<p><strong>American postdoctoral researcher and ERA Postdoctoral Fellow William Morton came to CEITEC Masaryk University from the United Kingdom two years ago to join Robert Vácha’s research group. During his time in Brno, he focused on computational research of disordered proteins and experienced not only the Czech research environment, but also everyday life in the city. Now, as he prepares to return to the UK, he reflects on what CEITEC has given him, where he sees room for improvement, and why science depends not only on excellent results, but also on ordinary day-to-day conversations between researchers.&nbsp;</strong></p><h5><strong>When you were looking for your next research step, what made CEITEC stand out to you?</strong></h5><p>For me, the decision was primarily about people rather than place. I had already spent a month in Brno during my PhD, so I knew the environment and had a sense that I enjoyed both the institute and the city. But the key factor was the opportunity to work with <strong>Robert Vácha</strong>. I knew that his expertise aligned perfectly with where my research was heading, and I made a conscious decision not to apply elsewhere until I knew whether I could join his group. Once that opportunity came through, the decision was straightforward.</p><h5><strong>Before coming here, what were your expectations about Brno and CEITEC – and what turned out to be completely different, in a good way?</strong></h5><p>Honestly, I didn’t have strong expectations. I had seen Prague, but I knew Brno would be different, so I arrived with a fairly open mind. What surprised me most was how rich the city is despite its size. At first glance, Brno seems small, but it offers an incredible variety of communities, activities, and hidden places. Whatever your interests are, you can usually find people who share them and spaces that support them. That depth and accessibility of life here was something I didn’t expect at all.</p><h5><strong>How has your day-to-day life in Brno felt as an international researcher? If someone from abroad was hesitating about moving here, what would you tell them?</strong></h5><p>Day-to-day life can be quite intense, especially at the beginning. As an early-career researcher, you’re expected to quickly become independent, manage your own projects, build collaborations, and often mentor others at the same time. In my case, I arrived while still finishing my PhD, so I was navigating two major transitions at once, while also adapting to a new country.</p><p>That said, Brno is a place where this transition feels manageable. One of the reasons I’ve come to really enjoy living here is that despite its size, the city offers everything I need both professionally and personally. It’s easy to find communities, activities, and a good balance outside the lab.</p><p>If someone from abroad was hesitating about moving here, I’d say to expect a steep learning curve at first, but also a very rewarding experience once you settle in.</p><h5><strong>What has it been like working within your team here – how would you describe the collaboration and overall atmosphere?</strong></h5><p>Within Robert Vácha’s group, one of the biggest strengths is the breadth of expertise. There’s a really wide range of computational techniques in the group, and people are generally very willing to help each other and share knowledge. That creates an environment where you can learn a lot very quickly.</p><p>One thing I realised during my time here is how important it is to create spaces where researchers – not only group leaders, but also early-career people working directly on experiments and data – can openly discuss and challenge each other’s ideas. Those conversations are incredibly valuable. They help people improve their research, prepare for criticism, and feel more connected to the wider scientific community around them. And I don’t think this necessarily starts with big institutional goals or public-facing topics.</p><p>It mostly requires cooperation, communication, and leadership that creates opportunities for those interactions to happen regularly.</p><h5><strong>I heard you were receiving rather unique ‘packages’ from your neighbours – can you tell me a bit about that experience and what it says about life here?</strong></h5><p>Yes – this was one of my favourite parts of living here. I would occasionally get a knock on my window, and there would be jars of tomatoes, homemade syrup, pastries, or herbs from my neighbour.</p><p>More broadly, I found that people in the Czech Republic are incredibly kind, even without a shared language. I had many experiences – whether with neighbours or complete strangers – where people were welcoming and generous without expecting anything in return. That says a lot about the culture here.</p><h5><strong>Finding housing is often one of the first challenges when moving abroad – how was your experience in Brno?</strong></h5><p>I was fortunate to receive help with housing from CEITEC Welcome Officer, so my personal experience was relatively smooth. In fact, the apartment I originally stayed in is now being used by another postdoc arriving to Robert Vácha’s group, which says a lot about how important that kind of support network can be.</p><p>At the same time, I know from others that finding housing in Brno can be quite difficult, especially for non-EU researchers who need formal rental contracts for visa and administrative purposes. There are many informal rental options available, but they don’t always meet the official requirements, which makes the whole process more stressful and complicated.</p><p>I think departments like the CEITEC Welcome Office do a huge amount to help international researchers navigate this, but it also shows how important it is to make the system itself more accessible for highly qualified people coming from abroad.</p><h5><strong>Did you find it difficult to settle in without speaking Czech, or were you able to navigate most situations comfortably in English?</strong></h5><p>In general, it’s very manageable to live in Brno using English. You might encounter occasional misunderstandings, but if you approach situations with patience and flexibility, it works well.</p><p>I found that most interactions were positive, and people were generally willing to help – even when communication wasn’t perfect.</p><h5><strong>You’re now moving on to your next position – what are you taking with you from Brno into this next chapter?</strong></h5><p>I’m taking both professional experience and a broader perspective on research environments. The experience of working independently, managing multiple responsibilities, and navigating an international setting will be valuable wherever I go next.</p><h5><strong>If a young researcher was considering CEITEC, what would be your honest pitch to them?</strong></h5><p>My honest advice would be to focus on finding the right research group – and by that, I mean the whole environment around you. Not only the supervisor, but also the PhD students, technicians, and postdocs you’ll work with every day. Those relationships shape your experience much more than people sometimes expect.</p><p>I think if you find the right fit, you can absolutely succeed at CEITEC, have a really wonderful experience, and take advantage of everything the institute offers.</p><p>I would also encourage people to take the interview process seriously – not just as candidates trying to get a position, but also as an opportunity to evaluate whether the group feels right for them. If that fit is there, CEITEC offers strong support and a great environment to grow.</p>

William S. Morton: The Best Part of Living in Brno? Probably the Tomatoes Through the Window 

<p><strong>If you’re considering a nitrogen generator for your lab, one of the first questions that often comes up is: “What kind of maintenance am I signing up for?”</strong></p><p>It’s a fair concern. Many labs are used to equipment that requires frequent service, costly parts, or ongoing vendor support. The good news is that the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1902"><strong> NITRO-GEN nitrogen generator</strong></a> was specifically designed to keep <strong>maintenance simple, infrequent, and affordable</strong>.</p><p>In fact, compared to many laboratory nitrogen generators, it offers one of the<strong> lowest overall maintenance burdens</strong>, making it an easy transition for labs looking to move away from gas cylinders without adding complexity.</p><h3><strong>Simple Maintenance, Minimal Time Commitment</strong></h3><ul><li>For most labs, maintaining the NITRO-GEN comes down to one straightforward task: <strong>periodic filter replacement</strong>.</li></ul><p>The system uses a<strong> two-stage filtration setup</strong>. The coarse filter, which serves as the first stage, captures larger particulates from your compressed air supply and protects the rest of the system. This element should be replaced about <strong>once per year</strong>. Downstream, the fine filter removes smaller contaminants and typically lasts much longer, generally <strong>2–5 years</strong>, depending on usage and air quality.</p><p>Replacing the coarse filter annually is key. Not only does it maintain consistent nitrogen output, but it also helps extend the life of the fine filter, keeping overall maintenance both minimal and cost-effective.</p><p>Actual filter lifespan will vary depending on how heavily the generator is used and how clean your incoming compressed air is. However, most labs find that these intervals are more than sufficient to keep the system running smoothly. And if you ever need to access the filters, it’s quick and easy—just unscrew the rear plate of the generator to reach the filter elements. <strong>No specialized tools or service calls required</strong>.</p><h3><strong>Low Maintenance Costs Without the Surprises</strong></h3><p>Beyond the low frequency of maintenance, the cost of keeping a NITRO-GEN running is also very low.</p><p>With the coarse filter replaced annually and the fine filter only occasionally,<strong> typical annual maintenance costs are under $100</strong>. That’s a fraction of what many labs expect when evaluating nitrogen generation systems, and significantly lower than the ongoing costs associated with gas cylinders or more complex generators.</p><p>There are also clear indicators when maintenance is needed. If you notice a drop in nitrogen flow or that the drain port is no longer draining properly, it’s likely time to replace one or both filter elements. These simple visual and performance cues make it easy to stay ahead of maintenance without overthinking it.</p><h3><strong>How NITRO-GEN Compares to Other Nitrogen Generators</strong></h3><p>Not all nitrogen generators are created equal—especially when it comes to maintenance.</p><p>Many laboratory nitrogen generators rely on more complex technologies such as pressure swing adsorption (PSA) or multi-stage membrane systems. While these approaches are effective at producing nitrogen, they often come with additional maintenance considerations that aren’t always obvious upfront.</p><ul><li><strong>PSA systems</strong>, for example, use adsorption columns filled with specialized materials along with valves that continuously switch during operation. Over time, these components can require servicing or replacement, and the systems are highly sensitive to moisture and oil in the compressed air supply, making air preparation and filtration even more critical.</li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-do-membrane-nitrogen-generators-work"><strong>Membrane-based generators </strong></a>are somewhat simpler, but still depend heavily on consistent air quality and multiple pre-filtration stages. If those upstream systems aren’t maintained properly, performance can decline and internal components may need replacement.</li></ul><p>Across both types of systems, maintenance often extends beyond the generator itself. Supporting equipment like air compressors, dryers, and filtration systems typically require their own upkeep, adding to the total cost and complexity of ownership.</p><p><strong>The NITRO-GEN was designed with a different philosophy:</strong> keep nitrogen generation simple and accessible for the lab environment. Instead of relying on complex internal systems, it focuses on a streamlined design where routine upkeep is limited to quick, infrequent filter changes. There are no adsorption beds to replace, no complex valve systems to service, and no specialized maintenance procedures required.</p><h3><strong>A Simpler Alternative to Gas Cylinders</strong></h3><p>For labs currently relying on nitrogen cylinders, <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/how-much-could-i-save-switching-to-a-nitrogen-generator"><strong>switching to a generator</strong></a> can feel like trading one set of responsibilities for another. But with the NITRO-GEN, that tradeoff is minimal.</p><p>Instead of managing tank deliveries, monitoring supply levels, and handling cylinder changes, you get a reliable, on-demand nitrogen source with only occasional, low-cost maintenance. The result is a more streamlined workflow, fewer interruptions, and greater long-term cost control.</p><h3><strong>The Bottom Line</strong></h3><p>If maintenance concerns have been holding you back from switching to a nitrogen generator, the NITRO-GEN was built to eliminate that barrier.</p><p>With one quick annual filter replacement, infrequent long-term maintenance, and annual costs under $100, it’s one of the simplest and most cost-effective nitrogen generation solutions available for laboratory use.</p>

How Much Maintenance Does the NITRO-GEN generator really require?

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 15th June 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, Shimadzu </strong>and<strong> Thermo Fisher Scientific, </strong>technical note by<strong> KNAUER </strong>and brochure by <strong>Waters Corporation!</strong></p><h3><strong>1. Agilent Technologies: Large-Volume Dilute-and-Shoot Analysis of PFAS in Drinking Water Using the Altura PFAS Column</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_analysis_pfas_drinking_water_altura_5994_9186en_agilent_a66334e5b0.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per‑ and polyfluoroalkyl substances (PFAS) are synthetic fluorinated compounds valued for their oil‑ and water‑repellent properties, but their environmental persistence and mobility have driven the development of increasingly stringent regulations for drinking water monitoring. Existing dilute-and-shoot methods, such as EPA 8327 and ASTM D7979, were originally designed for screening PFAS in nonpotable water. These methods typically rely on 10 to 30&nbsp;µL injection volumes, setting practical quantitation limits appropriately 10 ng/L.<sup>1,2&nbsp;</sup></p><p>We present a large‑volume injection workflow that extends the capabilities of these methods toward trace PFAS quantitation in drinking water. Using the Agilent 6495D triple quadrupole LC/MS (LC/TQ) coupled with a 1290 Infinity II LC, we achieved injections of 200 µL of methanol‑diluted water on the Altura PFAS column without requiring SPE concentration. The Altura PFAS column maintained peak symmetry and retention stability under these injection conditions. This configuration enabled a working calibration range of 0.25 to 25 ng/L, extending the low-end sensitivity substantially relative to published dilute-and shoot methods.<sup>1,2&nbsp;</sup></p><p>This performance enhancement simplifies operations by removing labor‑intensive extraction steps, while maintaining sensitivity required for regulatory guidelines thereby supporting high‑throughput PFAS workflows suitable for routine drinking water analysis. The PFAS compounds analyzed were PFBS, HFPO-DA, PFHpA, PFHxA, PFHxS, PFOA, PFOS, PFNA, and PFDA. These compounds were selected due to their relevance to ongoing regulatory actions and proposed maximum contaminant level (MCL) considerations for drinking water.&nbsp;</p><p>Specific highlights of this experiment include:&nbsp;</p><ul><li>Minimized peak tailing and solvent effects with 200 µL injections water/methanol (1:1) injections.</li><li>Increased throughput by elimination of solid phase extraction (SPE).&nbsp;</li><li>Enhanced sensitivity of 6495D LC/TQ at low end (0.25&nbsp;ng/L) for the dilute-and-shoot method in drinking&nbsp;water.</li></ul><h4><strong>Experimental&nbsp;</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=+1290+Infinity+II"><strong>Agilent 1290 Infinity II LC</strong></a> coupled to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=6495D"><strong>Agilent 6495D LC/TQ system</strong></a> was utilized for the LC/MS/MS analysis. An Infinity&nbsp;II multisampler with an extended multidraw capillary tube (G7137-68307) was connected to the needle seat and injection valve with a union for large volume injection (200&nbsp;µL). The data were acquired with MassHunter acquisition software version 12.2. All LC/MS parameters are shown in Table 1 and 2. PFAS multiple reaction monitoring (MRM) transition methods were imported from the PFAS MRM database (G1736AA) while labelled homologues were optimized to obtain correct MRM transitions (Table 3).</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This study demonstrates a practical large‑volume dilute-and-shoot workflow for the determination of PFAS in drinking water using the Agilent 1290 Infinity II LC coupled to the 6495D triple quadrupole LC/MS, and Agilent Altura Poroshell PFAS column. With 200 µL water samples diluted in methanol can be injected directly, eliminating the need for SPE concentration and significantly reducing sample preparation time. This method exhibits good sensitivity, accuracy, and reproducibility. The Altura PFAS column maintained consistent peak performance and retention stability even at low sub‑ppt concentrations, supporting long‑term reliability for trace‑level PFAS monitoring. Overall, the findings highlight the method potential to support routine, high‑sensitivity PFAS monitoring in drinking water laboratories.</p><h3><strong>2. KNAUER: Size matters - How to perform narrow calibration using the ClarityChrom® GPC Extension</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VTN_0049_knauer_size_matters_how_to_perform_narrow_calibration_using_the_claritychrom_gpc_extension_3cfdc7a45b.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a separation technique that separates molecules based on their hydrodynamic size rather than chemical interactions. In a GPC column, separation is based on the ability of molecules to access the pores of the stationary phase. Smaller molecules can penetrate these pores and therefore spend more time inside the column, resulting in a delayed elution. Larger molecules, on the other hand, cannot enter the pores and pass through the column more quickly, leading to earlier elution.&nbsp;</p><p>As a result, molecules are separated by size in solution, providing the basis for the determination of molecular weight and molecular weight distributions. Calibration is therefore a fundamental requirement for ensuring the accuracy and reliability of the results. The ClarityChrom® GPC Extension enables users to efficiently create and apply different calibration models for precise analysis. The workflow presented here focuses on narrow calibration using standards with defined molecular weights and low polydispersity (PD ≈ 1).</p><h4><strong>Material and Methods</strong></h4><ul><li><strong>Software&nbsp;</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=503&amp;search=ClarityChrom"><strong>ClarityChrom</strong></a>® 10.1 - station single instrument license one time base</li><li>ClarityChrom® 10.1 - GPC license for GPC data processing &nbsp;</li></ul></li><li><strong>Pump: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2372"><strong>AZURA P 6.1L isocratic HPLC pump</strong></a> with 10 ml pump head for normal phase applications, stainless steel&nbsp;</li><li><strong>Degasser: </strong>Analytical 2 channel GPC degasser&nbsp;</li><li><strong>Autosampler:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2375"><strong>AZURA® AS 6.1L</strong></a>, analytical HPLC autosampler, 862 bar&nbsp;</li><li><strong>Detector:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2429"><strong>AZURA® RID 2.1L</strong></a>, analytical refractive index detector&nbsp;</li><li><strong>Thermostat: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2376"><strong>AZURA® CT 2.1</strong></a> ATC00 Capillaries Start-Up Kit with flexible, precut capillaries for analytical HPLC systems with 1/16" connections</li></ul><h4><strong>Conclusion</strong></h4><p>This technical note demonstrates how to successfully create and apply a narrow calibration using the ClarityChrom® GPC Extension. By following the outlined workflow, users can ensure reliable calibration and determination of molecular weight and molecular weight distributions. The described approach supports consistent and reproducible results, making it a valuable tool for routine GPC/SEC analysis. For further optimization and advanced applications, additional related technical and application notes can be consulted.</p><h3><strong>3. Shimadzu: UHPLC Method for Sensitive Automatic Analysis of Thirty-Seven D/L-Amino Acids and for Liquor Profiling</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01169_en_2dab331398.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Enables high-sensitivity simultaneous fast analysis of thirty-seven D/L-amino acids using simple operations.</li><li>Good reproducibility of analytical results can be achieved by keeping the derivatization reaction time constant.</li><li>Statistical analysis software enables easy multivariate analysis of multiple samples.</li></ul><p>Recent advances in analytical techniques have revealed the presence of D-amino acids in fermented foods and biological samples and clarified their role in the taste, preservation, and aroma of foods , and as potential disease biomarkers. Therefore, the demand for D/L separation of amino acids is increasing. Because D-amino acids are only present in trace amounts in fermented foods and biological systems, unlike L-amino acids, it is necessary to determine the concentration of each D-amino acid by separating them from the high concentrations of Lamino acids.&nbsp;</p><p>A comprehensive method for quantitating the thirty-seven D/Lamino acids was previously reported1), in which two chiral derivatizing reagents were employed to provide different diastereomers for each amino acid, with the instrument automatically switching between two separation methods to analyze each sample twice.&nbsp;</p><p>This article introduces an improved method that employs a single chiral derivatizing reagent to enable simultaneous analysis of D/L-amino acidsin a shorter time.</p><h4><strong>D/L-Amino Acid Analysis by UHPLC&nbsp;</strong></h4><p>In general, LC/MS or multi-dimensional LC is used to analyze D/L-amino acids by HPLC, because it is difficult to separate proteinogenic D/L-amino acids with a single separation mode. However, it is known that LC/MS is susceptible to matrix effects and less quantitative than HPLC. It is also known that the multidimensional LC method requires a long analysis time and very complicated HPLC setup. Therefore, a simple operational method that provides good separation for D/L-amino acids in a short time is needed.&nbsp;</p><p>For food analysis, a small particle column is used to achieve appropriate separation of the small amounts of D-amino acids from the large amounts of L-amino acids and co-existing contaminants. A <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=X3"><strong>UHPLC system (Nexera X3</strong></a>) was employed in this study due to the increased system pressure caused by the use of a small particle column.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A method was developed for simultaneous separation of OPA/NIBC diastereomers for thirty-seven D/L-amino acids using a simple UHPLC system in approximately half the time of the conventional methods. By optimizing the derivatization reaction, all compounds were determined sensitively, accurately, and precisely. Separation of the target compounds from the contaminants was good in the liquor samples when evaluated using real liquor samples. It is expected to be easily applicable to D/L-amino acid profiling in food and beverage samples without using expensive MS detection or complicated multidimensional HPLC configurations as long as samples are prepared properly. Moreover, D/L-amino acid profiling could be used to research and develop foods containing D-amino acids intended to help to maintain and improve the intestinal environment, and could help in the early detection of diseases and determining optimal treatment strategies through biomarker discovery</p><h3><strong>4. Thermo Fisher Scientific: Screening of per- and polyfluoroalkyl substances (PFAS) in cosmetics: Utilizing a new combustion-ion chromatography system for total organic fluorine (TOF) analysis</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ap_004098_ic_systems_combustion_ic_environmental_ap004098_na_en_a3a1d33a24.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This application note describes a method for <strong>screening per- and polyfluoroalkyl substances (PFAS) in textiles</strong> using total organic fluorine (TOF) analysis by combustion-ion chromatography (C-IC). PFAS are widely used in textiles to provide water, oil, and stain resistance, but increasing concerns about their environmental persistence and potential health effects have led to stricter regulations worldwide. California’s AB 1817 legislation, for example, limits TOF concentrations in textiles to 100 ppm beginning in 2025 and 50 ppm by 2027, creating a need for reliable analytical methods capable of assessing PFAS content in textile products.</p><p>The study evaluates a new <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2150"><strong>Thermo Scientific Cindion Combustion Ion Chromatography System</strong></a>, which combines a Dionex Inuvion IC system with a Cindion combustion/absorption module. The system features an optimized Z-fold combustion tube design that improves combustion efficiency, shortens analysis time, reduces instrument footprint, and allows complete control through Chromeleon software. Unlike surface-sensitive techniques such as PIGE, the combustion-IC approach analyzes the entire sample, providing results that are independent of sample thickness. The method measures total fluorine (TF) after combustion and total inorganic fluorine (TIF) by direct IC analysis, with TOF calculated as the difference between TF and TIF.</p><p>To validate the approach, six textile samples representing waterproof and stain-resistant consumer products were analyzed and compared with results previously obtained using a Nittoseiko combustion-IC system. TOF concentrations ranged from approximately 1 ppm in one nylon fabric to nearly 375 ppm in a polyester baby bib. The values generated by the new Cindion system showed excellent agreement with the reference system, achieving between 100% and 105% of the previously reported results. Reproducibility was also strong, with relative standard deviations below 8% for all samples.</p><p>The authors conclude that the new Cindion C-IC platform provides an accurate, reliable, and efficient solution for PFAS screening in textiles. In addition to matching the performance of the established combustion-IC method, the enhanced system offers a flexible “2-in-1” configuration that allows seamless switching between combustion-IC and standalone IC operation. This improves workflow efficiency, reduces manual intervention, and provides manufacturers and testing laboratories with a practical tool for monitoring compliance with evolving PFAS regulations in textile products.</p><h3><strong>5. Waters Corporation: Advanced Acquisition Modes for the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2433"><strong>Xevo MRT P10 Mass Spectrometer</strong></a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009362_9baa39e7de.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>The Waters solution sheet introduces the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2433"><strong>Xevo MRT P10 Mass Spectrometer</strong>,</a> a next-generation high-resolution mass spectrometer designed to provide significantly greater analytical depth, sensitivity, and flexibility for modern omics workflows. Compared with the previous Xevo MRT platform, the instrument delivers a reported <strong>20-fold increase in MS/MS sensitivity</strong>, incorporates Wideband Enhanced Duty Cycle (WB EDC) technology, and supports ultrafast acquisition rates of up to <strong>100 Hz for MS data</strong> and <strong>200 Hz for MS/MS data</strong>. These performance improvements are intended to enhance the detection of low-abundance compounds while maintaining high-quality spectral information across complex biological samples.</p><p>A major focus of the document is the introduction of the new <strong>SONAR Pulse Acquisition Mode</strong>, an advanced data-independent acquisition (DIA) approach. SONAR Pulse improves selectivity by rapidly stepping a quadrupole isolation window across a defined precursor mass range, allowing fragment ions to be associated with narrower precursor windows than in conventional DIA experiments. This strategy reduces spectral complexity, improves confidence in compound identification, and increases the likelihood of detecting low-level analytes that might be missed by traditional data-dependent acquisition (DDA) methods. The method supports precursor and product ion scans up to m/z 2000, multiple quadrupole isolation window sizes, acquisition speeds up to 200 Hz, and full compatibility with WB EDC technology.</p><p>The second major innovation described is <strong>Mixed Mode Acquisition</strong>, a hybrid workflow that combines targeted and untargeted analysis within a single injection. In this approach, high-sensitivity <strong>Tof MRM</strong> quantification is performed simultaneously with untargeted DIA (MSE) acquisition. This enables users to obtain quantitative data for predefined targets while also collecting comprehensive full-scan information for discovery and screening purposes. The workflow integrates seamlessly with Waters software tools, allowing targeted quantification through the MS Quan application and untargeted analysis through UNIFI or export to open data formats such as mzML for processing in third-party software packages including MZmine, MS-DIAL, DIA-NN, PEAKS, and Progenesis QI.</p><p>According to Waters, both acquisition strategies are designed to maximize information obtained from each sample injection. SONAR Pulse emphasizes deeper molecular coverage, improved selectivity, and simplified interpretation of complex DIA datasets, while Mixed Mode provides a unified quantitative–qualitative workflow that combines targeted measurement and discovery screening without compromising sensitivity or acquisition speed. Together, these capabilities position the Xevo MRT P10 as a versatile platform for metabolomics, lipidomics, proteomics, and other multiomics applications where both comprehensive characterization and accurate quantification are required.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 25, 2026

Article

Product

Application

Scientists

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Tosoh Bioscience

Agilent Technologies

Phenomenex

Thermo Fisher Scientific

SelectScience

Shimadzu Corporation

Waters Corporation

<p><strong>In the race to launch GLP‑1 generics and novel agonists, complex impurity analyses directly impact your speed to market. Conventional columns often obscure peaks of critical impurities, leading to costly rework and increased regulatory scrutiny.</strong></p><p>Join us and learn about new analytical tools designed to streamline your process and deliver reproducible, high-resolution separations of GLP‑1 receptor agonists (GLP-1 RAs) and insulin-related impurities without relying on suppressive mobile‑phase additives.</p><p>Learn how improved resolution can accelerate method development, increase confidence in your results, and support faster time to market for your GLP-1 RA and insulin products.</p><h4><strong>In this webinar you will learn:</strong></h4><ul><li>How to gain greater resolution for your GLP-1 RA and insulin impurity analysis separations</li><li>How to achieve up to 3x faster separations</li><li>How to identify subtle impurities, such as single amino-acid substitutions and deamidation, beyond the detection limits of conventional reversed-phase technologies</li></ul><h4><strong>Who should attend</strong></h4><p><strong>This webinar is designed for you if you work in:</strong></p><ul><li>Analytical development</li><li>Process development</li><li>R&amp;D</li><li>CXOs dealing with GLP-1 RAs or insulin</li></ul><blockquote><p><strong>Presenter: </strong>Michael Zagieboylo (Principal Product Manager, Waters Corporation)</p><p>Michael Zagieboylo is a Principal Product Manager at Waters Corporation whose responsibilities involve assisting in the development and commercialization of innovative reagents and chromatography-based technologies for the separation, purification, and characterization of biological molecules, focusing on peptide and protein separations.</p></blockquote><blockquote><p><strong>Presenter: </strong>Steve Shiner (Senior Manager, R&amp;D for Biopharma Solutions, Waters Corporation)</p></blockquote>

Clear the Noise: Improving Resolution of GLP-1 Receptor Agonist and Insulin Impurities

Resolve GLP-1 receptor agonist and insulin impurities faster. Discover analytical tools for high-resolution separation of deamidation and amino-acid changes.

Improving Resolution of GLP-1 and Insulin Impurities

<p><strong>Advancing protein and viral vector characterization requires detection strategies that deliver higher sensitivity without adding complexity to established workflows. Traditional UV detection can introduce challenges such as labelling steps, baseline drift, and lower signal‑to‑noise ratios, making it harder to resolve critical quality attributes in capillary electrophoresis–sodium dodecyl sulfate (CE‑SDS) as workflows scale and regulatory expectations increase.</strong></p><p>In this SelectScience® TechTalk, Staff Application Scientist, Peter Holper, with 15+ years of biopharma industry experience, will demonstrate how native fluorescence detection (NFD) on the BioPhase 8800 system is raising the bar for CE-SDS analysis. By harnessing the natural fluorescence of aromatic amino acids, NFD eliminates protein labeling while delivering improved signal-to-noise ratios and cleaner baselines.</p><p>You will also discover how 8‑capillary parallel processing accelerates throughput across workflows such as CE‑SDS purity analysis and AAV capsid protein characterization, supported by real data showing accuracy and repeatability across detection modes. With streamlined sample preparation and stable baselines, your lab can get to answers faster and with greater confidence.</p><h5><strong>Certificate of attendance</strong></h5><p>If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</p><p>If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.</p><h5><strong>TechTalk details</strong></h5><ul><li><strong>Cost: Free to attend</strong></li><li><strong>Location: Online</strong></li><li><strong>Duration: 20 minutes</strong></li></ul><p><i>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.</i></p><h5><strong>This event is perfect for:</strong></h5><ul><li>Analytical development scientists</li><li>Process development scientists</li><li>CMC Directors</li></ul><blockquote><p><strong>Speaker:</strong> Peter Holper (Staff Application Scientist, SCIEX)</p><p>Peter Holper earned his degree in Biochemistry and Cell Biology from the University of California, San Diego. He has over 15 years of experience in biopharma, including as an analytical chemist at Eli Lilly and Company where he was responsible for developing the analytical control strategy for bioproducts. Holper currently works at SCIEX where he is responsible for developing and optimizing CE applications and providing customer demo sample analysis support.</p></blockquote>

SelectScience: Native fluorescence detection for high-throughput CE-SDS and AAV characterization in drug development SCIEX

Native fluorescence detection for high-throughput CE-SDS and AAV characterization in drug development

Discover native fluorescence detection (NFD) on the BioPhase 8800 system for label-free, high-throughput CE-SDS purity analysis and AAV characterization

Native Fluorescence for CE-SDS and AAV Characterization

<p><strong>On June 23, Abbie Breton, Applications Development Manager, will present the next edition of Tosoh Tuesday, a webinar series held by Chromatography Experts. Yuliya McAnany, Applications Scientist – Process Resins at Tosoh Bioscience, will showcase a suite of high-performance tools for reliable separation and analysis of AAV particles. Yuliya will start by discussing Tosoh’s novel full capsid enrichment method for TOYOPEARL GigaCap Q-650S resin combined with choline chloride, achieving 90% purity and 75% recovery. The conversation will include a look into Tosoh’s analytical toolkit for increased reliability, and improved sensitivity for critical quality monitoring.</strong></p><p>Participants will learn how to simplify the development of a high-performing enrichment step and will learn how Tosoh’s TSKgel Q-STAT, TSKgel GMPWxl, and LenS3 MALS detector can be used to advance quality monitoring of AAV products.</p><p>After the webinar, ask your questions during the live Q&amp;A session.&nbsp;</p><blockquote><p><strong>Presenter:</strong> Abbie Breton (Applications Development Manager, Tosoh Bioscience)</p></blockquote><blockquote><p><strong>Presenter:</strong> Yuliya McAnany (Applications Scientist – Process Resins, Tosoh Bioscience)</p></blockquote>

Tosoh Bioscience: Tosoh Tuesday - Exploring the AAV Toolkit

Tosoh Tuesday - Exploring the AAV Toolkit

Advance your AAV quality monitoring. Explore Tosoh's full capsid enrichment methods using TOYOPEARL resins and precise TSKgel SEC analysis with MALS detection

Exploring the AAV Toolkit: Tosoh Chromatography Webinar

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>GLP-1 receptor agonists are among the most impactful peptide therapeutics, but their structural complexity presents significant analytical challenges. From sequence modifications to lipidation and manufacturing variability, achieving confident characterization requires advanced approaches.</strong></p><p>Join us to learn how a streamlined LC-MS workflow can simplify GLP-1 analysis. This session will highlight integrated strategies combining UHPLC separation, high-resolution mass spectrometry, and automated data analysis to support robust characterization and impurity monitoring of peptides such as semaglutide and tirzepatide.</p><h5><strong>What You Will Learn</strong></h5><ul><li>How to optimize LC-MS workflows for comprehensive GLP-1 peptide characterization</li><li>Practical strategies for improving separation of closely related peptide species</li><li>Approaches to enhance sequence coverage using advanced fragmentation techniques</li><li>Methods for confident impurity profiling and structural heterogeneity assessment</li></ul><p>Secure your spot today and gain practical insights to simplify complex GLP-1 analysis.</p><blockquote><p><strong>Presenter: </strong>Dr. Sara Carillo (Bioanalytical Research Lead, NIBRT)</p><p>Dr. Carillo specializes in structural characterization of complex biomolecules using mass spectrometry and NMR. At NIBRT, she develops advanced analytical strategies to better understand biomanufacturing processes and the structural complexity of biopharmaceuticals.</p></blockquote><blockquote><p><strong>Presenter: </strong>Dr. Kai Sheffler (Senior Manager, Product Manager for BioPharma Workflows, Thermo Fisher Scientific)</p><p>Dr. Scheffler is a biochemist specializing in LC-MS technologies for biopharmaceutical analysis. His expertise includes peptide mapping, intact mass analysis, and impurity profiling using HRAM MS. He focuses on developing LC-MS solutions for comprehensive characterization and quality assessment of biopharmaceuticals.</p></blockquote><blockquote><p><strong>Moderator:</strong> Dr. Kelly Broster (Sr Manager, Market Development &amp;&nbsp;Collaborations, Pharma Biopharma, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Simplifying Complexity in GLP-1 Receptor Agonist Analysis: From Structural Characterization to Impurity Monitoring

Simplifying Complexity in GLP-1 Receptor Agonist Analysis: From Structural Characterization to Impurity Monitoring

Optimize LC-MS workflows for GLP-1 analysis. Master impurity profiling, peptide separation, and structural characterization of semaglutide and tirzepatide

Simplifying GLP-1 Agonist Analysis & Impurity MS

<h4><strong>One webinar, two viewing options</strong></h4><p><strong>We know you're busy, select a viewing session that works best for you.</strong></p><h5><br><strong>Viewing Options</strong></h5><p><strong>Session 1</strong></p><ul><li>Tuesday, June 23, 2026</li><li>Los Angeles: 10:00 AM PT | New York: 1:00 PM EST</li><li>Mexico City: 12:00 PM CDT</li></ul><p><strong>Session 2</strong></p><ul><li>Wednesday, June 24, 2026</li><li>London: 9:00 AM BST | Berlin: 10:00 AM CEST&nbsp;</li><li>Mumbai: 1:30 PM IST</li></ul><p>Supported Liquid Extraction (SLE) for the cleanup of biological matrices has several advantages over Solid Phase Extraction (SPE). SLE requires fewer steps and less method development compared to SPE. For most samples that can be processed by liquid-liquid extraction, SLE can usually be used to provide cleaner and faster solvent partitioning. Historically, to get the cleanest SLE extracts, halogenated solvents like dichloromethane were used for elution of target analytes from the sorbent. A supported liquid extraction (SLE) approach that produced clean extracts with high recoveries and low matrix interferences using ethyl acetate, a more sustainable organic solvent, will be presented. Results for steroids, methylmalonic acid (MMA), and underivatized estrogens in human serum, in addition to optimized LC-MS/MS conditions and LC column considerations, are also discussed.</p><h4><strong>Key Learning Points</strong></h4><ul><li>Discover how SLE provides clean extracts for LC-MS/MS quantitation at low concentrations.</li><li>Describe conditions for the extraction and analysis of MMA from human serum.</li><li>Define method parameters for low-level quantitation of estrogens without derivatization.</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>All clinical, CROs, and forensic/toxicology analysts using LC/MS-MS.</li></ul><blockquote><p><strong>Presenter: </strong>Stephanie J Marin (Sr. Global Market Development Manager - Applied Markets, Phenomenex)</p><p>Stephanie J. Marin is the Clinical and Forensics Global Market Development Manager at Phenomenex. She received her Ph.D. in chemistry from Arizona State University and has expertise in sample preparation, liquid chromatography, and mass spectrometry. She has over 10 years of experience developing and validating clinical methods from her tenure at the ARUP Institute for Clinical and Experimental Pathology. Dr Marin has worked in marketing, product development, and applications development, in addition to customer-facing roles in customer and technical support, service, and customer education and training. She has also held positions at Hamilton Company, Selerity Technologies, and Biotage, and in analytical services for specialty chemicals and polymers at Rohm and Haas (now Dow). She was also a supervisor at an EPA-certified laboratory. She is the author of over 30 peer-reviewed publications, book chapters, and over 100 abstracts presented at national and international meetings.&nbsp;</p></blockquote>

Phenomenex: Sustainable Strategies for High Sensitivity Analysis for Clinical Research LC-MS/MS Methods 

Sustainable Strategies for High Sensitivity Analysis for Clinical Research LC-MS/MS Methods

Advance clinical LC-MS/MS analysis. Discover sustainable Supported Liquid Extraction (SLE) methods for steroids, MMA, and underivatized estrogens in serum

Sustainable SLE and LC-MS/MS for Clinical Analysis

<p><strong>Advances in metabolomics and lipidomics are generating unprecedented volumes of complex data, but confident identification and biological interpretation of small molecules remain significant challenges. Limitations in annotation, data dimensionality, and reproducibility can slow discovery and reduce confidence in downstream decision‑making across clinical, translational, and applied research.</strong></p><p>In this live broadcast event, leading experts explore how next‑generation mass spectrometry technologies, ion mobility, isotope‑based filtering, and computational tools are helping researchers move from complex datasets to confident insight. Through two short, focused scientific talks, speakers will share real‑world examples of how multi‑dimensional data and advanced workflows are being used to improve metabolite and lipid annotation, accelerate small‑molecule discovery, and enable more robust and reproducible analyses.</p><p>Broadcast as a single, high‑impact session and presented in partnership with Bruker, this webinar provides practical and conceptual guidance for scientists looking to push the boundaries of metabolomics and lipidomics research using modern analytical platforms such as timsMetabo™.</p><h5><strong>This broadcast is designed for:</strong></h5><ul><li>Scientists using mass spectrometry in metabolomics, lipidomics, and small‑molecule analysis</li><li>Researchers in clinical, translational, biopharmaceutical, and toxicology settings</li><li>Teams working in biomarker discovery, exposomics, and pathway analysis</li><li>Lab leaders evaluating next‑generation MS and ion mobility platforms</li></ul><blockquote><p><strong>Speaker: </strong>Dr. Michael Witting (Deputy Head Metabolomics and Proteomics Core &amp; Executive Manager Metabolomics, Helmholtz Munich)</p><p><strong>Speaker:</strong> Prof. Pieter Dorrestein (Skaggs School of Pharmacy and Pharmaceutical Sciences, Departments of Pharmacology and Pediatrics)</p><p><strong>Speaker: </strong>Pelle Simpson (Principal Scientist, Enveda)</p><p><strong>Moderator</strong>: Cameron Smith-Craig (Pharma and Applied Sciences Editor, SelectScience)</p></blockquote>

Bruker: Next‑generation metabolomics: From annotation to discovery at scale

Next‑generation metabolomics: From annotation to discovery at scale

Advance small-molecule discovery with Bruker's next-gen metabolomics. Learn how ion mobility and timsMetabo™ improve metabolite and lipid annotation

Next-Generation Metabolomics and Lipidomics Discovery

<h3><strong>Stop Guessing, Start Separating - A Smarter Path to Robust LC Methods</strong></h3><h4><strong>Overview</strong></h4><p>Developing robust LC methods doesn’t need to rely on trial and error. In this webinar, we introduce a systematic, tiered approach to chromatographic method development - from verifying system health and understanding instrument dispersion to screening multiple column chemistries and optimizing for selectivity and robustness.</p><p>Through a real-world case study, we demonstrate how to separate a complex steroid mixture using six different column chemistries, including our new ACQUITY™ Biphenyl RP column, which delivers notable selectivity advantages for this challenging application.</p><p>Join us to see how a structured screening strategy can accelerate method development and help you make confident, data-driven decisions for your next chromatographic challenge.</p><h4><strong>Why Attend?</strong></h4><ul><li>Improve method robustness with a structured development strategy</li><li>Reduce guesswork and accelerate column selection decisions</li><li>Compare multiple column chemistries for challenging separations</li><li>Understand how system dispersion impacts chromatographic performance</li><li>Apply a proven workflow to your next LC method challenge</li></ul><blockquote><p><strong>Speaker: </strong>Tobias Langrock (Senior Application Specialist Chemistry, Europe, Waters Corporation)</p><p>During his time as a PhD student Tobias discovered his passion for LC and LC-MS/MS and has not lost it since. Joining Waters in 2008 was the perfect opportunity to expand his understanding and expertise in chromatography and mass spectrometry. Since then, he has been involved with a very wide range of instruments and applications, whether small or large molecules, reversed phase LC, IEX or SEC, SFC or GPC. His focus is always on the customers and their daily chromatographic challenges.</p></blockquote>

Creating Better Chromatographic Methods Using a Systematic Approach

Master robust LC method development. Discover a systematic tiered workflow to screen column chemistries and optimize challenging steroid separations

Creating Better Chromatographic Methods

<h4><strong>DMPK workflows, not workarounds</strong></h4><p>Current LC-MS/MS platforms can routinely achieve sub ng/mL levels of sensitivity for large molecule bioanalysis. However, as therapeutic modalities become more effective, or as the delivery mechanism changes from IV to oral, there is an increasing demand for bioanalytical workflows that can achieve even lower levels of sensitivity.</p><p>Join us to learn how moving to microflow can allow you to improve your limits of quantification, and unlock the full potential of the complete, end-to-end bioanalytical workflow.</p><h5><strong>Topics we’ll explore</strong></h5><ul><li>Advantages of using microflow to improve sensitivity for large molecule bioanalysis</li><li>Key learnings for deploying microflow LC-MS/MS in routine bioanalytical environments</li><li>How using microflow can help reduce solvent usage, increase cost savings and reduce environmental footprint</li></ul><h5><strong>Who should attend</strong></h5><p>This webinar is designed for Research Associates, Scientists, Directors, Lab managers in pharma, biopharma, biotech and contract research organizations performing bioanalysis.</p><blockquote><p><strong>Speaker: </strong>Dr. Robert Plumb (Scientific Advisor, DMPK, Pharma Quan Program, Waters Corporation)</p><p>Dr Plumb is currently a scientific advisor in the LCMS Business Unit at Waters Corporation. &nbsp;He has several years of experience in the pharmaceutical industry beginning in 1987 at Glaxo R&amp;D DMPK Department focusing on regulatory bioanalysis and metabolite identification.</p><p>In 2001 he moved to Waters Corporation in Milford, MA, USA where he has worked in R&amp;D, pharmaceutical business development, metabolic phenotyping and discovery omics.</p><p>Research interest includes application of fast chromatography and advanced mass spectrometry in bioanalysis and omics studies. Dr Plumb has published over 150 papers on LC/MS(MS) and NMR for bioanalysis, metabolomics and metabolite identification.</p></blockquote><blockquote><p><strong>Speaker: </strong>Nikunj Tanna (Pharma Marketing Manager, Waters Corporation)</p><p>Nikunj Tanna is the Pharma Marketing Manager at Waters corporation. His role at Waters focuses on complete workflow solutions for quantitation of small and large molecules.</p><p>These end-to-end workflows include automation, novel sample preparation and chromatographic separation approaches, followed by detection using TQ platforms.</p></blockquote>

Lower the Flow to see even more

Maximize large molecule bioanalysis sensitivity. Discover how microflow LC-MS/MS enhances limits of quantification and lowers laboratory solvent costs

Lower the Flow to See More: Microflow LC-MS/MS Benefits

<p><strong>Whether you’re starting a new method or running a routine one, having a checklist to review before starting can help avoid chromatography problems.</strong></p><h4><strong>In this webinar, we will discuss:</strong></h4><ul><li>Sample characteristics (target analytes, matrix, etc.) and how to prepare the sample for LC analysis</li><li>Which supplies to use to get the best results possible</li><li>How to select the appropriate column, equilibrate it, benchmark it with your system, and how to take care of it</li><li>Getting to know your LC system, the importance of maintenance and having a “housekeeping” list.</li></ul><blockquote><p><strong>Speaker:</strong> Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)</p><p>Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.</p><p>Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.</p><p>Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.</p></blockquote>

Agilent Technologies: Becoming A Better Chromatographer Webinar Series

Preparing for LC Analysis: What to Consider Ahead of Time

Master LC analysis preparation. Discover essential checklists for sample matrix prep, column benchmarking, and routine liquid chromatography maintenance

Preparing for LC Analysis: Checklists and Maintenance

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Analytical laboratories face a challenging reality: Lower regulatory limits demand higher sensitivity, yet complex sample matrices can compromise data precision and instrument uptime. Shimadzu's latest LCMS-8065XE addresses this challenge with advanced ion source design, optimised ion transmission, and ultra-fast polarity switching technology.</strong></p><p>In this webinar, we will analyze real-world performance data demonstrating how LCMS-8065XE enables high sensitivity analysis even in complex matrices. You will see how to maintain exceptional quantitative precision during rapid chromatographic runs across environmental, pharmaceutical, and food safety workflows.</p><h4><strong>Learning Objectives</strong></h4><ul><li>Explore the engineering innovations behind the LCMS-8065XE that deliver a new benchmark in triple quadrupole sensitivity and ion transmission</li><li>Learn how improved sensitivity and signal stability can be translated into ROI - maximize daily throughput, reduced downtime, and increase overall data confidence</li><li>See how the LCMS-8065XE seamlessly integrates into a complete, high-efficiency LCMS workflow</li></ul><blockquote><p><strong>Presenter: </strong>Yap Siew Qi (Senior Product Specialist (LCMS), Shimadzu (Asia Pacific), Pte Ltd</p></blockquote></div></div></div>

Shimadzu: Meet LCMS-8065XE: Achieving High-Throughput Ultra-Trace Analysis 

Meet LCMS-8065XE: Achieving High-Throughput Ultra-Trace Analysis

we will analyze real-world performance data demonstrating how LCMS-8065XE enables high sensitivity analysis even in complex matrices.

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