<p><strong>Metabolomics researchers are often forced to choose between two powerful but different approaches. </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/metabolomics/untargeted-metabolomics.html"><strong>Untargeted metabolomics</strong></a><strong> is great for discovery: it surveys as many metabolites as possible to reveal biology you didn’t know to look for. </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/metabolomics/targeted-metabolomics.html"><strong>Targeted metabolomics</strong></a><strong> is built for precision: it measures a defined list of metabolites with high sensitivity and quantitative confidence. The challenge is that running both typically costs time, sample, and can introduce variability between workflows.</strong></p><p>In order to deal with this the researchers at Thermo Fisher Scientific have developed <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/metabolomics-lipidomics/simultaneous-quantitation-discovery-squad.html"><strong>Simultaneous Quantitation and Discovery (SQUAD)</strong></a> analysis as shown in this technical note <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004327_ov_squad_metabolomics_orbitrap_astral_tn004327_na_en_290c75edd9.pdf"><strong>Simultaneous Quantitation and Discovery Analysis: Combining Targeted and Untargeted Metabolomics on Orbitrap Mass Spectrometers</strong></a>,<strong> </strong>a hybrid strategy that combines targeted quantitation and untargeted discovery in a single experiment. In practice, SQUAD lets you quantify a predefined metabolite panel using calibration curves built from authentic standards and isotopically labeled internal standards, while still capturing rich full-scan data that supports retrospective mining and identification of unknowns.</p><p>A key theme of the technical note is that results are only as strong as the experiment design and quality controls. The workflow emphasizes calibration strategy, careful extraction choices (aligned to metabolite classes), and the smart use of blanks, pooled QCs, and system suitability tests to monitor drift, contamination, and reproducibility across a batch.</p><p>SQUAD is also designed to scale across different Thermo Scientific Orbitrap mass spectrometers. The technical note outlines how the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1491"><strong>Thermo Scientific Orbitrap Exploris mass spectrometers</strong></a><strong> </strong>can use MS1-based SQUAD with polarity switching and optionally add tSIM/tMS2 for targeted sensitivity, while the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=Tribrid"><strong>Thermo Scientific Orbitrap Tribrid mass spectrometers</strong></a> can pair high-resolution MS1 discovery with rapid ion-trap tMS2 quantitation, boosted by tools like <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763"><strong>Thermo Scientific AcquireX Intelligent Data Acquisition</strong></a><strong> </strong>and Real-Time Library Search (RTLS).</p><p>Finally, the data story comes together in software: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>Thermo Scientific TraceFinder Software</strong></a> for targeted quantitation and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Thermo Scientific Compound Discoverer Software </strong></a>for untargeted discovery, annotation, and statistics, turning one injection into both confident numbers and new biological leads.</p><blockquote><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004327_ov_squad_metabolomics_orbitrap_astral_tn004327_na_en_290c75edd9.pdf"><span><strong>Download the SQUAD technical note</strong></span></a></div></blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#SQUAD #Metabolomics #Lipidomics</p>

One Injection, Two Answers: Introducing Squad Metabolomics on Orbitrap Mass Spectrometers

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/"><strong>ISC 2026</strong></a></h3><p><strong>The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314"><strong>International Symposium on Chromatography (ISC)</strong></a><strong> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/644"><strong>35th International Symposium on Chromatography</strong></a></h4><p>📆<strong>6. - 10. September 2026</strong></p><p>📍<strong>Prague, Czech Republic</strong></p><h3><strong>Registration</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register HERE for the ISC 2026</strong></a></p><p><strong>Late Registration until 25 August 2026!</strong></p><p><strong>From 26 August 2026 only Onsite Registration.</strong></p></blockquote><h4><strong>Publishing Workshop</strong></h4><ul><li>Wednesday, 9 September 2026&nbsp;</li><li>12:30–14:00&nbsp;</li></ul><p>This interactive workshop will provide practical guidance on scientific publishing in the field of separation science. Participants will have the opportunity to hear directly from journal editors about key aspects of the publication process and how to improve their chances of successful publication.</p><p>Topics will include <strong>manuscript preparation, peer review</strong>, <strong>editorial decision-making, open access publishing</strong>, and the responsible <strong>use of artificial intelligence in scientific publishing</strong>. Editors will share insights into what they look for in submissions, common reasons for rejection, and strategies for preparing strong manuscripts. The workshop will also cover selected Wiley-specific topics, including the publisher’s submission platform and current guidelines on the use of AI in scientific publications.</p><p>The session will include opportunities for questions and discussion, allowing participants to interact directly with editors and gain valuable advice for their future publishing activities.</p><h5><strong>Attending Editors-in-Chief:</strong></h5><ul><li><strong>Michael Lämmerhofer</strong> — Journal of Separation Science and Separation Science Plus&nbsp;</li><li><strong>Sebastiaan Eeltink</strong> — Analytical Science Advances&nbsp;</li><li><strong>Mario Thevis</strong> — Drug Testing &amp; Analysis&nbsp;</li></ul>

Publishing Workshop at ISC 2026

<p><strong>We are excited to announce that the 18th MDCW will take place from January 25-27, 2027, in Liège, Belgium. This in-person event will feature:</strong></p><ul><li><strong>Keynote presentations</strong> from leading researchers</li><li><strong>Flash talks and poster sessions</strong> highlighting the latest innovations</li><li><strong>Focus group discussions</strong> addressing current challenges and future developments</li><li>💸<strong>FREE registration </strong>ensures that this event remains accessible to all researchers, students, and industry professionals interested in multidimensional chromatography. ​​We hope to see you there!</li></ul><h3><strong>Registration</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://app.oxfordabstracts.com/auth?redirect=https%3A%2F%2Fapp.oxfordabstracts.com%2Fregister%2Fevent%2F77272%3Fpreview%3Dfalse"><strong>Register HERE</strong></a></p><p><strong>Registration deadline: December 1, 2026</strong></p></blockquote><h3><strong>Abstract Submission</strong></h3><p>Abstracts for <strong>oral presentations</strong> must be submitted by <strong>September 15, 2026</strong>, to be considered.</p><p><strong>​Poster abstracts</strong> submitted by <strong>September 15, 2026</strong>, will be included in the <strong>preliminary program</strong>. Additional <strong>last-minute poster submissions </strong>will be accepted until <strong>November 30, 2026</strong>, for inclusion in the final program.</p><blockquote><p class="cke-user_style-important">👉<a target="_blank" rel="noopener noreferrer" href="https://app.oxfordabstracts.com/auth?redirect=/stages/81780/submitter"><strong>Submit your abstract HERE</strong></a></p><p><strong>&nbsp;Deadline for abstract submission: September 15, 2026</strong></p></blockquote><h4><strong>Presentation guidelines</strong></h4><h5><strong>Poster Presentations</strong></h5><ul><li><strong>Presenters must print and bring their own posters</strong>—onsite printing services and mailed submissions are not available.</li><li>Posters should be in <strong>landscape format: 36" tall × 48" wide</strong>.</li><li>Set up your poster <strong>during registration</strong> on the day of your assigned session and remove it at the <strong>end of the same day</strong>.</li><li>Poster presenters <strong>must</strong> be present at their posters during the designated poster session.</li><li>Posters will also be available for viewing <strong>during coffee and lunch breaks</strong>.</li><li>Presenters may optionally stand by their posters during these times for further discussions.</li></ul><h5><strong>Oral Presentations</strong></h5><ul><li><strong>Keynote presentations: </strong>30 minutes (25–28 min + Q&amp;A)</li><li><strong>Full oral presentations: </strong>20 minutes (18 min + 2 min Q&amp;A)</li><li><strong>Flash presentations: </strong>10 minutes (8 min + 2 min Q&amp;A)</li></ul><p><strong>Presentation Format:</strong></p><ul><li>Submit your slides as a <strong>PowerPoint (PPT)</strong> file (.ppt or .pptx).</li><li>Name your file with program code and surname, e.g. "O-28 Smith.pptx".</li><li>For optimal display, use <strong>16:9 slide format </strong>(4:3 is also supported).</li></ul><p><strong>Technical &amp; Session Logistics:</strong></p><ul><li>A <strong>headset or portable microphone</strong> will be available.</li><li>A <strong>laser pointer with a slide change button</strong> will be provided.</li><li>Ensure your presentation allows time for <strong>questions</strong> within your allocated time.</li><li><strong>Before your session</strong>, check in and introduce yourself to the conference or session chairs.</li></ul><h3><strong>Program</strong></h3><h4><strong>Keynote Speakers</strong></h4><h5><strong>Finding Clarity in Challenging Samples: Multiple Heart-Cutting 2D-LC and the Technologies That Enable It &nbsp; &nbsp;</strong></h5><ul><li>Stephan Buckenmaier (Principal Scientist R&amp;D, Agilent Technologies)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Stephan_Buckenmaier_c84239ec30.jpg" alt="MDCW: Stephan Buckenmaier" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Stephan_Buckenmaier_c84239ec30.jpg 151w," sizes="100vw" width="284" height="294"></p><p>Stephan Buckenmaier is a Principal Scientist in R&amp;D at Agilent Technologies, specializing in advanced separation science and the development of two-dimensional liquid chromatography (2D-LC) solutions. Since joining Agilent in 2006, he has held a variety of scientific and technical roles, with a particular focus on innovative chromatographic technologies. He earned his Ph.D. from the University of the West of England (Bristol, UK) and conducted postdoctoral research at the University of Tübingen. Stephan has authored numerous scientific publications, contributed a book chapter, and is listed as an inventor on numerous patents in the field of separation science. He regularly presents his work at international scientific conferences.</p><h4><strong>Short Course</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/18th_MDCW_short_course_41ecd3c6cf.jpg" alt="18th MDCW: Short course" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_18th_MDCW_short_course_41ecd3c6cf.jpg 245w," sizes="100vw" width="1100" height="619"></p><p>There will be <strong>20 spaces available</strong> in a short course related to multidimensional chromatography. If you want to register for the short course, indicate so during your registration. We will send a separate link to pay for the short course to reserve your seat (<strong>$50 USD</strong>).&nbsp;</p><h4><strong>A Beginner’s Guide to Multidimensional Chromatography short course</strong></h4><ul><li><strong>Instructors:</strong> Pierre-Hugues Stefanuto, Katelynn Perrault Uptmor, Dwight Stoll, Petr Vozka</li></ul><h5><strong>Course Description&nbsp;</strong></h5><p>So...you want to do multidimensional chromatography? If you are getting started in the field using either liquid or gas chromatography, you’re in the right place. This course will cover a brief history and introduction to both multidimensional gas chromatography and multidimensional liquid chromatography. Discussion will also include basic system components and data handling strategies to apply after acquiring your data. A hands-on portion of the course will also include familiarization with common system components and consumables for both GC and LC, as well as the opportunity to use a commercial GC×GC instrument.</p><h5><strong>Target Participants&nbsp;</strong></h5><p>This course is intended to be an initial touchpoint for those who are looking to explore multidimensional chromatography as a new option/capability, or who might be using it for the first time. The course is intended for new users to obtain a background on the techniques as a primer to the workshop. &nbsp;Advanced topics will not be discussed.</p><h5><strong>Course Logistics&nbsp;</strong></h5><ul><li>Morning Session (8:30 AM – 12:00 PM)</li><li>Afternoon Session (1:00 PM – 4:30 PM)</li></ul><p><strong>Lunch and coffee will be provided.</strong></p><h5><strong>Cost&nbsp;</strong></h5><p>A <strong>$50 fee</strong> is required to reserve a spot in the course. <strong>20 seats are available</strong>. An expression of interest form will be available to indicate interest in a seat within the course. On November 10th, participants will be informed about seat availability and the payment process will be communicated.</p><h4><strong>Outline (Total Time ~ 4 hrs)&nbsp;</strong></h4><h5><strong>Part I (1 hr) – History, Terminology, Fundamental Concepts&nbsp;</strong></h5><ul><li>Brief history of the development of multidimensional separations&nbsp;</li><li>Terminology&nbsp;</li><li>Fundamental Concepts&nbsp;<ul><li>In what ways are multidimensional separations useful for analytical chemistry / measurement science?&nbsp;</li><li>First and second separations should be orthogonal / complementary&nbsp;</li><li>Fast second dimension separations are important to avoid undersampling&nbsp;</li><li>Structured chromatograms can provide chemical insight and facilitate data interpretation&nbsp;</li><li>Highlights of an example data processing workflow – from raw data to actionable information &nbsp;</li></ul></li><li>Break (30 min)&nbsp;</li></ul><h5><strong>Part II (1.5 hrs) Introduction to Multidimensional Gas Chromatography&nbsp;</strong></h5><ul><li>Method basics&nbsp;<ul><li>Column selection&nbsp;</li><li>Method parameters&nbsp;</li><li>Carrier gas choices&nbsp;</li><li>Detector considerations&nbsp;</li></ul></li><li>Modulator selection with a focus on current market options&nbsp;<ul><li>Thermal modulators&nbsp;</li><li>Flow modulators&nbsp;</li><li>Other commercial options&nbsp;</li></ul></li><li>Method development made simple&nbsp;</li><li>Data preprocessing and initial handling&nbsp;</li><li>Lunch (1 hr)&nbsp;</li></ul><h5><strong>Part III (1 hr) Introduction to Multidimensional Liquid Chromatography&nbsp;</strong></h5><ul><li>Modes of multidimensional separation commonly used with LC&nbsp;<ul><li>Heartcut&nbsp;</li><li>Multiple heartcut / selective comprehensive&nbsp;</li><li>Fully comprehensive&nbsp;</li></ul></li><li>Interfaces used for multidimensional LC (i.e., the hardware that does the transfer from first to second dimension)&nbsp;</li><li>Common use cases of multidimensional LC illustrated using examples from industry and academic research&nbsp;<ul><li>Evaluating peak purity&nbsp;</li><li>Unknown identification via multidimensional and MS or NMR detection&nbsp;</li><li>Multi-stage separation with analyte transformation between stages&nbsp;</li><li>Multi-attribute methods&nbsp;</li><li>Making complete analysis of moderately complex samples attainable in a reasonable analysis time&nbsp;</li><li>Digging deeper – comprehensive separations for comprehensive analysis&nbsp;<br>Introduction to method development strategies&nbsp;</li></ul></li></ul><h5><strong>Part IV (2 hrs) Laboratory Instrument Familiarization</strong></h5><h5><strong>Part V (30 min) Wrap-up and Q&amp;A &nbsp;</strong></h5><h4><strong>Venue</strong></h4><ul><li>University of Liege</li><li>Pl. du Vingt Août 7</li><li>4000 Liège</li><li>​Belgium</li><li><strong>​Main Room:</strong> Salle Academique</li></ul>

18th MDCW - Registration and abstract submission opens

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The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

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Thermo Fisher Scientific

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Separation Science

Technology Networks

Phenomenex

SCIEX

Waters Corporation

<p><strong>Mass spectrometry has become a cornerstone technology across the 'omics' sciences, enabling researchers to characterise complex biological systems with unprecedented depth and confidence. As advances in instrumentation, separation science, ion mobility, tandem mass spectrometry, and computational data analysis continue to evolve, laboratories can achieve broader molecular coverage and more meaningful biological insights.</strong></p><p>This webinar explores the latest innovations shaping modern mass spectrometry workflows and examines how these technologies are advancing applications across proteomics, metabolomics, lipidomics, spatial omics, and related fields. Attendees will gain practical insight into how complementary mass spectrometry approaches are improving analytical performance, supporting systems-level biological understanding, and driving progress in biomarker discovery, disease research, and precision health.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li>Explain why mass spectrometry is a foundational technology across multiple 'omics' disciplines</li><li>Describe recent advances in mass spectrometry instrumentation, separation science, ion mobility, and data analysis</li><li>Understand how integrated mass spectrometry workflows are enabling systems-level insights into biological function</li><li>Recognise the impact of mass spectrometry innovations on disease research, biomarker discovery, and precision health</li></ul><blockquote><p><strong>Presenter:</strong> &nbsp;James McCullagh, PhD (Professor of Biological Chemistry, University of Oxford)</p><p>&nbsp;James McCullagh is a professor of biological chemistry and director of the Mass Spectrometry Research Facility at the University of Oxford. His research focuses on understanding the function of small molecules in complex biochemical systems with applications at the interface between chemistry, biology and medicine.&nbsp;</p></blockquote><blockquote><p><strong>Presenter:</strong> Vladimir Kardelis, PhD (Technical Product Manager, PerkinElmer)</p><p>&nbsp;Vladimir Kardelis is the Technical Product Manager for LC and LC/MS solutions at PerkinElmer. Since joining the company in 2019 as a Software Quality Assurance Engineer, he has progressed through an Application Scientist role to lead product development for LC/MS solutions. His work focuses on evaluating the QSight system’s detection limits and robustness across complex environmental and food samples, helping advance reliable LC/MS performance in real-world laboratory settings.&nbsp;</p></blockquote>

Technology Networks: Tech Spotlight - Mass Spectrometry 2026

Tech Spotlight: Mass Spectrometry 2026

Discover 2026 mass spectrometry innovations across omics disciplines. Learn how advances in separation, ion mobility, and data analysis drive precision health

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Trifluoroacetic acid (TFA) is an ultra-short-chain PFAS of growing concern due to its extreme persistence, high mobility, and widespread occurrence in environmental and drinking water sources. This presentation reviews the emerging regulatory attention, and the analytical challenges associated with trace-level measurement, including background contamination, matrix effects, ion suppression, and confirmatory analysis.</strong></p><p>The webinar introduces a fully automated SCIEX LC-MS/MS workflow for rapid, sensitive quantification of TFA across multiple matrices, with the flexibility to incorporate DFA and TFMS into the same analytical approach.</p><p>Validation data demonstrates excellent linearity, repeatability, accuracy, robustness, and matrix tolerance in drinking water, surface water, wastewater, mineral water, and a wide variety of food matrices. With 40 samples plus standards analyzed in less than four hours, the workflow supports high-throughput routine monitoring for environmental, food, regulatory, and contract testing laboratories.</p><h5><strong>By attending this webinar you will be able to:</strong></h5><ul><li>Implement strategies to minimize contamination and matrix effects during trifluoroacetic acid (TFA) analysis.&nbsp;</li><li>Evaluate the benefits of automated internal standard addition and automated calibration preparation.</li><li>Apply a high-throughput LC-MS/MS workflow capable of quantifying TFA down to 20 ng/L with confirmation by two MRM transitions.</li><li>Understand how trifluoromethanesulfonic acid (TFMS) and difluoroacetic acid (DFA) can be incorporated into the same analytical workflow.</li></ul><h5><strong>Who should attend?</strong></h5><p>This webinar is designed for laboratory professionals and decision-makers involved in ultra-short-chain PFAS analysis, particularly those working in environmental, drinking water, wastewater, PFAS, regulatory, and contract testing laboratories:</p><ul><li>Commercial laboratory managers, technical directors, and QA/validation specialists responsible for method implementation, data quality, ROI and regulatory readiness.&nbsp;</li><li>LC-MS/MS method developers, analytical chemists, and application scientists working on trace-level TFA, DFA, TFMS, or broader PFAS workflows.&nbsp;</li><li>Environmental scientists, researchers, and laboratory staff focused on emerging contaminants in drinking water, surface water, wastewater, mineral water, and other complex water matrices such as food.</li></ul><h5><strong>What you need to know:</strong></h5><p><strong>Start times:</strong></p><ul><li><strong>Broadcast 1:</strong> 10 am BST (London/Lisbon) / 11 am CEST (Paris/Berlin) / 2:30 pm IST (New Delhi)</li><li><strong>Broadcast 2:</strong> 10 am PDT (Los Angeles) / 12 pm CDT (Chicago) / 1 pm EDT (New York)</li></ul><blockquote><p><strong>Presenter: </strong>Carlos Bueno (Senior Aftermarket Workflow Specialist, Food, Environmental and Forensics, SCIEX EMEA)</p><p>Carlos Bueno is a Senior Aftermarket Workflow Specialist for EMEA at SCIEX with more than 20 years of experience in chromatography and mass spectrometry. After earning his bachelor’s degree in chemistry in 2001 and spending four years at the Madrid Doping Control Laboratory, he built an extensive career focused on analytical application development for food safety and environmental testing markets. Since joining SCIEX in 2023, he has supported laboratories across EMEA in implementing advanced LC-MS/MS solutions and optimizing analytical workflows, and is currently leading SCIEX EMEA's PFAS initiative.</p></blockquote></div></div></div>

SCIEX: The TFA & DFA Challenge Solved: Ultra-Sensitive Detection with End-to-End Automation

The TFA & DFA Challenge Solved: Ultra-Sensitive Detection with End-to-End Automation

Automate TFA and DFA analysis down to 20 ng/L. Join this SCIEX webinar to explore high-throughput LC-MS/MS workflows for ultra-short-chain PFAS

Automated Ultra-Short-Chain PFAS Analysis: LC-MS/MS

<p><strong>This webinar provides a foundational overview of magnetic bead-based extraction technologies used in modern bioanalytical and biopharmaceutical workflows. We will explore the scientific principles behind paramagnetic bead technology, including bead composition, surface chemistry, and the role of functionalized ligands in enabling selective capture of a wide range of biomolecules.</strong></p><p>The session will also cover common extraction workflows and how magnetic bead-based approaches compare to traditional sample preparation techniques in terms of scalability, selectivity, and reproducibility. Attendees will gain insight into how these workflows are applied across biologics research, with practical examples illustrating real-world use cases.</p><h4><strong>Key Learning Points</strong></h4><ul><li>Learn the basic principles of magnetic bead-based extraction and paramagnetic bead function.</li><li>Find how bead composition, surface chemistry, and functional ligands enable selective analyte capture.</li><li>Identify key advantages of magnetic bead workflows compared to traditional extraction methods.</li><li>Understand common workflow designs and their role in supporting downstream LC and LC-MS analysis. &nbsp;</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any scientists and professionals working in biopharma, life sciences, or analytical laboratories interested in learning about biomolecular extraction techniques for mAbs, ADCs, nucleic acids, mRNA, and oligonucleotides. &nbsp;</li></ul><blockquote><p><strong>Speaker:</strong> Namrata Saxena (Technical Manager, Phenomenex)</p><p>&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains. Namrata is based in Sydney, Australia and can be reached through e-mail or phone.&nbsp;</p></blockquote>

Phenomenex: Fundamentals First Bio Series - Understanding Magnetic Bead-Based Extraction Techniques

Fundamentals First Bio Series: Understanding Magnetic Bead-Based Extraction Techniques

Learn magnetic bead extraction fundamentals for bioanalysis. Discover how surface chemistry enables selective capture of mAbs, mRNA, and oligos for LC-MS

Magnetic Bead Extraction for Bioanalysis & LC-MS

<p><strong>High‑throughput LC‑MS/MS workflows using complex matrices are often limited by column degradation, leading to poor peak shape, rising backpressure, and unplanned downtime that impact productivity and cost. Endrix LC columns address these challenges through a hardware‑driven approach, combining proven Kinetex and Luna Omega chemistries with proprietary design to extend usable column lifetime without compromising performance. Real‑world results from a 75‑analyte pain management panel demonstrate significantly increased column lifetime while maintaining consistent chromatographic integrity. By reducing column replacement frequency and minimizing troubleshooting, Endrix enables greater instrument uptime, improved efficiency, and lower cost per injection in demanding, high‑throughput workflows.</strong></p><h4><strong>By attending this webinar, you will:</strong></h4><ul><li>Identify key factors that limit LC column lifetime in high throughput and complex matrix workflows</li><li>Understand how hardware design impacts column durability, beyond stationary phase chemistry</li><li>Implement strategies to extend column lifetime, reduce downtime, and lower cost per injection</li><li>Assess when guard columns are optional and how to simplify workflows without sacrificing performance</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any LC-MS/MS scientists in clinical, toxicology, and pharmaceutical laboratories, as well as analytical chemists working with complex or “dirty” matrices such as urine, plasma, and tissue samples.</li></ul><h4><strong>What you need to know:</strong></h4><p><strong>Start times: </strong>9 am CDT (Chicago) / 10 am EDT (New York) / 2 pm CEST (Paris/Berlin) / 3 pm BST (London/Lisbon)</p><blockquote><p><strong>Presenter: </strong>Grace Guo &nbsp;(Senior Technical Specialist, Phenomenex)</p><p>Grace Guo graduated from Johns Hopkins University with a Master’s degree in Material Science and Engineering. She joined the Phenomenex Technical Team in 2017 providing technical support globally. With more than 9 years of experience in SPE, HPLC and GC, she has delivered 90+ seminars and webinars globally covering the food and environmental, clinical, pharma and biopharma industries.</p></blockquote>

Phenomenex: From Downtime to Data - How Long-Life LC Columns Transform High-Throughput Labs

From Downtime to Data: How Long-Life LC Columns Transform High-Throughput Labs

Maximize LC column lifetime in high-throughput LC-MS/MS workflows. Discover Phenomenex Endrix columns to reduce downtime, cost, and matrix impact

Long-Life LC Columns: Cut Downtime in High-Throughput Labs

<h4><strong>Build Confidence in Your Laboratory Data</strong></h4><p><strong>Reliable laboratory data doesn't happen by chance, it is the result of a quality assurance program designed to detect risk, drive consistency, and support continuous improvement.</strong></p><p><strong>In this webinar, we'll explore the four foundational elements of an effective QA program: method development, analyst training, ongoing performance monitoring, and corrective action. Learn how laboratories can use precision, accuracy, control charting, trending analysis, and root cause investigations to identify issues before they impact data quality.</strong></p><p>We'll also discuss practical strategies for verifying method performance, demonstrating analyst competency, sustaining long-term process control, and using certified reference materials as independent tools to strengthen confidence in analytical results.</p><p>Whether you are building a new QA program or looking to improve an existing one, this session provides actionable guidance for creating a robust and sustainable framework for quality.</p><h5><strong>Key takeaways</strong></h5><ul><li>Build a more effective and sustainable laboratory QA program.</li><li>Use precision, accuracy, and control charting to improve data quality and identify issues early.</li><li>Apply root cause analysis and certified reference materials to strengthen performance and corrective actions.</li></ul><p><strong>Who should attend</strong></p><p>This webinar is designed for Quality Assurance (QA) and Quality Control (QC) managers, analytical chemists and laboratory scientists, laboratory managers and supervisors.</p><p>Don't miss it!</p><blockquote><p><strong>Speaker:&nbsp;</strong>Christy Abbas, PhD (Sr. Product Marketing Manager, Waters ERA)</p><p>Christy has been with Waters ERA for six and a half years. Her career spans roles at an instrument manufacturer, a biopharmaceutical laboratory, and a mining company. She earned her PhD in Applied Chemistry from the Colorado School of Mines.</p><p>Throughout her career, Christy has supported the nuclear, pharmaceutical, and chemical industries, as well as academia. Drawing on her background in analytical chemistry, product development, marketing, and sales, she is focused on expanding Waters ERA’s product portfolio to better meet evolving customer needs.</p></blockquote>

Foundations of a Sustainable, High-Performing QA Program

Build a sustainable QA program for your laboratory. Learn how control charting, root cause analysis, and reference materials drive data confidence

Sustainable Laboratory QA: Control Charts & Data Integrity

<p><strong>Accurate identification of immunopeptides is essential for understanding immune recognition in cancer. In this webinar, Reza presents how hybrid ExCID fragmentation (EAD+CID) on SCIEX ZenoTOF platforms enables the differentiation of isobaric isoleucine (Ile) and leucine (Leu) peptide variants in immunopeptidomics workflows. He also highlights the importance of chromatographic optimization for detecting naturally presented Ile/Leu sequence variants, demonstrating how advanced MS technologies can improve confidence in antigen identification.</strong></p><h4><strong>Key learning points</strong></h4><ul><li>Learn how hybrid ExCID fragmentation can distinguish isobaric Ile and Leu residues in immunopeptides</li><li>Understand how the combination of EAD and CID improves peptide sequence characterization and identification confidence</li><li>Discover why chromatographic optimization is critical for detecting naturally presented Ile/Leu variants in the immunopeptidome</li></ul><blockquote><p><strong>Speaker: </strong>Reza (Mohammadreza) Dorvash, Ph.D. (Postdoctoral Researcher, Bio21 Molecular Science and Biotechnology Institute)</p></blockquote>

SCIEX: Distinguishing Ile/Leu variant ligands in the immunopeptidome using hybrid ExCID fragmentation on SCIEX accurate mass instrument

Distinguishing Ile/Leu variant ligands in the immunopeptidome using hybrid ExCID fragmentation on SCIEX accurate mass instrument

Differentiate Ile/Leu variants in immunopeptidomics using hybrid ExCID (EAD+CID) fragmentation on SCIEX ZenoTOF. Improve antigen identification confidence

Distinguishing Ile/Leu Variants with SCIEX ExCID MS

<div><h4><strong>Tiny Plastics, Big Questions: Advances in Microplastics &amp; Nanoplastics Analysis</strong></h4><p><strong>Plastic particles are now recognized as widespread environmental contaminants, ranging from nanoplastics (&lt;1 µm) to microplastics (&lt;5 mm), and have been detected in drinking water, food, air, soil, and consumer products. As concerns over human exposure continue to grow, there is an increasing need for analytical technologies that can accurately detect, size, separate, and characterize these particles across a broad size range.</strong></p><p>This webinar explores complementary analytical approaches for comprehensive plastic particle characterization. The first presentation highlights light scattering-based techniques for nanoplastics, demonstrating how Dynamic Light Scattering (DLS) enables rapid screening of particle size and concentration, while Asymmetrical Flow Field-Flow Fractionation coupled with Multi-Angle Light Scattering (AF4-MALS) provides high-resolution size separation, absolute particle sizing, and fraction collection for downstream chemical identification.</p><p>The second presentation focuses on high-throughput methodologies for microplastics in drinking water, illustrating approaches that detect, count, size, and characterize particles from a variety of water sources. Case studies will examine commercially available drinking water products and discuss how packaging materials, storage conditions, and temperature can influence measured microplastic levels.</p><p>Together, these presentations demonstrate how complementary analytical technologies provide a more complete understanding of plastic particle populations across the nano- and microscale, enabling researchers to address emerging environmental and human exposure questions with greater confidence.</p><blockquote><p><strong>Presenter:&nbsp;</strong>Udayabagya (Bud) Halim (Sr. Product Marketing Analyst, Waters Corporation)</p><p>Bud Halim is a senior marketing analyst at Waters, where he applies his background in materials science and biochemistry to scientific and technical marketing. He holds a PhD in physical chemistry from UCLA. Prior to joining Waters, Bud worked as an applications scientist, supporting customers across chemistry and manufacturing environments. At Waters, he supports the light scattering and particle analysis portfolio, translating advanced characterization technologies into practical solutions for polymer, biopharma, and other scientific and industrial applications.</p></blockquote><blockquote><p><strong>Presenter:&nbsp;</strong>Karessa White (Sr. Market Applications Scientist, Waters)</p><p>Dr. Karessa White is a Sr. Market Application Scientist at Waters Corporation. She obtained her Ph.D. from the University of Florida in Communication Sciences and Disorders emphasizing auditory neuroscience. After spending time serving her country as a United States Army Medical Service Officer, Karessa now leverages her expertise and training in molecular biology and analytical science to help biotherapeutic developers create safe and stable drugs.</p></blockquote></div>

Waters Corporation: Tiny Plastics, Big Questions: Advances in Microplastics & Nanoplastics Analysis

Tiny Plastics, Big Questions: Advances in Microplastics & Nanoplastics Analysis

Discover advanced microplastics and nanoplastics analysis using DLS and AF4-MALS. Learn how high-throughput methods characterize particles in drinking water

Microplastics & Nanoplastics Analysis: DLS & AF4-MALS

<p><strong>Gene expression profiling is a cornerstone of clinical and translational research, providing critical insights into disease biology, biomarker discovery, patient stratification, and therapeutic response. Yet many transcriptome analysis workflows remain limited by complex library preparation, long turnaround times, and inconsistent performance with precious or degraded clinical research samples.</strong><br><strong>Join this webinar to learn how the Ion AmpliSeq™ Transcriptome portfolio enables fast, sensitive, and reproducible transcriptome analysis designed to meet the demands of translational research.</strong></p><p>We'll explore how targeted transcriptome sequencing can quantify the expression of more than 20,000 RefSeq genes from as little as 10 ng of input RNA, including challenging FFPE specimens commonly used in clinical research, while delivering results in as little as two days.</p><p>Whether you're investigating disease mechanisms, researching biomarkers, or developing gene expression signatures, discover how Ion AmpliSeq™ Transcriptome solutions can help accelerate your research with a fast, scalable, and easy-to-implement NGS workflow.</p><p>For Research Use Only. Not for use in diagnostic procedures.</p><blockquote><p><strong>Presenter: &nbsp;</strong>Phil Waggoner, PhD (Director, Chemistry &amp; Data Analytics R&amp;D, Thermo Fisher Scientific)</p><p>Phil Waggoner, Ph.D. is a genomics professional with experience supporting the development and adoption of next-generation sequencing (NGS) technologies for research and clinical applications. At Thermo Fisher Scientific, he collaborates across technical, commercial, and customer-facing teams to implement NGS solutions that support precision medicine. Phil earned his Ph.D. in Applied Physics from Cornell University, where his research focused on semiconductor technologies and biosensors, and he has authored several peer-reviewed publications in nanotechnology and genomics. His background spans scientific research, technology development, and commercial strategy, providing him with a broad perspective on the opportunities and challenges of applying NGS in clinical settings.</p></blockquote>

Thermo Fisher Scientific: Simplifying Transcriptomics for Clinical Research with Ion AmpliSeq™ Technology

Simplifying Transcriptomics for Clinical Research with Ion AmpliSeq™ Technology

Simplify transcriptomics with Ion AmpliSeq technology. Quantify 20,000+ RefSeq genes from 10 ng RNA or FFPE samples with a fast 2-day NGS workflow

Ion AmpliSeq Transcriptomics: Fast NGS for FFPE Samples

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Leverage unique capabilities and powerful tools to streamline sample analysis.</strong></h4><p>Join this webinar to discover the multiple tools in Thermo Scientific Chromeleon software that drive sample throughput from acquisition to data processing and deliver reduced errors through advanced automation.&nbsp;</p><h5><strong>Why attend</strong></h5><p>Uncover the Chromeleon software features that drive sample throughput and deliver unique capabilities in combination with liquid chromatography systems such as the Thermo Scientific Vanquish UHPLC systems. In this webinar, you will see how Chromeleon software can help:</p><ul><li>Increase sample throughput through streamlined workflows</li><li>Leverage the full capabilities of your LC systems to drive productivity</li><li>Deliver automation to common analyses to reduce errors</li></ul><p>Through practical examples and live software demonstrations, attendees will learn how to improve day-to-day laboratory efficiency and reduce errors.</p><h5><strong>What you will learn</strong></h5><p>By attending, participants will be able to:</p><ul><li>Streamline analysis in Chromeleon software from acquisition to result</li><li>Understand and leverage unique capabilities to get more from your LC systems</li><li>Drive automation in common workflows to reduce errors</li></ul><p>Save your spot to discover practical ways to optimize LC system workflows with Chromeleon software.</p><p><i>Cannot attend the live broadcast? Please register anyway to automatically receive the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Darren Barrington-Light (Senior Manager, Product Marketing, Thermo Fisher Scientific)</p><p>Darren Barrington-Light’s background includes over 25 years of experience in the field of analytical chemistry, chromatography hardware and computer software. Having worked in chromatography throughout his career, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, he has worked with clients across multiple industries to show them how software solutions can help them to improve their day to day operations and drive fast, informed decisions.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Tips to power up your LC with Chromeleon software

Tips to power up your LC with Chromeleon software

Optimize LC workflows with Thermo Scientific Chromeleon software. Learn how automation drives throughput and reduces errors on Vanquish UHPLC systems

Chromeleon Tips: Vanquish LC Workflows

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Building on the foundations of LC method development, this webinar explores practical strategies for optimizing chromatographic separations through smarter mobile phase selection, column selectivity, and sample handling. Learn how small changes in solvent composition, pH, buffer selection, and stationary phase chemistry can significantly improve resolution, reproducibility, and method robustness.</strong></p><p>The session will also examine common but often overlooked causes of method variability, including mobile phase stability and sample adsorption, and share practical approaches to improving analyte recovery and overall analytical performance.</p><p>Whether you're developing new methods or troubleshooting existing ones, this webinar will provide practical insights and actionable tips to help you achieve more reliable and efficient LC separations.</p><h5><strong>Who Should Attend?</strong></h5><p>This webinar is ideal for scientists and laboratory professionals involved in liquid chromatography method development, optimization, transfer, or troubleshooting, including:</p><ul><li>Analytical chemists and chromatography specialists</li><li>HPLC and UHPLC users</li><li>Pharmaceutical, biopharmaceutical, food, environmental, and chemical testing professionals</li><li>Method development, validation, and quality control scientists</li><li>Researchers looking to improve separation performance, analyte recovery, and method reproducibility</li><li>Laboratory professionals experiencing challenges related to selectivity, mobile phase selection, sample handling, or unexpected LC method variability</li></ul><p>The session will be valuable for both newer LC users seeking practical guidance and experienced chromatographers looking to strengthen method robustness and troubleshoot difficult separations more efficiently.</p><blockquote><p><strong>Presenter: </strong>Detlev Lennartz (Product Manager, Thermo Fisher Scientific)</p><p>Dr. Detlev Lennartz joined Thermo Fisher Scientific in 2011 and has 3 years of active end customer sales experience and worked previously 12 years as a worldwide product manager for chromatography consumables (HPLC columns, GC columns, SPE cartridges, TLC products and vials and closures).</p><p>In his current position at Thermo Fisher Scientific Detlev works as global product manager for the branded sample handling portfolio (autosampler vials, closures and well plates) close together with a team of specialists, focusing on developing and launching new and innovative products, business development and technical support and trainings for all chromatography consumables.</p></blockquote><blockquote><p><strong>Presenter: </strong>Adham Ahmed, PhD. (Global Product Manager, Thermo Fisher Scientific)</p><p>Adham Ahmed has over 15 years of experience in chromatography, specialising in particle development and functionality for small molecules applications. As Global Product Manager at Thermo Fisher Scientific, he oversees the Hypersil BDS, Hypersil Classical, Acclaim and Hypercarb HPLC column portfolio.</p><p>His experience across research &amp; development, applications support, and product management has provided him with a broad understanding of chromatographic method development, laboratory workflows, and customer needs across a wide range of analytical applications.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Tips and Tricks II - Optimising LC Column Separation

Tips and Tricks II: Optimising LC Column Separation

Optimize LC column separation and method robustness. Learn how mobile phase selection, pH, and column selectivity improve resolution and analyte recovery

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