Traditional ducted fume hoods remain the gold standard for chemical containment in most laboratories, but several innovative alternatives can provide effective protection while offering unique advantages. These alternatives include glove boxes, snorkel systems, and specialized containment units that address specific laboratory needs while potentially reducing energy consumption and installation complexity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Alternatives_to_Traditional_Fume_Hoods_A_Comprehensive_Guide_to_Laboratory_Containment_Solutions_9c39f814df.jpg" alt="Organomation: Alternatives to Traditional Fume Hoods: A Comprehensive Guide to Laboratory Containment Solutions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Alternatives_to_Traditional_Fume_Hoods_A_Comprehensive_Guide_to_Laboratory_Containment_Solutions_9c39f814df.jpg 208w," sizes="100vw" width="2016" height="1512"><h3>Glove Boxes: Maximum Containment for High-Risk Materials</h3>Glove boxes, also known as isolation enclosures, represent the highest level of containment available for laboratory operations. These fully enclosed systems create a complete physical barrier between operators and hazardous materials while maintaining precise environmental control.<h4>Key Features and Applications</h4>Glove boxes consist of hermetically sealed stainless steel or transparent enclosures equipped with integrated gloves that allow manipulation without breaking containment. Modern systems include sophisticated transfer airlocks, sensors, regulators, and automatic safety flow systems that compensate for pressure drops or accidental containment breaches.These systems excel in applications requiring extremely low occupational exposure limits (OELs). For materials classified as OEB 4 (1-50 μg/m³) or OEB 5 (&lt;1 μg/m³), glove boxes provide containment levels as low as 0.1 μg/m³ or even 0.01 μg/m³. This makes them essential for handling highly potent pharmaceutical compounds, radioactive materials, and other extremely hazardous substances.<h4>Specialized Configurations</h4>The versatility of glove box technology extends to numerous specialized applications. Compounding Aseptic Isolators (CAI) create positive pressure environments for sterile pharmaceutical compounding, meeting USP 797 requirements. Conversely, Compounding Aseptic Containment Isolators (CACI) operate under negative pressure for handling hazardous drugs per USP 800 guidelines.Inert atmosphere glove boxes utilize nitrogen or argon purging to create oxygen-free environments essential for moisture-sensitive materials and anaerobic research. These systems feature automated purge cycles and one-touch operation for seamless anaerobic transitions.<h4>Construction Materials and Performance</h4>Stainless steel construction (316L grade) provides optimal chemical resistance and durability, with continuous seam welds and wide radius corners facilitating easy decontamination. Leak rates typically specification below 0.05% chamber volume per hour, verified through pressure decay testing. Advanced systems incorporate built-in sterilization capabilities using vaporized hydrogen peroxide (VHP) generators for thorough decontamination between uses.<h4>Advantages and Limitations</h4>Glove boxes offer unparalleled containment performance with complete environmental isolation, precise atmospheric control, and robust decontamination capabilities. The closed design eliminates airflow disturbances that can compromise containment in open-front systems.However, glove boxes require larger footprints, higher initial investment, and more complex maintenance compared to open containment systems. The enclosed design may limit accessibility for larger equipment or rapid material transfers, and extended use can cause operator fatigue due to the ergonomic constraints of glove manipulation.<h3>Snorkel Systems: Localized Fume Extraction</h3>Snorkel systems, also known as articulating extraction arms or fume extraction arms, provide targeted fume capture at the source while maintaining workspace flexibility.<h4>Design and Operation</h4>These systems feature flexible, articulating arms typically 3-8 inches in diameter with working radii ranging from 3-14 feet. The arms incorporate three adjustable joints allowing 360-degree rotation and positioning flexibility. Standard configurations handle airflow rates from 30-1000 CFM depending on arm diameter and application requirements.Multiple specialized configurations address specific laboratory needs. The Original model provides general-purpose fume extraction for standard laboratory applications. ESD/EX models incorporate conductive materials to eliminate electrostatic discharge risks in electronic environments. CHEM models feature double anodized aluminum construction for enhanced corrosion resistance in aggressive chemical environments.<h4>Installation and Integration</h4>Snorkel systems mount to walls, ceilings, workbenches, or specialized support structures. They integrate with facility HVAC systems or standalone filtration units depending on application requirements. Mobile configurations with integrated collectors provide complete portability for applications requiring frequent repositioning.Advanced mounting systems include swing boom configurations for extended reach applications (18-35 feet) and rail-mounted trolley systems for linear positioning along extended work areas. These systems require minimal operator force for positioning and repositioning.<h4>Hood Options and Customization</h4>Extraction hoods vary based on application requirements. Transparent dome hoods optimize visibility for precision work while providing effective capture for high-dispersion particles. Metal hoods offer enhanced durability and chemical resistance for aggressive environments. Specialized hood geometries optimize capture efficiency for specific processes like chromatography or analytical instrumentation.<h4>Performance and Applications</h4>Snorkel systems excel in applications requiring localized fume extraction from specific equipment like chromatographs, analytical instruments, or small-scale chemical processes. They provide effective capture distances of 12-20 inches from the source with capture areas up to 20 inches in diameter.These systems prove particularly valuable in laboratories with limited space, flexible furniture arrangements, or applications where full fume hood installation is impractical. Educational laboratories benefit from their overhead mounting that preserves floor space while providing necessary ventilation.<h4>Energy Efficiency Considerations</h4>Snorkel systems typically require lower airflow rates than full-sized fume hoods, reducing energy consumption and HVAC demands. When integrated with variable speed controls and demand-based operation, they provide energy-efficient alternatives to constant-volume hood operation.<h3>Ductless Fume Hoods: Energy-Efficient Alternatives</h3>Ductless fume hoods represent a growing alternative to traditional ducted systems, offering significant energy savings and installation flexibility while maintaining safety standards.<h4>Energy Performance Advantages</h4>Ductless systems achieve remarkable energy efficiency improvements over traditional ducted hoods. Studies indicate energy efficiency improvements of 18-25 times compared to total exhaust systems, primarily through air recirculation rather than continuous exhaust of conditioned air. This translates to substantial reductions in HVAC loads and operational costs.A comparative analysis of a hypothetical 30-hood facility demonstrated that ductless systems consume only 2.4 kBTU per square foot annually compared to 127.5 kBTU for constant volume hoods and 74.1 kBTU for VAV systems. Carbon dioxide emissions similarly decrease from 873 tons annually for constant volume systems to just 55 tons for ductless alternatives.<h4>Filtration Technology and Safety</h4>Modern ductless hoods employ sophisticated multi-stage filtration systems combining carbon, HEPA, and specialized chemical filters. Advanced monitoring systems continuously assess filter performance and provide alerts when replacement is required. These systems maintain face velocities of 100 feet per minute, meeting OSHA recommendations while achieving ASHRAE 110 certification standards.Filter replacement costs range from $350-2,000 annually, representing significant savings compared to ongoing HVAC operational costs of ducted systems. Filter life varies based on application but typically extends 6-12 months under normal laboratory conditions.<h4>Installation and Flexibility Benefits</h4>Ductless hoods arrive fully certified and ready for immediate use without requiring building modifications or HVAC integration. This eliminates lengthy installation timelines and coordination requirements associated with ducted systems. Mobile configurations provide additional flexibility for laboratories requiring equipment relocation.The plug-and-play nature of ductless systems allows rapid deployment and adaptation to changing laboratory needs without facility downtime or infrastructure modifications.<h4>Application Limitations and Considerations</h4>Ductless systems prove most effective for applications involving naturally evaporating chemicals in limited volumes. They are not suitable for heated chemicals, highly volatile solvents, or applications generating large volumes of hazardous vapors. Regular filter monitoring and replacement are essential to maintain protection effectiveness.<h3>Specialized Containment Solutions</h3>Beyond traditional glove boxes and snorkel systems, several specialized containment solutions address specific laboratory needs.<h4>Downflow Booths</h4>Downflow booths utilize unidirectional airflow to carry contaminants away from operator breathing zones into low-level exhaust systems. These systems prove effective for powder handling operations requiring containment levels of 50-100 μg/m³.Recirculatory configurations suit powder operations while single-pass designs handle applications involving solvents or vapor generation. HEPA filtration and controlled airflow patterns (typically 90 FPM) provide effective containment while maintaining operator accessibility.<h4>Mobile Fume Extractors</h4>Portable fume extraction units combine the benefits of source capture with complete mobility. These self-contained systems feature integrated filtration, typically 3-stage systems with aluminum mesh pre-filters, MERV 15 cartridge filters, and activated carbon after-filters.Units range from 750-1200 CFM capacity with 6-8 inch diameter extraction arms in lengths from 7-14 feet. Advanced models incorporate pulse-cleaning systems extending filter life 6-7 times beyond traditional reverse-pulse systems.<h4>Biosafety Cabinets and Biological Containment</h4>While primarily designed for biological applications, Class III biosafety cabinets function as glove box systems for maximum biological containment. These systems provide complete enclosure with HEPA filtration for handling BSL-3 and BSL-4 materials.Class II biosafety cabinets offer open-front operation with HEPA filtration for lower-risk biological materials while providing some chemical containment capabilities for limited applications.<h3>Selection Criteria and Implementation Considerations</h3><h4>Material Hazard Assessment</h4>The selection of appropriate fume hood alternatives depends primarily on the occupational exposure limits and toxicological properties of materials being handled. OEB classifications provide guidance for containment requirements:<ul><li>OEB 1-2 (100-5000 μg/m³): Standard downflow booths with minimal additional controls</li><li>OEB 3 (10-100 μg/m³): Enhanced downflow booths or limited containment systems</li><li>OEB 4 (1-10 μg/m³): Specialized containment or glove box systems recommended</li><li>OEB 5 (&lt;1 μg/m³): Full isolation systems required</li></ul><h4>Economic Considerations</h4>Initial investment costs vary significantly among alternatives. Ductless hoods typically require lower upfront investment due to eliminated infrastructure requirements. Glove boxes represent higher initial costs but provide superior long-term containment assurance for high-risk materials.Operational costs favor ductless systems through reduced energy consumption, while glove boxes may require higher maintenance but offer lower risk exposure costs.<h4>Laboratory Design Integration</h4>Space constraints and laboratory layout significantly influence alternative selection. Snorkel systems optimize overhead space utilization while maintaining floor accessibility. Ductless hoods provide location flexibility without ducting constraints. Glove boxes require dedicated space but offer maximum containment assurance.Future laboratory needs and potential application changes should inform selection decisions, with modular and mobile solutions providing greater adaptability.The landscape of fume hood alternatives continues expanding with advancing filtration technology, improved energy efficiency, and enhanced safety monitoring systems. Each alternative offers distinct advantages addressing specific laboratory requirements while potentially providing economic and operational benefits over traditional ducted systems. Proper selection requires careful assessment of material hazards, operational requirements, and facility constraints to ensure both safety and efficiency objectives are met.

Alternatives to Traditional Fume Hoods: A Comprehensive Guide to Laboratory Containment Solutions

The research group of associate professor Bob Pirok at the University of Amsterdam’s Van ’t Hoff Institute for Molecular Sciences (HIMS) is partnering with Agilent Technologies to develop advanced analytical methodologies for polymer characterisation. As part of the collaboration, the scientific instruments company has provided state-of-the-art analytical equipment that has been integrated into the self-driving analytical AI laboratory at HIMS.As modern polymers become increasingly complex in their molecular architecture and functionality, the demand for more powerful and comprehensive analytical approaches, such as two-dimensional liquid chromatography coupled to mass spectrometry (2D-LC-MS), has never been greater.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_The_collaborative_team_in_the_HIMS_self_driving_analytical_lab_5ee413fe5e.jpg" alt="HIMS: he collaborative team in the HIMS self-driving analytical lab. From left to right: Danny van Oevelen (Agilent), Herman Breukink (Agilent), Bob Pirok (UvA), Tijmen Bos (UvA), Gerben van Henten (UvA), Michael Rodammer (Agilent) &amp; Carola Damen (Agilent)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_The_collaborative_team_in_the_HIMS_self_driving_analytical_lab_5ee413fe5e.jpg 208w," sizes="100vw" width="700" height="527">To advance the field of polymer analysis, the research group of Bob Pirok combines fundamental insights in separation science with automation and machine learning approaches to accelerate method development and improve polymer and materials analysis. In doing so, the group builds upon the strong foundation established by the former Polymer Analysis Group led by Prof. Peter Schoenmakers.Pirok’s research is in many cases carried out in collaboration with industrial partners. An example is the STREAMLINED consortium led by Pirok and his HIMS colleague Dr Alina Astefanei, developing analytical tools to investigate nanoplastics. It includes researchers at the Vrije Universiteit Amsterdam and various polymer companies and instrument manufacturers.<h4>Self-driving laboratory</h4>In a new partnership, the Pirok group has now joined forces with scientific instrument company Agilent Technologies. The aim is to develop and evaluate advanced workflows that meet current and emerging challenges in polymer and materials characterisationAs part of the collaboration, an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=Revident+LC%2FQ-TOF">Agilent Revident LC/Q-TOF system</a> has been installed in the HIMS self-driving analytical AI laboratory. “There, we design AI strategies that directly interact with analytical instrumentation to optimise 1D and 2D-LC-MS methods autonomously,” Pirok explains. “This project allows us to combine state-of-the-art instrumentation with cutting-edge AI so that we can explore new solutions to complex questions in polymer analysis.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HIMS_A_liquid_chromatography_system_operates_autonomously_in_the_development_of_a_method_for_analysis_of_an_industrial_sample_ac32a2000f.jpg" alt="HIMS: A liquid chromatography system operates autonomously in the development of a method for analysis of an industrial sample. In the project, Bob Pirok and Tijmen Bos will explore synergies between cutting-edge AI developments and advanced LC–MS technologies to deliver improved solutions for polymer characterization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HIMS_A_liquid_chromatography_system_operates_autonomously_in_the_development_of_a_method_for_analysis_of_an_industrial_sample_ac32a2000f.jpg 208w," sizes="100vw" width="700" height="524">The new instrument is a welcome addition to the group’s <a target="_blank" rel="noopener noreferrer" href="https://cast-amsterdam.org/automated-method-development/">AutoLC </a>self-driving laboratory, an autonomous method-development platform for which Pirok received the <a target="_blank" rel="noopener noreferrer" href="https://hims.uva.nl/content/news/2024/06/bob-pirok-wins-2024-htc-innovation-award.html">HTC Innovation Award</a>. It also fits in the research line of Dr Tijmen Bos, who designs data-analysis workflows specifically for polymers and has published solutions for several parties from industry. A recent example was the <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.macromol.5c00297">characterisation of the block-length distribution of copolymers</a> using machine learning.

Advanced equipment for self-driving analytical AI laboratory

Join us in this fascinating episode of Concentrating on Chromatography as Dr. Rachael Guenter, PhD, shares her eight-year journey researching neuroendocrine tumors. Discover how her background in plant pathology and engineering shaped her translational medicine approach, and learn about the crucial role of mass spectrometry in uncovering protein-level insights in these rare cancers.&nbsp;Dr. Guenter also discusses the challenges of translating lab discoveries into clinical trials, the promise of spatial mass spectrometry for tumor heterogeneity, and the importance of collaboration between scientists, clinicians, and patients. Whether you're interested in cancer biology, mass spec applications, or cutting-edge cancer research, this episode delivers valuable perspectives and inspiring advice from a leading expert in the field. &nbsp;<h3>Video Transcription</h3>Dr. Rachael Guenter shares how her path into neuroendocrine tumor (NET) research began with an early love of math and science, then accelerated through hands-on research experiences in college. She describes studying Phytophthora infestans (the pathogen linked to the Irish potato famine) as a formative training ground for genetics, disease pathology, and core lab techniques—including work with historical DNA to understand how the disease spread in the 1800s. In parallel, she applied chemical engineering knowledge to process control and water purification, building confidence in practical, problem-solving approaches that later carried into biomedical research.Driven by a desire to apply these skills to challenges she felt deeply passionate about, Dr. Guenter pursued a PhD in cancer biology at the University of Alabama at Birmingham (UAB). She explains that she “stumbled into” a lab focused on neuroendocrine cancers—an area she hadn’t known existed at the time—but quickly realized the field was under-researched and urgently needed new insights. Nearly eight years later, she describes NET research as both a continuing scientific puzzle and a powerful motivator: the complexity is high, but so is the impact of every meaningful discovery.A major theme of the interview is translational medicine—moving ideas from bench science toward clinical application. Dr. Guenter emphasizes that this is only possible through close collaboration with clinicians and surgeons who work directly with patients. These partnerships help align laboratory questions with real patient needs (for example, therapies that slow or stop metastasis) and enable access to patient samples through informed consent and surgical collection. She also highlights the reality behind “bench to bedside”: long timelines, extensive safety work, regulatory documentation, and a coordinated team effort.Mass spectrometry is central to her workflow, supporting both mechanistic studies and tumor profiling. Dr. Guenter describes using MS-based approaches to answer fundamental questions—such as identifying proteins involved in gene regulation—and to compare differential protein expression across tumor models, including engineered cell lines tested in vivo. She notes that rare cancers like NETs bring a unique analytical challenge: there is often limited prior literature to interpret results, making the work more pioneering and requiring careful communication and iterative problem-solving. Looking ahead, she is especially excited about spatial mass spectrometry as a way to preserve tumor architecture and heterogeneity—capturing interactions among tumor cells, immune cells, and the microenvironment—to potentially unlock new insights into why some NET subtypes show limited response to immunotherapies.Finally, Dr. Guenter underscores that progress in rare cancers depends on community: scientists, clinicians, and patients working together through open communication and sustained collaboration—often across institutions and borders despite administrative hurdles. She also advocates for broader awareness of neuroendocrine cancer, explaining the “zebra” symbol and the mindset shift it represents: when symptoms are vague and diagnoses can take years, clinicians and the public may need to “think zebras,” not just the most common explanations. She closes on an optimistic note—mass spectrometry and collaborative networks are accelerating discoveries, and she hopes to share more soon as upcoming research is published.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Unraveling Neuroendocrine Cancer Research with Mass Spectrometry

Article

Academy

Video

Scientists

Interview

Science and research

Laboratories

The University of Amsterdam is one of the largest comprehensive universities in Europe. With some 40,000 students, 6,000 staff, 3,000 PhD candidates, and an annual budget of more than 850 million euros, it is also one of Amsterdam’s biggest employers.

There is an inseparable link between the university and its host city. The freedom and creativity with which Amsterdam has long been associated have worked their way into the fabric of the university. This is a place where individuality, authenticity and diversity are celebrated as sources of stimulation, inspiration and innovation.

Professional and personal development, challenges and collaboration are undertaken in a versatile and multidimensional (inter)national ecosystem with leading stakeholders. Staff at the UvA make a meaningful contribution to uncovering solutions to some of the world’s most significant problems and to developing the next generation of talent.

University of Amsterdam

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Mettler-Toledo

Agilent Technologies

Milestone

Phenomenex

Thermo Fisher Scientific

SelectScience

Shimadzu Corporation

SCIEX

Waters Corporation

<h4>Online HPLC Analysis Enabled by DirectInject-LC</h4>Join us for the first DirectInject-LC Virtual User Forum, a unique opportunity to connect with industry peers and share insights into the application of this advanced technology in chemical process development. This event will deepen your understanding of how online HPLC analysis enabled by DirectInject-LC is being used to streamline development workflows with real-time reaction monitoring and insight.<h5>Event Program</h5><ul><li>User Case Studies: Hear directly from users at AstraZeneca, Genentech, and Takeda about how they have implemented DirectInject-LC into their workflow</li><li>Practical Tips and Techniques: Discover strategies and best practices from peers and technical experts</li><li>Q&amp;A with Users and Experts: Ask questions and engage with the user community and technology and application experts from Telescope Innovations and METTLER TOLEDO</li></ul><h4>Guest Presenters</h4><h5>Real-Time HPLC with DirectInject-LC in 2nd Generation Small-Molecule Process Development at Pfizer PDC</h5><ul><li>Barry Doherty, Sr. Analytical Development Manager - Pfizer</li></ul><h5>Telescope DirectInject-LC – Applications from Lab to Plant</h5><ul><li>Christian Lautz, Sr. Principal Scientist, PAT Specialist - Roche</li></ul><h5>What Happens at the End of Your Reactions: Online LC-MS to Investigate Mechanisms of Impurity Formation</h5><ul><li>Kenji Kurita, Sr. Principal Scientist, Process Analytical Group Lead - Genentech</li></ul>

Mettler Toledo: DirectInject-LC Virtual User Forum

DirectInject-LC Virtual User Forum

Join the DirectInject-LC Virtual User Forum to explore real-time HPLC process monitoring, user case studies, and best practices from industry leaders.

Separation of highly polar compounds such as pharmaceuticals, metabolites, and biomarkers can be challenging using traditional reversed-phase methods on regular C18 columns.&nbsp;In this webinar, we will discuss available alternatives such as:<ul><li>Ion-pairing reversed-phase chromatography.</li><li>Use of polar-bonded phases or polar-modified columns</li><li>Alternative modes of separation, such as HILIC and Ligand Exchange chromatography.</li></ul><blockquote>Presenter: Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.</blockquote>

Agilent Technologies: Dealing With Polar Analytes – What Are the Options?

Dealing With Polar Analytes – What Are the Options?

Discover how to separate highly polar analytes using ion-pairing RP, polar-modified phases, HILIC, and ligand-exchange chromatography beyond traditional C18.

Dealing With Polar Analytes

As regulatory scrutiny around PFAS (Per- and Polyfluoroalkyl Substances) continues to intensify, laboratories face growing challenges in achieving accurate, low-level detection. Analytical methods have become more sensitive and complex, while regulators demand consistent, defensible data to guide environmental and public health policies. This expert-led roundtable explores the historical evolution of PFAS methods—from early protocols to current EPA 1633 and ASTM standards—and their impact on today’s testing environment.We examine the regulatory trends shaping method adoption, the technical barriers labs must overcome (such as background contamination and instrument sensitivity), and how purpose-designed solutions—PFAS low background consumables—are essential for ensuring data integrity. As PFAS contamination can originate from the very materials used in sample collection and analysis, using certified low-background consumables has become a critical step in achieving reliable results.The discussion also highlights real-world laboratory solutions, including platforms from SCIEX and others, and explores future innovations in sample preparation—for example, solid phase extraction (SPE)—and MS platform enhancements. Whether you're responsible for PFAS method development, compliance, or lab operations, this session will provide the practical and strategic insights needed to stay ahead in a rapidly shifting regulatory and analytical landscape.<h4>Key Learning Points</h4><ul><li>Understand the evolution of PFAS analytical methods.</li><li>Navigate the current regulatory landscape.</li><li>Solve real-world analytical challenges.</li></ul><h4>Who Should Attend</h4><ul><li>Analysts from environmental testing laboratories facing PFAS method validation or implementation.</li><li>Regulatory stakeholders seeking to understand lab capabilities and constraints.</li><li>Chemical analyst and researchers interested in designing sampling and treatment protocols.</li><li>Academics and researchers working on PFAS analysis or environmental toxicology.</li></ul><blockquote>Speaker: Sam Lodge (Environmental Senior Business Development Manager, Phenomenex)Sam Lodge is the Phenomenex Senior Business Development Manager for the Environmental industry. He has been at Phenomenex for over 30 years in various positions, including Key Account Manager and Senior International Sales Manager, and is a product expert in SPE and HPLC chemistries. Over the past 8 years, he has worked extensively with commercial and government labs in the development and support of PFAS analytical methods, including the validation of EPA 533, the MLV for DM 1633, and many internal (MOD) methods. Sam was instrumental in the collaborations that led to the development of several new SPE formats for PFAS, including several different stacked tubes and pass-through GCB cartridges that can help commercial labs to increase productivity and reduce costs. In his spare time, Sam enjoys fishing and surfing (but not at the same time!)Speaker: Dr. Karl Oetjen (Market Development Manager for Environmental, Industrial, Food &amp; Beverage, SCIEX)Karl Oetjen is a Market Development Manager for Environmental, Industrial, Food &amp; Beverage at SCIEX and has over 10 years of mass spectrometry experience. Before joining SCIEX, he completed his PhD at Colorado School of Mines (Golden, Colorado) in Hydrologic Science and Engineering. Karl’s dissertation research focused on nontarget characterization of complex surfactant mixtures, including aqueous film-forming foams. This work led to the discovery of several novel per- and polyfluorinated alkyl substances (PFAS) that have since been found in a variety of environmental samples and industrial chemicals. Since joining SCIEX, Karl has worked with numerous labs creating and implementing both regulated and unregulated quantitative and qualitative screening methods.Speaker: Simon Roberts (Staff Scientist, SCIEX)Simon Roberts is a Staff Scientist at SCIEX and completed a postdoctoral fellowship at the Colorado School of Mines, where he worked with Dr. Christopher Higgins and Dr. Jennifer Field to identify novel classes of PFAS chemicals in aqueous film-forming foams (AFFFs). At SCIEX, Simon specializes in method optimization and data reporting, helping labs across the country set up PFAS and other environmental analytical methods.</blockquote>

Phenomenex: The Future of PFAS Testing: Regulations, Innovation, and Contamination Mitigation

The Future of PFAS Testing: Regulations, Innovation, and Contamination Mitigation

This roundtable discussion highlights regulatory scrutiny and trends around PFAS  as well as real-world laboratory solutions.

PFAS Testing: Regulations, Innovation, Contamination

Environmental laboratories face increasing pressure to process complex matrices for both inorganic and organic contaminants with higher efficiency, lower cost, and full regulatory compliance. This four-part webinar series provides a comprehensive overview of modern sample preparation solutions for heavy metals, mercury, and organic pollutants, including PFAS.&nbsp;Through practical guidance and real-world examples, we will explore how advanced digestion, extraction, and direct analysis tools streamline workflows, minimize errors, and improve data quality. Participants will gain actionable strategies to enhance productivity and achieve more reliable environmental results across the entire sample-to-analysis journey.<h4>Episode 4: Sample preparation workflow for organic pollutants and PFAS in environmental samples</h4>Environmental laboratories must increasingly process samples for a wide range of organic contaminants, from legacy pollutants such as PAHs, PCBs, and pesticides to emerging compounds like PFAS, which require exceptional contamination control. This webinar presents a modern, integrated sample preparation workflow using Milestone’s ETHOS X extraction platform. Attendees will learn how advanced microwave extraction improves recoveries, reduces solvent use, and accelerates turnaround time across soils, sediments, and sludges. A dedicated focus on PFAS will provide best practices aligned with EPA 1633A to ensure consistency, low blanks, and regulatory compliance.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://share.hsforms.com/1b7diMdH_QtaH4bNUuW_T9Q5dmem">Register HERE</a></blockquote><blockquote>🎤Speaker: Luca Rota (Application Specialist, Milestone Srl)</blockquote>

Milestone: Environmental Sample Prep Series 2026

Sample preparation workflow for organic pollutants and PFAS in environmental samples

Discover efficient sample preparation workflows for organic pollutants and PFAS using microwave extraction.

Sample preparation workflow for organic pollutants and PFAS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Fast, reliable microbial identification is essential across industries such as food safety, environmental analysis, and clinical research. MALDI-TOF MS has set the standard for fast species identification, and with Shimadzu’s MicrobialTrack software, labs can achieve even greater accuracy and coverage. In this Digital Classrooms session, explore how MicrobialTrack’s genomics-driven algorithm transforms workflows by making identification broader, clearer, and easier.Discover how MicrobialTrack pushes your lab’s capabilities further. Its extensive reference database - about 18,000 validated and 85,000 genomically predicted species—enables accurate identification of both common and tough-to-culture organisms. Advanced algorithms match your results to theoretical protein profiles, helping you achieve precise, trustworthy answers in less time.You’ll also see how MicrobialTrack’s vendor-neutral, cloud-based workflow makes it easy to upload and analyse your data with clear, color-coded results for faster interpretation. Whether your focus is environmental microbiology, food and beverage testing, fermentation, microbiome work, or clinical studies and more, this session delivers practical strategies to boost clarity, accuracy, and lab efficiency.Streamline your microbial identification process today. Register Now!<h4>Learning Objectives:</h4><ul><li>Understand how MicrobialTrack enhances Shimadzu MALDI workflows</li><li>Learn best practices for sample preparation, spectral acquisition, and quality assessment</li><li>Gain practical skills in database and library management</li><li>Explore real-world applications and troubleshooting approaches</li></ul><blockquote>Presenter: Keisuke Shima (Group Manager, MALDI Group, Diagnostic Division, Shimadzu Corporation Japan)After graduating from Osaka University Graduate School, Keisuke Shima worked in drug discovery research at Ono Pharmaceutical Co., Ltd. Subsequently, he joined Shimadzu Corporation, where he focused on application development and customer support, primarily in MALDI microbial identification. In 2021, Keisuke was assigned to the Shimadzu China Innovation Center, where he engaged in collaborative research with Key Opinion Leaders (KOLs). Since 2025, he has served as the MALDI Product Manager in the Diagnostics Division at Shimadzu Corporation's headquarters.</blockquote></div></div></div>

Shimadzu: Unlock Faster Microbial Identification: A Guide To MicrobialTrack For Shimadzu's MALDI

Unlock Faster Microbial Identification: A Guide To MicrobialTrack For Shimadzu's MALDI

How Shimadzu’s MicrobialTrack software enhances MALDI-TOF MS with genomics-driven algorithms, broader databases, and clearer workflows

Guide To MicrobialTrack For Shimadzu's MALDI

Next-generation sequencing (NGS) has opened new frontiers in disease discovery, diagnosis, and treatment, but biobanking and reliable sequencing demands consistent nucleic acid concentrations and quality. Fluorescent dye-based quantification is costly, time consuming, error-prone, and says nothing about purity. As biospecimen throughput increases, so does the need for fast, accurate low-volume quantification and QC.Lunatic combines full-spectrum UV/Vis absorbance with a microfluidic plate to deliver one-step DNA or RNA purity and concentration from 96 samples in 10 minutes or less, without dyes or dilutions. For true high-throughput workflows, Lunatic integrates seamlessly with liquid handlers and plate loaders and always uses 2 µL per sample.During this SelectScience webinar, you will learn how Lunatic quantifies DNA and RNA with 2% accuracy and 1% precision, and see direct comparisons to fluorescence assays. You will also discover how full-spectrum UV/Vis with Unmix enables rapid purity assessment and decision-making. Plus, we will highlight real-world biobank applications for DNA quantification, normalization, and QC.<h4>Key learning objectives:</h4><ul><li>Learn how Lunatic combines UV/Vis absorbance measurements with a low volume 96-well plate to provide quick and easy reagent-free, dilution-free, and standard-free genomics quantification</li><li>Understand the limitations of fluorescence-based quantification for NGS workflows</li><li>Explore how to use Unmix to identify and quantify common contaminants</li><li>See how biobanks and high-throughput labs use Lunatic for DNA quantification, normalization, and QC</li></ul><h4>Who should attend?</h4>This webinar is ideal for genomics-focused scientists/R&amp;D scientists in biotech and pharma, biologists, and geneticists.<h4>Certificate of attendance</h4>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.<h4>Webinar details</h4><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 60 minutes</li></ul>Registration is required to secure your place. If you register but cannot attend live, you will receive a link to the on‑demand recording once it becomes available.<blockquote>Presenter: Ross Walton, Ph.D. (Senior Application Scientist , Unchained Labs)Ross Walton is a Senior Application Scientist for Biologics at Unchained Labs. He has published works on single-particle protein analysis by transmission electron microscopy, and the interaction of the innate immune system and viruses in cancer. He was an undergraduate at UC Berkeley and earned his Ph.D. in Molecular Genetics and Microbiology from Duke University.Moderator: Matilde Marques (Assistant Editor, SelectScience)</blockquote>

SelectScience: Cruise through genomics quantification and QC with Lunatic

Cruise through genomics quantification and QC with Lunatic

Learn how Lunatic uses full-spectrum UV/Vis to deliver rapid, low-volume DNA and RNA quantification and QC for NGS and high-throughput biobanking workflows.

<div><h4>Join Our Experts from the USP and Waters on a live webinar!</h4>Discover the latest strategies for managing API impurities with insights from USP and Waters experts. Learn how USP approaches organic impurities in small molecules then explore how Waters modernizes impurity methods using advanced LC technologies combined with Empower Software. &nbsp;Don’t miss this opportunity to combine regulatory guidance with cutting-edge solutions that drive compliance and innovation.<h5>Key learning objectives</h5><ul><li>Understand impurity fundamentals and regulatory expectations: Gain a high-level overview of impurity definitions, classifications, and global guidelines for small molecule APIs.</li><li>Explore USP approaches to impurity analysis: Learn how USP Reference Standards (RS) and Potential Applicable Impurities (PAIs) support qualitative and quantitative assessments, illustrated through real-world case studies.</li><li>Discover modern tools for impurity method optimization: See how Waters’ LC technologies, column chemistries, and Empower™ software enable modernization of USP impurity methods with enhanced data intelligence and compliance.</li></ul><h5>Who should attend</h5>Pharmaceutical R&amp;D and QC laboratory staff, Contract research and manufacturing organizations (CROs/CMOs), Regulatory affairs professionals<blockquote>Presenter: Christian Zeine, Ph.D. (Sr Manager, Scientific Affairs, US Pharmacopeia)Christian joined USP in 2019 as Senior Manager in the Scientific Affairs Group for the EMEA region, with a focus on Small Molecules, USP’s General Chapters and Impurities. Christian collaborates with scientific experts and stakeholders and is responsible for protecting and growing USP’s scientific reputation in the region and globally. Before joining USP, Christian worked for seventeen years in the field of pharmaceutical reference standards with a focus on impurities, and before that in the IVD (In Vitro Diagnostic) industry. His scientific expertise includes impurity testing, reference standards characterization and adjacent fields. Christian has published several articles and white papers on topics such as impurities, overview of (certified) reference materials and the use of reference standards in method development and validation.Presenter: Stephanie N. Harden, Ph.D. (Senior Manager, Small Molecule Core Solutions – LC/MS, Waters Corporation)Stephanie Harden leads the Product Marketing and Scientific teams for Waters’ small molecule HPLC portfolio. With over 25 years of experience in product and segment marketing, she has a proven track record in strategic program development, cross-functional leadership, and market-driven innovation. Her work connects scientific insight with commercial strategy to drive customer-focused solutions and sustained business growth. Stephanie holds a PhD in Chemistry from the University of Bristol, UK.Moderated by: Samuel Seal (Biopharma Market Development Manager, Waters Corporation)Samuel Seal is a market development manager specializing in the biologics space. He loves LC and MS – especially on how this technology provides benefit and value.Sam joined Waters in January of 2014 as a Sales Technical Support Specialist in the Irvine office/lab. As a TSS he performed demonstrations on various instruments, provided training for customers, often presented on technical information at varying events, and assisted with troubleshooting from Colorado to Los Angeles.He previously worked at Pyxant Labs in Colorado Springs, CO where he gained extensive experience developing and validating methods for small/large molecules in bioanalytical assays, agricultural commodities, registration of pesticides, and worker exposure studies. He also has experience in column chromatography, sample extraction, sample clean-up, reporting and data management. Sam has hands on experience with running and maintaining various manufacturers' LC/MS/MS systems. Prior to Pyxant, Sam was a Laboratory Instructor at the University of Colorado at Colorado Springs where he earned his Bachelor of Arts in Biology and Bachelor of Arts in Chemistry.</blockquote></div>

Waters Corporation: Impurity Testing: Definitions, Guidelines, Analytical Reference Materials and Technologies, and Other Considerations

Impurity Testing: Definitions, Guidelines, Analytical Reference Materials and Technologies, and Other Considerations

Webinar with USP and Waters on managing API impurities, covering regulatory guidance, USP reference standards, and modern LC method optimization tools.

Latest strategies for managing API impurities

This presentation describes a proof-of-concept mass spectrometry strategy to improve early diagnosis of congenital toxoplasmosis by distinguishing maternal and newborn immune responses. The work focuses on detecting IgG polymorphisms specific to Toxoplasma gondii using advanced LC-MS approaches, with particular emphasis on the Thermo Scientific Orbitrap Astral MS operated in DIA mode. Current diagnostic methods struggle to confirm fetal infection due to low parasite burden and the presence of maternal IgG in newborns. To address this, the team developed workflows to purify IgG subclasses, target parasite-specific antibodies, and identify subtle sequence variants differing by only one or two amino acids. While middle-down approaches lacked sensitivity for parasite-specific IgG, bottom-up DIA on the Thermo Scientific Orbitrap Astral MS enabled detection of low-abundance, discriminating peptides. Manual validation and fragment correlation were critical to eliminate false positives caused by high sequence homology. Overall, the study demonstrates Astral’s sensitivity and DIA capability for tackling extremely challenging, clinically relevant immunoproteomics problems.<h4>Learning points:</h4><ul><li>Congenital toxoplasmosis diagnosis requires discrimination between maternal and newborn IgG</li><li>Orbitrap Astral MS DIA enables detection of ultra-low-abundance, polymorphic IgG peptides</li><li>Manual validation remains essential when analyzing highly homologous antibody sequences</li></ul><h4>Who should attend?</h4><ul><li>Researchers in clinical proteomics and infectious disease diagnostics</li><li>Scientists studying antibody polymorphisms, immunoproteomics, or neonatal immunity</li><li>Mass spectrometry experts interested in DIA strategies for extreme sensitivity challenges</li></ul>This webinar is a recording from the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5672">Omics innovations for the biopharmaceutical industry</a> seminar on December 11, 2025 in Strasbourg.Cannot attend on February 26? Please register anyway to automatically receive access to the recording.<blockquote>Presenter: Joëlle Vinh (Head of SMBP CNRS Biological MS and Proteomics Lab, ESPCI Paris)</blockquote>

Thermo Fisher Scientific: Omics innovations for the biopharmaceutical industry

Toward early detection of congenital disease using Orbitrap Astral DIA MS/MS

Webinar on LC-MS DIA using Orbitrap Astral MS to distinguish maternal and newborn IgG in congenital toxoplasmosis diagnostics.

Detection of congenital disease by Orbitrap Astral DIA MS/MS

Are you considering a transition from Analyst software to SCIEX OS software, but unsure where to begin? Join us for an engaging and practical live session designed to demystify the migration process and give you direct access to ask questions to the experts who support SCIEX customers every day.During this discussion, our experienced SCIEX migration team—including specialists in workflows, professional services, technical support, and compliance—will answer your questions about what it really takes to move your lab from Analyst to SCIEX OS software. Hear about readiness assessments, tailored implementation planning, installation and validation considerations, and the full support ecosystem available to make your transition smooth and successful.<blockquote>Speaker: Lindsay Flagg, Professional Services ConsultantSpeaker: Cindy Sanderson, Software Technical SpecialistSpeaker: Patrick Quinn-Paquet​, Senior Technical Product Manager, Professional Services – Compliance​Speaker: Ernest Kwok, Senior Manager, Compliance Services​</blockquote>

SCIEX: SCIEX OS software migration: Connect with the experts and ask your questions

SCIEX OS software migration: Connect with the experts and ask your questions

Live webinar on migrating from Analyst to SCIEX OS software, covering readiness, validation, compliance, and expert support.

SCIEX OS software migration: Connect with experts

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join this practical, admin-focused session to get more out of the Thermo Scientific Chromeleon Administration Console. We’ll walk through proven tips, lesser-known features, and real-world best practices that help simplify user management, control access, improve performance, and reduce day-to-day admin headaches.<ul><li>Work smarter, not harder – Learn time-saving shortcuts and new features that streamline routine admin tasks.</li><li>Avoid common pitfalls – Discover best practices that help maintain system stability, security, and compliance.</li><li>Get expert insights – Pick up practical guidance you can apply immediately in your Chromeleon environment.</li></ul>This session is designed for anyone wanting to learn more about administration of Chromeleon CDS. &nbsp;Learn how to configure, maintain and support your Chromeleon software environment. You should attend if you want to learn how to manage users and permissions, control access and security, or discover best practices to reduce day-to-day admin effort. Get practical, immediately usable tips to keep your Chromeleon setup running smoothly, securely, and compliantly.Cannot attend the broadcast on February 26? Please register anyway to automatically receive the link to the recording.<blockquote>Presenter: Darren Barrington-Light (Senior Manager, Product Marketing, Thermo Fisher Scientific)Darren Barrington-Light’s background includes over 25 years of experience in the field of analytical chemistry, chromatography hardware and computer software. Having worked in chromatography throughout his career, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, he has worked with clients across multiple industries to show them how software solutions can help them to improve their day to day operations and drive fast, informed decisions.</blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon Admin Console I: Expert Tips and Tricks

Chromeleon Admin Console I: Expert Tips and Tricks

Chromeleon Administration Console webinar: improve user management, security, performance, and compliance with practical admin best practices.

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