Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer’s Disease Using OrbiSIMS and LC-MS/MS

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 30th September 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Shimadzu, Thermo Fisher Scientific, Waters Corporation, and Metrohm and a tech nical note by Agilent Technologies!<h4>1. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_openlab_oligo_analysis_accelerator_5994_7798en_agilent_d8503d3d3c.pdf">Purity, Assay, and Impurity Profiling of Single-Stranded Oligonucleotides Using Agilent Oligo Analysis Accelerator for OpenLab CDS</a></h4><ul><li>Technical note</li></ul>IntroductionChallenges with therapeutic synthetic oligonucleotides include determining the sample purity, label claim or assay, and quantitation of impurities. Traditional HPLC methods that rely on 260 nm UV detection may not have the necessary sensitivity or specificity for quality control (QC) testing. Using a more selective detector such as a mass spectrometer is a viable approach for QC testing needs. Although LC/MS methods are a mainstay for characterization of oligos, many high-resolution accurate mass detectors may not have the robustness needed in a routine testing environment such as QC. Additionally, a high level of technical expertise is often required for MS operation, data analysis, and data interpretation.A more practical approach uses a single quadrupole detector that is both sufficiently selective and sensitive enough for purity, assay, and impurity profiling of oligos. Given its relatively high mass range and sensitivity in full scan mode, the Agilent InfinityLab LC/MSD XT can meet the demands for LC/MS QC.As demonstrated by Rentel et al.,1 the LC/MSD XT can be used and validated for the QC lot release of oligos. However, one challenge that remains is the complex, multistep data analysis which requires the extraction of several extracted ion chromatograms and manual integrations. Performing these operations in a chromatography data system (CDS) while meeting compliance requirements can be time consuming. Manual transcriptions by the analyst may lead to a high margin of error, further delaying decision making.This technical overview will address the Oligo Analysis Accelerator (OAA) for Agilent OpenLab CDS. This software add-on acts as the data analysis front end to OpenLab CDS, leveraging built-in technical controls that help meet data integrity and compliance requirements. By performing overlays, integrations, and calculations in a fit-for-purpose user interface, data analysis is significantly streamlined. This not only saves time-on-task but also improves data quality.SummaryThe final step in the workflow is to review the results. This includes the SST results shown in previous steps, as well as purity and identity results. Assay results may vary depending on which formulation was selected for the sample.It is important to note that the summary itself is not the report. An OpenLab CDS report template must still be used to report the results for review. Further, any electronic signatures and approvals occur within OpenLab CDS, not in OAA. Again, this is because OAA leverages the already existing data compliance engine within the OpenLab CDS platform.Future considerationsLC/MS data analytical workflows have been confined to data systems either used to interpret spectra or chromatograms. However, the need for more user-friendly, fit-for-purpose data analysis is becoming increasingly important for the development of complex therapeutics such as oligonucleotides.&nbsp;Agilent Oligo Analysis Accelerator for OpenLab CDS is a paradigm shift in the way software is being developed.<h4>2. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008495_en_8ac74493e3.pdf">Repeatability and Reproducibility of the Oasis™ WAX/GCB for PFAS Analysis Cartridges in Aqueous Samples for EPA Method 1633</a></h4><ul><li>Application</li></ul>AbstractIn January 2024, EPA Method 1633 was finalized. EPA Method 1633 is the first method to incorporate the determination of 40 PFAS compounds across many challenging environmental sample matrices outside of drinking water, including non-potable waters (ground water, surface water, and wastewater) as well as soil, biosolids, and tissue by LC-MS/MS analysis. EPA Method 1633 requires use of both weak anion exchange (WAX) solid phase extraction with graphitized carbon black (GCB) cleanup and is a performance-based method allowing for modifications as long as acceptance criteria for recoveries and %RSDs are met.This application note highlights the sample extraction for non-potable aqueous samples in EPA Method 1633 using a dual-phase, or bilayer cartridge: Oasis WAX/GCB for PFAS Analysis meeting the method acceptance criteria and displays reproducibility of the cartridges.Benefits<ul><li>Oasis WAX/GCB for PFAS Analysis, a dual-phase cartridge is reproducible and repeatable for EPA Method 1633 aqueous samples in both inter- and intra-batch assays</li><li>Reduction of manual steps, overall sample preparation time by use of the dual-phase SPE cartridge</li><li>Acceptance criteria for recoveries and %RSDs are met for EPA Method 1633 for aqueous samples</li></ul>ConclusionThis study demonstrates the reproducibility of the dual-phase Oasis WAX/GCB for PFAS Analysis cartridges for determination of 40 PFAS and standards using the ACQUITY UPLC I-Class System and Xevo TQ-XS Mass Spectrometer. The cartridges are suitable for PFAS analysis in accordance with EPA 1633 guidelines for recovery and %RSD. The WAX/GCB cartridges show excellent repeatability across multiple product lots and within multiple replicates of each lot across non-potable water samples. The data demonstrates Oasis WAX/GCB for PFAS Analysis cartridges are ideally suited for PFAS analysis from complex matrices, such as non-potable waters like those described in EPA Method 1633. Out of the box performance is expected lot to lot and within a lot for SPE when using Oasis WAX/GCB for PFAS Analysis.<h4>3. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ab_003164_en_dllme_triplus_pfas_15478b8469.pdf">Dispersive liquid-liquid micro-extraction for the automated sample preparation of PFAS in drinking water</a></h4><ul><li>Application</li></ul>Application benefits<ul><li>Improved sensitivity: DLLME provides high enrichment factors, which can improve the detection sensitivity of PFAS in drinking water samples, down to challenging regulatory detection and reporting limits.</li><li>Cost-effective: DLLME uses a small volume of solvent, which not only reduces the cost but also makes the method more environmentally friendly.</li><li>Versatility: DLLME can be employed for the analysis of a wide range of PFAS classes, followed by either high performance liquid chromatography or gas chromatography as a separation technique, coupled to tandem mass spectrometry or high-resolution accurate mass as detection method.</li></ul>GoalTo demonstrate a comprehensive method for the analysis of per- and polyfluoroalkyl substances (PFAS) by harnessing the potential of automated sample preparation on the Thermo Scientific™ TriPlus™ RSH SMART liquid handling station, with dispersive liquid-liquid micro extraction (DLLME) as a simple, cost-effective, and versatile extraction and pre-concentration technique. This was performed on LC-MS, but the same workflow can be also applied to GC-MS.Keywords: DLLME, PFAS, sample preparation, automation, liquid handling, drinking waterConclusionsThe DLLME method presented in this work is a promising technique for the extraction and pre-concentration of PFAS from drinking water samples. Thanks to the described careful optimization and validation of the method, it provides an automated, fast, efficient, and green alternative to traditional and manual extraction methods. As compared to SPE procedures, the only manual steps consist in adding internal standards and an acidic solution to the sample, and then the TriPlus RSH SMART instrument will perform the extraction automatically, while for SPE procedures, the rest of the steps are mostly manual. This workflow allows laboratories to overcome the challenges associated with this analysis, providing high enrichment factors for all the different compound classes studied, as well as good reproducibility and robustness of the extraction process. In summary, the presented automated DLLME sample preparation has the following advantages:<ul><li>Reduced sample volume (15 mL) for easy sample handling, transportation, and storage.</li><li>Cost reduced by low solvent usage and no need for filters or SPE cartridges.</li><li>Automation enables reproducible and accurate results, with low inner- and cross-contamination.</li><li>Short runtime and automated process managed by Chromeleon software saves time and allows staff to perform more profitable activities.</li><li>The short runtime of the TriPlus RSH SMART instrument opens the possibility to feed one or more analytical instruments, including HPLC-MS or GC-MS technologies.</li><li>The extraction protocol without using filters and based on the use of low-density solvent for extraction can open the way for the extraction of other matrices such as wastewater.</li></ul><h4>4. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00658_en_79d68e6421.pdf">Efficient Data Analysis with Peakintelligence - Application for Analyzing Per- and Polyfluoroalkyl Substances (PFAS)</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Peakintelligence peak integration software substantially reduces the time and effort required for data analysis in PFAS analysis.</li><li>Since it does not require parameter settings, Peakintelligence allows even inexperienced users to perform peak integration and achieve results on par with experienced workers.</li></ul>IntroductionPer- and polyfluoroalkyl substances (PFAS) are lyophobic, heat resistant, and chemically resistant compounds used extensively as coatings, surface treatment agents, emulsifiers, and fire-extinguishing agents. Concerns about PFAS and their persistence in the environment, accumulation in living organisms, toxicity to living organisms, and ability to travel long distances have recently led to fact-finding studies on PFAS and the introduction of regulations. As of October 2023, only three PFAS are subject to regulatory restrictions in Japan (PFOS, PFOA, and PFHxS), but more are subject to restrictions in the USA and Europe. Throughout the world, an increasing number of PFAS are expected to require analysis. These changes will create more analytical data that will have to be processed, creating a need for more efficient methods of data analysis.Peakintelligence is a peak integration software equipped with peak-finding algorithms that have been developed with the help of artificial intelligence (AI). This Application News describes a case example in which it was used to process chromatogram data of PFAS analysis and reduce the effort required and increase the efficiency of the analysis.ConclusionUsing Peakintelligence to process peaks in PFAS analysis substantially reduced the number of false detections and falsely identified peaks. It also significantly reduced the number of peaks that required manual processing, and it did not need pre-analysis adjustment of parameters. These improvements enable substantial reductions in the time and effort required to perform data analysis. Avoiding parameter settings by the user also eliminates variability in the results between users, which helps eliminate dependency on specific personnel. As the number of PFAS requiring analysis increases throughout the world, a more efficient method of analyzing peaks will be needed; Peakintelligence is an effective solution for this need.<h4>5. Metrohm: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_v_239_download_6884b899af.pdf">Iron speciation in LiFePO4 batteries</a></h4><ul><li>Application</li></ul><h5>Simultaneous determination of Fe(II) and Fe(III) in lithium iron phosphate with the Multi-Mode Electrode pro</h5>Lithium iron phosphate (also known as LiFePO4 or lfp) batteries last for over 2000 charges and are safer because of their lower risk of overheating. LiFePO4 batteries have a slightly lower energy density compared to lithium-ion batteries. However, high discharge rates of lfp batteries make them ideal for electric vehicles, renewable energy storage, and backup power systems. Lithium iron(II) phosphate is used as a cathode material in lithium iron phosphate batteries. Characterization of lfp and monitoring the oxidation state of iron in lfp batteries is relevant to battery performance in terms of durability, capacity, and safety. Additionally, analyzing chemical composition can be useful for battery research and can aid eco-friendly recycling practices. This is essential for driving battery technology forward and promoting clean energy solutions.Polarographic speciation of Fe(II) and Fe(III) can be used to evaluate the purity of LiFePO4 and its usability as a cathode material in lithium iron phosphate batteries. It can further be used to study the concentrations of Fe(II) and Fe(III) in the cathode material after several charging and discharging cycles to evaluate the aging behavior.

News from LabRulezLCMS Library - Week 40, 2024

What chemicals are we exposed to on a daily basis? That is the central question of ‘non-targeted analysis’ or NTA, an emerging field of analytical science that aims to identify all chemicals around us. A daunting task, because how can you be sure to detect everything if you don’t know exactly what you’re looking for? In a paper in Environmental Science and Technology, researchers at the Universities of Amsterdam (UvA, the Netherlands) and Queensland (UQ, Australia) assess this problem. In a meta-analysis of NTA results published over the past six years, they estimate that less than 2% of all chemicals have been identified.According to Viktoriia Turkina who performed the research as a PhD student with Dr Saer Samanipour&nbsp; at the UvA’s Van ‘t Hoff Institute for Molecular Sciences, this limitation underscores the urgent need for a more proactive approach to chemical monitoring and management. “We need to incorporate more data-driven strategies into our studies to be able to effectively protect the human and environmental health”, she says.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Viktoriia_Turkina_de5a1652e1.jpg" alt="University of Amsterdam / HIMS: Viktoriia Turkina." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Viktoriia_Turkina_de5a1652e1.jpg 164w," sizes="100vw" width="700" height="665">Samanipour explains that current monitoring of chemicals is rather limited since it’s expensive, time consuming, and requires specialized experts. “As an example, in the Netherlands we have one of the most sophisticated monitoring programs for chemicals known to be of concern to human health. Yet we target less than 1000 chemicals. There are far more chemicals out there that we don't know about.”<h4>A vast chemical space</h4>To deal with those chemicals, some 15 to 20 years ago the concept of non-targeted analysis was introduced to look at possible exposure in an unbiased manner. The idea is to take a sample from the environment (air, water, soil, sewer sludge) or the human body (hair, blood, etc ) and analyse it using well-established analytical techniques such as chromatography coupled with high resolution mass spectroscopy. The challenge then is to trace the obtained signal back to the structures of chemicals that may be present in the sample. This will include already known&nbsp; chemicals, but also chemicals of which the potential presence in the environment is yet unknown.In theory, this ‘chemical space’ includes as many as 1060 compounds, an incomprehensible number that exceeds the number of stars in the universe by far. On the other hand, the number of organic and inorganic substances published in the scientific literature and public databases is estimated at around 180 million. To make their research even more manageable, Turkina, Samanipour and co-workers focused on a subset of 60.000 well-described compounds from the NORMAN database. Turkina: “This served as the reference to establish what is covered in NTA studies, and more importantly, to develop an idea about what is being overlooked.”<blockquote>The vast ‘exposome’ of chemicals that humans are exposed to on a daily basis is a sign of our times, according to Samanipour. “These days we are soaking in a giant ocean of chemicals. The chemical industry is part of that, but also nature is running all a whole bunch of reactions that result in exposure. And we expose ourselves to chemicals by the stuff we use - think for instance of the problem of microplastics. To solve all this we have to be able to go beyond pointing fingers. With our research, we hope to contribute to finding a solution together. Because we all are in the same boat.”</blockquote><div><div><div><div><h4>Much room for improvement</h4>The meta analysis, which included 57 NTA papers, revealed that only around 2% of the estimated chemical space was covered. This can indicate that the actual exposure to chemicals is indeed quite low, however, it can also point to shortcomings in the applied analyses. According to Turkina and Samanipour, the latter is indeed the case. They focused on NTA studies applying liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) -one of the most comprehensive methods for the analysis of complex environmental and biological samples.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Saer_Samanipour_5c78a79b5b.jpg" alt="University of Amsterdam / HIMS: Saer Samanipour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Saer_Samanipour_5c78a79b5b.jpg 180w," sizes="100vw" width="700" height="606"><div>It turned out that there was much room for improvement. For instance in sample preparation, they observed a bias towards specific compounds rather than capturing a more diverse set of chemicals. They also observed poor selection and inconsistent reporting of LC-HRMS parameters and data acquisition methods. “In general”, Samanipour says, “the chemical analysis community is to a great extent driven by the available technology that vendors have developed for specific analysis purposes. Thus the instrumental set-up and data processing methods are rather limited when it comes to non-targeted analysis.”To Samanipour, the NTA approach is definitely worth pursuing. “But we need to develop it further and push it forward. Together with vendors we can develop new powerful and more versatile analytical technologies, as well as effective data analysis protocols.” He also advocates a data-driven approach were the theoretical chemical space is ‘back calculated’&nbsp; towards a subset of chemicals that are highly likely to be present in our environment. “Basically we have to better understand what is the true chemical space of exposure. And once those boundaries are defined, then it becomes a lot easier to assess that number of 2% we have determined.”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_EST_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Distribution_of_all_chemicals_found_in_the_reviewed_articles_orange_overlaid_on_top_6a16bff0b0.jpg" alt="University of Amsterdam / HIMS / EST: Distribution of all chemicals found in the reviewed articles (orange), overlaid on top." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_EST_There_is_much_to_improve_in_identifying_all_the_chemicals_around_us_Distribution_of_all_chemicals_found_in_the_reviewed_articles_orange_overlaid_on_top_6a16bff0b0.jpg 245w," sizes="100vw" width="777" height="441"></div></div></div></div></div>

There is much to improve in identifying all the chemicals around us 

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The University of Amsterdam is one of the largest comprehensive universities in Europe. With some 40,000 students, 6,000 staff, 3,000 PhD candidates, and an annual budget of more than 850 million euros, it is also one of Amsterdam’s biggest employers.

There is an inseparable link between the university and its host city. The freedom and creativity with which Amsterdam has long been associated have worked their way into the fabric of the university. This is a place where individuality, authenticity and diversity are celebrated as sources of stimulation, inspiration and innovation.

Professional and personal development, challenges and collaboration are undertaken in a versatile and multidimensional (inter)national ecosystem with leading stakeholders. Staff at the UvA make a meaningful contribution to uncovering solutions to some of the world’s most significant problems and to developing the next generation of talent.

University of Amsterdam

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Thermo Fisher Scientific

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Waters Corporation

<h3>Solving Problems That Matter - a Waters webinar series featuring USP speakers</h3>
<h3>Episode 11: Complex excipients: LG Polymers</h3>
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Presenter: Peng Zhang (US Pharmacopeia)
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Presenter: Michelle Chen (Sr Director, Research and Development, Waters l Wyatt Technology)
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Dr. Michelle Chen is a senior director at Waters | Wyatt Technology located in Santa Barbara, California. Michelle obtained her Ph.D. from the Chemical Engineering Department at Yale University, where she focused on developing novel HPLC approaches for high-speed and high-efficiency separations of biopolymers. Since joining Wyatt, Michelle has incorporated multi-angle light scattering and dynamic light scattering detection with HPLC and field-flow fractionation, for characterizing synthetic and biological polymers, proteins, and nanoparticles. In recent years she has led the application team at Wyatt Technology to develop novel methods to characterize and quantify emerging therapeutics and delivery vehicles including new protein conjugates, viral vectors, lipid nanoparticles, and extracellular vesicles.
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Moderated by: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas, Waters Corporation)
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Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.
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Waters Corporation: Solving Problems That Matter - a Waters webinar series featuring USP speakers.

Complex excipients: LG Polymers

Solving Problems That Matter - a Waters webinar series featuring USP speakers. Episode 11: Complex excipients: LG Polymers.

Learn how Light Scattering can benefit your drug development!
A critical step in the development process for an antibody drug conjugate (ADC) is establishing scientifically sound analytical methods that measure key product quality attributes to support pre-clinical activities and downstream clinical release and stability testing. By leveraging key technologies and platform analytical methods, drug developers can expedite an early-phase biologics’ path to IND by removing analytical method development from the critical path.
Join us on an exploration of the analytical characterization required to confidently assess the ID, safety and efficacy of an antibody drug conjugate (ADC). We will start with a practitioners view on the requisite analytics and then shift to several case studies where multiple techniques, from mass spectrometry to light scattering, were used to interrogate these complex protein conjugates.
This webinar promises a comprehensive look at the analytical processes and technologies needed to successfully advance ADC development.
Key learning topics:
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<li>How to assess Identification, safety and efficacy of ADCs
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<li>The requirements for characterisation are for ADCs
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<li>How multiple techniques (such as mass spectrometry and light scattering) can be used together to understand complex protein conjugates.
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</ul>
 Who should attend?
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<li>Quality Control and Drug Development Analytical Scientists, Lab Managers and Scientific Directors who are working with ADC characterisation or protein therapeutics in Pharma</li>
</ul>
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Presenter: Eric Miller (Abzena)
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Dr. Eric Miller is an accomplished professional with a strong background in analytical chemistry. He has made significant contributions to the biotech industry, particularly through his work on the LabZient™ Analytical Platform.
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Eric began his journey as a Scientist at ClinMet. He has worked for Agilent Technologies and Pacira Pharmaceuticals before joining Abzena as Senior Director, Scientific Project Leaders, Analytical.
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His expertise lies in addressing the unique needs of biopharmaceuticals.
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Presenter: Colette Quinn, Ph.D. (Sr. Business Development Manager, Waters Corporation)
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Colette Quinn is a Sr. business development manager in the biopharmaceutical group at Waters Corporation. Her focus is around biophysical solutions and how to integrate biophysical and biochemical approaches to enable a “totality of evidence” based approach to problems.
</blockquote>

Waters Corporation: Learning Advanced Analytical Technologies to Expedite the development of Antibody Drug Conjugates

Learning Advanced Analytical Technologies to Expedite the development of Antibody Drug Conjugates

Learn how Light Scattering can benefit your drug development.

Analytical Technologies for Antibody Drug Conjugates

Learn how Light Scattering can benefit your drug development!
The scientific community aims to enhance transparency and reliability in published research, with a specific focus on the quality of biological reagents, notably recombinant proteins. Concerns have been raised regarding irreproducible results, prompting discussions on common quality issues associated with recombinant proteins and their impact on downstream applications. In response, professionals in protein purification and characterization have collaboratively developed guidelines for improved quality control.
These guidelines include minimal information requirements for protein identity, production parameters, and long-term stability, as well as a minimal set of quality tests for purity, homogeneity, and identity. Additional recommendations cover DNA contamination, “spectral and thermal denaturation signatures”, homogeneity, “competent fraction”, storage conditions, batch-to-batch reproducibility, and other factors based on intended applications. 
Evaluation of these guidelines over a one-year period suggests that their implementation can enhance experimental reliability and optimize protein quality. Investing in protein QC benefits all stakeholders in life sciences, including researchers, editors, and funding agencies, by improving data accuracy and minimizing resource wastage
Key learning topics:
<ul>
<li>The latest guidelines for Quality control of Protein purification and characterisation 
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<li>How these guidelines can enhance reliability and improve protein quality in your labs
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<li>How to reduce wastage and improve data accuracy in protein quality control
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Who should attend?
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<li>Lab Managers and Scientists working in upstream recombinant protein production and QC
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<li>Lab Managers and Scientists working in downstream protein purification QC
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</ul>
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Presenter: Dr. André Matagne (Full Professor, University of Liège, Belgium)
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Dr. Matange is a Full Professor at the University of Liège, Belgium, where he is the chair at the Centre for Protein Engineering within the Faculty of Sciences.
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With a background in biochemistry, his research is primarily focused on proteins, particularly exploring their folding, stability, and biological activity. Notably, he has played a pivotal role in the development of Robotein®, an advanced technological platform designed for to high throughput protein expression, purification, formulation, and analysis.
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Since 2016, Dr.Matagnehas been honored as an elected titular member of the Royal Academy of Sciences in Belgium.
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Waters Corporation: Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Quality Control of Purified Proteins to Improve Research

From developability assessment to commercial manufacturing, the development of biopharmaceutical drug products entails multiple characterization challenges, made all the more complex when considering the range of diverse molecular formats from proteins to advanced therapy medicinal products (ATMPs).
Light scattering technologies provide key characterization tools that are key to addressing many of these challenges. Chief among these are multi-angle light scattering coupled to size-exclusion chromatography (SEC-MALS) and dynamic light scattering (DLS) performed without separation. Both techniques determine essential biophysical attributes in an absolute manner, rapidly and with no need for calibration against reference material or laborious sample preparation.
Following an introduction to light scattering technology and applications, this webinar will cover three case studies in the uses of SEC-MALS and DLS to characterize different types of biopharmaceuticals: antibodies, pegylated enzyme therapeutics and polyA-LNP. Attributes measured range from size and polydispersity, molar mass distribution and PEG-protein ratio to solution viscosity. These studies showcase the effectiveness of light scattering in supporting biopharmaceutical development towards successful commercialization.
Key Learning Objectives:
<ul>
<li>Strategies for assessing developability and optimizing drug formulations.
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<li>Technology and applications of light scattering for biopharmaceutical characterization.
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<li>Application of advanced analytical techniques (DLS, SEC-MALS) for biopharmaceutical characterization.
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<li>Addressing challenges specific to different biopharmaceutical molecule formats.
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Presenter: Andrei Hutanu, Ph.D. (ten23 health)
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Andrei Hutanu attended the Technical University of Munich from 2012-2018 where he got his degree in Biochemistry. He then started his Ph.D. at F. Hoffmann - La Roche Ltd with research focus on enhancing capillary electrophoresis (CE) methods for biopharmaceuticals. During his Ph.D., Andrei has established analytical methods for new modalities like mAb co-formulations and bispecific mAbs. In 2019, he switched his focus to method development for cell and gene therapy products with a special focus on recombinant adeno associated viruses. Since 2023, he is part of the analytical development team of ten23, a CDMO that aims to develop, manufacture, and test tomorrow’s medicines.
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Presenter: Michal M. Raczy, Ph.D. (ten23 health)
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Dr. Michal M. Raczy is a Senior Scientist for Drug Product Design at ten23 health. Since joining the company in January 2022, he has led formulation and process development projects, while also driving innovation within biologics and surfactants analytics. With a strong background in chemistry and nanotechnology, Dr. Raczy obtained his PhD in molecular engineering from the University of Chicago (USA). During his doctoral studies, he conducted research on novel drug delivery systems and immunomodulatory biomaterials, leading to several published papers in prestigious peer-reviewed journals.
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Presenter: Daniel Some, Ph.D. (Waters | Wyatt Technology)
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Dan Some leads product marketing for Wyatt’s process analytical and macromolecular interaction instrumentation. Prior to joining Wyatt he was involved in semiconductor and military electro-optics industries. Dan obtained his Ph.D in Physics from Brown University and carried out postdoctoral research at Los Alamos National Lab and Weizmann Institute of Science.
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Waters Corporation: Developing Diverse Biopharmaceuticals with Light Scattering

Developing Diverse Biopharmaceuticals with Light Scattering

Strategies for assessing developability and optimizing drug formulations.

Heightened interest in mRNA therapeutics has accelerated the need for analytical methodologies that facilitate the production of supplies for clinical trials. This webinar will present a concise panel of chromatography-based stability-indicating assays for evaluating thermally stressed in vitro transcribed mRNA as part of a forced degradation study.Our expert speakers will demonstrate the application of these methods to evaluate the critical quality attributes (CQAs) of mRNAs as well as to detect intrinsic process- and product-related impurities.<h4>Key learning objectives</h4><ul><li>Characterization of thermally stressed mRNA using a panel of chromatographic assays</li><li>Implementation of SEC-MALS to confirm transcripts reflect full-length sequence design</li><li>Platform 5’ cap/3’ tail analyses, circumventing antisense probe design</li><li>Design of QC-friendly methods fit for research, release, and comparability testing</li></ul><h4>Who should attend?</h4><ul><li>QC lab technicians or lab assistants.</li><li>Lab managers of development, process development, or QC.</li><li>Directors/Senior directors of development, process development or QC</li><li>VP of Quality; VP of Development or VP of CMC.</li><li>Anyone interested in learning more about light scattering and its applications on mRNA characterization.</li><li>Industry and academic researchers working in gene therapy and biotherapeutics.</li><li>Any scientist in discovery, development, and quality control.</li></ul><blockquote>Presenter: Jaclyn Cika (Scientist – Protein Biochemistry group, Regeneron)Jaclyn Cika joined the Protein Biochemistry group at Regeneron Pharmaceuticals in 2019. She provides late-stage development and commercial support through the biophysical characterization of Regeneron antibody and AAV reference standards. She also oversees the qualification status of various SEC-MALS systems, and is responsible for SEC-MALS method qualification for commercial products. Additionally, she focuses on the biophysical characterization of nucleic acids, primarily using light scattering techniques, for early research and development support.Presenter:&nbsp;James Greco (Regional Account Manager, Wyatt Technology, Waters | Wyatt Technology)James Greco is a Regional Account Manager at Wyatt Technology, bringing over 16 years of experience in the biopharma industry. He has a B.Sc. in Biology from Salve Regina University. He began his career at BMS, where he spent eight years specializing in biophysical characterization. In 2017, he joined Wyatt Technology as a Field Application Scientist, where he supported and provided advanced training to customers across various fields. He later transitioned to his current role as Regional Account Manager.Presenter:&nbsp;Charlie Carter (Life Sciences Editor, SelectScience)</blockquote>

SelectScience: Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

The application of these methods to evaluate the critical quality attributes (CQAs) of mRNAs as well as to detect impurities.

Comprehensive chromatographic assessment of forced

Waters/Wyatt Technology's regional Midwest Virtual Dynamic Light Scattering (DLS) workshop is a great opportunity to learn more about DLS and latest DLS applications in the Biopharma and Gene Therapy fields. Get a refresher on biophysical characterization using dynamic light scattering, pick up some tips and tricks on DLS measurements using Wyatt instruments, learn about the capabilities and solutions beyond DLS and virtually interact with Wyatt scientists. Overall, learn how DLS can complement your existing suite of analytical tools. Registration is free for this event.This meeting will address several advanced topics presented by Wyatt scientists including:<ul><li>Determining size distributions and aggregation state using Dynamic Light Scattering (DLS)</li><li>Beyond size distributions: particle concentration, turbidity, viscosity, &amp; molecular weight</li><li>Zeta potential innovations: gentler, lower volume, better buffer compatibility with the new Wyatt Technology ZetaStar™</li><li>Overview of applications and case studies using the Wyatt DLS instruments in the biopharma and gene therapy space</li></ul>Who should attend:Active users of dynamic light scattering instruments seeking to learn more about advanced topics in dynamic light scattering physics and how it applies to our instruments and software.

Waters Corporation: Midwest Virtual Dynamic Light Scattering (DLS) Workshop

Midwest Virtual Dynamic Light Scattering (DLS) Workshop

Waters/Wyatt Technology's Dynamic Light Scattering (DLS) workshop about DLS and latest DLS applications in the Biopharma and Gene Therapy fields.

Details<ul><li>9:30-10:30 – Light scattering in the life sciences: biophysical characterization, from proteins to viruses and vesicles</li><li>10:30-10:45 – Coffee break</li><li>10:45-11:15 – Insights into the human chaperone system - Ofra Faust, Ph,D Weizmann</li><li>11:15-11:45 - Biophysical Characterization of RNA G-quadruplex and Protein Interactions - Neomi Winter, HUJI (MALS application)</li><li>11:45-12:30 – Wyatt solutions review, ZetaStar introduction</li><li>12:30-13:30 – Lunch break</li><li>13:30-14:00 - ZetaStar demo</li><li>14:00-14:30 - Interrogating biomolecular interactions with light scattering: CG-MALS</li><li>14:30-15:15 - Light scattering in pharma/biopharma: candidate screening to process analytics to stability characterization</li><li>15:15-15:30 – Coffee break</li><li>15:30-16:30 – ZetaStar playtime, Q&amp;A, one-on-one customer application review</li></ul><blockquote>Presenter: <span style="background-color:rgb(255,255,255);color:rgb(36,36,36);font-family:&quot;Segoe UI&quot;, &quot;Segoe UI Web (West European)&quot;, -apple-system, BlinkMacSystemFont, Roboto, &quot;Helvetica Neue&quot;, sans-serif;font-size:18px;"><span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:center;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:nowrap;widows:2;word-spacing:0px;">Dan Some, Ph.DPresenter: <span style="background-color:rgb(255,255,255);color:rgb(36,36,36);font-family:&quot;Segoe UI&quot;, &quot;Segoe UI Web (West European)&quot;, -apple-system, BlinkMacSystemFont, Roboto, &quot;Helvetica Neue&quot;, sans-serif;font-size:18px;"><span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:center;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:nowrap;widows:2;word-spacing:0px;">Ofrah Faust, Ph.DPresenter: <span style="background-color:rgb(255,255,255);color:rgb(36,36,36);font-family:&quot;Segoe UI&quot;, &quot;Segoe UI Web (West European)&quot;, -apple-system, BlinkMacSystemFont, Roboto, &quot;Helvetica Neue&quot;, sans-serif;font-size:18px;"><span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;letter-spacing:normal;orphans:2;text-align:center;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:nowrap;widows:2;word-spacing:0px;">Naomi Winter</blockquote>

Waters Corporation: Characterization of biomolecules and nanoparticles with light scattering

Characterization of biomolecules and nanoparticles with light scattering

Light scattering in the life sciences: biophysical characterization, from proteins to viruses and vesicles.

Characterization with light scattering

This dynamic symposium will include six 15-minute lightening talks featuring leading academics, industry professionals, and regulatory experts in the field of polymer research and characterization.During the event our speakers will provide cutting-edge insights into the latest developments in polymer characterization and the application of light scattering techniques. In addition to the lecture portion, we are delighted to include two live round table sessions as our speakers engage in lively discussions around topics raised by attendees and those top-of-mind in the industry. Don't miss this opportunity to connect and learn from these leading experts.<h4>Key Learnings:</h4><ul><li>Advances in light scattering and differential viscosity techniques for polymers and innovative applications</li><li>Polymers for industrial applications</li><li>Comparative analysis of complementary techniques</li><li>How to maintain quality data at high-use facilities</li><li>Regulatory considerations in the realm of polymers and light scattering</li></ul><h4>Agenda:</h4><ul><li>10:30 AM EDT - Welcome &amp; Meeting Overview, Introductions of Speakers</li><li>10:35 AM EDT - Prof. Stepan Podzimek, University of Pardubice and SYNPO "Wyatt Technology Advanced SEC/GPC Detectors Over the Past Four Decades"</li><li>10:50 AM EDT - Dr. Phil Griffin, University of Chicago (talk to be announced)</li><li>11:05 AM EDT - Prof. Timothy Lodge, University of Minnesota (talk to be announced)</li><li>11:30 AM EDT - Dr. Peng Zhang, USP "USP's Characterization of LG polymers Utilizing GPC-Multi-Angle Light Scattering and Refractive Index Techniques"</li><li>11:45 AM EDT - Roundtable 1 (all speakers)</li><li>12:00 PM EDT - Prof. Matthew Golder, University of Washington "Analyzing Cyclic Polymer Architectures Synthesized via Ruthenim Catalysis Using GPC-MALS-IV-RI"</li><li>12:15 PM EDT - Dr. Wei Gao, The Dow Chemical Company "Polymers for Industrial Applications"</li><li>12:30 PM EDT - Roundtable 2 (all speakers)</li><li>12:50 PM EDT - Wrap up</li></ul><blockquote>Presenter:&nbsp;Dr. Wei Gao (The Dow Chemical Company)&nbsp;Dr. Gao is a R&amp;D and TS&amp;D Fellow in Analytical Science, Core R&amp;D of Dow. She has made significant contributions on polymer and particle characterization using separation-based analytical techniques, sustainable polymeric product development, and has received numerous awards, including the US EPA Presidential Green Chemistry Challenge Awards and R&amp;D 100 awards. Gao is an active member of the American Chemical Society and leads advanced biodegradation platform development at Dow.Presenter:&nbsp;Prof. Stepan Podzimek (University of Pardubice and SYNPO)Prof. Podzimek holds a professorial position at the University of Pardubice and is a head of the Analytical Chemistry department at the Czech R&amp;D company SYNPO. He is also a scientific consultant for Wyatt technology focusing on applications of multi-angle light scattering for the characterization of all types of synthetic and natural polymers. He has authored over 70 scientific papers and the author of a book entitled “Light Scattering, Size Exclusion Chromatography and Asymmetric Flow Field Flow Fractionation”.Presenter:&nbsp;Prof. Timothy Lodge (University of Minnesota)Prof. Lodge is a Regents Professor and the Prager Chair in Macromolecular Science at the University of Minnesota. He is renowned for his research on polymer systems, particularly in the areas of polymer characterization and nanostructures. Lodge has received numerous prestigious awards, including the American Chemical Society's Award in Polymer Chemistry, and is a Fellow of the American Academy of Arts and Sciences and a member of the National Academy of Engineering.Presenter:&nbsp;Prof. Matthew Golder (University of Washington)Matt received his BS in Chemistry from the University of Rochester in 2010 working with Prof. Patrick Holland. Following graduation, he was a graduate student in the lab of Prof. Ramesh Jasti at Boston University/University of Oregon where he earned his PhD in 2015. Matt was then an NIH Postdoctoral Fellow in Prof. Jeremiah Johnson’s laboratory at MIT. He began his independent career in the Department of Chemistry at the University of Washington in 2019. His group works at the interface of physical organic and polymer chemistries to explore novel structural motifs for solving broad challenges across materials science.Presenter:&nbsp;Prof. Phil Griffin (University of Chicago)Dr .Griffin is an Engineering and Design, Sr. Specialist and Director of the Soft Matter Laboratory at the Pritzker School of Molecular Engineering at the University of Chicago. He supports multiple groups across the university as well as external universities and companies in their investigations into the design and development of advanced materials. He also instructs a graduate-level laboratory course focused on soft materials and regularly guest lectures in other Pritzker School of Molecular Engineering courses.&nbsp;Presenter: Dr. Peng Zhang (USP)Dr. Peng Zhang is a Principal Scientist at the United States Pharmacopeia (USP) in Rockville, MD. In his current role, he is primarily responsible for standard setting activities related to the development and update of high-priority excipient quality standards, including those for lactide (or lactic acid) and glycolide (or glycolic acid) (LG) polymers and phospholipids, under the Excipient Expert Committees. Before joined USP, he worked as an analytical scientist in the pharmaceutical industry for 10 years. He holds a Ph.D. degree in Analytical Chemistry from Vanderbilt University.</blockquote>

Waters Corporation: Light Scattering Symposium and Roundtable on Polymer Development and Analysis

Light Scattering Symposium and Roundtable on Polymer Development and Analysis

Cutting-edge insights into the latest developments in polymer characterization and the application of light scattering techniques.

Light Scattering Symposium and Roundtable on Polymer

In this webinar, we will present several case studies of how different light scattering techniques can be used for advanced characterization of biopharmaceutical samples.In particular, we will focus on dynamic light scattering (DLS), size-exclusion chromatography coupled to multi-angle light scattering (SEC-MALS) and real-time multi-angle light scattering (RT-MALS).<h4>Key Takeaways:</h4><ul><li>Learn basics of light scattering techniques &nbsp;</li><li>Distinguish between different light scattering methods – DLS, SLS, SEC-MALS, RT-MALS &nbsp;</li><li>Understand how different light scattering can be used to characterize therapeutic proteins</li></ul><h4>Who should attend:</h4><ul><li>Scientists interested in analytical characterization of biopharmaceuticals using light scattering techniques.</li></ul><blockquote>Presenter: Hristo L. Svilenov, Ph.D. (Ghent University)Dr. Svilenov is an Associate Professor in Biopharmaceutical Technology. His research interests are in the development, formulation and manufacturing aspects of biotherapeutics. Previously, Dr. Svilenov was a postdoctoral researcher funded by a Peter and Traudl Engelhorn Fellowship at the TU Munich. From 2016 to 2019, Dr. Svilenov did his PhD supported by a Marie Sklodowska-Curie Fellowship at the Ludwig Maximilian University of Munich. He defended his doctoral thesis with the highest distinctions in Germany (summa cum laude) and received the AbbVie prize and the Carl-Wilhelm-Scheele of the German Pharmaceutical Society for his work.Presenter:&nbsp;Lorenzo Gentiluomo, Ph.D. (Waters | Wyatt Technology)Lorenzo Gentiluomo, Ph.D. in Pharmaceutical Technology and currently concluding an Executive MBA, has several years of experience in drug product development. He has successfully managed the development of 26 biological drug candidates, including 3 BLA projects, during his tenure at Coriolis and Lonza. Lorenzo now serves as Senior Account Sales Manager for Wyatt Technology, overseeing the portfolio in Switzerland, where he applies his deep technical expertise to support and expand the use of advanced analytical solutions in the biopharmaceutical industry.</blockquote>

Waters Corporation: Leveraging light scattering techniques for enhanced biotherapeutic characterization and development

Leveraging light scattering techniques for enhanced biotherapeutic characterization and development

How different light scattering techniques can be used for advanced characterization of biopharmaceutical samples.

Leveraging light scattering techniques

<h4>Overview</h4>We invite you to our 2nd Annual Virtual Biosymposium. This year, we will explore novel analytical characterization and quantitation of emerging modalities, such as DNA and mRNA, along with key method development considerations with global thought leaders.We look forward to seeing you! Key Event Objectives:<ul><li>Learn about novel approaches to characterizing established and modern biotherapeutic modalities</li><li>Understand key considerations when developing characterizing and quantitating methods for biomolecules</li><li>Take a deep dive into the values of fit-for-purpose methods to make critical drug decisions</li></ul>AGENDA7:30am AM (PT) - Welcoming Introductions<ul><li>Tran N. Pham, Global Biopharma Market Development Manager at Phenomenex</li></ul>7:35 AM (PT) - "Solutions &amp; Characterization Strategies for IVT mRNA Therapy Development"<ul><li>Charles Bai, Lead Application Scientist, VectorBuilder, Chicago, USA</li></ul>8:05 AM (PT) - &nbsp;"Utilizing Size Exclusion Chromatography for the Quality Control Analysis of Gene Therapeutics”<ul><li>Rebecca Hirschberger, QC Manager Bioanalytical Implementation, and Dr. Christopher Gawlig, QC Manager Research and development, Biospring, Germany</li></ul>8:35 AM (PT) "Impurity Profiling Optimization of GalNAc-conjugated Oligonucleotides by LC-MS-UV"<ul><li>Roxana Eggleston-Rangel, Senior Applications Scientist, Phenomenex, California, USA</li></ul>9:05 AM (PT) – Round Table Q&amp;A<ul><li>Tran N. Pham, Global Biopharma Market Development Manager at Phenomenex</li></ul>9:25 AM (PT) – Closing Remarks<blockquote>Presenter: Charles Bai (Lead Application Scientist)Charles has received his PhD in Microbiology at Purdue University. As a Lead Application Scientist at VectorBuilder, his main responsibilities are to provide technical consultation for clients regarding gene delivery using viral and non-viral vectors. Regarding the application of in vitro transcribed (IVT) RNA, Charles has been helping researchers with the design, production and encapsulation of IVT mRNA, circRNA or saRNA for therapy and vaccine development.Presenter: Rebecca Hirschberger (Quality Control Bioanalytical Method Development)Rebecca has been in the chromatography industry for over 2 years and has practical experience in the quality control of gene therapeutics. She has earnt a Masters in pharmaceutical science from Ludwig-Maximilians University, Munich, focused on instrumental analytics. Since Dezember 2022 she is a licensed Pharmacist in Germany. Rebecca Hirschberger joined BioSpring in August of 2021 and she serves as QC Manager Bioanalytical Implementation. Her area of responsibility includes: Various analyses of oligonucleotides, including (tandem) mass spectrometry via qToF, biochemical techniques, i.e. ELISA, enzymatic transformation of oligonucleotides for analytical and quality control purposes and the Separation of oligonucleotides by chromatographic methods.Presenter: Roxana Eggleston-Rangel (Senior Applications Scientist, Phenomenex)Roxana joined Phenomenex in 2018 as an Applications Scientist and is currently working with the applications team to produce analytical solutions for scientist in the biopharma industry. Roxana’s current work focuses on characterization of mRNA, sgRNA and siRNA. Prior to Phenomenex, Roxana worked for Caltech and the University of Southern California developing LM-CS workflows for the proteomics community. Roxana Eggleston-Rangel received her bachelor’s and master’s degree in Chemistry and Biochemistry from California State University, Los Angeles.</blockquote>

Phenomenex: 2nd Annual Virtual Biosymposium

2nd Annual Virtual Biosymposium

Explore novel analytical characterization and quantitation of emerging modalities, such as DNA and mRNA

LCMS webinars focusing on GPC/SEC | LabRulez LCMS

Leveraging light scattering techniques for enhanced biotherapeutic characterization and development

2nd Annual Virtual Biosymposium

Complex excipients: LG Polymers

Light Scattering Symposium and Roundtable on Polymer Development and Analysis

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results

Developing Diverse Biopharmaceuticals with Light Scattering

Characterization of biomolecules and nanoparticles with light scattering

Midwest Virtual Dynamic Light Scattering (DLS) Workshop

Learning Advanced Analytical Technologies to Expedite the development of Antibody Drug Conjugates

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Leveraging light scattering techniques for enhanced biotherapeutic characterization and development

2nd Annual Virtual Biosymposium

Complex excipients: LG Polymers

Light Scattering Symposium and Roundtable on Polymer Development and Analysis

Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA

Quality Control of Purified Proteins to Improve Research Data Reproducibility: Improving the Time-Efficiency and Quality of Your Results​

Developing Diverse Biopharmaceuticals with Light Scattering

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Learning Advanced Analytical Technologies to Expedite the development of Antibody Drug Conjugates

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