<p><strong>The team of Professor&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Michal Hocek</strong></a><strong> at IOCB Prague explores the limits of the structure and function of DNA and successfully pushes forward known boundaries. An article presenting the results of their latest research has just been published in the major scientific journal </strong><i><strong>Nucleic Acids Research</strong></i><strong>. They prove that even heavily modified double helices of DNA are stable enough to be used for special applications. This discovery might expand the possibilities of utilizing modified DNA, for example, in medicine.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg" alt="ÚOCHB: Scientists from IOCB Prague are pushing the limits of DNA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg 245w," sizes="100vw" width="1910" height="1000"></p><p>DNA consists of two long negatively charged chains that hold together even though they repel each other. This is made possible by what is known as stacking interactions and base pairing. Michal Hocek and his colleagues advanced the known limits when they modified DNA by adding an extra negative charge to each letter of the genetic code. This doubled the repulsive forces, yet the DNA double helix remained stable. They also found that such modified DNA not only holds together but that it can also be synthesized or replicated and sequenced using the enzyme DNA polymerase.</p><p><i>"Think of DNA as a scaffold on which you can attach various chemical compounds with different functions. These are small molecules, such as side chains of amino acids, which occur naturally only in peptides and proteins. In current medicine, we are able to use these molecules only to a relatively limited extent. The reason is that they are markedly unstable and get decomposed rapidly when inside an organism. One solution to this would be a stable skeleton to which they could be firmly attached. And DNA could be just such a base structure in the future,"</i> says Prof. Michal Hocek.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg" alt="ÚOCHB / Tomáš Belloň: Prof. Michal Hocek, Distinguished Chair and head of Bioorganic and Medicinal Chemistry of Nucleic Acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg 234w," sizes="100vw" width="1500" height="1001"></p><p>The aim of this research carried out at IOCB Prague is to create DNA molecules that will mimic other chemical compounds. This would enable us to leverage the medicinal potential of certain biomolecules that are difficult to retain in the body. Examples of such biomolecules are the already mentioned peptides or proteins.</p><p>The Hocek group has already made significant progress, although research in this direction is at its beginning worldwide. The team has, for example, succeeded at developing a novel modified aptamer, which is a short DNA sequence that can bind to a specific target molecule, most frequently a protein. Aptamers have similar properties to antibodies, but they are much more stable. For this reason, aptamers can potentially replace antibodies employed in medicine. However, the number of approved therapeutic aptamers globally can still be counted on the fingers of one hand.</p><p>The current research exploring the limits of DNA is part of a larger project led by Michal Hocek, for which he has secured a prestigious EXPRO grant from the Czech Science Foundation. This is the second time its results have drawn interest from the journal <i>Nucleic Acids Research</i>. Previously, scientists from IOCB Prague published a method for the enzymatic synthesis of fully artificial DNA. During this synthesis, all nucleotides forming natural DNA are replaced by their modified versions with attached hydrophobic (i.e. water-repelling) molecules.</p>

Scientists from IOCB Prague are pushing the limits of DNA

<p><strong>Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease caused by the protozoan parasite </strong><i><strong>Trichomonas vaginalis</strong></i><strong>, especially because of the recent appearance of strains that are resistant to conventional treatment. In an effort to find a new weak spot of this parasite, the </strong><a target="_blank" rel="noopener noreferrer" href="https://boura.group.uochb.cz/en"><strong>research group</strong></a><strong> led by Dr. Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome. This has made it possible to gain knowledge that is indispensable for the development of new effective medicines. The research was carried out in collaboration with colleagues from the University of California San Diego. An article presenting the work has been published in the scientific journal </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p><p>The proteasome is a complex protease that works as a device for recycling old proteins in cells. It is a cylindrical enzyme complex composed of seven subunits arranged in four superposed circles. When old proteins enter this cylinder, they get broken down into small pieces later used by the cell to make new proteins. If it functions incorrectly, old proteins accumulate, leading to the cell’s demise. This is why the blocking of proteasome activity is used, for example, against certain types of malignant tumours.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg" alt="IOCB Prague / Tomáš Belloň: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg 234w," sizes="100vw" width="1500" height="1001"></p><div><p>In the same way, it should also be possible to treat the widespread sexually transmitted infection trichomoniasis, which increases the risk of contracting HIV. The aim is therefore to identify substances that block the function of the proteasome inside <i>Trichomonas vaginalis</i> cells. However, the proteasome of this single-cell organism had never been satisfactorily isolated, so the research group from IOCB Prague prepared an artificial proteasome that is identical to the natural one. Curiously, they used insect cells to do so. This part of their research, on which the success of the whole project was hinged, proved the most complicated. That the team has prevailed in describing the previously unknown structure of the parasite’s proteasome is therefore of critical importance.</p><p><i>‘The proteasome looks the same in every animal or protozoan, but the details of this cylindrical structure differ. It is these details that we need to know in order to create a substance that is toxic to the parasite but not harmful to the human body. That is a crucial precondition for drug development. Our greatest success is that we have been able to prepare a recombinant, artificial proteasome that can provide us with the necessary information,’</i> explains Evžen Bouřa.</p><p>The researchers used advanced electron microscopy, allowing them to see almost every single atom. Armed with this capability, they tested the effects of two potential proteasome-inhibiting substances. They saw how they bind to the active site of the proteasome and under what circumstances the proteasome stops working, which is fatal to the cell of the parasite.</p><p>The research was carried out within the <a target="_blank" rel="noopener noreferrer" href="https://nivb.cz/en/">National Institute of Virology and Bacteriology</a> (LX22NPO5103), funded by the <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/en/exceles">EXCELES</a> program.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg" alt="IOCB Prague: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg 245w," sizes="100vw" width="1386" height="632"></p><p>&nbsp;</p></div>

Scientists from IOCB Prague help to improve medical drugs

<p><strong>In the week of October 14, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Metrohm: Electrochemical techniques for battery research and testing</strong></h5><ul><li><div><div>Tu, 15.10.2024 10:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4337">Registration</a></div></li></ul><p>Theoretical and practical aspects of various electrochemical techniques for battery research and testing.</p><h5><strong>2.&nbsp;Waters Corporation: Leveraging light scattering techniques for enhanced biotherapeutic characterization and development</strong></h5><ul><li><div><div>Tu, 15.10.2024 10:30 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4336">Registration</a></div></li></ul><p>How different light scattering techniques can be used for advanced characterization of biopharmaceutical samples.</p><h5><strong>3.&nbsp;Thermo Fisher Scientific: Solutions for environmental and food contaminant testing</strong></h5><div><ul><li><div>Tu, 15.10.2024 10:30 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4238">Registration</a></div></li></ul></div><p>New and advancing workflows to meet and exceed European regulations.</p><h5><strong>4.&nbsp;Agilent Technologies: Single Quad mass detection for Chromatographers</strong></h5><ul><li><div><div>Tu, 15.10.2024 11:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4261">Registration</a></div></li></ul><p>We will look at the development of single quads together and highlight the possibilities offered by today's single quads and how they support the user.</p><h5><strong>5.&nbsp;Agilent Technologies: MassHunter Acquisition Q-TOF Part II – Advance Settings</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 14:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4343">Registration</a></div></li></ul></div><p>Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.</p></div><h5><strong>6.&nbsp;Thermo Fisher Scientific: High-throughput and automation in novel modalities (msAbs, ADCs, AOCs) screening, characterization, and beyond</strong></h5><ul><li><div><div>Tu, 15.10.2024 17:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4352">Registration</a></div></li></ul><p>Integrated advanced techniques such as automation and machine learning to achieve unprecedented mass spectrometry-focused sample handling capabilities and rapid turnover rates.</p><h5><strong>7.&nbsp;Phenomenex: Solid Phase Extraction Troubleshooting Tips and Tricks</strong></h5><ul><li><div><div>Tu, 15.10.2024 19:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4338">Registration</a></div></li></ul><p>Identify the common challenges associated with solid phase extraction methods.</p><h5><strong>8.&nbsp;Waters Corporation: Streamlined Proteomics with the Power of Andrew+</strong></h5><ul><li><div><div>We, 16.10.2024 11:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4339">Registration</a></div></li></ul><p>How the Andrew+ liquid handling robot has helped streamline their sample preparation workflows for proteomic analysis.</p><h5><strong>9.&nbsp;Agilent Technologies: Advancements in Host Cell Protein Analysis</strong></h5><div><ul><li><div>We, 16.10.2024 11:30 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4357">Registration</a></div></li></ul></div><p>Join us in this unique webinar where experts from Industry, pharmacopeia and Agilent will share insights on latest advancements on HCP analysis.</p><h5><strong>10.&nbsp;Waters Corporation: Free Testosterone and Free T3/T4</strong></h5><div><ul><li><div>We, 16.10.2024 14:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4356">Registration</a></div></li></ul></div><p>Simplified Equilibrium Dialysis and SPE Method for the UPLC-MS/MS Analysis of Free Thyroxine (FT4) and Triiodothyronine (FT3) for Clinical Research.</p><h5><strong>11.&nbsp;Technology Networks/Thermo Fisher Scientific: Streamlining Data for Superior Therapeutic Manufacturing</strong></h5><div><ul><li><div>We, 16.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4377">Registration</a></div></li></ul></div><p>This webinar explores how to implement digitization to accelerate decision-making, meet regulatory demands and eliminate bottlenecks in biotherapeutic development.</p><h5><strong>12.&nbsp;Waters Corporation: Analyzing mRNA and sgRNA with Advanced Enzymes, Mass Spectrometry, and Informatics</strong></h5><div><ul><li><div>We, 16.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4355">Registration</a></div></li></ul></div><p>This webinar will feature insights from Quality Assistance a leading European Contract Research Organisation (CRO) offering a range of services including mRNA and CRISPR sgRNA testing.</p><h5><strong>13.&nbsp;Separation Science/Merck: Empowering Tomorrow’s Therapeutics with LC-MS Capillary Chromatography</strong></h5><div><ul><li><div>Th, 17.10.2024 10:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4359">Registration</a></div></li></ul></div><p>This webinar emphasizes the significance of capillary HPLC coupled with mass spectrometry.</p><h5><strong>14.&nbsp;Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 2</strong></h5><div><div><ul><li><div>Th, 17.10.2024 16:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4360">Registration</a></div></li></ul></div><p>This is the second in our three-part Ask Me Anything webinar series on one of the most frequently asked about topics - processing data.</p></div><h5><strong>15.&nbsp;Waters Corporation: Nitrosamines</strong></h5><div><div><ul><li><div>Th, 17.10.2024 19:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3445">Registration</a></div></li></ul></div><p>This webinar will address analytical challenges in the detection and control of nitrosamines and Nitrosamine Drug-Substance Related Impurities (NDSRIs).</p></div>

Webinars LabRulezLCMS Week 42/2024

Article

Webinars

Scientific article

Science and research

Video

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Metrohm

Mettler-Toledo

Technology Networks

C&EN

<p><strong>Modern titration offers a simple, yet highly accurate method to ensure the quality and safety of many products we consume daily. While not a complicated technique, there are some subtleties that can ensure your titration results are accurate. Simple electrode care and optimization of basic titration parameters are crucial to helping you obtain results you can trust.</strong></p>
<p>During this webinar, Sagar Irrinki, Quality Control Manager at Coastal Gulf &amp; International, Inc. will share how his laboratory navigates executing these tests on various types of titration applications. and how to overcome challenges with helpful titration tips. Eduardo Simoes, Product Specialist for Titration at Metrohm USA, will provide guidance for electrode selection and best practices for electrode care and maintenance. Don’t miss the live Q&amp;A at the end to get all your questions answered by Sagar and Eduardo.  </p>
<h5><strong>Key Learning Objectives:</strong></h5>
<ul>
<li>Understand potentiometric electrode care and maintenance </li>
<li>Learn how to overcome titration challenges with useful tips</li>
<li>Receive simple guidelines to remove doubt from titration results </li>
<li>Learn how to select the appropriate electrode for your titration</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<ul>
<li>Anyone who wants to learn more about electrode care and maintenance</li>
<li>People interested in improving the consistency of their titration results</li>
<li>Anyone who needs a refresher on titration best practices</li>
<li>Chemists who want simple tips to improve confidence in titration analysis</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Eduardo Simoes (Titration Product Specialist, Metrohm USA)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Sagar Irrinki (Quality Control Manager, Coastal Gulf &amp; International, Inc.)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)</p>
</blockquote>


Mastering Potentiometric Titration through Effective Electrode Selection and Method Optimization

Simple electrode care and how to overcome challenges with helpful titration tips.

Mastering Potentiometric Titration

<p><em>Key Analytical Measurements to Increase Yield</em></p>
<p><strong>Semiconductor FABS are the largest industrial user of pure and ultrapure water (UPW), which are vital to quality and yield in the production of wafers and integrated circuits.</strong></p>
<p>Today&#39;s industry is challenged to produce more accurate measurements and higher-quality UPW, as well as reduce the volume of water and energy used in production; along with maintaining a focus on water reclaim, reuse, recycle.</p>
<p>With demand for semiconductors continuing to grow and rapid advancements in the industry, critical analytical parameters required for the production of UPW for improved process control and knowledge on how to use these measurements for maximum output are key.</p>
<p><strong>Program</strong></p>
<ul>
<li><p>Total Organic Carbon control to ensure detection of sub-ppb organics and prevent bacterial contamination.</p>
</li>
<li><p>Resistivity to monitor the ionic UPW quality and its quality in the RCA process and other SEMI tools.</p>
</li>
<li><p>Dissolved oxygen and its monitoring and control in UPW.</p>
</li>
<li><p>pH control as a critical parameter to the CMP process and HF, ammonia waste neutralization Recommendations for segregation of reclaim/reuse/recycle streams.</p>
</li>
<li><p>The Role and Importance of UPW Measurements.</p>
</li>
</ul>
<p><em>This webinar is by courtesy of Semiconductor Digest.</em></p>
<blockquote>
<p><strong>Presenter:</strong> Jim Cannon (Head of OEM &amp; Markets, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>After receiving a B.S. in Biology, he continued with graduate degrees in Microbiology and in Biophysics, and an MBA in Marketing and International Management. Mr. Cannon has over 40 years of experience in the management, design and development of ultrapure water treatment and technology. This includes measuring differential conductivity and UV oxidation for the detection of TOC in UPW and the design and commercialization of Electrodeionization modules. Mr. Cannon is currently involved in the standards and regulatory organizations for the Semiconductor, Photovoltaic and Pharmaceutical markets, including the facilities and liquids committee, Reclaim/Reuse/Recycle Task Force and the UPW task Force. He has also been intimately involved in the development and the commercialization of alternative online microbial detection technology.</p>
</blockquote>


Mettler-Toledo: Water Sustainability Trends in MicroE

Water Sustainability Trends in MicroE

Critical UPW measurements: Organic carbon, resistivity, dissolved oxygen, pH control. Stream segregation recommendations.

<p><strong>The metal-finishing industry faces the ongoing challenge of managing wastewater effectively, especially when treating dissolved metals such as copper and hexavalent chromium. These metals pose significant environmental risks and introduce compliance and financial challenges. Traditional ion exchange and chemical precipitation methods exhibit limitations in selectively targeting specific metals and rely on hazardous chemical handling and secondary waste product treatment. Both methods have limited effectiveness with increased metal concentrations, competing ions&#39; presence, and dissolved solids&#39; overall concentration.</strong></p>
<p>Join James Landon, Chief Technology Officer at ElectraMet, as he introduces an innovative solution to conventional dissolved metal approaches, employing an electrochemical process to efficiently remove or convert dissolved metals. Beyond treatment, both sustainability and operational optimization hinge on real-time data. Learn how online Process Analyzer Technology (PAT) can revolutionize wastewater management, offering precise, real-time monitoring and analysis.</p>
<h5><strong>Key Learning Objectives:</strong></h5>
<ul>
<li>Understand how the innovative electrochemical process overcomes challenges in metal finishing.</li>
<li>Learn how real-time monitoring and analysis can optimize the wastewater treatment process</li>
<li>Learn how integrating electrochemical processes with PAT can transform wastewater into revenue</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<ul>
<li>Process Engineers looking to optimize wastewater treatment processes or who are looking to implement PAT in their metal finishing lines</li>
<li>Sustainability and Operations Managers tasked with implementing eco-friendly practices within their organizations and overseeing the day-to-day operations of metal finishing lines</li>
<li>Environmental Compliance Officers tasked with ensuring their facilities meet regulatory standards for wastewater</li>
<li>Wastewater Treatment Consultants advising on wastewater management strategies</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> James Landon, PhD (Chief Technology Officer and Co-founder, ElectraMet)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Brett Lane (Field Applications Specialist, Process Wet Chemistry, Metrohm USA)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Ann Thayer (Contributing Editor, C&amp;EN Media Group)</p>
</blockquote>


Metrohm: Beyond Ion Exchange: Advancing Wastewater Treatment in Metal Finishing

Beyond Ion Exchange: Advancing Wastewater Treatment in Metal Finishing

Process Analyzer Technology (PAT) can revolutionize wastewater management, offering precise, real-time monitoring and analysis.

Beyond Ion Exchange: Advancing Wastewater Treatment

<p><strong>Harvest time has come for modern biotechnology and biotherapeutics, bringing a cornucopia of products – CRISPR Cas nucleases, therapeutic viruses, cells and engineered tissue constructs.</strong></p>
<p>Along with superior therapeutic efficacy, these products feature unprecedented complexity of biomolecular features and range of scales that define their identity, efficacy and safety.</p>
<p>In this webinar, our expert speaker Dr. Stefano Menegatti from NC State University, will discuss his team’s approach in leveraging affinity technology to introduce new tools for purifying and characterizing biotherapeutics to match the growing demands of clinics and biotech industries worldwide. </p>
<p><strong>Attend this webinar to:</strong></p>
<ul>
<li>Learn about affinity ligands operating in negative and positive capture mode for the continuous purification of biotherapeutics</li>
<li>Discover first of its kind RNA triggers for the purification of CRIPSR-CAS nucleases via affinity chromatography</li>
<li>Explore the complexity of EIS sensors for one-step quantification of total virus particle and empty capsid quantification</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Stefano Menegatti, PhD (Associate Professor, Chemical and Biomolecular Engineering, NC State University)</p>
</blockquote>


Technology Networks: Modernizing the Purification Toolbox for Multi-Specific Antibodies, CRISPR and Cell and Gene Therapies

Modernizing the Purification Toolbox for Multi-Specific Antibodies, CRISPR and Cell and Gene Therapies

Leveraging affinity technology to introduce new tools for purifying and characterizing biotherapeutics.

Purification of Antibodies, CRISPR, Cell and Gene Therapies

<p><strong>Insights and Strategies for Maintaining High Water Quality</strong></p>
<p><strong>Event Program</strong></p>
<ul>
<li>Common misconceptions about impurities in pharmaceutical waters</li>
<li>Differences between chemical and microbial properties in WFI and PW</li>
<li>Recommended approaches for measuring different impurities</li>
<li>Insights on maintaining a healthy water loop</li>
</ul>
<p><strong>Enhancing Quality and Safety in Pharmaceutical Manufacturing</strong></p>
<p>Without proper impurity control, pharmaceutical manufacturers risk compromising the safety and efficacy of their products. Microbial and organic impurities can enter water systems at various points in the manufacturing process and impact quality and safety.</p>
<p>Misunderstandings surrounding controlling impurities in pharma waters can lead to improper measurement and treatment approaches.</p>
<p>It is a common belief that chemical and microbiological properties in Water for Injection (WFI) and Purified Water (PW) are the same in pharmaceutical water systems. However, this is far from the truth. These properties react differently and are distributed unevenly in storage and distribution loops, which can have different effects on the health of the water system.</p>
<p>In this live roundtable discussion, we will dispel the most common myths about microbes and organics and controlling impurities in pharma waters. We will discuss the differences between chemical and microbiological properties in WFI and PW and recommend measurement approaches for each impurity. Additionally, we will cover how to maintain a healthy water loop to ensure high quality and safety in pharmaceutical manufacturing.</p>
<blockquote>
<p><strong>Presenter:</strong> Maura Rury (Senior Product Manager, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Maura manages METTLER TOLEDO&#39;s Total Organic Carbon (TOC) product line, along with related services and training. Her prior roles include marketing, product management, and technical applications at LGC and Thermo Fisher Scientific. She received her Ph.D. in Analytical Chemistry from the University of Massachusetts, Amherst.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Anthony C. Bevilacqua (Principal Scientist, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Anthony Bevilacqua earned a doctorate in Analytical/Physical Chemistry from Tufts University. Since 1994, he has led several areas of Research and Product Development that include: impact of CO2 on pure water, ultrapure water as a conductivity solution standard, development of digital sensors, and expansion of real-time analytical parameters (conductivity, TOC, microbial detection, ozone, sodium, and silica) for measurement/control of high purity water systems, including pharmaceutical water systems. Anthony was Chair of the inaugural USP Pharmaceutical Water Expert Committee from 2000-2005, and re-elected from 2005-2010. Anthony’s role continued in the 2010-2015 and 2015-2020 cycles for the USP Chemical Analysis Expert Committee, and he is currently serving on the current committee for 2020-2025.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Areen Kalantari (Global Segment Manager, Pharma &amp; Life Sciences, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Areen Kalantari holds a B.S. in Biological/Chemical Engineering and a Master of Business Administration (MBA) in International Business. He has experience in both biotechnology applications and pharmaceutical waters. Areen is a voting member of the American Society of Mechanical Engineers – Bioprocess Equipment (ASME-BPE) standards committee. He contributes to the Process Instrumentation subgroup to help implement standards for the bioprocessing and pharmaceutical industries, focusing on conductivity, pH, TOC, and other process technologies.</p>
</blockquote>


Mettler-Toledo: Controlling Impurities in Pharma Waters

Controlling Impurities in Pharma Waters

Dispeling the most common myths about microbes and organics and controlling impurities in pharma waters.

<p><strong>CVS (Cyclic Voltammetric Stripping) is the preferred method for monitoring the concentration of suppressors, brighteners, and levelers used in the production of high-quality printed circuit boards (PCBs) and in advanced packaging of semiconductors. Automating this monitoring can help manufacturers to significantly save time and effort while helping them to keep pace with increasing numbers of samples.</strong></p>
<p>In her webinar, Barbara Zumbrägel, Product Manager Voltammetry at Metrohm International Headquarters, will present the latest technology to take fully automated quality control in PCB manufacturing with CVS to the next level of performance, efficiency, and convenience. Following the webinar, Barbara will be available for a Q&amp;A Session to answer any questions you may have.</p>
<p><strong>Key learnings of this webinar:</strong></p>
<ul>
<li>How automated sample transfer and dosing can make your determination of suppressors, brighteners, and levelers more efficient</li>
<li>How to handle the increasing number of auxiliary solutions with an automated pipetting system</li>
<li>How to optimize your workflow by customizing methods in the viva software to meet the specific requirements of your analysis protocol</li>
</ul>
<p><strong>Who should attend?</strong></p>
<ul>
<li>Lab technicians and lab managers from the PCB, PWB, and semiconductor manufacturing industries</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Barbara Zumbrägel (Product Manager Voltammetry, Metrohm International Headquarters)</p>
</blockquote>
<blockquote>
<p>Barbara Zumbrägel earned her diploma in chemistry from Technische Universität Clausthal, Germany, and joined Metrohm International Headquarters in 1999 as a product and application specialist for voltammetry. Since 2003, she has also played a significant role in the ongoing development of the Metrohm portfolio of CVS products and applications. In 2006, Barbara was promoted to Product Manager Voltammetry.</p>
</blockquote>


Metrohm: Next level of CVS automation - how to increase the efficiency of your routine analysis

Next level of CVS automation - how to increase the efficiency of your routine analysis

Fully automated quality control in PCB manufacturing with CVS for the next level performance, efficiency, and convenience.

CVS automation - how to increase the efficiency

<p><strong>Event Program</strong></p>
<ul>
<li>Discover the fundamentals of multiparameter analysis and its role in increasing the productivity.</li>
<li>Explore real-world applications in pharmaceuticals, food &amp; beverage, and water testing.</li>
<li>Learn how automation in electrochemistry revolutionizes efficiency and empowers sustainable practices.</li>
<li>Gain insights into navigating compliance regulations seamlessly with METTLER TOLEDO&#39;s products and services.</li>
</ul>
<p><strong>In today&#39;s world, maximizing productivity is no longer optional. Across industries, there&#39;s a growing need for efficient and reliable methods to evaluate and optimize solutions. This is where multiparameter analysis emerges as a promising tool.</strong></p>
<p>Precise pH measurement plays a crucial role in various sustainability initiatives. From ensuring optimal growth conditions in biofuel production to maintaining safe drinking water quality, pH data is essential. METTLER TOLEDO pH meters offer exceptional accuracy and reliability, making them an indispensable tool for reliable data in your sustainability journey.</p>
<p>The true strength of these meters also lies in their ability to seamlessly connect with other instruments for measuring critical parameters like refractive index, density, spectroscopic data etc. This enables analysis of a wider range of parameters simultaneously or in parallel. This comprehensive approach provides a holistic view of the samples, empowering one to optimize resource utilization, ensure product quality and safety, and develop sustainable solutions. By combining pH with other key parameters as mentioned above, deeper insights can also be obtained to minimize waste, maximize efficiency, and guarantee consistent product quality that adheres to safety regulations – all crucial aspects of sustainable practices.</p>
<p>This webinar, led by Dr. Reena Mascarenhas, Assistant Manager of Market Development, will explore multiparameter analysis and its role in streamlining the processes across various industries.</p>
<p>Join us for a Live Webinar on Multiparameter Analysis for Sustainable Solutions!</p>
<p>Register now and secure your spot!</p>
<p><strong>For multiparameter analysis, what instruments can a pH meter be connected to?</strong></p>
<p>Beyond parameters like conductivity, DO, ISE, and Redox, which can be measured by the same meter, a pH meter can be connected to other instruments like a refractometer, density meter, UV/VIS spectrometer, titrator, and balance.</p>
<p><strong>In which industries can quality control labs leverage multiparameter analysis to improve their processes?</strong></p>
<p>Multiparameter analysis empowers quality control labs across various industries. In the pharmaceutical sector, labs can ensure consistent drug quality by simultaneously measuring parameters like pH, conductivity, and concentration. The food and beverage industry, including the wine industry, benefits by monitoring key parameters like pH, conductivity, density, and dissolved oxygen to guarantee consistent taste, texture, and shelf life. It also plays a crucial role in monitoring safe drinking water (concentration of ions, pH, conductivity) and optimizing agricultural soil conditions (pH, conductivity, nutrient levels). By measuring multiple parameters simultaneously, labs achieve efficiency and ensure high-quality products across diverse industries.</p>
<blockquote>
<p><strong>Presenter:</strong> Dr Reena Mascarenhas</p>
</blockquote>
<blockquote>
<p>Reena is an electrochemist, working for METTLER TOLEDO, with over five years of experience in training others in various aspects of the field. Her in-depth understanding, technical expertise, and engaging and informative training style make her a prominent speaker for this webinar.</p>
</blockquote>


Mettler-Toledo: Multiparameter Analysis for the Lab: from Complexity to Simplicity

Multiparameter Analysis for the Lab: from Complexity to Simplicity

A Live Webinar for Optimizing Workflows for pH, Refractometry, and Density Determination.

Multiparameter Analysis for the Laboratories

<p><strong>Electrochemical methods are useful for determining various material properties of the components in electrochemical devices. Specifically, electrochemical impedance spectroscopy (EIS) performed on cells containing only the essential components can provide detailed information about each part of the device. This approach allows for a clearer distinction of each component&#39;s contribution to the overall performance. It also helps explain the electrochemical behavior of the complete system.</strong></p>
<p>In this webinar, Dr. Christoffer Karlsson will show some examples of this methodology, focusing on battery component properties such as the MacMullin number of separators, tortuosity of active material coatings, and electrolyte conductivity. A workflow for simple and reliable impedance data fitting and parameter evaluation will also be shown.</p>
<p><strong>Who should attend?</strong></p>
<ul>
<li>Professionals working on the design and optimization of electrochemical devices such as batteries, fuel cells, and supercapacitors, etc. </li>
<li>Professionals in industries related to energy storage, renewable energy, and electronic devices</li>
<li>Researchers interested in high-throughput EIS analysis</li>
<li>Researchers curious for better understanding of material transfer and interface tortuosity</li>
</ul>
<p><strong>Key Learning Points</strong></p>
<ul>
<li><strong>Learn about device components of lithium-ion batteries</strong></li>
<li><strong>Learn how to determine conductivity, MacMullin number, tortuosity electrolytes by EIS</strong></li>
<li><strong>Learn how to set up a test cell for component analysis</strong></li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr. Christoffer Karlsson (Senior R&amp;D Scientist, rhd instruments)</p>
</blockquote>
<blockquote>
<p>Dr. Christoffer Karlsson is a Senior R&amp;D Scientist at rhd instruments with a background in electrochemical analysis and material development for batteries and supercapacitors. With a proven track record of designing and carrying out investigative research projects, he has developed active materials and electrolytes for all-organic proton batteries, as well as active material formulations for lithium-metal batteries. He is keen to be a part of creating a sustainable society by developing new solutions for energy applications.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Kia Williams, PhD (Electrochemistry Product Manager, Metrohm USA)</p>
</blockquote>
<blockquote>
<p>Kia has a PhD in chemistry from the University of South Florida. Her work included analyzing and characterizing Metal-Organic Frameworks and carbon materials for energy storage and conversion applications. She joined Metrohm in 2018 as the Electrochemistry Product Manager where she focuses on electrochemical and spectroelectrochemical applications.</p>
</blockquote>


Metrohm: Accessing Battery Material Properties with Electrochemical Techniques

Accessing Battery Material Properties with Electrochemical Techniques

Focusing on battery component properties such as the MacMullin number of separators, tortuosity of active material coatings, and electrolyte conductivity.

Battery Material Properties with Electrochemical Techniques

<p><strong>Understanding and measuring pH accurately is crucial in both chemical and biological contexts, affecting a range of applications.</strong></p>
<p>For example, in lithium batteries, precise pH control optimizes its performance and ensures safety. In paint, it determines the color consistency, stability, and product longevity. Similarly, in plant-based proteins, pH influences protein extraction and quality, affecting texture and nutritional value. However, the complex matrices and diverse physical properties of these samples often interfere with pH measurements, posing significant challenges.</p>
<p>Join our webinar to learn how to overcome these challenges and optimize your pH measurement results in both chemical and biological samples. Let our experts guide you through advanced techniques, best practices, and practical solutions tailored to different applications.</p>
<h4>Program Overview</h4>
<ul>
<li><p><strong>Introduction to pH measurement: Learn about the importance of pH accuracy in fields like chemistry and biology.</strong></p>
</li>
<li><p><strong>pH in chemicals: Discover how precise pH monitoring ensures chemical stability, reactivity, and shelf life. Learn tips for managing pH-dependent chemical processes for optimal results.</strong></p>
</li>
<li><p><strong>pH in biological samples: Explore the critical role of pH in physiological functions, enzyme activity, and disease diagnosis.</strong></p>
</li>
<li><p><strong>Techniques and best practices: Discuss pH measurement techniques, calibration, buffers, and overcoming common challenges.</strong></p>
</li>
<li><p><strong>Interactive Q&amp;A session</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr Reena Mascarenhas</p>
</blockquote>
<blockquote>
<p>Dr. Reena is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Reena is committed to sharing her insights and contributing to the growth of the scientific community.</p>
</blockquote>


Mettler Toledo: How to Measure pH in Chemicals and Biological Samples

How to Measure pH in Chemicals and Biological Samples

How to overcome these challenges and optimize your pH measurement results in both chemical and biological samples.

<p><strong>Whether you are developing new materials for batteries electrodes, testing full or half cells or working on new electrolytes, electrochemical methods are at the core of your daily activities.&nbsp;</strong></p><p>In this webinar we will cover theoretical and practical aspects of various electrochemical techniques for battery research and testing. From the most fundamental CC cycling, to more advanced &nbsp;techniques such as galvanostatic intermittent titration technique (GITT), this webinar is meant to help you navigate this field and chose with confidence with techniques are most fit for your research.</p><p>This webinar is accessible to anyone working in the field of battery, materials research, with or without a background in electrochemistry.</p><blockquote><p><strong>Presenter: </strong>Thomas Touzalin, PhD.&nbsp;</p><p>Product Manager at Metrohm Autolab, helping the electrochemistry researchers achieve their goals by providing the right solution for any research problems as well as offering technical support for the Autolab product range.</p></blockquote>

Metrohm: Electrochemical techniques for battery research and testing

Electrochemical techniques for battery research and testing

Theoretical and practical aspects of various electrochemical techniques for battery research and testing.

LCMS webinars focusing on Electrochemistry | LabRulez LCMS