In forensic toxicology, understanding what is in a sample and how much of it is there, quickly, accurately, and confidently, can make all the difference. Whether it is an overdose investigation, a sudden death case, or surveillance for emerging public health risks, laboratories are under pressure to deliver high-quality results with tighter turnaround times and broader analytical scope.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Sharper_Faster_Smarter_HRAM_Orbitrap_Mass_Spectrometry_Meets_Postmortem_Toxicology_0ea871cfc2.jpg" alt="Thermo Fisher Scientific - Sharper, Faster, Smarter - HRAM Orbitrap Mass Spectrometry Meets Postmortem Toxicology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Sharper_Faster_Smarter_HRAM_Orbitrap_Mass_Spectrometry_Meets_Postmortem_Toxicology_0ea871cfc2.jpg 245w," sizes="100vw" width="1024" height="512">That is where high-resolution, accurate-mass (HRAM) <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3">Orbitrap mass spectrometry</a> really shines, especially when paired with streamlined workflows and intelligent data analysis.<h3>What’s new?</h3>A recent <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_002551_cl_phsa_orbitrap_forensic_tn002551_na_en_a34276b79b.pdf">Technical Note (TN-002551) </a>details a rapid LC-HRAM-Orbitrap method developed collaboratively with the B.C. Provincial Toxicology Centre for postmortem blood analysis. This workflow was designed to deliver routine screening and quantitation while also enabling retrospective data mining to identify unknown or emerging compounds in circulation.Here is what makes this approach compelling:<ul><li>High sensitivity and resolution: The Thermo Scientific Q Exactive HF hybrid quadrupole-Orbitrap system enables faster scan speeds and precise mass measurement, which boosts confidence in detecting drugs, even at low levels, in complex postmortem matrices.</li><li>Robust routine productivity: Running routine screens in approximately 12.5 minutes significantly speeds workflow throughput, which is critical as labs face growing caseloads.</li><li>Retrospective analysis: One of the biggest advantages of HRAM data is the ability to re-interrogate stored data files for novel psychoactive substances after the initial screen is complete. This capability eliminates the need to re-run samples, saving time and preserving limited sample material.</li></ul>A standout example from the technical note was the identification of bromazolam, a designer benzodiazepine that was not part of the original routine panel. Through retrospective analysis, its prevalence in postmortem cases was revealed and quantified, demonstrating the real-world value of full-scan HRAM data.<h5>Supporting broad drug panels</h5>As highlighted in a previous THC tips and tricks blog post, cannabinoids and their metabolites can be challenging when analyzed alongside other drugs of abuse. HRAM MS improves selectivity and confidence when multiple drug classes are analyzed together, making it easier to integrate THC and related compounds into comprehensive toxicology workflows.<h5>Why this matters for forensic toxicology today</h5>The opioid crisis, the continued emergence of novel psychoactive substances, and evolving public health threats demand analytical tools that are both robust and adaptable. HRAM Orbitrap LC-MS not only improves detection and quantitation across a wide range of drugs of abuse, but also enables:<ul><li>Retrospective discovery of unknown compounds</li><li>Faster delivery of actionable results to coroners and public health agencies</li><li>Improved surveillance of emerging drug trends</li></ul>As toxicology laboratories look to future-proof their operations, combining powerful instrumentation, intelligent software, and optimized workflows will be key. Methods like those described in TN-002551 demonstrate how HRAM Orbitrap mass spectrometry continues to elevate forensic toxicology workflows.<h3>Resources</h3><ul><li>Featured technical note: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_002551_cl_phsa_orbitrap_forensic_tn002551_na_en_a34276b79b.pdf">Rapid, high-resolution postmortem toxicology analysis using Orbitrap mass spectrometry</a></li><li>Previous blogs in this series:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6189">Sample Preparation Strategies for Toxicology Workflows</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6587">Beyond Blood: HRAM-Powered Postmortem Toxicology at Sheffield Teaching Hospitals</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6860">Advancing Drug Analysis with VeriSpray PaperSpray Mass Spectrometry</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6953">Boosting Productivity in Toxicology Labs</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7190">Behind the Bench: Tips to Simultaneously Analyze THC, Its Metabolites, and Other Drugs of Abuse</a></li></ul></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/forensics/forensic-toxicology.html">Forensic toxicology webpage</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html">Affordability resources</a></li></ul><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PostmortemAnalysis #HRAMOrbitrapMS #ForensicToxicology #NPS</blockquote>

Sharper, Faster, Smarter: HRAM Orbitrap Mass Spectrometry Meets Postmortem Toxicology

A laboratory will occasionally have a poor performance in a PT scheme. When this occurs, the laboratory should acknowledge it, carry out an investigation and document a review of possible causes, even if it decides not to take any specific action. The purpose of this leaflet is to advise laboratories on how to best address such events. A good management of the poor performance in a PT can save you time and money.&nbsp;<h4>Evaluation of poor performance&nbsp;</h4>Every unsatisfactory performance score indicates a problem which needs to be investigated. In addition the laboratory should set its own criteria for launching an investigation with regards to other indicators of possible poor performance, such as questionable performance scores or observed trends.<h4>Root cause investigation&nbsp;</h4>The depth of the investigation will depend on several factors, such as the importance of the analysis, the frequency of unsatisfactory results and evidence of trends.&nbsp;The laboratory should check whether the PT report gives an explanation for the unsatisfactory performance. If no reason is provided, a stepwise approach is preferable to maximize the chances of determining the root cause of the problem. This approach is described in Annex B of the Eurachem Guide [1].<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_Annex_B_be140d5b39.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing - Annex B" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_Annex_B_be140d5b39.jpg 153w," sizes="100vw" width="726" height="740">The investigation should consist of the following steps and involve the personnel that performed the analysis and where approporiate, also involve the laboratory management:&nbsp;<ol><li>Analyse the raw data, internal quality control data, any trend from previous PT rounds and the overall performance of the participants in that round;&nbsp;</li><li>After investigation is complete, make a plan for corrective action and consider implications for previous test results;&nbsp;</li><li>Execute and record the corrective action(s);&nbsp;</li><li>Check whether the corrective action(s) was effective.&nbsp;</li></ol><h4>Causes for poor performance&nbsp;</h4>The causes of poor performance can be grouped into three categories:&nbsp;<ol><li>Clerical errors are not directly linked to the laboratory’s technical competence, but can underline that the laboratory may have a potential problem when reporting results to its customers. Clerical errors can include transcription errors, mislabelling, incorrect units and decimal point errors. Identifying them is an important first step of an investigation. If such errors are a regular cause of poor performance, the investigation should focus on the related aspects of the quality management system.&nbsp;</li><li>Technical problems can occur at any step of the analytical procedure. If the investigation does not enable the laboratory to identify the root cause, it may be necessary to review the method validation.&nbsp;</li><li>Problems related to the PT scheme. Poor performance could also be due to the PT scheme not being entirely appropriate. The Eurachem Guide [1] provides information on selecting an appropriate PT scheme. In other cases, a problem may have occurred with the PT items. The laboratory is encouraged to discuss its findings with the PT provider.&nbsp;</li></ol>The “Fishbone diagram” or “5 Whys” are useful tools to investigate the root cause of a problem.<h4>Case studies&nbsp;</h4><h5>Example 1</h5>A medical laboratory has provided results in a PT scheme for tumor markers in serum with a 20 % deviation from the assigned value, although the daily internal controls performed well. The laboratory investigates the process and discovers the mistake was due to an incorrect unit conversion factor being introduced for PT results when the IT system was last updated. Since patient results are reported in a different unit than the one used by the PT provider no patient results were affected.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_0df20b3875.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_0df20b3875.jpg 245w," sizes="100vw" width="1539" height="815"><h5>Example 2</h5>A laboratory performing food and feed analyses obtained poor performance scores on Listeria monocytogenes enumeration, because the number of microorganisms found was underestimated. Laboratory investigations showed an issue in incubation time and temperature applied by the analyst. The laboratory found that the analyst used an out-of-date procedure.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_2_4e56101bbb.jpg" alt="Eurachem: How to investigate poor performance in proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_How_to_investigate_poor_performance_in_proficiency_testing_2_4e56101bbb.jpg 245w," sizes="100vw" width="1185" height="526">

How to investigate poor performance in proficiency testing

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

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<h3>Pharma and biopharma fundamentals masterclasses</h3><h5>Build confidence in your analytical decisions across pharma and biopharma workflows</h5>The pharma and biopharma fundamentals masterclasses are a year-long educational series designed for scientists who want to strengthen their knowledge, compare analytical strategies, and apply best practices across regulated workflows.Each session focuses on a real analytical challenge — from quantitation and metabolite identification to biopharma characterization and extractables and leachables — with practical guidance from SCIEX experts.Attend live or watch on demand and choose the sessions most relevant to your work.<h4>Available now:</h4><h5>Pharma fundamentals: Metabolite Identification Metabolite identification is essential in drug discovery, supporting confident decisions in compound design and toxicology</h5>This session shows how alternative fragmentation strategies can overcome limitations of traditional CID and improve MetID accuracy for complex metabolites.<ul><li>Speaker: Heather Chassaing, Senior Accurate Mass Workflow Specialist, SCIEX</li></ul><h4>Upcoming sessions</h4><h5>2. Biopharma fundamentals: Fragment analysis by CE</h5>This masterclass introduces protein fragment analysis using capillary electrophoresis, with a focus on CE-SDS in biopharmaceutical workflows. Learn the core principles behind size-based separation, along with practical guidance on sample preparation, method optimization, and data interpretation to support reliable characterization and quality control in regulated biopharma environments.<blockquote>Speaker: Stephen Lock, Sr. Market Development Manager – Biopharma, SCIEXSteve obtained his PhD in Physical Organic Chemistry from the University College of Swansea in 1993 and is a chartered chemist and a member of the Royal Society of Chemistry. He has worked for SCIEX in various technical roles for over 20 years and has presented at over 80 international meetings around the world. He currently works closely with customers in the biopharmaceutical industry. Steve is also currently an Adjunct Professor at the University of Pannonia.</blockquote>

SCIEX: Pharma and biopharma fundamentals masterclasses

Biopharma fundamentals: Fragment analysis by CE

Biopharma masterclass on fragment analysis by CE-SDS, covering protein separation, method optimization, and QC in regulated environments.

In the third webinar of the Small Molecules, Big Impact series, we will explore how MaxPeak Premier Columns are being applied in discovery workflows, with real-world examples of recently approved drug compounds analyzed using this technology.Attendees will see how improved surface chemistry can enable more accurate and reliable characterization of in-flight drug products, helping scientists generate high-quality chromatographic data when it matters most. This session is designed for analytical scientists supporting discovery programs who want a deeper understanding of current LC technologies on the market and how MaxPeak Premier Columns can be leveraged to strengthen confidence in their analytical results. Examples will also be given to how Waters technologies can improve throughput using ultra-short columns.<h4>Who should attend</h4><ul><li>Analytical scientist supporting discovery groups.</li></ul><h4>Why you should attend</h4><ul><li>Understand how MaxPeak Premier Columns can be used to improve. characterization of new and in-flight drug compounds during discovery workflows</li><li>Review examples of recently approved drugs analyzed with MaxPeak Premier technology and the resulting improvements in chromatographic performance.</li><li>Learn where and how to apply MaxPeak Premier Columns within discovery.&nbsp;</li></ul><h4>What you will walk away with</h4><ul><li>A stronger understanding of how MaxPeak Premier Columns can help characterize new compounds more easily and accurately.</li><li>Expert insights and perspectives on applying this technology to real-world drug development challenges.</li><li>Access to resources that enable you to further evaluate and research MaxPeak Premier technology for your own analytical workflows.</li><li>Learn practical strategies for increasing throughput in discovery experiments, including the use of ultra-short UPLC columns.</li></ul><blockquote>Speaker: Kenneth Berthelette (Principal Scientist, Waters Corporation)Ken earned his Bachelor of Science in Professional Chemistry from Bridgewater State University in Bridgewater, Massachusetts in 2010.He joined Waters Corporation in March 2012, where he contributed to multiple product launches as part of the Research and Development team. In 2021, Ken transitioned into a role supporting Chemistry Aftermarket initiatives.With a strong focus on applications and customer education, he has delivered numerous seminars and webinars covering topics such as method development, method modernization and transfer, HILIC separation techniques, and LC system troubleshooting.</blockquote>

Enhancing Next-Gen Drug Discovery with High-Performance Inert LC Solutions

Discover how MaxPeak Premier Columns improve LC analysis of new drugs, enhancing accuracy, performance, and throughput in discovery workflows.

Next-Gen Drug Discovery with Inert LC Solutions

<h4>Tackle Real Workflows for Complex Bioanalysis Challenges</h4><ul><li>Working in DMPK?</li><li>Curious how modern software is making workflows for new modalities easier?</li></ul>We’re excited to invite you to DMPK in Action, a new 3-part webinar series designed for &nbsp;bioanalysis scientists that brings real workflows to your screen through practical demonstrations of our system and software.<h5>See real DMPK workflows in action - designed for the challenges of modern, complex therapeutics.</h5>In short 30 min sessions, we’ll show real workflows, with a focus on practical applications, efficiency, and how DMPK scientists can move from sample to result with greater confidence.<h5>Episodes</h5><ul><li>Explore the DMPK workflow in action</li><li>From Sample to Result</li><li>Data handling and analysis with confidence</li></ul><h5>Why you should attend</h5>Each session shows how our system and software support practical DMPK tasks, improve visibility, and help teams work more efficiently.<h5>You'll see:</h5><ul><li>Real DMPK workflow demonstrations.</li><li>Practical use cases for bioanalysis scientists.</li><li>How our system and software support consistency, reliability, and efficiency.</li></ul><h5>Who should attend</h5>If you’re involved in DMPK, bioanalysis, or ADME workflows, this series is designed to give you a clear look at how the process works in practice, delivered straight to your officeCan't attend the webinars live? Register today and watch the episodes on-demand at your convenience.<blockquote>Speaker: Antonia Wierzbicki (Principal MS Market Dev Manager, EMEA, Waters Corporation)Antonia Wierzbicki is a MS market development manager at Waters working in EMEA. Antonia has BSc in Pharmaceutical Science and a MSc in Cancer Pharmacology.Following several years working as an analytical chemist in drug development roles within both academic labs and contract research organizations, Antonia has more recently spent time working with analytical chemists to provide solutions using cutting edge technologies to meet their needs and requirements, with a specific interest in ultra-sensitive quantitation of small molecules.Antonia is based in Cambridge UK and keen to connectwith like-minded scientists in the field.Speaker: Henry Foddy (Associate Scientist, Waters Corporation)Henry is a Scientist in the Routine Mass Detection Team at Waters, working on applications to support Waters’ single quadrupole portfolio that span a variety of market segments. He has almost 3 years of experience with Waters, working previously in a food and environmental role support regulatory testing of Pesticides, PFAS, and Pyrrolizidine Alkaloids. Prior to joining Waters, Henry obtained an MSc in Neuroscience from King’s College London.</blockquote>

Data handling and DMPK analysis with confidence

Join Waters webinars on DMPK bioanalysis workflows, data handling, and modern software tools supporting efficient ADME and bioanalysis applications.

Data handling and DMPK analysis

Bringing innovative antibody therapeutics to market quickly requires more than upstream efficiency. It demands adaptable and robust downstream purification strategies.As novel mAb formats increase in complexity, purification challenges grow. Achieving required purity and yield often extends beyond traditional 2–3 step platform processes, requiring expanded chromatography options and optimized buffer systems.<h5>In this webinar, we will discuss:</h5><ul><li>Practical strategies for designing a flexible downstream purification toolkit</li><li>Approaches to buffer optimization for challenging antibody molecules</li><li>Ways to streamline process development while maintaining performance</li></ul>Register to learn how a well-designed purification toolkit can help accelerate development timelines and improve process robustness.<blockquote>Speaker:&nbsp;Chantelle Gaskin (Field Application Scientist, Purification, Thermo Fisher Scientific)Chantelle Gaskin is a Field Applications Staff Scientist specializing in protein and viral vector purification. She previously held leadership roles at Applied Genetic Technology Corporation and Brammer Bio before joining Thermo Fisher Scientific in 2020. With over 10 years of gene therapy experience, she has extensive knowledge of industry practices and regulatory standards, contributing to therapies for ocular, CNS, and systemic diseases. Chantelle holds a Master’s in Chemistry from the University of Florida and a Bachelor’s from Smith College.Speaker: Carlos Ferrero (Field Application Scientist, Thermo Fisher Scientific)Biotechnology graduate from Madrid with a Master’s in Biochemical Engineering from London. He brings over 5 years of experience in the biopharmaceutical industry—over three years in downstream manufacturing and two years as a Field Application Scientist specializing in process liquids at Thermo Fisher Scientific. Passionate about bridging technical expertise with real-world application to support innovation in bioprocessing.Speaker: Ryan Hubbell (Product Manager, Process Liquids, Thermo Fisher Scientific)Ryan Hubbell serves as the Associate Product Manager for Process Liquid Preparation Services at Thermo Fisher. He has professional experience in Quality Control, Operations, and Clinical Research. Ryan holds a master’s degree in biomedical engineering and is set to complete his MBA in May 2025.</blockquote>

Thermo Fisher Scientific: Supporting Efficient mAb Development with a Flexible Downstream Purification Toolkit

Supporting Efficient mAb Development with a Flexible Downstream Purification Toolkit

Optimize downstream purification for complex mAb formats. Learn buffer and chromatography strategies to streamline development and boost yield

Flexible Downstream Toolkit for Efficient mAb Development

<div>Persistent challenges in RNA manufacturing—such as immunogenic double-stranded RNA (dsRNA) impurities and unreliable quantitation methods—can limit product quality, scalability, and confidence in process decisions. These bottlenecks are increasingly critical as RNA is applied beyond vaccines into therapeutics and gene editing.This webinar explores practical strategies to reduce immunogenicity and improve RNA quality across manufacturing workflows. Attendees will gain insight into how purification and analytical approaches can enhance consistency and yield, alongside advances in quantitation methods that enable more reliable measurement.&nbsp;Join to better understand how to optimize RNA purity and analysis to strengthen process control and downstream success.<h5>Attend this webinar to:</h5><ul><li>Identify and characterize dsRNA impurities in RNA manufacturing workflows</li><li>Apply purification strategies to reduce immunogenic byproducts and improve RNA quality across applications</li><li>Evaluate and validate analytical methods for accurate and reliable RNA quantitation</li><li>Use decision frameworks to integrate purification and measurement approaches for scalable, reproducible manufacturing</li></ul><blockquote>Presenter: Nathaniel Clark, PhD ( Senior Scientist at Repligen Corporation)Dr. Nathaniel Clark is a senior scientist at Repligen. He has a doctorate in biochemistry and structural biology from UMass Amherst and studied RNA as a postdoctoral researcher at the University of Texas. At Repligen, he uses structural biology, protein engineering, and modeling to design novel affinity resins.</blockquote></div>

Repligen: Improving RNA Purity and Measurement for Reliable Bioprocessing

Improving RNA Purity and Measurement for Reliable Bioprocessing

Optimize RNA purity and analysis. Learn to reduce immunogenic dsRNA impurities and validate analytical methods for reliable quantitation in RNA manufacturing

Improving RNA Purity and Measurement for Bioprocessing

Ion chromatography remains central to environmental water analysis, but the way established methods such as EPA 300 A/B and perchlorate are being applied today has evolved. Advances in eluent generation, column design, and system configuration are changing how laboratories approach sensitivity, robustness, and method reliability often without formally changing the method itself.This webinar focuses on recent, practical developments in the most widely used environmental IC applications. Topics include updated perchlorate workflows using potassium hydroxide eluents, modernized EPA 300 A/B approaches enabled by the most current column formats, and emerging strategies for haloacetic acid (HAA) analysis. The discussion goes beyond method names to examine how implementation options influence performance in routine laboratory use.The session will be led by Metrohm IC experts Jay Gandhi and Linx Waclaski, who bring extensive hands‑on experience supporting environmental laboratories and developing practical IC workflows for regulated water analysis. Drawing from real‑world method optimization, troubleshooting, and application support, the speakers will connect today’s IC hardware and column advances to the challenges labs encounter every day. Attendees can expect technically grounded guidance that goes beyond theory, with insights shaped by direct experience helping environmental labs improve method performance, reliability, and efficiency.<h4>Key Learning Objectives:</h4><ul><li>Optimize IC methods for key environmental applications, including perchlorate, EPA 300 A/B, and haloacetic acids (HAAs)&nbsp;</li><li>Apply best practices to improve data quality, robustness, and reproducibility&nbsp;</li><li>Compare eluent and column strategies, including carbonate vs. hydroxide (KOH) workflows&nbsp;</li><li>Identify opportunities to increase sample throughout</li></ul><h4>Who Should Attend:</h4><ul><li>Environmental lab analysts performing water analysis by ion chromatography</li><li>Lab managers and supervisors seeking to improve data quality, robustness, and consistency</li><li>Laboratories looking to increase sample throughput and reduce analysis time</li><li>IC users interested in optimizing methods, including modern column strategies</li></ul><blockquote>Speaker: Jay Gandhi, Ph.D. (Vertical Market Manager, Metrohm USA)Speaker:&nbsp;Linx Waclaski (Product Manager for Ion Chromatography, Metrohm USA)Speaker:&nbsp;Melissa O'Meara (Forensic Science Consultant, ACS Media Group)</blockquote>

Metrohm: New Approaches to Established Environmental IC Methods

New Approaches to Established Environmental IC Methods

Optimize environmental water analysis by ion chromatography. Learn advanced column strategies and workflows for perchlorate, EPA 300 A/B, and HAAs.

<h4>Key Learning Points</h4><ul><li>Understand the correct steps to take when first receiving a new column, including inspection procedures and initial test runs.</li><li>Learn practical techniques to extend column lifetime and maintain performance over time.</li><li>Identify when a column should be retired by recognizing key end-of-life indicators.</li><li>Apply best practices for column conditioning, activation, and proper storage.</li></ul><h4>Who Should Attend</h4>Any analysts and scientists routinely working with HPLC/UHPLC columns who want practical care, maintenance, and lifetime‑extension tips.&nbsp;<blockquote>Presenter: Duilio Romanello (Senior Technical Specialist, Phenomenex)Duilio Romanello earned his MSc in Pharmaceutical Chemistry and Technology from the University of Bologna. He joined Phenomenex in 2008 as an Inside Technical Sales Consultant, later leading GC/SPE and Env/Food teams in Italy. Since 2016, he has been Account Manager for Southern Italy and GC Specialist. In 2023, he became Senior Technical Specialist for Phenomenex’s Technical team supporting scientists globally with method development, troubleshooting, and application support.</blockquote>

Phenomenex: Tips for Getting the Best Out of Your LC Phenomenex Column

Tips for Getting the Best Out of Your LC Phenomenex Column

Discover best practices for HPLC/UHPLC column care, conditioning, storage, troubleshooting, and lifetime extension.

Getting Best Out of Your LC Phenomenex Column

Join us for an insightful webinar exploring reliable quantitation of GLP 1 analogues in bioanalysis and IP 2026 updates.This session will cover the strategic approaches for robust quantitation of GLP 1 analogues, emphasizing control strategy and method robustness over sensitivity. It also covered challenges such as matrix effects and analyte instability, along with key updates on Indian Pharmacopoeia monograph development, harmonization, and global recognition. in short as per the guideline's<blockquote>Speaker: Dr. Pankaj Partani (Head-Application Support at SCIEX, PhD in Pharmaceutical Sciences)Key highlights<ul><li>Robust GLP 1 quantitation is not about pushing limits—it’s about making the right strategic choices at every step.</li><li>Reliable GLP 1 data is built on control strategy, robustness, not just sensitivity.</li><li>Challenges in GLP 1 quantitation arise from matrix effects, instability, and non specific losses, not instrument capability.</li></ul>Dr. Gaurav Pratap Singh Jadaun, Ph.D. (Senior Principal Scientific Officer Indian Pharmacopoeia Commission, Ghaziabad)Key highlights<ul><li>The monograph development process</li><li>Their revision and harmonization, updates of the general chapters, international recognition of the IP, and IP Online portal</li></ul></blockquote>

SCIEX: Reliable quantitation of GLP‑1 analogues in bioanalysis and IP 2026 updates

Reliable quantitation of GLP‑1 analogues in bioanalysis and IP 2026 updates

Join us for an insightful webinar exploring reliable quantitation of GLP 1 analogues in bioanalysis and IP 2026 updates.

Quantitation of GLP‑1 analogues in bioanalysis

Migrating legacy LC Method doesn't have to introduce riskIn regulated QC environments, LC method migration requires confidence, consistency, and control. This webinar explores how a structured, automated approach can help QC laboratories transition legacy LC methods to Alliance™ iS while maintaining compliance, method integrity, and operational continuity.<h5>What you will learn</h5><ul><li>How an automated Empower™ workflow enables confident, compliant migration of legacy LC methods to Alliance™ iS in regulated QC environments</li><li>Best practices for transitioning legacy LC methods while preserving method intent, system suitability, and data integrity</li><li>How a risk‑based migration strategy can support long‑term QC efficiency, performance, and laboratory scalability</li></ul><h5>Who should attend</h5><ul><li>Analyst, Supervisors and Lab Managers working in QC Pharmaceuticals Quality Control Labs &nbsp;</li></ul><blockquote>Presenter: Andrea Gheduzzi (Principal LC Market Dev. Manager, EMEA, Waters Corporation)Andrea Gheduzzi, is a principal LC market development manager for EMEA at Waters Corporation. Andrea Gheduzzi has spent more than 30 years in the chromatography field. Across his career he had various roles, service engineer, chromatography lab manager position, and technical manager for chromatography columns.He has mainly been dealing with pharma accounts, also supporting LC method development activities using DoE/QbD approaches. In his previous role as Pharma Business Development Manager at Waters he has further expanded his expertise in AQbD and related applications.Since 2023 he became principal LC market development manager for EMEA and member of the AQbD working party at the EDQM.</blockquote>

Waters Corporation: De‑Risking LC Method Migration: Transitioning Legacy Methods to Alliance™ iS System in Regulated QC Labs

De‑Risking LC Method Migration: Transitioning Legacy Methods to Alliance™ iS System in Regulated QC Labs

Smooth LC method migration to Alliance iS. Discover automated Empower workflows to maintain compliance and data integrity in regulated pharma QC labs

De‑Risking LC Method Migration

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join us for a free, hands-on Thermo Scientific™ Proteome Discoverer™ software online workshop. This session is designed to walk you through the latest best practices for Data Independent Acquisition (DIA) analysis, featuring the powerful new DIA-NN node.Whether you are a novice or an intermediate user, this workshop provides the practical knowledge needed to leverage the novel InfinDIA mode for ultra-fast analysis against unlimited search spaces<h4>What We’ll Cover</h4><ul><li>Proteome Discoverer 3.3 SP1 updates: A deep dive into the latest release, including news, installation, and licensing.</li><li>DIA-NN &amp; InfinDIA: Guest speaker Vadim Demichev introduces DIA-NN 2.5 and the breakthrough InfinDIA mode for handling near-unlimited search spaces and selected applications.</li><li>Practical processing walkthrough: Michaela Scigelova leads a step-by-step guide using DIA-NN:<ul><li>training materials, study, analysis</li><li>workflow parameter settings</li><li>DIA-NN node (discussion of all parameters, recommendet settings)</li><li>Results review</li></ul></li><li>Tips for efficient data processing</li></ul>Can’t attend the live broadcast? Register anyway! All registrants will receive a link to the session recording.<blockquote>Presenter: Michaela Scigelova (Product Support, Thermo Fisher Scientific)Michaela provides customer support to Thermo Scientific Proteome Discoverer software users.Presenter: Vadim Demichev (MSTARS Group Leader, Charité - Universitätsmedizin Berlin)Vadim Demichev is a founder of Aptila Biotech and a research group leader at the Charité – Universitätsmedizin Berlin, focusing on developing of LC-MS methods and data analysis approaches for quantitative proteomics.</blockquote></div></div></div>

Thermo Fisher Scientific: Proteome Discoverer 3.3 SP1: Processing DIA data with DIA-NN node

Proteome Discoverer 3.3 SP1: Processing DIA data with DIA-NN node

Join this workshop to explore DIA-NN, InfinDIA, and Proteome Discoverer 3.3 SP1 for efficient DIA proteomics data analysis and review.

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