada, a Scientist with the Ontario Ministry of the Environment, as well as Adjunct Assistant Professor in the Department of Chemistry of his alma mater and in the Department of Physical and Environmental Sciences at the University of Toronto Scarborough. His current research focuses on the identification of emerging contaminants and understanding their environmental and human health impacts using novel mass spectrometry and computational methods. Dr. Jobst has (co)authored over 100 publications in peer-reviewed journals, and serves on the editorial board of Current Opinion in Environmental Science &amp; Health.Presenter: Frank Dorman &nbsp;(Senior Business Development Manager, Waters)Frank Dorman is currently Senior Business Development Manager for Waters focusing on their global environmental business and, concurrently, a resident scholar in the Chemistry Department at Dartmouth College in Hanover, NH where he is active in teaching analytical chemistry to undergraduates and graduate students. In his role at Waters, Frank manages the research-focused environmental market, external collaborations, and interfaces with R&amp;D for new product development. Prior to this, Frank was an Associate Professor in the Department of Biochemistry and Molecular Biology (BMB) at Penn State University in University Park, PA. At Penn State, Frank served as a member of the Graduate Faculty in Biochemistry, Microbiology and Molecular Biology (BMMB), Chemistry (CHEM), Biogeochemistry (BGC) and the Forensic Science Program (FRNSC) and the Center for Molecular Toxicology and Carcinogenesis. Frank's scientific interests are in gas and liquid chromatography and fundamental characterization, instrumentation and column development, as well as mass spectrometry and atomic spectroscopy as applied to trace analysis in complex sample matrices.</blockquote>

SeparationScience: Emerging Strategies in PFAS Identification: Advanced Analytical Approaches for Environmental Samples

Emerging Strategies in PFAS Identification: Advanced Analytical Approaches for Environmental Samples

Explore how advanced non-targeted workflows using ion mobility and HRMS reveal hidden PFAS in environmental samples

PFAS Identification: Advanced Strategies for Environment

A 3-part webinar series to help you stay ahead in nitrosamines &amp; NDSRI analysis, from regulatory clarity to method mastery and compliance confidence.<h4>Session 1: Nitrosamines Landscape in Tandem with Analytical Technologies: Is Your Lab Nitrosamine Ready?</h4>Nitrosamines and NDSRIs continue to challenge the pharmaceutical industry with evolving regulations and analytical complexities. This session focuses on understanding the distinctions between nitrosamines and NDSRI's and aligning your lab with the latest regulatory expectations and technology advancements.Get expert insights into risk assessment, mitigation strategies, and the analytical technologies critical to staying compliant and efficient. The session will feature an exclusive panel discussion with Dr. Saji Thomas, Associate Vice President, Analytical Research &amp; Development, Sun Pharma, who will share practical, real-world insights from the frontlines of nitrosamine testing and regulatory preparedness.<h5>Key Takeaways:</h5><ul><li>Understanding the difference between Nitrosamines and NDSRI's</li><li>Regulatory scenarios: API, Formulations, and NDSRI's</li><li>Key updates in global guidance and risk assessment</li><li>Mitigation strategies for NDSRI's</li><li>Industry discussion: evolving testing landscape, workflow challenges, and future directions</li><li>Live Q&amp;A with Agilent and industry experts</li></ul><blockquote>Presenter: Dr. Saji Thomas (Associate Vice President, Analytical Development, Sun Pharmaceutical Industries Limited)Dr. Saji Thomas earned his Ph.D. in chemistry from Kumaun University, Nainital, Uttarakhand. With 32 years of diverse experience in the pharmaceutical industry, he has developed cost-competitive, IP, EHS, and regulatory-compliant technologies for generic APIs, intermediates, radiopharmaceuticals, onco APIs, life science ingredients, animal nutrition products, fine chemicals, CRAMS/CDMO, and drug discovery functions.He is skilled in chemical analysis, chromatography, solid-state characterization, spectroscopy, impurity profiling, impurity isolation, and structural elucidation using techniques such as LC-MS/MS, HRMS, IR, NMR, and EA. Also excels in developing and validating highly sensitive MS methods for nitrosamines, NDSRIs, and GTIs.He has extensive experience in pharmaceutical quality management systems (QMS), creating state-of-the-art manufacturing and QA systems, conducting OOT and OOS investigations, identifying root causes, implementing CAPA, and engaging in FDA remediation activities. He is a co-inventor of 25 process patents and has published 14 research papers in international journals.Currently, Dr. Thomas serves as the Associate Vice President of Analytical Development at Sun Pharmaceutical Industries Limited in Gurugram. His previous roles include positions at Jubilant Pharmova Limited, Indoco Remedies, Jubilant Life Sciences Limited, Solaris Chemtech, and Alta Laboratories Limited.Presenter: Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)Kuldeep Sharma has over 19 years of experience in the areas of bioanalytical research, drug metabolism &amp; pharmacokinetics, and pharma regulatory compliance. He has accomplished a PhD in biotechnology. His professional journey covers over 12 years in analytical research (associated with R&amp;D at Zydus Cadila, Lambda, Pliva, and Jubilant Biosys) and the last 7 years in analytical instrument sales, marketing, and business development. With over 21 research articles published in international journals, he presents the convention of continuous learning.</blockquote>

Agilent Technologies: Nitrosamines Navigator: Be Confident with Agilent Workflows

Nitrosamines Landscape in Tandem with Analytical Technologies: Is Your Lab Nitrosamine Ready?

Is your lab nitrosamine-ready? Join Session 1 to explore regulatory trends, risk strategies, and tech updates with expert insights from Sun Pharma and Agilent.

Is Your Lab Nitrosamine Ready?

<div id="contentLeft"><div id="realLeftContent"><div id="summary2" dir="ltr" aria-live="off"><div><div dir="" aria-atomic="true">Ion chromatography (IC) has long been a trusted technique for ionic analysis, with conductivity detection as its standard workhorse. However, alternate detection technologies are unlocking new possibilities for sensitivity, selectivity, and broader application coverage. In this webinar, we’ll explore three powerful alternatives: UV/Vis, amperometric, and mass spectrometry (MS) detection, and examine how each can enhance your IC workflows.We’ll discuss practical examples of when to apply each detection method, helping you understand which technologies are best suited for different analytes, sample types, and industry needs. Whether you're analyzing food and beverage products, monitoring environmental contaminants, or working with other complex matrices, alternate detectors can offer significant advantages. Along the way, we’ll share key insights on optimizing your methods for each detector type—covering considerations like system setup, sample prep, and choosing the right chemistry. Whether you're expanding into new applications or looking to refine existing methods, this session will offer actionable guidance to help you get the most out of your IC system.<h4>Who should attend?</h4><ul><li>Analytical chemists and method development scientists looking to expand or refine their use of ion chromatography</li><li>Lab managers and technical staff seeking to evaluate or implement alternate detection technologies</li><li>Professionals in environmental, food, pharmaceutical, or industrial sectors aiming to enhance analytical capabilities</li></ul><h4>Key learning points</h4><ul><li>Learn the core principles and application benefits of UV/Vis, amperometric, and mass spectrometry (MS) detection in ion chromatography</li><li>Understand how to choose the right detection method based on sample type, analyte characteristics, and application requirements</li><li>Explore practical method development tips to optimize performance with each detection technology</li></ul><blockquote>Presenter: Jay Gandhi. PhD (Vertical Market Manager, Metrohm USA)Dr. Gandhi brings 38+ years of proficiency with virtually all analytical instrumentation and the techniques of Environmental, Petrochemical and Pharmaceutical testing and research. Jay is currently involved with the development of «Total Fluorine» analysis using combustion ion chromatography (CIC). Since 2003, Dr. Gandhi is a non-paid adjunct faculty at University of Houston-Clearlake where he enjoys guiding graduate and post-graduate students in their independent study program.Presenter: Bikash Chouhan, PhD (Applications Specialist, Ion Chromatography, Metrohm USA)Bikash Chouhan is an Applications Specialist for Ion Chromatography at Metrohm USA. He completed his PhD in Analytical Chemistry from the University of Texas at Arlington (UTA). His area of research during his PhD was in Capillary Scale Ion Chromatography. He has worked as a Post Doc at Department of Chemistry and Biochemistry, UTA and as a Senior Scientist in IC at Eurofins, before joining Metrohm USA. He is currently involved in expanding IC applications to more unique and challenging sample matrices.</blockquote></div></div></div></div></div>

Metrohm: Expanding Ion Chromatography with Advanced Detection Technologies

Expanding Ion Chromatography with Advanced Detection Technologies

Boost your IC performance with UV/Vis, amperometric, and MS detection. Learn when and how to apply alternate detectors for better sensitivity and selectivity.

Expanding IC with Advanced Detection Technologies

Since the 1940s, the global utilization of per- and polyfluorinated alkyl substances (PFAS) in the production of various commodities, including firefighting foams and textiles, has been extensive. PFAS are now recognized as toxic to both humans and wildlife, necessitating their control and monitoring worldwide. While the initial focus of PFAS analysis has primarily been on environmental samples such as water and soil, there is a growing interest in quantifying their presence in the food chain. PFAS can enter our food through soil or water, as well as via cookware or food packaging.&nbsp;This webinar we will help you to understand more about the latest advancements in sample preparation strategies to enable accurate PFAS determination in challenging food matrices. It will also outline the end-to-end analytical workflows for LC/MS/MS multi-target PFAS determinations.<h5>Key learning objectives:</h5><ul><li>Understand the various EU regulations for PFAS in different food matrices&nbsp;</li><li>Understand why effective sample preparation is required to fulfill the regulations &nbsp;</li><li>Attendees will be equipped with a LC/MS/MS workflow solution they can implement right away</li></ul><h5>Who should attend?</h5>Anyone who is working in a laboratory environment preparing food samples for PFAS analysis:<ul><li>Private CRO food safety testing laboratories &nbsp;</li><li>Government food testing laboratories &nbsp;</li><li>Academic food science laboratories &nbsp;</li><li>Food lab managers &nbsp;</li><li>Food lab instrument operators&nbsp;</li></ul><blockquote>Presenter: Carola Damen (LC/MS Product Specialist Benelux, Agilent Technologies)Carola Damen PhD PharmD obtained her master's degree in pharmacy at the University of Groningen, after which she completed her pharmacist training at the same university. She obtained her PhD at the Netherlands Cancer Institute in Amsterdam. During her studies, she specialized fully in analytical chemistry, particularly liquid chromatography coupled with mass spectrometry.Carola fulfilled various laboratory functions focusing on small molecule analysis using LC/MS. She has been working as a product specialist LC/MS at Agilent since 2020 and has a special point of interest in the analysis of PFAS components in various matrices.Presenter: Scott Bollen (Business Development Manager EMEA, Agilent Technologies)Scott specializes in small molecule LC columns, ranging from HPLC to UHPLC. Scott has worked at Agilent for 17 years. He started as a technical support manager, and now supports new LC products in R&amp;D as well as the entirety of the existing small molecule LC column portfolio in business development.</blockquote>

Agilent Technologies: Unlocking Accurate PFAS Analysis: Advanced Sample Prep and LC/MS/MS Workflows for Complex Food Matrices

Unlocking Accurate PFAS Analysis: Advanced Sample Prep and LC/MS/MS Workflows for Complex Food Matrices

This webinar will help you to understand more about latest advancements in sample prep to enable PFAS determination in food matrices.

PFAS Analysis - Sample Prep and LC/MS/MS for Food Matrices

Despite the incredible advances in metabolomics, translating vast amounts of untargeted data into meaningful biological insights remains a major challenge. Many metabolites go unidentified, limiting the impact of these powerful techniques on real-world applications. This event brings together leading experts to discuss strategies and technologies that can bridge this gap and enhance metabolite identification.Gain insights from experts in a two-part discussion: a master class highlighting key metabolomics challenges and solutions, followed by a roundtable discussion featuring industry leaders tackling the bottlenecks in metabolite identification. Choose to attend one or both sessions.<h4>Part 1: Master class: Lost in translation – advancing untargeted metabolomics</h4>Dr. Philippos Michopoulos from Astrazeneca will share his insights into the key challenges of metabolite identification in untargeted workflows, including:<ul><li>The limitations of current retention time libraries and how much information remains untapped</li><li>The role of untargeted SWATH acquisition and data mining in improving metabolite identification</li><li>Practical strategies for closing the gap between experimental data and meaningful biological interpretation</li></ul>This session will feature a discussion with SCIEX experts on potential solutions.<blockquote>Presenter: Filippos Michopoulos (Astrazeneca)Filippos Michopoulos is an analytical chemist who has obtained his PhD from University of Thessaloniki (Greece) in “Biomarker Discovery and drug efficacy in studying autoimmune diseases”. Filippos has 20 years of experience in metabolic profiling technologies across the academia and industry. Filippos has developed a wide range of robust analytical technologies using U(H)PLC separations hyphenated to mass spectrometry predominantly focused on polar metabolite analysis and quantitation. He is interested to utilise advancements in analytical science to unravel biological complexity and enhance understanding of pathophysiological mechanism. Filippos has more than &gt;30 peer reviewed scientific publication and an active reviewer in &gt;10 scientific journals.Presenter: Ferran Sanchez (Market Development Manager, Pharma/CRO (MS &amp; CE), EMEAI, SCIEX)Ferran obtained his PhD in Pharmaceutical Sciences at the University of Barcelona in 2005 and has been involved with mass spectrometry ever since. He has worked for SCIEX for 18 years holding different positions in sales, marketing and business development covering the EMEAI region. During this time, Ferran has been working closely with customers in the pharmaceutical industry to deepen his understanding of the market and user needs for delivering the right solutions at the right time.Presenter:&nbsp;Martin Giera, Ph.D.Martin Giera, Ph.D., studied pharmacy in Heidelberg and Munich. He is professor for translational metabolomics and lipidomics and vice-chair of the center for proteomics and metabolomics at the Leiden University Medical Center. He is involved in several multi-national consortia, member of several editorial boards and chairman of the interdisciplinary committee at FWO. Martin has a keen interest in metabolomics technology, drug development and biochemistry. He has published more than 250 scientific publications, patents and books.</blockquote>

SCIEX: Metabolomics during the Drug Discovery: Master class and roundtable discussion

Master class: Lost in translation – advancing untargeted metabolomics

Explore key challenges in untargeted metabolomics and discover strategies to improve metabolite ID with SWATH data and insights from AstraZeneca and SCIEX.

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