<p>The pioneering research of Prof. Michal Holčapek and his team at the University of Pardubice is now being tested on patients in a clinical setting.</p><p><strong>A clinical trial has begun in the Czech Republic to assess the effectiveness of an early detection test for pancreatic cancer. This trial will evaluate the sensitivity of a novel blood test designed to detect precancerous changes. If successful, this lipidomics-based test could revolutionise pancreatic cancer screening, offering a major advance in early diagnosis.</strong></p><p>The trial is a collaborative effort between Lipidica – a company jointly owned by the University of Pardubice and FONS JK Group – and specialists in gastroenterology and oncology. Lipidica will perform sample analyses for the clinical study. Key partners include the University Hospital Olomouc and the Masaryk Memorial Cancer Institute, with a total of 15 centres nationwide expected to participate.</p><blockquote><h4><strong>Career: Postdoctoral Positions in Lipidomics and Glycomics</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/job/1713">more details and contacts</a></li></ul><p><strong>You will be joining the dynamic Lipidomics Group at the University of Pardubice, working on high-impact research funded by prestigious grants:</strong></p><ol><li><strong>ERC Advanced grant “Oncolipidomics:</strong> Why is lipidomic dysregulation pattern in blood similar for various cancers? (ONCOLIPID)”</li><li><strong>OP JAK grant “Saving lives through research in early cancer detection and prevention:</strong> Molecular, genomic and societal factors (SALVAGE)”</li></ol><h5><strong>Two Postdoctoral Positions in Lipidomics and Glycomics</strong></h5><ul><li><strong>Start Date:</strong> January 2025 (or as soon as possible)</li><li><strong>Duration:</strong> 12 months, with a possibility of extension until the end of the project (August 2028)</li><li><strong>Location:</strong> Lipidomics Group of Prof. Michal Holčapek, University of Pardubice, Faculty of Chemical Technology, Department of Analytical Chemistry, Czech Republic</li><li><strong>Salary:</strong> Competitive, based on university guidelines, and commensurate with experience and skills.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Pardubice_University_of_Pardubice_254470ec4e.jpg" alt="University of Pardubice: University of Pardubice" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Pardubice_University_of_Pardubice_254470ec4e.jpg 234w," sizes="100vw" width="1200" height="803"></p></blockquote><p>This methodology, which allows for early diagnosis, was developed by Prof. Michal Holčapek, a prominent analytical chemist and world-renowned expert in lipids at the University of Pardubice’s Faculty of Chemical Technology. Holčapek, a recipient of the prestigious European ERC Advanced grant, and his team achieved this breakthrough by analysing lipids in standard blood samples and applying advanced multivariate statistical analysis. <i><strong>"The lipidomics test is non-invasive and could pave the way for a structured screening programme,”</strong></i> explains Prof. Holčapek. <i><strong>"It may enable earlier detection of pancreatic cancer, where treatment success rates are higher and patient survival outcomes improve."</strong></i></p><p>This innovative method has been published in Nature Communications, one of the world’s leading scientific journals, and is protected by two patents held by the University of Pardubice.</p><p>Experts from the Czech Gastroenterological Society (CGS) report that approximately 2 400 people are diagnosed with pancreatic cancer each year in the Czech Republic, and nearly 2 200 die from the disease within the same period. By 2030, experts project that pancreatic cancer will become the second leading cause of cancer deaths. <i>"Pancreatic cancer is among the most aggressive forms of cancer – it develops asymptomatically over more than a decade but remains undetected until it is too advanced for effective treatment,"</i> says Prof. Ondřej Urban, M.D., Ph.D., Head of the Second Internal Gastroenterology and Geriatric Clinic at University Hospital Olomouc. <i>"By the time symptoms appear, it is often too late for curative treatment, with surgery remaining the only potential cure, but only about 20% of patients qualify. The rest receive palliative care focused on extending life with as much quality as possible."</i> For those with advanced pancreatic cancer, the average survival rate is about 1.5 years. However, patients diagnosed at an early stage can live up to six times longer. <i>"We know that lipid profiles vary significantly in patients with pancreatic cancer,"</i> Prof. Urban adds.<i> "This study aims to determine if the lipidomics test can detect these early lipid changes in high-risk individuals who feel healthy but may already have underlying disease."</i></p><p>According to doc. MUDr. Jan Trna, Ph.D., Chief Physician of the Gastroenterology Department at the Masaryk Memorial Cancer Institute, the successful validation of the new lipidomics test would represent a major breakthrough in pancreatic cancer treatment.<i> "Currently, our options for identifying individuals at risk for pancreatic cancer are limited. Due to financial, capacity, and medical constraints, specialised preventive testing cannot be offered to everyone. However, blood sampling presents a different approach. For decades, we have sought methods to detect the disease early – which is absolutely critical for this particular cancer," </i>says MUDr. Trna. The Pancreatic Cancer Early Detection Programme now enables the identification of precancerous changes or early-stage cancer. Under this programme, gastroenterologists collaborate closely with clinical geneticists and radiologists who conduct specialised tests such as magnetic resonance imaging (MRI).</p><p>Currently, the screening programme is available only to individuals with a lifetime risk of pancreatic cancer exceeding 5%. <i>"In the newly established centres of highly specialised care for digestive endoscopy, including our department, at-risk individuals undergo regular pancreatic examinations using MRI and endoscopic ultrasonography,"</i> explains doc. MUDr. Ilja Tachecí, Ph.D., Chair of the CGS and Head of the Second Internal Gastroenterology Clinic at the Faculty of Medicine, Charles University in Hradec Králové. Individuals considered at risk include those with a hereditary form of chronic pancreatitis, those with two or more direct relatives diagnosed with pancreatic cancer, and carriers of specific genetic mutations – such as mutations in the BRCA1 and BRCA2 genes, which are also associated with breast and ovarian cancer.</p><p><i>"People at risk visit us for annual check-ups. As part of this study, we collect blood samples with their informed consent, which are then processed into plasma and sent to the Lipidica laboratory,"</i> explains Prof. Urban. The study thus analyses blood from both healthy high-risk individuals and patients with small, operable tumours. <i>"Current diagnostic methods are highly effective but also costly and uncomfortable for patients. A test based on a simple blood draw would be a tremendous benefit for clinical practice. Our LDPC lipidomics test relies on a patent-protected methodology developed at the University of Pardubice, integrating insights from analytical chemistry, biostatistics, and other scientific disciplines,"</i> adds Ing. Karolína Kašparová, Director of Lipidica, which is also an accredited medical laboratory.</p><p><strong>Lipidica, a.s., a joint venture between the University of Pardubice and FONS JK Group a.s., has been </strong><a target="_blank" rel="noopener noreferrer" href="https://www.upce.cz/en/neuron-awards-goes-to-lipidica-spin-off-of-the-university-of-pardubice"><strong>recognised with the Neuron Prize</strong></a><strong> for its exceptional bridging of science and business.</strong></p><p><strong>The study began this year and is expected to conclude in 2027, involving over 400 participants. </strong>If the test's specificity and sensitivity are confirmed, experts note it may still take time before the test becomes a standard part of clinical care and before it is determined whether health insurers will cover it or if individuals will need to pay out of pocket. The manufacturer has indicated, however, that the price should not exceed a few thousand Czech korunas.&nbsp;</p>

Clinical trial begins in Czech Republic to test groundbreaking pancreatic cancer detection method

<blockquote><p><i>Maciej Stopa<sup>1, 2</sup>; Rafał Szewczyk<sup>1, 2</sup>; Adrianna Radulska<sup>3</sup>, Anna Lenartowicz<sup>2</sup>; Julia Mironenka<sup>2</sup>; Adrian Soboń<sup>1, 2</sup>; Katarzyna Krupczyńska-Stopa<sup>1, 2</sup>; Tomasz Borkowski<sup>3</sup>; Ewelina Marciniak<sup>3</sup>, Leszek Kalinowski<sup>3</sup></i></p><p><i><sup>1</sup></i><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/315"><i><strong>Bioanalytic</strong></i></a><i><strong> </strong>Sp. z o.o., Gdansk, Poland; <sup>2</sup>LabExperts Sp. z o.o., Gdansk, Poland; <sup>3</sup> Medical University of Gdansk, Gdansk, Poland</i></p></blockquote><h4><strong>Abstract</strong></h4><p>Cardiac arrhythmia affects approximately 12.6% of people over the age of 65. Ventricular arrhythmias are considered as responsible for 75% to 80% of sudden cardiac deaths. Therapy of the disease include ablation, use of cardioverter or defibrillator and pharmacological treatment where the key for successful therapy lays in maintaining the necessary concentration of drugs. The goal can be achieved by therapeutic drug monitoring (TDM). Developed assay named “CardioCarePack” is based on the use of capillary blood collected and dried at home by a patient with volumetric absorptive microsampling (VAMS), quantitative analysis of selected drugs and their metabolites and a telemedical system that integrates all data between a doctor, patient and laboratory supporting the therapy process. CardioCarePack is ready for commercialization.</p><h4><strong>Methods</strong></h4><p>Blood collected with a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?distributorItems=315&amp;search=MITRA"><strong>MITRA® microsampling device</strong></a> (20 µl) is prepared with full validated protocol that include sonication with 0.1% formic acid in water followed by acetonitrile extraction, evaporation under nitrogen stream and resuspension in LC mobile phase. Sample is subjected to LC-MS/MS analysis in positive ionization MRM mode with QTRAP 5500+ mass spectrometer (SCIEX) or similar one. Analysis covers simultaneous quantitation of 15 drugs: Sotalol, Metoprolol, Bisoprolol, Propafenone, Carvedilol, Nebivolol, Amiodarone, Digoxin, Perindopril, Ramipril, Eplerenone, Spironolactone, Zofenopril and 2 metabolites: 5-hydroxypropafenone and Desethylamiodarone. Results are placed in a server-based telemedical system where depending on accession rights history, doses, therapeutic index flagging, cardiograms, sample tracking and many other data are available for patient, doctor and laboratory staff, respectively.</p><h4><strong>Preliminary Data</strong></h4><p>The project involved more than 300 patients who had been monitored for 2 years during regular pharmacological therapy. Every half a year during a visit in medical facility venous blood for serum testing and capillary blood on the MITRA® sorbent were collected. Between the visits patients were collecting samples by VAMS themselves at home. All samples were analyzed by fully validated procedure where among the others linearity (r ≥ 0.995), accuracy (80 – 120%), reproducibility (%CV ≤ 15%) for both MITRA® and serum samples were calculated. The LC-MS/MS method developed for 17 compounds covers therapeutic range of the tested drugs: 0.25 – 25 ng/ml (Digoxin and Nebivolol) 2.5 – 250 ng/ml (Metoprolol, Bisoprolol, Propafenone, Carvedilol, Perindopril, Ramipril, Spironolactone, Zofenopril and 25 – 2500 ng/ml (Sotalol, Desethylamiodarone, Eplerenone, Amiodarone, 5-hydroxypropafenone). Results generated during LC-MS/MS analysis were analyzed with SCIEX OS 1.7 software.</p><p>On the basis of samples collected during 4 visits in medical facility a correlation between drugs concentration in venous blood (serum) and capillary blood (MITRA®) (S/M) was calculated. For some compounds S/M ratio was close to 1 (ex. Sotalol – 0.95, %CV – 5.12%, Nebivolol – 1.03, %CV – 3.17%) or moderately to more than 2-fold different (ex. Digoxin – 0.69, %CV – 1.46%, Ramipril – 1.18, %CV – 11.1, Perindopril – 1.86, %CV – 4.73%, Amiodarone – 2.17, %CV – 10.78). The correlation factors are statistically significant (p &lt; 0.05) and can be used for accurate concentration estimation in venous blood.</p><p>Developed telemedicine system integrate CardioCarePack service – a patient, doctor and LC-MS/MS laboratory. The system helps in Doctor’s supervision over the patient’s condition on the basis of collected within the system data ex.: autonomous verification of the therapeutic index with flagging, visualization of results, tracking samples on the patient-doctor line, schedule of visits, results history and many more.</p><h4><strong>Novel aspect</strong></h4><p>A modern telemedicine system for TDM of cardiological drugs based on LC-MS/MS analysis of samples collected at home with VAMS.</p>

CardioCarePack – personalized medicine system to improve live quality of patients suffering from cardiac arrhythmias

<p><strong>In the week of January 13, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Waters Corporation: Light scattering-based solutions for excipients and advanced formulations</strong></h5><div><div><ul><li><div>Tu, 14.1.2025 05:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4545">Registration</a></div></li></ul></div><p>In this webinar, we will showcase case studies demonstrating how SEC-MALS and FFF-MALS are utilized to characterize, quantify, and deformulate advanced excipients and formulations.</p></div><h5><strong>2.&nbsp;Thermo Fisher Scientific: Well characterized biological products, challenging yet rewarding</strong></h5><div><div><ul><li><div>Tu, 14.1.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4578">Registration</a></div></li></ul></div><p>The presentation emphasizes the importance of developing innovative methods and technologies to support the ecosystem and enhance data workflows. It introduces the concept of a new facility, named "Concept".</p></div><h5><strong>3.&nbsp;Agilent Technologies: Getting the Most from Your Agilent HPLC Pump</strong></h5><div><div><ul><li><div>Tu, 14.1.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4519">Registration</a></div></li></ul></div><p>We will focus on your Agilent HPLC pump. We will look at some of its capabilities and how to choose the right column for it. We will discuss best practices to help maximize up-time.</p></div><h5><strong>4.&nbsp;Restek Corporation: Incorporating ultrashort-chain compounds into the comprehensive analysis of PFAS</strong></h5><div><div><ul><li><div>We, 15.1.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4569">Registration</a></div></li></ul></div><p>Join Dr. Shun-Hsin Liang, as he explores the simultaneous analysis of C1 to C14 PFCA and PFSA, along with other PFAS types, using two alternative chromatographic approaches.</p></div><h5><strong>5.&nbsp;SCIEX: Unlocking precision: nitrosamine and NDSRI analysis</strong></h5><div><div><ul><li><div>Th, 16.1.2025 10:30 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4682">Registration</a></div></li></ul></div><p>We invite you to join our webinar on nitrosamine and NDSRIs, specifically examining their analysis and implications in the pharmaceutical industry.</p></div><h5><strong>6.&nbsp;Thermo Fisher Scientific: The merger of automated LC fractionation &amp; in-depth characterization</strong></h5><div><div><ul><li><div>Th, 16.1.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4579">Registration</a></div></li></ul></div><p>Dr. Kristensen discusses how the shift from traditional data handling methods to cloud solutions has revolutionized their workflow, enabling access to vast amounts of data from anywhere.</p></div><h5><strong>7.&nbsp;Waters Corporation: Mastering the Quantitative Bioanalysis of Large Peptides and Proteins: A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma</strong></h5><div><div><ul><li><div>Th, 16.1.2025 15:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4384">Registration</a></div></li></ul></div><p>We present new data demonstrating a comprehensive and streamlined approach to optimized LC-MS/MS quantification of peptides, addressing the common challenges.</p></div><h5><strong>8.&nbsp;Waters Corporation:</strong> <strong>Method Validation</strong></h5><div><div><ul><li><div>Th, 16.1.2025 19:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4669">Registration</a></div></li></ul></div><p>We´ll discuss practical guidance around accuracy, precision, limit of quantitation and limit of detection and next we´ll walk you through an Empower CDS tool.</p></div>

Webinars LabRulezLCMS Week 3/2025

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<p><strong>The metal-finishing industry faces the ongoing challenge of managing wastewater effectively, especially when treating dissolved metals such as copper and hexavalent chromium. These metals pose significant environmental risks and introduce compliance and financial challenges. Traditional ion exchange and chemical precipitation methods exhibit limitations in selectively targeting specific metals and rely on hazardous chemical handling and secondary waste product treatment. Both methods have limited effectiveness with increased metal concentrations, competing ions&#39; presence, and dissolved solids&#39; overall concentration.</strong></p>
<p>Join James Landon, Chief Technology Officer at ElectraMet, as he introduces an innovative solution to conventional dissolved metal approaches, employing an electrochemical process to efficiently remove or convert dissolved metals. Beyond treatment, both sustainability and operational optimization hinge on real-time data. Learn how online Process Analyzer Technology (PAT) can revolutionize wastewater management, offering precise, real-time monitoring and analysis.</p>
<h5><strong>Key Learning Objectives:</strong></h5>
<ul>
<li>Understand how the innovative electrochemical process overcomes challenges in metal finishing.</li>
<li>Learn how real-time monitoring and analysis can optimize the wastewater treatment process</li>
<li>Learn how integrating electrochemical processes with PAT can transform wastewater into revenue</li>
</ul>
<h5><strong>Who Should Attend:</strong></h5>
<ul>
<li>Process Engineers looking to optimize wastewater treatment processes or who are looking to implement PAT in their metal finishing lines</li>
<li>Sustainability and Operations Managers tasked with implementing eco-friendly practices within their organizations and overseeing the day-to-day operations of metal finishing lines</li>
<li>Environmental Compliance Officers tasked with ensuring their facilities meet regulatory standards for wastewater</li>
<li>Wastewater Treatment Consultants advising on wastewater management strategies</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> James Landon, PhD (Chief Technology Officer and Co-founder, ElectraMet)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Brett Lane (Field Applications Specialist, Process Wet Chemistry, Metrohm USA)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Ann Thayer (Contributing Editor, C&amp;EN Media Group)</p>
</blockquote>


Metrohm: Beyond Ion Exchange: Advancing Wastewater Treatment in Metal Finishing

Beyond Ion Exchange: Advancing Wastewater Treatment in Metal Finishing

Process Analyzer Technology (PAT) can revolutionize wastewater management, offering precise, real-time monitoring and analysis.

Beyond Ion Exchange: Advancing Wastewater Treatment

<p><strong>Harvest time has come for modern biotechnology and biotherapeutics, bringing a cornucopia of products – CRISPR Cas nucleases, therapeutic viruses, cells and engineered tissue constructs.</strong></p>
<p>Along with superior therapeutic efficacy, these products feature unprecedented complexity of biomolecular features and range of scales that define their identity, efficacy and safety.</p>
<p>In this webinar, our expert speaker Dr. Stefano Menegatti from NC State University, will discuss his team’s approach in leveraging affinity technology to introduce new tools for purifying and characterizing biotherapeutics to match the growing demands of clinics and biotech industries worldwide. </p>
<p><strong>Attend this webinar to:</strong></p>
<ul>
<li>Learn about affinity ligands operating in negative and positive capture mode for the continuous purification of biotherapeutics</li>
<li>Discover first of its kind RNA triggers for the purification of CRIPSR-CAS nucleases via affinity chromatography</li>
<li>Explore the complexity of EIS sensors for one-step quantification of total virus particle and empty capsid quantification</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Stefano Menegatti, PhD (Associate Professor, Chemical and Biomolecular Engineering, NC State University)</p>
</blockquote>


Technology Networks: Modernizing the Purification Toolbox for Multi-Specific Antibodies, CRISPR and Cell and Gene Therapies

Modernizing the Purification Toolbox for Multi-Specific Antibodies, CRISPR and Cell and Gene Therapies

Leveraging affinity technology to introduce new tools for purifying and characterizing biotherapeutics.

Purification of Antibodies, CRISPR, Cell and Gene Therapies

<p><strong>Insights and Strategies for Maintaining High Water Quality</strong></p>
<p><strong>Event Program</strong></p>
<ul>
<li>Common misconceptions about impurities in pharmaceutical waters</li>
<li>Differences between chemical and microbial properties in WFI and PW</li>
<li>Recommended approaches for measuring different impurities</li>
<li>Insights on maintaining a healthy water loop</li>
</ul>
<p><strong>Enhancing Quality and Safety in Pharmaceutical Manufacturing</strong></p>
<p>Without proper impurity control, pharmaceutical manufacturers risk compromising the safety and efficacy of their products. Microbial and organic impurities can enter water systems at various points in the manufacturing process and impact quality and safety.</p>
<p>Misunderstandings surrounding controlling impurities in pharma waters can lead to improper measurement and treatment approaches.</p>
<p>It is a common belief that chemical and microbiological properties in Water for Injection (WFI) and Purified Water (PW) are the same in pharmaceutical water systems. However, this is far from the truth. These properties react differently and are distributed unevenly in storage and distribution loops, which can have different effects on the health of the water system.</p>
<p>In this live roundtable discussion, we will dispel the most common myths about microbes and organics and controlling impurities in pharma waters. We will discuss the differences between chemical and microbiological properties in WFI and PW and recommend measurement approaches for each impurity. Additionally, we will cover how to maintain a healthy water loop to ensure high quality and safety in pharmaceutical manufacturing.</p>
<blockquote>
<p><strong>Presenter:</strong> Maura Rury (Senior Product Manager, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Maura manages METTLER TOLEDO&#39;s Total Organic Carbon (TOC) product line, along with related services and training. Her prior roles include marketing, product management, and technical applications at LGC and Thermo Fisher Scientific. She received her Ph.D. in Analytical Chemistry from the University of Massachusetts, Amherst.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Anthony C. Bevilacqua (Principal Scientist, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Anthony Bevilacqua earned a doctorate in Analytical/Physical Chemistry from Tufts University. Since 1994, he has led several areas of Research and Product Development that include: impact of CO2 on pure water, ultrapure water as a conductivity solution standard, development of digital sensors, and expansion of real-time analytical parameters (conductivity, TOC, microbial detection, ozone, sodium, and silica) for measurement/control of high purity water systems, including pharmaceutical water systems. Anthony was Chair of the inaugural USP Pharmaceutical Water Expert Committee from 2000-2005, and re-elected from 2005-2010. Anthony’s role continued in the 2010-2015 and 2015-2020 cycles for the USP Chemical Analysis Expert Committee, and he is currently serving on the current committee for 2020-2025.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Areen Kalantari (Global Segment Manager, Pharma &amp; Life Sciences, METTLER TOLEDO Thornton)</p>
</blockquote>
<blockquote>
<p>Areen Kalantari holds a B.S. in Biological/Chemical Engineering and a Master of Business Administration (MBA) in International Business. He has experience in both biotechnology applications and pharmaceutical waters. Areen is a voting member of the American Society of Mechanical Engineers – Bioprocess Equipment (ASME-BPE) standards committee. He contributes to the Process Instrumentation subgroup to help implement standards for the bioprocessing and pharmaceutical industries, focusing on conductivity, pH, TOC, and other process technologies.</p>
</blockquote>


Mettler-Toledo: Controlling Impurities in Pharma Waters

Controlling Impurities in Pharma Waters

Dispeling the most common myths about microbes and organics and controlling impurities in pharma waters.

<p><strong>CVS (Cyclic Voltammetric Stripping) is the preferred method for monitoring the concentration of suppressors, brighteners, and levelers used in the production of high-quality printed circuit boards (PCBs) and in advanced packaging of semiconductors. Automating this monitoring can help manufacturers to significantly save time and effort while helping them to keep pace with increasing numbers of samples.</strong></p>
<p>In her webinar, Barbara Zumbrägel, Product Manager Voltammetry at Metrohm International Headquarters, will present the latest technology to take fully automated quality control in PCB manufacturing with CVS to the next level of performance, efficiency, and convenience. Following the webinar, Barbara will be available for a Q&amp;A Session to answer any questions you may have.</p>
<p><strong>Key learnings of this webinar:</strong></p>
<ul>
<li>How automated sample transfer and dosing can make your determination of suppressors, brighteners, and levelers more efficient</li>
<li>How to handle the increasing number of auxiliary solutions with an automated pipetting system</li>
<li>How to optimize your workflow by customizing methods in the viva software to meet the specific requirements of your analysis protocol</li>
</ul>
<p><strong>Who should attend?</strong></p>
<ul>
<li>Lab technicians and lab managers from the PCB, PWB, and semiconductor manufacturing industries</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Barbara Zumbrägel (Product Manager Voltammetry, Metrohm International Headquarters)</p>
</blockquote>
<blockquote>
<p>Barbara Zumbrägel earned her diploma in chemistry from Technische Universität Clausthal, Germany, and joined Metrohm International Headquarters in 1999 as a product and application specialist for voltammetry. Since 2003, she has also played a significant role in the ongoing development of the Metrohm portfolio of CVS products and applications. In 2006, Barbara was promoted to Product Manager Voltammetry.</p>
</blockquote>


Metrohm: Next level of CVS automation - how to increase the efficiency of your routine analysis

Next level of CVS automation - how to increase the efficiency of your routine analysis

Fully automated quality control in PCB manufacturing with CVS for the next level performance, efficiency, and convenience.

CVS automation - how to increase the efficiency

<p><strong>Event Program</strong></p>
<ul>
<li>Discover the fundamentals of multiparameter analysis and its role in increasing the productivity.</li>
<li>Explore real-world applications in pharmaceuticals, food &amp; beverage, and water testing.</li>
<li>Learn how automation in electrochemistry revolutionizes efficiency and empowers sustainable practices.</li>
<li>Gain insights into navigating compliance regulations seamlessly with METTLER TOLEDO&#39;s products and services.</li>
</ul>
<p><strong>In today&#39;s world, maximizing productivity is no longer optional. Across industries, there&#39;s a growing need for efficient and reliable methods to evaluate and optimize solutions. This is where multiparameter analysis emerges as a promising tool.</strong></p>
<p>Precise pH measurement plays a crucial role in various sustainability initiatives. From ensuring optimal growth conditions in biofuel production to maintaining safe drinking water quality, pH data is essential. METTLER TOLEDO pH meters offer exceptional accuracy and reliability, making them an indispensable tool for reliable data in your sustainability journey.</p>
<p>The true strength of these meters also lies in their ability to seamlessly connect with other instruments for measuring critical parameters like refractive index, density, spectroscopic data etc. This enables analysis of a wider range of parameters simultaneously or in parallel. This comprehensive approach provides a holistic view of the samples, empowering one to optimize resource utilization, ensure product quality and safety, and develop sustainable solutions. By combining pH with other key parameters as mentioned above, deeper insights can also be obtained to minimize waste, maximize efficiency, and guarantee consistent product quality that adheres to safety regulations – all crucial aspects of sustainable practices.</p>
<p>This webinar, led by Dr. Reena Mascarenhas, Assistant Manager of Market Development, will explore multiparameter analysis and its role in streamlining the processes across various industries.</p>
<p>Join us for a Live Webinar on Multiparameter Analysis for Sustainable Solutions!</p>
<p>Register now and secure your spot!</p>
<p><strong>For multiparameter analysis, what instruments can a pH meter be connected to?</strong></p>
<p>Beyond parameters like conductivity, DO, ISE, and Redox, which can be measured by the same meter, a pH meter can be connected to other instruments like a refractometer, density meter, UV/VIS spectrometer, titrator, and balance.</p>
<p><strong>In which industries can quality control labs leverage multiparameter analysis to improve their processes?</strong></p>
<p>Multiparameter analysis empowers quality control labs across various industries. In the pharmaceutical sector, labs can ensure consistent drug quality by simultaneously measuring parameters like pH, conductivity, and concentration. The food and beverage industry, including the wine industry, benefits by monitoring key parameters like pH, conductivity, density, and dissolved oxygen to guarantee consistent taste, texture, and shelf life. It also plays a crucial role in monitoring safe drinking water (concentration of ions, pH, conductivity) and optimizing agricultural soil conditions (pH, conductivity, nutrient levels). By measuring multiple parameters simultaneously, labs achieve efficiency and ensure high-quality products across diverse industries.</p>
<blockquote>
<p><strong>Presenter:</strong> Dr Reena Mascarenhas</p>
</blockquote>
<blockquote>
<p>Reena is an electrochemist, working for METTLER TOLEDO, with over five years of experience in training others in various aspects of the field. Her in-depth understanding, technical expertise, and engaging and informative training style make her a prominent speaker for this webinar.</p>
</blockquote>


Mettler-Toledo: Multiparameter Analysis for the Lab: from Complexity to Simplicity

Multiparameter Analysis for the Lab: from Complexity to Simplicity

A Live Webinar for Optimizing Workflows for pH, Refractometry, and Density Determination.

Multiparameter Analysis for the Laboratories

<p><strong>Electrochemical methods are useful for determining various material properties of the components in electrochemical devices. Specifically, electrochemical impedance spectroscopy (EIS) performed on cells containing only the essential components can provide detailed information about each part of the device. This approach allows for a clearer distinction of each component&#39;s contribution to the overall performance. It also helps explain the electrochemical behavior of the complete system.</strong></p>
<p>In this webinar, Dr. Christoffer Karlsson will show some examples of this methodology, focusing on battery component properties such as the MacMullin number of separators, tortuosity of active material coatings, and electrolyte conductivity. A workflow for simple and reliable impedance data fitting and parameter evaluation will also be shown.</p>
<p><strong>Who should attend?</strong></p>
<ul>
<li>Professionals working on the design and optimization of electrochemical devices such as batteries, fuel cells, and supercapacitors, etc. </li>
<li>Professionals in industries related to energy storage, renewable energy, and electronic devices</li>
<li>Researchers interested in high-throughput EIS analysis</li>
<li>Researchers curious for better understanding of material transfer and interface tortuosity</li>
</ul>
<p><strong>Key Learning Points</strong></p>
<ul>
<li><strong>Learn about device components of lithium-ion batteries</strong></li>
<li><strong>Learn how to determine conductivity, MacMullin number, tortuosity electrolytes by EIS</strong></li>
<li><strong>Learn how to set up a test cell for component analysis</strong></li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr. Christoffer Karlsson (Senior R&amp;D Scientist, rhd instruments)</p>
</blockquote>
<blockquote>
<p>Dr. Christoffer Karlsson is a Senior R&amp;D Scientist at rhd instruments with a background in electrochemical analysis and material development for batteries and supercapacitors. With a proven track record of designing and carrying out investigative research projects, he has developed active materials and electrolytes for all-organic proton batteries, as well as active material formulations for lithium-metal batteries. He is keen to be a part of creating a sustainable society by developing new solutions for energy applications.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Kia Williams, PhD (Electrochemistry Product Manager, Metrohm USA)</p>
</blockquote>
<blockquote>
<p>Kia has a PhD in chemistry from the University of South Florida. Her work included analyzing and characterizing Metal-Organic Frameworks and carbon materials for energy storage and conversion applications. She joined Metrohm in 2018 as the Electrochemistry Product Manager where she focuses on electrochemical and spectroelectrochemical applications.</p>
</blockquote>


Metrohm: Accessing Battery Material Properties with Electrochemical Techniques

Accessing Battery Material Properties with Electrochemical Techniques

Focusing on battery component properties such as the MacMullin number of separators, tortuosity of active material coatings, and electrolyte conductivity.

Battery Material Properties with Electrochemical Techniques

<p><strong>Understanding and measuring pH accurately is crucial in both chemical and biological contexts, affecting a range of applications.</strong></p>
<p>For example, in lithium batteries, precise pH control optimizes its performance and ensures safety. In paint, it determines the color consistency, stability, and product longevity. Similarly, in plant-based proteins, pH influences protein extraction and quality, affecting texture and nutritional value. However, the complex matrices and diverse physical properties of these samples often interfere with pH measurements, posing significant challenges.</p>
<p>Join our webinar to learn how to overcome these challenges and optimize your pH measurement results in both chemical and biological samples. Let our experts guide you through advanced techniques, best practices, and practical solutions tailored to different applications.</p>
<h4>Program Overview</h4>
<ul>
<li><p><strong>Introduction to pH measurement: Learn about the importance of pH accuracy in fields like chemistry and biology.</strong></p>
</li>
<li><p><strong>pH in chemicals: Discover how precise pH monitoring ensures chemical stability, reactivity, and shelf life. Learn tips for managing pH-dependent chemical processes for optimal results.</strong></p>
</li>
<li><p><strong>pH in biological samples: Explore the critical role of pH in physiological functions, enzyme activity, and disease diagnosis.</strong></p>
</li>
<li><p><strong>Techniques and best practices: Discuss pH measurement techniques, calibration, buffers, and overcoming common challenges.</strong></p>
</li>
<li><p><strong>Interactive Q&amp;A session</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr Reena Mascarenhas</p>
</blockquote>
<blockquote>
<p>Dr. Reena is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Reena is committed to sharing her insights and contributing to the growth of the scientific community.</p>
</blockquote>


Mettler Toledo: How to Measure pH in Chemicals and Biological Samples

How to Measure pH in Chemicals and Biological Samples

How to overcome these challenges and optimize your pH measurement results in both chemical and biological samples.

<p><strong>Whether you are developing new materials for batteries electrodes, testing full or half cells or working on new electrolytes, electrochemical methods are at the core of your daily activities.&nbsp;</strong></p><p>In this webinar we will cover theoretical and practical aspects of various electrochemical techniques for battery research and testing. From the most fundamental CC cycling, to more advanced &nbsp;techniques such as galvanostatic intermittent titration technique (GITT), this webinar is meant to help you navigate this field and chose with confidence with techniques are most fit for your research.</p><p>This webinar is accessible to anyone working in the field of battery, materials research, with or without a background in electrochemistry.</p><blockquote><p><strong>Presenter: </strong>Thomas Touzalin, PhD.&nbsp;</p><p>Product Manager at Metrohm Autolab, helping the electrochemistry researchers achieve their goals by providing the right solution for any research problems as well as offering technical support for the Autolab product range.</p></blockquote>

Metrohm: Electrochemical techniques for battery research and testing

Electrochemical techniques for battery research and testing

Theoretical and practical aspects of various electrochemical techniques for battery research and testing.

<p><strong>In laboratory analysis, pH measurement is a fundamental yet often overlooked hero. However, even the most straightforward tasks can lead to unexpected pitfalls if not performed with precision.</strong></p><p>Imagine a lab where every pH reading is spot-on—analyses are consistent, reliable, and yield top-notch results. This isn’t just a dream; it can be your reality! Join our informative webinar, where we'll guide you through the essentials of pH theory and measurement processes. We’ll also provide expert tips on sensor maintenance and troubleshooting, ensuring you have all the guidance to measure pH confidently.</p><p>With a solid foundation in pH measurement practices, you’ll sharpen your skills and transform the overall quality of your results. Don’t miss this opportunity to enhance your expertise in pH measurement—let’s embark on this journey together!</p><p><strong>Event Program</strong></p><ul><li>The Fundamentals of pH: A Deep Dive into the Basics</li><li>pH Measurement Setup and Workflow: Simplifying and Streamlining Your Measurement Process</li><li>Sensor Maintenance and Troubleshooting: Optimizing Your Sensor Performance</li><li>Good Electrochemistry Practices: Elevating Your Expertise for Precise Results</li><li>Interactive Q&amp;A Session with Our Speaker</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Reena Mascarenhas</p><p>Dr. Mascarenhas is a seasoned electrochemist with over 5 years of dedicated experience at METTLER TOLEDO. Her in-depth knowledge and expertise in the field have made her a sought-after speaker for live webinars. With a strong academic foundation and a passion for electrochemical advancements, Dr. Mascarenhas is committed to sharing her insights and contributing to the growth of the scientific community.</p></blockquote>

What Is pH?

Engage, Explore, and Learn the Key Concepts of pH Measurement.

<p><strong>Fuel cells and electrolyzers are paving the way for a sustainable energy future. But unlocking their full potential demands a deep understanding of the electrochemical processes at work.</strong></p><p>Electrochemical methods are essential for understanding the complex phenomena underlying the operation of electrolyzers and fuel cells, advancing clean energy innovation.</p><p>This webinar offers three focused sessions:</p><ul><li><strong>Scientific Insights:</strong> Francisco Jose Fernandez Carretero will explore key research questions addressed through potentiostats and other electrochemical techniques.</li><li><strong>Best Practices:</strong> Olivier Roux will discuss Electrochemical Impedance Spectroscopy (EIS), emphasizing how to avoid experimental artifacts and ensure accurate measurements.</li><li><strong>Advanced Tools:</strong> Cedric Georges will present BioLogic’s cutting-edge instruments, optimized for advanced electrochemical research.</li></ul><p>The session will conclude with a Q&amp;A, providing attendees an opportunity to engage directly with the speakers.</p><p><strong>Hosted by Dr. Lindsey Monger and Dr.GianLuca Santoni, this webinar will provide actionable strategies for both academic and industrial researchers.</strong></p>

BioLogic: Electrochemical methods for the characterization of electrolyzers and fuel cells

Electrochemical methods for the characterization of electrolyzers and fuel cells

This webinar will provide critical insights into electrochemical methods and best practices, helping you refine your research and achieve more reliable results.

LCMS webinars focusing on Electrochemistry | LabRulez LCMS